Life-threatening bronchiolitis related to electronic cigarette use in a Canadian youth

CMAJ

Volumn 191, Issue 48, 2019, Pages E1321-E1331

  Landman, Simon T ^a   Dhaliwal, Inderdeep ^a   MacKenzie, Constance A ^a,b   Martinu, Tereza ^b   Steele, Andrew ^c   Bosma, Karen J ^a  

^a WESTERN UNIVERSITY   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; AZITHROMYCIN; CEFTRIAXONE; CODEINE; CORTICOSTEROID; FLAVORING AGENT; FORMOTEROL FUMARATE PLUS MOMETASONE FUROATE; GABAPENTIN; METHYLPREDNISOLONE; PIPERACILLIN PLUS TAZOBACTAM; PREDNISONE; SALBUTAMOL; TETRAHYDROCANNABINOL; TIOTROPIUM BROMIDE;

ADOLESCENT; AIRWAY OBSTRUCTION; ARTICLE; ARTIFICIAL VENTILATION; BRONCHIECTASIS; BRONCHIOLITIS; CANADIAN; CASE REPORT; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; COUGHING; CRACKLE; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE DURATION; DRUG MEGADOSE; DYSPNEA; EXERCISE TOLERANCE; EXTRACORPOREAL OXYGENATION; FEVER; GROUPS BY AGE; HOSPITAL DISCHARGE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERCAPNIA; HYPOXEMIA; LIFE THREAT; LUNG AUSCULTATION; LUNG BIOPSY; LUNG FUNCTION TEST; LUNG LAVAGE; MALAISE; MALE; PHYSICAL EXAMINATION; PNEUMOTHORAX; RESPIRATORY TRACT INTUBATION; SMOKING CESSATION; TACHYCARDIA; TREATMENT WITHDRAWAL; VAPING; ACUTE DISEASE; ADVERSE EVENT; BRONCHIOLITIS OBLITERANS; DIAGNOSTIC IMAGING; ELECTRONIC CIGARETTE; LUNG; PATHOLOGY; THORAX RADIOGRAPHY; X-RAY COMPUTED TOMOGRAPHY;

ACUTE DISEASE; ADOLESCENT; BRONCHIOLITIS OBLITERANS; ELECTRONIC NICOTINE DELIVERY SYSTEMS; EXTRACORPOREAL MEMBRANE OXYGENATION; HUMANS; LUNG; MALE; RADIOGRAPHY, THORACIC; RESPIRATION, ARTIFICIAL; TOMOGRAPHY, X-RAY COMPUTED; VAPING;

EID: 85076125261     PISSN: 08203946     EISSN: 14882329     Source Type: Journal    
DOI: 10.1503/cmaj.191402     Document Type: Article

References (79)

