Systematic review on respiratory syncytial virus epidemiology in adults and the elderly in Latin America

International Journal of Infectious Diseases

Volumn 90, Issue , 2020, Pages 170-180

  Ali, Abraham ^a   Lopardo, Gustavo ^b   Scarpellini, Bruno ^c   Stein, Renato T ^d   Ribeiro, Diogo ^e  

^a FUNDACIÓN NEUMOLÓGICA COLOMBIANA   (Colombia)

^b Hospital Bernardo Houssay in northern Buenos Aires   (Argentina)

^c Avenida Presidente Juscelino Kubitschek   (Brazil)

^d PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^e CTI Clinical Trial and Consulting Services   (Portugal)

Author keywords

Adults; Burden; Latin America; Respiratory Syncytial Virus; Upper respiratory tract infections

Indexed keywords

ANTIBIOTIC AGENT; ANTIVIRUS AGENT; STEROID;

ADULT; AGED; ANTIVIRAL THERAPY; CLINICAL PRACTICE; COMMUNITY ACQUIRED PNEUMONIA; FLU LIKE SYNDROME; HOSPITALIZATION; HUMAN; HUMAN RESPIRATORY SYNCYTIAL VIRUS; INFECTION PREVENTION; PREVALENCE; RESPIRATORY SYNCYTIAL VIRUS INFECTION; REVIEW; RISK FACTOR; SOUTH AND CENTRAL AMERICA; SYSTEMATIC REVIEW; SYSTEMIC THERAPY; VIRAL RESPIRATORY TRACT INFECTION; VIRUS DETECTION; CLASSIFICATION; COMMUNITY ACQUIRED INFECTION; FEMALE; GENETICS; ISOLATION AND PURIFICATION; MALE; META ANALYSIS; MIDDLE AGED; VERY ELDERLY; VIROLOGY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; COMMUNITY-ACQUIRED INFECTIONS; FEMALE; HOSPITALIZATION; HUMANS; LATIN AMERICA; MALE; MIDDLE AGED; PREVALENCE; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; RISK FACTORS; YOUNG ADULT;

EID: 85075313909     PISSN: 12019712     EISSN: 18783511     Source Type: Journal    
DOI: 10.1016/j.ijid.2019.10.025     Document Type: Review

References (50)

