The epidemiology and clinical characteristics of respiratory syncytial virus infection in children at a public pediatric referral hospital in Mexico

International Journal of Infectious Diseases

Volumn 16, Issue 7, 2012, Pages

  Rodríguez Auad, Juan Pablo ^a   Nava Frías, Margarita ^a   Casasola Flores, Jesús ^a   Johnson, Kyle M ^b   Nava Ruiz, Alejandra ^a   Pérez Robles, Víctor ^a   Caniza, Miguela A ^b,c  

^a HOSPITAL INFANTIL DE MÉXICO FEDERICO GÓMEZ   (Mexico)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^c UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

Author keywords

Children; High risk; Latin America; Mexico; Nosocomial; Respiratory infection; Respiratory syncytial virus

Indexed keywords

AMIKACIN; AMOXICILLIN PLUS CLAVULANIC ACID; AMPICILLIN; CEFEPIME; CEFOTAXIME; CEFUROXIME; CLARITHROMYCIN; DICLOXACILLIN; PALIVIZUMAB; RIBAVIRIN;

ABNORMAL RESPIRATORY SOUND; ADOLESCENT; ADULT; ARTICLE; ARTIFICIAL VENTILATION; BACTERIAL PNEUMONIA; BRONCHIOLITIS; CAUSE OF DEATH; CHILD; CLINICAL FEATURE; CONGENITAL HEART DISEASE; DISEASE SEVERITY; FEMALE; HOSPITAL INFECTION; HOSPITALIZATION; HUMAN; INFANT; INTENSIVE CARE UNIT; LUNG INFILTRATE; MAJOR CLINICAL STUDY; MALE; MEDICAL INFORMATION; MEXICO; OBSERVATIONAL STUDY; OTITIS; PHARYNGITIS; PNEUMONIA; PRESCHOOL CHILD; PUBLIC HOSPITAL; RESPIRATORY SYNCYTIAL VIRUS INFECTION; RETROSPECTIVE STUDY; RHINITIS; SCHOOL CHILD; THORAX RADIOGRAPHY; TREATMENT OUTCOME; WHEEZING;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; CROSS INFECTION; FEMALE; HOSPITALS, PEDIATRIC; HOSPITALS, PUBLIC; HUMANS; INFANT; INFANT, NEWBORN; MALE; MEXICO; REFERRAL AND CONSULTATION; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; YOUNG ADULT;

EID: 84862532574     PISSN: 12019712     EISSN: 18783511     Source Type: Journal    
DOI: 10.1016/j.ijid.2012.03.001     Document Type: Article

References (44)