1. Canadian Tobacco, Alcohol and Drugs Survey (CTADS): Summary of results for 2017. Ottawa: Health Canada; modified 2019 Jan. 4. Available: www.canada. ca/en/health-canada/services/canadian-tobacco-alcohol-drugs-survey/2017 -summary.html (accessed 2019 Nov. 17).
2. Czoli CD, Hammond D, White CM. Electronic cigarettes in Canada: Prevalence of use and perceptions among youth and young adults. Can J Public Health 2014; 105:e97-102.
3. E-cigarette use among youth and young adults. a report of the Surgeon General. Rockville (MD): US Department of Health Human Services; 2016.
4. Hammond D, Reid JL, Rynard VL, et al. Prevalence of vaping and smoking among adolescents in Canada, England, and the United States: Repeat national cross sectional surveys. BMJ 2019; 365:l2219.
5. Attis M, King J, Hardison D, et al. The journey to ECMO could start with a single vape: A case of severe hypersensitivity pneumonitis in a pediatric patient [lecture]. Proceedings of the 29th Annual Extracorporeal Life Support Organization Conference; 2018 Sept. 13-16; Scottsdale (AZ). 2018:14.
6. Zaborniak K, Kalicinsky C. Hypersensitivity pneumonitis in the setting of electronic cigarette use: A case report [abstract]. Proceedings of the Canadian Society of Allergy and Clinical Immunology Annual Scientific Meeting 2018. Allergy Asthma Clin Immunol 2019; 15:A81.
7. Narang R, Narang D, Narang S, et al. Good, bad, and ugly on vaping. Chest 2015; 148(Suppl):385A. doi: 10.1378/chest.2279115.
8. Sommerfeld CG, Weiner DJ, Nowalk A, et al. Hypersensitivity pneumonitis and acute respiratory distress syndrome from e-cigarette use. Pediatrics 2018; 141: E20163927.
9. Agustin M, Yamamoto M, Cabrera F, et al. Diffuse alveolar hemorrhage induced by vaping. Case Rep Pulmonol 2018; 2018:9724530.
10. Baumann B. A case of organizing pneumonia secondary to use of an electronic nicotine delivery system [abstract]. Canadian Journal of Respiratory, Critical Care, and Sleep Medicine 2019; 3(Suppl 1):9.
11. Khan MS, Khateeb FM, Khan Z, et al. A case of organizing pneumonia related to electronic cigarette use [abstract]. Am J Respir Crit Care Med 2018; 197:A3566.
12. He T, Oks M, Esposito M, et al. "Tree-in-bloom": Severe acute lung injury induced by vaping cannabis oil. Ann Am Thorac Soc 2017; 14:468-70.
13. Mukhopadhyay S, Mehrad M, Dammert P, et al. Lung biopsy findings in severe pulmonary illness associated with e-cigarette use (vaping). Am J Clin Pathol 2019 Oct. 17 [Epub ahead of print]. doi: 10.1093/ajcp/aqz182.
14. Boland JM, Aesif SW. Vaping-associated lung injury: nonspecific histopathologic findings necessitate a clinical diagnosis. Am J Clin Pathol 2019 Oct. 25 [Epub ahead of print]. doi: 10.1093/ajcp/aqz191.
15. Arter ZL, Wiggins A, Hudspath C, et al. Acute eosinophilic pneumonia following electronic cigarette use. Respir Med Case Rep 2019; 27:100825.
16. Thota D, Latham E. Case report of electronic cigarettes possibly associated with eosinophilic pneumonitis in a previously healthy active-duty sailor. J Emerg Med 2014; 47:15-7.
17. McCauley L, Markin C, Hosmer D. An unexpected consequence of electronic cigarette use. Chest 2012; 141:1110-3.
18. Viswam D, Trotter S, Burge PS, et al. Respiratory failure caused by lipoid pneumonia from vaping e-cigarettes. BMJ Case Rep 2018; 2018. pii: Bcr-2018-224350.
19. Holdorf J, Carpenter D, Kopec S. Is it the E.N.D.S.? Chest 2016; 150(Suppl):502A. doi: 10.1016/j.chest.2016.08.516.
20. Modi S, Sangani R, Alhajhusain A. Acute lipoid pneumonia secondary to e-cigarettes use: An unlikely replacement for cigarettes. Chest 2015; 148(Suppl): 382A. doi: 10.1378/chest.2274860.