1. Ackerson, B., Tseng, H.F., Sy, L.S., Solano, Z., Slezak, J., Luo, Y., et al. Severe morbidity and mortality associated with respiratory syncytial virus versus influenza infection in hospitalized older adults. Clin Infect Dis 69:July 2 (2019), 197–203.
2. Ambrosch, A., Klinger, A., Luber, D., Arp, C., Lepiorz, M., Schroll, S., et al. Clinical characteristics and course of infections by influenza a- and respiratory syncytial virus (RSV) in hospitalized adults. Dtsch Med Wochenschr 1946 143:May 9 (2018), e68–75.
3. Bardach, A., Rey-Ares, L., Cafferata, M.L., Cormick, G., Romano, M., Ruvinsky, S., et al. Systematic review and meta-analysis of respiratory syncytial virus infection epidemiology in Latin America. Rev Med Virol 24:March 2 (2014), 76–89.
4. Belongia, E.A., King, J.P., Kieke, B.A., Pluta, J., Al-Hilli, A., Meece, J.K., et al. Clinical features, severity, and incidence of RSV Illness During 12 consecutive seasons in a community cohort of adults ≥60 Years Old. Open Forum Infect Dis, 5(November 12), 2018.
5. Bermúdez F, J.E., Gotera Z, J.L., Mavares M, A.R., Calles U, A.D., Paredes L, C.R., Pirela I, D.P., et al. Detección de anticuerpos contra agentes virales y bacterias atípicas en el suero de pacientes con infección respiratoria, Estado Zulia- Venezuela, periodo 2005 – 2010. Kasmera, 2014, 141–155.
6. Chatzis, O., Darbre, S., Pasquier, J., Meylan, P., Manuel, O., Aubert, J.D., et al. Burden of severe RSV disease among immunocompromised children and adults: a 10 year retrospective study. BMC Infect Dis, 18(1), 2018, 111.
7. Colosia, A.D., Yang, J., Hillson, E., Mauskopf, J., Copley-Merriman, C., Shinde, V., et al. The epidemiology of medically attended respiratory syncytial virus in older adults in the United States: a systematic review. PLoS One, 12(August 8), 2017.
8. Comach, G., Teneza-Mora, N., Kochel, T.J., Espino, C., Sierra, G., Camacho, D.E., et al. Sentinel surveillance of influenza-like illness in two hospitals in Maracay, Venezuela: 2006–2010. PLoS One, 7(September 9), 2012, e44511.
9. Comas-García, A., García-Sepúlveda, C.A., Méndez-de Lira, J.J., Aranda-Romo, S., Hernández-Salinas, A.E., Noyola, D.E., Mortality attributable to pandemic influenza A (H1N1) 2009 in San Luis Potosí, Mexico. Influenza Other Respir Viruses 5:March 2 (2011), 76–82.
10. Dowell, S.F., Anderson, L.J., Gary, H.E., Erdman, D.D., Plouffe, J.F., File, T.M., et al. Respiratory syncytial virus is an important cause of community-acquired lower respiratory infection among hospitalized adults. J Infect Dis 174:September 3 (1996), 456–462.
11. Falsey, A.R., Hennessey, P.A., Formica, M.A., Cox, C., Walsh, E.E., Respiratory syncytial virus infection in elderly and high-risk adults. N Engl J Med 352:April 17 (2005), 1749–1759.
12. Falsey, A.R., McElhaney, J.E., Beran, J., van Essen, G.A., Duval, X., Esen, M., et al. Respiratory syncytial virus and other respiratory viral infections in older adults with moderate to severe influenza-like illness. J Infect Dis 209:12 (2014), 1873–1881.
13. Falsey, A.R., Walsh, E.E., Respiratory syncytial virus infection in adults. Clin Microbiol Rev 13:July 3 (2000), 371–384.
14. Fang, G.D., Fine, M., Orloff, J., Arisumi, D., Yu, V.L., Kapoor, W., et al. New and emerging etiologies for community-acquired pneumonia with implications for therapy. A prospective multicenter study of 359 cases. Medicine (Baltimore) 69:September 5 (1990), 307–316.
15. Fernandes-Matano, L., Monroy-Muñoz, I.E., Angeles-Martínez, J., Sarquiz-Martinez, B., Palomec-Nava, I.D., Pardavé-Alejandre, H.D., et al. Prevalence of non-influenza respiratory viruses in acute respiratory infection cases in Mexico. PLoS One, 12(May 5), 2017, e0176298.
16. Freitas, F.T. de M., Sentinel surveillance of influenza and other respiratory viruses, Brazil, 2000-2010. Braz J Infect Dis Off Publ Braz Soc Infect Dis 17:February 1 (2013), 62–68.
