Chronic E-cigarette use increases neutrophil elastase and matrix metalloprotease levels in the lung

American Journal of Respiratory and Critical Care Medicine

Volumn 200, Issue 11, 2019, Pages 1392-1401

  Ghosh, Arunava ^a   Coakley, Raymond D ^a   Ghio, Andrew J ^b   Muhlebach, Marianne S ^a   Esther, Charles R ^a   Alexis, Neil E ^a   Tarran, Robert ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

BAL; Nicotine; Protease; Sputum; Vaping

Indexed keywords

ALBUMIN; ALPHA 1 ANTITRYPSIN; CALCIUM ION; COTININE; ELASTASE; GELATINASE A; GELATINASE B; INTERSTITIAL COLLAGENASE; LEUKOCYTE ELASTASE; MATRIX METALLOPROTEINASE; NICOTINE; PROTEINASE; PROTEINASE INHIBITOR; SECRETORY LEUKOCYTE PROTEINASE INHIBITOR; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; BIOLOGICAL MARKER; ELANE PROTEIN, HUMAN; HYDROXYCOTININE;

ADULT; ARTICLE; BRONCHOSCOPY; CIGARETTE SMOKING; CLINICAL ARTICLE; CONTROLLED STUDY; EC50; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; LUNG; LUNG LAVAGE; MACROPHAGE; MALE; NEUTROPHIL; NON-SMOKER; OSMOLARITY; OSMOTIC STRESS; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SPUTUM; WESTERN BLOTTING; ADVERSE EVENT; BRONCHOALVEOLAR LAVAGE FLUID; CHEMISTRY; DRUG EFFECT; ENZYMOLOGY; METABOLISM; VAPING;

ADULT; BIOMARKERS; BRONCHOALVEOLAR LAVAGE FLUID; COTININE; FEMALE; HUMANS; LEUKOCYTE ELASTASE; LUNG; MACROPHAGES; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASES; NEUTROPHILS; NICOTINE; VAPING;

EID: 85075705125     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201903-0615OC     Document Type: Article

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