21. Maddock SD, Cirulis MM, Callahan SJ, et al. Pulmonary lipid-laden macrophages and vaping. N Engl J Med 2019; 381:1488-9.
22. Layden JE, Ghinai I, Pray I, et al. Pulmonary illness related to e-cigarette use in Illinois and Wisconsin - preliminary report. N Engl J Med 2019 Sept. 6 [Epub ahead of print]. doi: 10.1056/NEJMoa1911614.
23. Outbreak of lung injury associated with the use of e-cigarette, or vaping, products. Atlanta: Centers for Disease Control and Prevention; updated 2019 Nov. 14. Available: www.cdc.gov/tobacco/basic_information/e-cigarettes/severe -lung-disease.html (accessed 2019 Nov. 14).
24. National outbreak case definitions: Severe pulmonary disease associated with vaping or dabbing. Ottawa: Public Health Agency of Canada; revised 2019 Sept. 25. Available: www.canada.ca/en/public-health/services/diseases/ vaping -pulmonary-illness/health-professionals/national-case-definition.html (accessed 2019 Nov. 7).
25. Severe lung illness related to vaping. Ottawa: Public Health Agency of Canada; modified 2019 Nov. 14. Available: www.canada.ca/en/public-health/services/ diseases/vaping-pulmonary-illness.html (accessed 2019 Nov. 14).
26. Butt YM, Smith ML, Tazelaar HD, et al. Pathology of vaping-associated lung injury. N Engl J Med 2019; 381:1780-1.
27. Itoh M, Aoshiba K, Herai Y, et al. Lung injury associated with electronic cigarettes inhalation diagnosed by transbronchial lung biopsy. Respirol Case Rep 2017; 6:e00282.
28. Bakre SA, Al-Farra TS, Al-Farra S. Diffuse alveolar damage and e-cigarettes: Case report and review of literature. Respir Med Case Rep 2019; 28:100935.
29. Marasco RD, Loizzi D, Ardò NP, et al. Spontaneous pneumomediastinum after electronic cigarette use. Ann Thorac Surg 2018; 105:e269-71.
30. Fastag E, DeBruin WJ. Spontaneous pneumomediastrinum in an adolescent: Case report and literature review.23rd Pediatric Critical Care Colloquium; 2016 Nov. 11-13. Pediatr Crit Care Med 2017; 18; 7:298-310
31. Lo T. Vaping and tension pneumothorax: A life-threatening association [abstract]. Am J Respir Crit Care Med 2017; 195:A2052.
32. Skertich NJ, Sullivan GA, Madonna MB, et al. Vaping is a risk factor for spontaneous pneumothorax: Two cases. J Pediatr Surg Case Rep 2019; 50: 101305. doi: 10.1016/j.epsc.2019.101305.
33. Bonilla A, Blair AJ, Alamro SM, et al. Recurrent spontaneous pneumothoraces and vaping in an 18-year-old man: A case report and review of the literature. J Med Case Rep 2019; 13:283.
34. Poponea N, Shehada E, Freeman N. The dark side of vaping; acute dyspnea and granulomatous lung disease associated with electronic cigarettes [abstract]. Am J Respir Crit Care Med 2018; 197:A3565.
35. Lin C, Choi H. Granulomatosis due to electronic cigarette use [poster]. Chest 2019; 156(Suppl):A2093.
36. Bradford LE, Rebuli ME, Ring BJ, et al. Danger in the vapor? ECMO for adolescents with status asthmaticus after vaping. J Asthma 2019 July 27 [Epub ahead of print]. doi: 10.1080/02770903.2019.1643361.
37. Hureaux J, Drouet M, Urban T. A case report of subacute bronchial toxicity induced by an electronic cigarette. Thorax 2014; 69:596-7.
38. Sturek J, Malik N. Acute hypoxic respiratory failure with crazy paving associated with electronic cigarette use. Chest 2017; 152(Suppl):A746. doi:10.1016/j.chest.2017.08.776.
39. Carter T, Tucker D, Kilic A, et al. Life-threatening vesicular bronchial injury requiring veno-venous extracorporeal membrane oxygenation rescue in an electronic nicotine delivery system user. Clin Pract Cases Emerg Med 2017; 1:212-7.
40. Atkins G, Drescher F. Acute inhalational lung injury related to the use of electronic nicotine delivery system (ENDS). Chest 2015; 148(Suppl):83A.