1. Nair H., Nokes D.J., Gessner B.D., Dherani M., Madhi S.A., Singleton R.J., et al. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet 2010, 375:1545-1555.
2. Stensballe L.G. An epidemiological study of respiratory syncytial virus associated hospitalizations in Denmark. Respir Res 2002, 3(Suppl 1):S34-S39.
3. Pezzotti P., Mantovani J., Benincori N., Mucchino E., Di Lallo D. Incidence and risk factors of hospitalization for bronchiolitis in preterm children: a retrospective longitudinal study in Italy. BMC Pediatr 2009, 9:56.
4. Blanchard S.S., Gerrek M., Siegel C., Czinn S.J. Significant morbidity associated with RSV infection in immunosuppressed children following liver transplantation: case report and discussion regarding need of routine prophylaxis. Pediatr Transplant 2006, 10:826-829.
5. Ebbert J.O., Limper A.H. Respiratory syncytial virus pneumonitis in immunocompromised adults: clinical features and outcome. Respiration 2005, 72:263-269.
6. World Health Organization. Respiratory syncytial virus and parainfluenza viruses. Geneva: WHO; 2009. Available at: (accessed September 24, 2010). http://www.who.int/vaccine_research/diseases/ari/en/index2.html.
7. Thompson W.W., Shay D.K., Weintraub E., Brammer L., Cox N., Anderson L.J., et al. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA 2003, 289:179-186.
8. Berkley J.A., Munywoki P., Ngama M., Kazungu S., Abwao J., Bett A., et al. Viral etiology of severe pneumonia among Kenyan infants and children. JAMA 2010, 303:2051-2057.
9. Noyola D.E., Rodriguez-Moreno G., Sanchez-Alvarado J., Martinez-Wagner R., Ochoa-Zavala R. Viral etiology of lower respiratory tract infections in hospitalized children in Mexico. Pediatr Infect Dis J 2004, 23:118-123.
10. Light M., Bauman J., Mavunda K., Malinoski F., Eggleston M. Correlation between respiratory syncytial virus (RSV) test data and hospitalization of children with lower respiratory tract illness in Florida. Pediatr Infect Dis J 2008, 27:512-518.
11. Simon A., Muller A., Khurana K., Engelhart S., Exner M., Schildgen O., et al. Nosocomial infection: a risk factor for a complicated course in children with respiratory syncytial virus infection-results from a prospective multicenter German surveillance study. Int J Hyg Environ Health 2008, 211:241-250.
12. Diez D.J., Ridao L.M., Ubeda S.I., Ballester S.A. [Incidence and cost of hospitalizations for bronchiolitis and respiratory syncytial virus infections in the autonomous community of Valencia in Spain (2001 and 2002)]. An Pediatr (Barc) 2006, 65:325-330.
13. Noyola D.E., Zuviri-Gonzalez A., Castro-García J.A., Ochoa-Zavala J.R. Impact of respiratory syncytial virus on hospital admissions in children younger than 3 years of age. J Infect 2007, 54:180-184.
14. Silverman W.A., Andersen D.H. A controlled clinical trial of effects of water mist on obstructive respiratory signs, death rate and necropsy findings among premature infants. Pediatrics 1956, 17:1-10.
15. Hall C.B. The nosocomial spread of respiratory syncytial viral infections. Annu Rev Med 1983, 34:311-319.
16. American Academy of Pediatrics. Respiratory syncytial virus. In: Pickering LK, Baker C, Kimberlin DW, Long SS, editors. Red book: 2009 report of the Committee on Infectious Diseases. Elk Grove Village, IL: American Academy of Pediatrics; 2009. p. 560-9.
17. Wahab A.A., Dawod S.T., Raman H.M. Clinical characteristics of respiratory syncytial virus infection in hospitalized healthy infants and young children in Qatar. J Trop Pediatr 2001, 47:363-366.
18. García C.G., Bhore R., Soriano-Fallas A., Trost M., Chason R., Ramilo O., et al. Risk factors in children hospitalized with RSV bronchiolitis versus non-RSV bronchiolitis. Pediatrics 2010, 126:e1453-e1460.
19. Simoes E.A. Respiratory syncytial virus. Lancet 1999, 354:847-852.
20. Tristram D.A., Welliver R.C. Respiratory syncytial virus. Principles and practices of pediatric infectious diseases 2003, 1140-1148. Churchill Livingstone, Philadelphia, PA. 2nd ed. S.S. Long, L.K. Pickering, C.G. Prober (Eds.).
21. Boyce T.G., Mellen B.G., Mitchel E.F., Wright P.F., Griffin M.R. Rates of hospitalization for respiratory syncytial virus infection among children in Medicaid. J Pediatr 2000, 137:865-870.