17. Galindo-Fraga, A., Ortiz-Hernández, A.A., Ramírez-Venegas, A., Vázquez, R.V., Moreno-Espinosa, S., Llamosas-Gallardo, B., et al. Clinical characteristics and outcomes of influenza and other influenza-like illnesses in Mexico City. Int J Infect Dis IJID Off Publ Int Soc Infect Dis, 17(July 7), 2013, e510-517.
18. Gamiño-Arroyo, A.E., Moreno-Espinosa, S., Llamosas-Gallardo, B., Ortiz-Hernández, A.A., Guerrero, M.L., Galindo-Fraga, A., et al. Epidemiology and clinical characteristics of respiratory syncytial virus infections among children and adults in Mexico. Influenza Other Respir Viruses 11:1 (2017), 48–56.
19. Gökçe, Ş., Kurugöl, Z., Koturoğlu, G., Çiçek, C., Aslan, A., Etiology, seasonality, and clinical features of viral respiratory tract infections in children hospitalized with acute bronchiolitis: a single-center study. Glob Pediatr Health, 4(June), 2017.
20. Hall, C.B., Respiratory syncytial virus and parainfluenza virus. N Engl J Med 344:June 25 (2001), 1917–1928.
21. Hall, W.J., Respiratory syncytial virus infection in adults: clinical, virologic, and serial pulmonary function studies. Ann Intern Med, 88(February 2), 1978, 203.
22. Johnstone, J., Majumdar, S.R., Fox, J.D., Marrie, T.J., Viral infection in adults hospitalized with community-acquired pneumonia: prevalence, pathogens, and presentation. Chest 134:December 6 (2008), 1141–1148.
23. Kestler, M., Muñoz, P., Mateos, M., Adrados, D., Bouza, E., Respiratory syncytial virus burden among adults during flu season: an underestimated pathology. J Hosp Infect 100:December 4 (2018), 463–468.
24. Kwon, Y.S., Park, S.H., Kim, M.-A., Kim, H.J., Park, J.S., Lee, M.Y., et al. Risk of mortality associated with respiratory syncytial virus and influenza infection in adults. BMC Infect Dis, 17(December), 2017.
25. Lee, N., Lui, G.C.Y., Wong, K.T., Li, T.C.M., Tse, E.C.M., Chan, J.Y.C., et al. High morbidity and mortality in adults hospitalized for respiratory syncytial virus infections. Clin Infect Dis Off Publ Infect Dis Soc Am 57:October 8 (2013), 1069–1077.
26. de Lima, C.R.A., Mirandolli, T.B., Carneiro, L.C., Tusset, C., Romer, C.M., Andreolla, H.F., et al. Prolonged respiratory viral shedding in transplant patients. Transpl Infect Dis Off J Transplant Soc 16:February 1 (2014), 165–169.
27. Luchsinger, V., Piedra, P.A., Ruiz, M., Zunino, E., Martínez, M.A., Machado, C., et al. Role of neutralizing antibodies in adults with community-acquired pneumonia by respiratory syncytial virus. Clin Infect Dis Off Publ Infect Dis Soc Am 54:April 7 (2012), 905–912.
28. McCracken, J.P., Prill, M.M., Arvelo, W., Lindblade, K.A., López, M.R., Estevez, A., et al. Respiratory syncytial virus infection in Guatemala, 2007-2012. J Infect Dis 208:December Suppl 3 (2013), S197–206.
29. Med Crave, Seasonality of respiratory syncytial virus - lower respiratory tract infection (RSV-LRTI) in children in developing countries. J Hum Virol Retrovirology [Internet], 2016 [cited 2019 Aug 9]; Vol 3 (January Issue 1). Available from: http://medcraveonline.com/JHVRV/JHVRV-03-00076.pdf.
30. Moher, D., Liberati, A., Tetzlaff, J., Altman, D.G., PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med, 6(July 7), 2009, e1000097.
31. Monteiro, C.C., Dezanet, L.N.C., França, E.B., Monteiro, C.C., Dezanet, L.N.C., França, E.B., Monitoramento de vírus respiratórios na região metropolitana de Belo Horizonte, 2011 a 2013. Epidemiol E Serviços Saúde 25:June 2 (2016), 233–242.
32. Moore, H.C., Jacoby, P., Hogan, A.B., Blyth, C.C., Mercer, G.N., Modelling the seasonal epidemics of respiratory syncytial virus in young children. PLoS One, 9(June 6), 2014.
33. Mullooly, J.P., Bridges, C.B., Thompson, W.W., Chen, J., Weintraub, E., Jackson, L.A., et al. Influenza- and RSV-associated hospitalizations among adults. Vaccine 25:January 5 (2007), 846–855.