41. Flower M, Nandakumar L, Singh M, et al. Respiratory bronchiolitis-associated interstitial lung disease secondary to electronic nicotine delivery system use confirmed with open lung biopsy. Respirol Case Rep 2017; 5:e00230.
42. Helgeson A, Brooks J, Lobo F. A case of hypereosinophilia and eosinophilic asthma due to electronic cigarette use. In: Allergy and Asthma Proceedings. Providence (RI): Oceanside Publications Inc.; 2017.
43. Ring Madsen L, Vinther Krarup NH, Bergmann TK, et al. A cancer that went up in smoke: Pulmonary reaction to e-cigarettes imitating metastatic cancer. Chest 2016; 149:e65-7.
44. Bitetzakis CJ, Diaz Leyva J, Mazalewski W, et al. Pleural effusion with electronic cigarette use: A not-so-safe alternative to tobacco [abstract]. Hospital Medicine meeting; 2018 Apr. 8-11; Orlando (FL).
45. Macedonia TV, Krefft S, Rose CS, et al. Severe fixed obstructive lung disease in a former smoker with heavy e-cigarette use [abstract]. Am J Respir Crit Care Med 2018; 197:A3572.
46. Frossard SM, Volansky PM, Endara-Bravo AS. Acute uvulitis secondary to electronic cigarette use [abstract]. Am J Respir Crit Care Med 2015; 191:A1556.
47. Perrine CG, Pickens CM, Boehmer TK, et al.; Lung Injury Response Epidemiology/ Surveillance Group. Characteristics of a multistate outbreak of lung injury associated with e-cigarette use, or vaping - United States, 2019. MMWR Morb Mortal Wkly Rep 2019; 68:860-4.
48. Canada Consumer Product Safety Act (S.C. 2010, c.21). Available: Https://laws. justice.gc.ca/eng/acts/C-1.68/index.html (accessed 2019 Nov. 7).
49. Information update [September 4, 2019] - Health Canada warns of potential risk of pulmonary illness associated with vaping products. Ottawa: Health Canada; modified 2019 Oct. 17. Available: Https://healthycanadians.gc.ca/ recall -alert-rappel-avis/hc-sc/2019/70919a-eng.php (accessed 2019 Nov. 7).
50. Information update [September 28, 2019]- Health Canada warns of potential risk of pulmonary illness associated with vaping products. Ottawa: Health Canada; modified 2019 Oct. 17. Available: Https://healthycanadians.gc.ca/ recall -alert-rappel-avis/hc-sc/2019/70919a-eng.php (accessed 2019 Nov. 7).
51. Henry TS, Kanne JP, Kligerman SJ. Imaging of vaping-associated lung disease. N Engl J Med 2019; 381:1486-7.
52. Lewis N, McCaffrey K, Sage K, et al. E-cigarette use, or vaping, practices and characteristics among persons with associated lung injury - Utah, April-October 2019. MMWR Morb Mortal Wkly Rep 2019; 68:953-6.
53. Triantafyllou GA, Tiberio PJ, Zou RH, et al. Vaping-associated acute lung injury: A case series. Am J Respir Crit Care Med 2019 Oct. 1 [Epub ahead of print]. doi: 10.1164/rccm.201909-1809LE.
54. Ghinai I, Pray IW, Navon L, et al. E-cigarette product use, or vaping, among persons with associated lung injury - Illinois and Wisconsin, April-September 2019. MMWR Morb Mortal Wkly Rep 2019; 68:865-9.
55. Kreiss K, Gomaa A, Kullman G, et al. Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant. N Engl J Med 2002; 347:330-8.
56. Kanwal R, Kullman G, Piacitelli C, et al. Evaluation of flavorings-related lung disease risk at six microwave popcorn plants. J Occup Environ Med 2006; 48:149-57.
57. Schwarz MI, King TE. Interstitial lung disease, 5th edition. Shelton (CT): People's Medical Publishing House; 2011.
58. Eisenhuber E. The tree-in-bud sign. Radiology 2002; 222:771-2.
59. Miller WT Jr, Panosian JS. Causes and imaging patterns of tree-in-bud opacities. Chest 2013; 144:1883-92.
60. King TJ. Bronchiolitis. In: Interstitial Lung Disease. 2011:1003.
