Effects of Lactobacillus reuteri DSM 17938 in preterm infants: A double-blinded randomized controlled study

Italian Journal of Pediatrics

Volumn 45, Issue 1, 2019, Pages

  Cui, Xuewei ^a   Shi, Yongyan ^a   Gao, Siyang ^a   Xue, Xindong ^a   Fu, Jianhua ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Feeding tolerance; Growth; Infection prevention; Lactobacillus reuteri; Preterm infant

Indexed keywords

ARTICLE; ARTIFICIAL MILK; BIRTH WEIGHT; BODY HEIGHT; BODY WEIGHT GAIN; CHILD GROWTH; COLONY FORMING UNIT; CONTROLLED STUDY; DEFECATION MEASUREMENT; DIARRHEA; ENTERIC FEEDING; FEEDING; FEMALE; FLATULENCE; GESTATIONAL AGE; HEAD CIRCUMFERENCE; HOSPITAL DISCHARGE; HOSPITALIZATION; HUMAN; INCIDENCE; INFANT; INFECTION PREVENTION; LACTOBACILLUS REUTERI; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; NUTRITIONAL TOLERANCE; PREMATURITY; RANDOMIZED CONTROLLED TRIAL; SEPSIS; THERAPY EFFECT; CHILD DEVELOPMENT; DEFECATION; DOUBLE BLIND PROCEDURE; INFANT NUTRITION; NEWBORN;

PROBIOTIC AGENT;

CHILD DEVELOPMENT; DEFECATION; DOUBLE-BLIND METHOD; FEMALE; GESTATIONAL AGE; HUMANS; INFANT NUTRITIONAL PHYSIOLOGICAL PHENOMENA; INFANT, NEWBORN; INFANT, PREMATURE; LACTOBACILLUS REUTERI; LENGTH OF STAY; MALE; PROBIOTICS;

EID: 85074742456     PISSN: 17208424     EISSN: 18247288     Source Type: Journal    
DOI: 10.1186/s13052-019-0716-9     Document Type: Article

References (32)

