Bronchiolitis obliterans in workers exposed to flavoring chemicals

Current Opinion in Pulmonary Medicine

Volumn 14, Issue 2, 2008, Pages 141-146

  Kanwal, Richard ^a  

^a NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

Bronchiolitis obliterans; Diacetyl; Flavorings; Occupational lung disease

Indexed keywords

2,3 BUTANEDIONE; FLAVORING AGENT;

BRONCHIOLITIS OBLITERANS; FOOD INDUSTRY; HUMAN; OCCUPATIONAL DISEASE; OCCUPATIONAL EXPOSURE; OCCUPATIONAL HAZARD; REVIEW; WORKER;

BRONCHIOLITIS OBLITERANS; FLAVORING AGENTS; HUMANS; INCIDENCE; OCCUPATIONAL DISEASES; OCCUPATIONAL EXPOSURE; RISK FACTORS; WORLD HEALTH;

EID: 40149097175     PISSN: 10705287     EISSN: 15316971     Source Type: Journal    
DOI: 10.1097/MCP.0b013e3282f52478     Document Type: Review

References (24)

1. Parmet A, Von Essen S. Rapidly progressive, fixed airway obstructive disease in popcorn workers: a new occupational pulmonary illness? J Occup Environ Med 2002; 44:216-218.
2. Centers for Disease Control and Prevention. Fixed obstructive lung disease in workers at a microwave popcorn factory: Missouri, 2000-2002. MMWR Morb Mortal Wkly Rep 2002; 51:345-347.
3. Kreiss K, Gomaa A, Kullman G, et al. Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant. N Engl J Med 2002; 347:330-338.
4. NIOSH. Hazard evaluation and technical assistance report: Gilster-Mary Lee Corporation, Jasper, Missouri. Cincinnati, Ohio: US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health; 2006. DHHS (NIOSH) Publication No. 2000-0401-2991. Summary of eight serial cross-sectional studies at an index popcorn plant, including evaluation of intervention effectiveness; more accessible publication likely to follow.
5. Kanwal R, Kullman G, Piacitelli C, et al. Evaluation of flavorings-related lung disease at risk at six microwave popcorn plants. J Occup Environ Med 2006; 48:149-157. Combined analyses of industry-wide epidemiologic and exposure assessment which demonstrate risk at apparently low diacetyl exposure levels.
6. NIOSH. Hazard evaluation and technical assistance report: Carmi Flavor and Fragrance Company, Inc., Commerce, California. Cincinnati, Ohio: US Department of Health andHuman Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health; 2007. DHHS (NIOSH) Publication No. 2006-0303-3043. Medical and environmental survey reveals association between severe fixed airways obstruction and work in the production and packaging of powdered flavorings.
7. Centers for Disease Control and Prevention. Fixed obstructive lung disease among workers in the flavor manufacturing industry: California, 2004-2007. MMWR Morb Mortal Wkly Rep 2007; 56:389-393. Article contains case reports and description of findings and prevention efforts of California public health and occupational safety and health agencies.
8. Hazard evaluation and technical assistance report: International Bakers Services, Inc., South Bend, Indiana. Cincinnati: National Institute for Occupational Safety and Health; 1986.DHHS (NIOSH) Publication No. 85-171-1710.
9. Lockey J, McKay R, Barth E, et al. Bronchiolitis obliterans in the food flavoring manufacturing industry [abstract]. Am J Respir Crit Care Med 2002; 165 (Suppl):A461.
10. CDC. Third National Health and Nutrition Examination Survey, 1988-1994, NHANES III Examination Data File [CD-ROM]. Hyattsville, Maryland: US Department of Health and Human Services, Public Health Service, CDC; 1996. Public use data file Documentation No. 76300.
11. Van Rooy F, Rooyackers J, Prokop M, et al. Bronchiolitis obliterans syndrome in chemical workers producing diacetyl for food flavorings. Am J Respir Crit Care Med 2007; 176:498-504. First report of bronchiolitis obliterans in workers who produced diacetyl at a European chemical plant.
12. Hubbs A, Battelli L, Goldsmith W, et al. Necrosis of nasal and airway epithelium in rats inhaling vapors of artificial butter flavoring. Toxicol Appl Pharmacol 2002; 185:128-135.
13. Hubbs A, Battelli L, Mercer R, et al. Inhalation toxicity of the flavoring agent, diacetyl (2,3-butanedione), in the upper respiratory tract of rats. Toxicol Sci 2004; 78 (S1):438-439.
14. Morgan DL, Flake G, Kirby PJ, et al. Respiratory tract toxicity of diacetyl in C57BL/6 mice. In: Program and Abstracts of the Society of Toxicology (SOT) Annual Meeting; 5-9 March 2006; San Diego, California. p. 1029.
15. Harber P, Saechao K, Boomus C. Diacetyl-induced lung disease. Toxicol Rev 2006; 25:261-272. A review of diacetyl toxicology data and discussion of health surveillance considerations for exposed workers.
16. Akpinar-Elci M, Travis W, Lynch D, Kreiss K. Bronchiolitis obliterans syndrome in popcorn plant workers. Eur Resp J 2004; 24:298-302.
17. NIOSH. Hazard evaluation and technical assistance report: American Pop Corn Company, Sioux City, Iowa. Cincinnati, Ohio: US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health; 2004. DHHS (NIOSH) Publication No. 2001-0474-2943.
18. NIOSH. Hazard evaluation and technical assistance report: ConAgra Snack Foods, Marion, Ohio. Cincinnati, Ohio: US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health; 2004. DHHS (NIOSH) Publication No. 2003-0112-2949.
19. Markopoulou K, Cool C, Elliot T, et al. Obliterative bronchiolitis: varying presentations and clinicopathologic correlation. Eur Respir J 2002; 19: 20-30.
20. King T. Bronchiolitis. In: Schwartz M, King T, editors. Interstitial lung disease, 4th ed. Hamilton, Ontario: BC Decker, Inc.; 2003. pp. 787-789.
21. FEMA. Respiratory health and safety in the flavor manufacturing workplace. Washington, DC: The Flavor and Extract Manufacturers Association of the United States; 2004.
22. NIOSH Alert. Preventing lung disease in workers that use or make flavorings. Cincinnati, Ohio: National Institute for Occupational Safety and Health; 2004. DHHS (NIOSH) Publication No. 2004-110.
23. NIOSH. Hazard evaluation and technical assistance report: Yatsko's Popcorn, Sand Coulee, Montana. Cincinnati, Ohio: US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health; 2007. DHHS (NIOSH) Publication No. 2006-0195-3044. Workers at a plant where popcorn was popped, flavored, and bagged had findings suggestive of bronchiolitis obliterans and asthma.
24. American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1995; 152:S77-S120.