61. Kreiss K. Occupational causes of constrictive bronchiolitis. Curr Opin Allergy Clin Immunol 2013; 13:167-72.
62. Kanwal R. Bronchiolitis obliterans in workers exposed to flavoring chemicals. Curr Opin Pulm Med 2008; 14:141-6.
63. Centers for Disease Control and Prevention (CDC). Fixed obstructive lung disease in workers at a microwave popcorn factory - Missouri, 2000-2002. MMWR Morb Mortal Wkly Rep 2002; 51:345.
64. Centers for Disease Control and Prevention (CDC). Fixed obstructive lung disease among workers in the flavor-manufacturing industry - California, 2004-2007. MMWR Morb Mortal Wkly Rep 2007; 56:389-93.
65. Centers for Disease Control and Prevention (CDC). Obliterative bronchiolitis in workers in a coffee-processing facility - Texas, 2008-2012. MMWR Morb Mortal Wkly Rep 2013; 62:305-7.
66. Christiani DC. Vaping-induced lung injury. N Engl J Med 2019 Sept. 6 [Epub ahead of print]. doi: 10.1056/NEJMe1912032.
67. National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Population Health and Public Health Practice; Committee on the Review of the Health Effects of Electronic Nicotine Delivery Systems. Public health consequences of e-cigarettes. Washington (DC): National Academies Press (US); 2018.
68. Klager S, Vallarino J, MacNaughton P, et al. Flavoring chemicals and aldehydes in e-cigarette emissions. Environ Sci Technol 2017; 51:10806-13.
69. Zhu S-H, Sun JY, Bonnevie E, et al. Four hundred and sixty brands of e-cigarettes and counting: Implications for product regulation. Tob Control 2014; 23(Suppl 3):iii3-9.
70. Safety assessment and regulatory authority to use flavors: Focus on electronic nicotine delivery systems and flavored tobacco products. Washington (DC): Flavor and Extract Manufacturers Association of the United States; 2013, revised 2016 Sept. 26.
71. Mathews JM, Watson SL, Snyder RW, et al. Reaction of the butter flavorant diacetyl (2, 3-butanedione) with N-a-acetylarginine: A model for epitope formation with pulmonary proteins in the etiology of obliterative bronchiolitis. J Agric Food Chem 2010; 58:12761-8.
72. Park H-R, O'Sullivan M, Vallarino J, et al. Transcriptomic response of primary human airway epithelial cells to flavoring chemicals in electronic cigarettes. Sci Rep 2019; 9:1400.
73. Morgan DL, Jokinen MP, Price HC, et al. Bronchial and bronchiolar fibrosis in rats exposed to 2, 3-pentanedione vapors: Implications for bronchiolitis obliterans in humans. Toxicol Pathol 2012; 40:448-65.
74. Palmer SM, Flake GP, Kelly FL, et al. Severe airway epithelial injury, aberrant repair and bronchiolitis obliterans develops after diacetyl instillation in rats. PLoS One 2011; 6:e17644.
75. Brass DM, Gwinn WM, Valente AM, et al. The diacetyl-exposed human airway epithelial secretome: new insights into flavoring-induced airways disease. Am J Respir Cell Mol Biol 2017; 56:784-95.
76. Farsalinos KE, Kistler KA, Gillman G, et al. Evaluation of electronic cigarette liquids and aerosol for the presence of selected inhalation toxins. Nicotine Tob Res 2015; 17:168-74.
77. Vas CA, Porter A, McAdam K. Acetoin is a precursor to diacetyl in e-cigarette liquids. Food Chem Toxicol 2019; 133:110727.
78. E-cigarettes in Canada. Ottawa: Heart and Stroke Canada; 2018. Available: www.heartandstroke.ca/-/media/pdf-files/position-statements/ecigarettes incanada.ashx?la=en&hash=8939FF52C37A5E11C551176982F2E4AC5D 38D605 (accessed 2019 Nov. 7).
79. Vazquez M, Klein B. Trump administration moves to ban flavoured e-cigarettes. CNN 2019 Sept. 11. Available: www.cnn.com/2019/09/11/politics/ donald -trump-vape-e-cigarette-flavors/index.html (accessed 2019 Nov. 7).