22. Thorburn K. Pre-existing disease is associated with a significantly higher risk of death in severe respiratory syncytial virus infection. Arch Dis Child 2009, 94:99-103.
23. Macartney K.K., Gorelick M.H., Manning M.L., Hodinka R.L., Bell L.M. Nosocomial respiratory syncytial virus infections: the cost-effectiveness and cost-benefit of infection control. Pediatrics 2000, 106:520-526.
24. Lavergne V., Ghannoum M., Weiss K., Roy J., Beliveau C. Successful prevention of respiratory syncytial virus nosocomial transmission following an enhanced seasonal infection control program. Bone Marrow Transplant 2011, 46:137-142.
25. Hall C.B. Nosocomial respiratory syncytial virus infections: the "Cold War" has not ended. Clin Infect Dis 2000, 31:590-596.
26. Groothuis J., Bauman J., Malinoski F., Eggleston M. Strategies for prevention of RSV nosocomial infection. J Perinatol 2008, 28:319-323.
27. Simon A., Khurana K., Wilkesmann A., Muller A., Engelhart S., Exner M., et al. Nosocomial respiratory syncytial virus infection: impact of prospective surveillance and targeted infection control. Int J Hyg Environ Health 2006, 209:317-324.
28. Bont L. Nosocomial RSV infection control and outbreak management. Paediatr Respir Rev 2009, 10(Suppl 1):16-17.
29. Tsitsikas D.A., Oakervee H., Cavenagh J.D., Gribben J., Agrawal S.G., Mattes F.M. Treatment of respiratory syncytial virus infection in haematopoietic stem cell transplant recipients with aerosolized ribavirin and the humanized monoclonal antibody palivizumab: a single centre experience. Br J Haematol 2009, 146:574-576.
30. Empey K.M., Peebles R.S., Kolls J.K. Pharmacologic advances in the treatment and prevention of respiratory syncytial virus. Clin Infect Dis 2010, 50:1258-1267.
31. Boeckh M., Berrey M.M., Bowden R.A., Crawford S.W., Balsley J., Corey L. Phase 1 evaluation of the respiratory syncytial virus-specific monoclonal antibody palivizumab in recipients of hematopoietic stem cell transplants. J Infect Dis 2001, 184:350-354.
32. Ghosh S., Champlin R.E., Englund J., Giralt S.A., Rolston K., Raad I., et al. Respiratory syncytial virus upper respiratory tract illnesses in adult blood and marrow transplant recipients: combination therapy with aerosolized ribavirin and intravenous immunoglobulin. Bone Marrow Transplant 2000, 25:751-755.
33. Kimpen J.L. Prevention and treatment of respiratory syncytial virus bronchiolitis and postbronchiolitic wheezing. Respir Res 2002, 3(Suppl 1):S40-S45.
34. Fretzayas A., Moustaki M. The challenges of RSV vaccines. Where do we stand?. Recent Pat Antiinfect Drug Discov 2010, 5:99-107.
35. Checchia P. Identification and management of severe respiratory syncytial virus. Am J Health Syst Pharm 2008, 65(Suppl 8):S7-S12.
36. Langley J.M., Smith M.B., LeBlanc J.C., Joudrey H., Ojah C.R., Pianosi P. Racemic epinephrine compared to salbutamol in hospitalized young children with bronchiolitis; a randomized controlled clinical trial [ISRCTN46561076]. BMC Pediatr 2005, 5:7.
37. Flores G., Horwitz R.I. Efficacy of beta2-agonists in bronchiolitis: a reappraisal and meta-analysis. Pediatrics 1997, 100:233-239.
38. Schuh S., Coates A.L., Binnie R., Allin T., Goia C., Corey M., et al. Efficacy of oral dexamethasone in outpatients with acute bronchiolitis. J Pediatr 2002, 140:27-32.
39. Bentur L., Shoseyov D., Feigenbaum D., Gorichovsky Y., Bibi H. Dexamethasone inhalations in RSV bronchiolitis: a double-blind, placebo-controlled study. Acta Paediatr 2005, 94:866-871.
40. McCarthy C.A., Hall C.B. Respiratory syncytial virus: concerns and control. Pediatr Rev 2003, 24:301-309.
41. Hess D.R. Retrospective studies and chart reviews. Respir Care 2004, 49:1171-1174.
42. Bezerra P.G., Britto M.C., Correia J.B., Duarte Mdo C., Fonceca A.M., Rose K., et al. Viral and atypical bacterial detection in acute respiratory infection in children under five years. PLoS One 2011, 6:e18928.
43. Stensballe L.G., Kofoed P.E., Nante E.J., Sambo M., Jensen I.P., Aaby P. Duration of secretory IgM and IgA antibodies to respiratory syncytial virus in a community study in Guinea-Bissau. Acta Paediatr 2000, 89:421-426.
44. Hall C.B., Weinberg G.A., Iwane M.K., Blumkin A.K., Edwards K.M., Staat M.A., et al. The burden of respiratory syncytial virus infection in young children. N Engl J Med 2009, 360:588-598.