34. Peñafiel, S.F., Gutiérrez, O.M., López, F.G., Aránguiz, E., Manuel, J., Monasterio, U.J., et al. Participación de los virus respiratorios en la neumonía del adulto inmunocompetente adquirida en la comunidad. Rev Médica Chile 144:December 12 (2016), 1513–1522.
35. Piedimonte, G., Perez, M.K., Respiratory syncytial virus infection and bronchiolitis. Pediatr Rev 35:December 12 (2014), 519–530.
36. Ramirez, J., Pulido Dominguez, P., Rey Benito, G., Mendez Rico, J., Castellanos, J., Páez Martinez, A., Human respiratory syncytial virus and metapneumovirus in patients with acute respiratory infection in Colombia, 2000 - 2011. Rev Panam Salud Publica Pan Am J Public Health 36:August 2 (2014), 101–109.
37. Rioseco, M.L., Riquelme, O.M., Inzunza, P.C., Oyarzún, G.P., Agüero, O.Y., Ferrés, G.M., et al. Etiología viral en la neumonía del adulto adquirida en la comunidad en un hospital del sur de Chile. Rev Médica Chile 140:August 8 (2012), 984–989.
38. Riquelme, R., Rioseco, M.L., Agüero, Y., Ubilla, D., Mechsner, P., Inzunza, C., et al. Respiratory virus infections in adult patients hospitalized in an internal medicine unit. Rev Med Chil 142:June 6 (2014), 696–701.
39. Rodríguez-Auad, J.P., Nava-Frías, M., Casasola-Flores, J., Johnson, K.M., Nava-Ruiz, A., Pérez-Robles, V., et al. The epidemiology and clinical characteristics of respiratory syncytial virus infection in children at a public pediatric referral hospital in Mexico. Int J Infect Dis 16:July 7 (2012), e508–513.
40. Rodríguez-Martínez, C.E., Rodríguez, D.A., Nino, G., Respiratory syncytial virus, adenoviruses, and mixed acute lower respiratory infections in children in a developing country. J Med Virol 87:May 5 (2015), 774–781.
41. Schweitzer, J.W., Justice, N.A., Respiratory Syncytial Virus Infection (RSV). StatPearls [Internet]. Treasure Island (FL), 2018, StatPearls Publishing Available from: http://www.ncbi.nlm.nih.gov/books/NBK459215/.
42. Thompson, W.W., Shay, D.K., Weintraub, E., Brammer, L., Cox, N., Anderson, L.J., et al. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA 289:January 2 (2003), 179–186.
43. Volling, C., Hassan, K., Mazzulli, T., Green, K., Al-Den, A., Hunter, P., et al. Respiratory syncytial virus infection-associated hospitalization in adults: a retrospective cohort study. BMC Infect Dis, 14(December), 2014, 665.
44. Walsh, E.E., Falsey, A.R., Respiratory syncytial virus infection in adult populations. Infect Disord Drug Targets 12:April 2 (2012), 98–102.
45. Walsh, E.E., Peterson, D.R., Falsey, A.R., Is clinical recognition of respiratory syncytial virus infection in hospitalized elderly and high-risk adults possible?. J Infect Dis 195:April 7 (2007), 1046–1051.
46. Watanabe, A.S.A., Carraro, E., Candeias, J.M.G., Donalísio, M.R., Leal, E., Granato, C.F.H., et al. Viral etiology among the elderly presenting acute respiratory infection during the influenza season. Rev Soc Bras Med Trop 44:February 1 (2011), 18–21.
47. Zambrano, G., Lucila, J., Montes, M., Rosana, A., Fereira, B., Enmanuel, J., et al. Seroprevalencia de virus respiratorios y bacterias atípicas en una población del estado Zulia, Venezuela. Rev Soc Venez Microbiol 32:December 2 (2012), 148–152.
48. PAHO, Influenza and RSV Percent Positivity / Influenza y VSR porcentaje de positividad. [Internet]. [Cited 2019a 9 August]. Available from:, 2019 http://ais.paho.org/phip/viz/ed_flu.asp.
49. WHO, WHO surveillance case definitions for ILI and SARI [Internet]. [Cited 2019c 12 August]. Available from:, 2014 http://www.who.int/influenza/surveillance_monitoring/ili_sari_surveillance_case_definition/en/.
50. WHO, RSV surveillance case definitions [Internet]. [Cited 2019b 12 August]. Available from:, 2017 http://www.who.int/influenza/rsv/rsv_case_definition/en/.