1. Tudehope D, Fewtrell M, Kashyap S, Udaeta E. Nutritional needs of the micropreterm infant. J Pediatr. 2013;162(3):S72-80. https://doi.org/10.1016/j.jpeds.2012.11.056.
2. Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, et al. Expert consensus document: the international scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014;11(8):506-14. https://doi.org/10.1038/nrgastro.2014.66.
3. Guarner F, Khan AG, Garisch J, Eliakim R, Gangl A, Thomson A, et al. World gastroenterology organisation global guidelines: probiotics and prebiotics october 2011. J Clin Gastroenterol. 2012;46(6):468-81. https://doi.org/10.1097/MCG.0b013e3182549092.
4. Indrio F, Riezzo G, Raimondi F, Bisceglia M, Cavallo L, Francavilla R. Effects of probiotic and prebiotic on gastrointestinal motility in newborns. J Physiol Pharmacol. 2009;60(Suppl 6):27-31.
5. Valeur N, Engel P, Carbajal N, Connolly E, Ladefoged K. Colonization and immunomodulation by lactobacillus reuteri ATCC 55730 in the human gastrointestinal tract. Appl Environ Microbiol. 2004;70(2):1176-81. https://doi.org/10.1128/AEM.70.2.1176-1181.2004.
6. Wolf B, Garleb K, Ataya D, Casas I. Safety and tolerance of lactobacillus reuteri in healthy adult male subjects. Microb Ecol Health Dis. 1995;8(2):41-50. https://doi.org/10.3109/08910609509141381.
7. Cameron D, Hock QS, Kadim M, Mohan N, Ryoo E, Sandhu B, et al. Probiotics for gastrointestinal disorders: proposed recommendations for children of the Asia-Pacific region. World J Gastroenterol. 2017;23(45):7952-64. https://doi.org/10.3748/wjg.v23.i45.7952.
8. Hojsak I, Fabiano V, Pop TL, Goulet O, Zuccotti GV, Çokuǧraş FC, et al. Guidance on the use of probiotics in clinical practice in children with selected clinical conditions and in specific vulnerable groups. Acta Paediatr. 2018;107(6):927-37. https://doi.org/10.1111/apa.14270.
9. Cai W, Tang Q, Wang Y, Fen Y, Wu J, Qian L. Guidelines for clinical application of neonatal nutrition support in China. J Clin Pediatr. 2013;31(12):1177-82.
10. Rudolph CD, Mazur LJ, Liptak GS, Baker RD, Boyle JT, Colletti RB, et al. Guidelines for evaluation and treatment of gastroesophageal reflux in infants and children: recommendations of the north American Society for Pediatric Gastroenterology and Nutrition. J Pediatr Gastroenterol Nutr. 2001;32:S1-S31. https://doi.org/10.1097/00005176-200100002-00001.
11. Stoll BJ. Infections of the neonatal infant. In: Behrman R, Kliegman R, HB J, editors. Nelson textbook of pediatrics. 17th ed. Philadelphia: WB Saunders; 2004.
12. Walsh MC, Kliegman RM, Fanaroff AA. Necrotizing enterocolitis: a practitioner's perspective. Pediatr Rev. 1988;9(7):219-26. https://doi.org/10.1542/pir.9-7-219.
13. Vandenplas Y, Gutierrez-Castrellon P, Velasco-Benitez C, Palacios J, Jaen D, Ribeiro H, et al. Practical algorithms for managing common gastrointestinal symptoms in infants. Nutrition. 2013;29(1):184-94. https://doi.org/10.1016/j.nut.2012.08.008.
14. Olsen R, Greisen G, Schrøder M, Brok J. Prophylactic probiotics for preterm infants: a systematic review and meta-analysis of observational studies. Neonatology. 2016;109(2):105-12. https://doi.org/10.1159/000441274.
15. Dermyshi E, Mackie C, Kigozi P, Schoonakker B, Dorling J. Antacid therapy for gastroesophageal reflux in preterm infants: a systematic review. BMJ Paediatr Open. 2018;2(1):e000287. https://doi.org/10.1136/bmjpo-2018-000287.
16. Garofoli F, Civardi E, Indrio F, Mazzucchelli I, Angelini M, Tinelli C, et al. The early administration of lactobacillus reuteri DSM 17938 controls regurgitation episodes in full-term breastfed infants. Int J Food Sci Nutr. 2014;65(5):646-8. https://doi.org/10.3109/09637486.2014.898251.
17. Wu R, Pasyk M, Wang B, Forsythe P, Bienenstock J, Mao YK, et al. Spatiotemporal maps reveal regional differences in the effects on gut motility for lactobacillus reuteri and rhamnosus strains. Neurogastroenterol Motil. 2013;25(3):e205-e14. https://doi.org/10.1111/nmo.12072.
18. Indrio F, Riezzo G, Raimondi F, Bisceglia M, Cavallo L, Francavilla R. The effects of probiotics on feeding tolerance, bowel habits, and gastrointestinal motility in preterm newborns. J Pediatr. 2008;152(6):801-6. https://doi.org/10.1016/j.jpeds.2007.11.005.
19. Oncel MY, Arayici S, Sari FN, Simsek GK, Yurttutan S, Erdeve O, et al. Comparison of lactobacillus reuteri and nystatin prophylaxis on Candida colonization and infection in very low birth weight infants. J Matern-Fetal Neonat Med. 2015;28(15):1790-4. https://doi.org/10.3109/14767058.2014.968842.
20. Khair K, Rahman M, Sultana T, Roy C, Rahman M, Ahmed A. Early diagnosis of neonatal septicemia by hematologic scoring system, C-reactive protein and serum haptoglobin. Mymensingh Med J. 2012;21(1):85-92.
21. Ouwehand AC. What role for probiotics in Necrotising enterocolitis. Arch Pediatr. 2014;2(3):e14912. https://doi.org/10.5812/pedinfect.14912.
22. De Weirdt R, Crabbé A, Roos S, Vollenweider S, Lacroix C, van Pijkeren JP, et al. Glycerol supplementation enhances L. reuteri's protective effect against S. typhimurium colonization in a 3-D model of colonic epithelium. PLoS One. 2012;7(5):e37116. https://doi.org/10.1371/journal.pone.0037116.
23. Schaefer L, Auchtung TA, Hermans KE, Whitehead D, Borhan B, Britton RA. The antimicrobial compound reuterin (3-hydroxypropionaldehyde) induces oxidative stress via interaction with thiol groups. Microbiology. 2010;156(6):1589-99. https://doi.org/10.1099/mic.0.035642-0.
24. Preidis GA, Saulnier DM, Blutt SE, Mistretta T-A, Riehle KP, Major AM, et al. Probiotics stimulate enterocyte migration and microbial diversity in the neonatal mouse intestine. FASEB J. 2012;26(5):1960-9. https://doi.org/10.1096/fj.10-177980.
25. Gutierrez-Castrellon P, Lopez-Velazquez G, Diaz-Garcia L, Jimenez-Gutierrez C, Mancilla-Ramirez J, Estevez-Jimenez J, et al. Diarrhea in preschool children and lactobacillus reuteri: a randomized controlled trial. Pediatrics. 2014;133(4):904-9. https://doi.org/10.1542/peds.2013-0652.
26. Oncel MY, Sari FN, Arayici S, Guzoglu N, Erdeve O, Uras N, et al. Lactobacillus reuteri for the prevention of necrotising enterocolitis in very low birthweight infants: a randomised controlled trial. Arch Dis Child-Fetal Matern Ed. 2014;99(2):F110-F5. https://doi.org/10.1136/archdischild-2013-304745.
27. Deshpande G, Rao S, Patole S, Bulsara M. Updated meta-analysis of probiotics for preventing necrotizing enterocolitis in preterm neonates. Pediatrics. 2010;125(5):2009-1301. https://doi.org/10.1542/peds.2009-1301.
28. Dylag K, Hubalewska-Mazgaj M, Surmiak M, Szmyd J, Brzozowski T. Probiotics in the mechanism of protection against gut inflammation and therapy of gastrointestinal disorders. Curr Pharm Des. 2014;20(7):1149-55. https://doi.org/10.2174/13816128113199990422.
29. Lau CS, Chamberlain RS. Probiotic administration can prevent necrotizing enterocolitis in preterm infants: a meta-analysis. J Pediatr Surg. 2015;50(8):1405-12. https://doi.org/10.1016/j.jpedsurg.2015.05.008.
30. Liu Y, Fatheree NY, Mangalat N, Rhoads JM. Lactobacillus reuteri strains reduce incidence and severity of experimental necrotizing enterocolitis via modulation of TLR4 and NF-κB signaling in the intestine. Am J Physiol Gastrointest Liver Physiol. 2012;302(6):G608-G17. https://doi.org/10.1152/ajpgi.00266.2011.
31. Hoang TK, He B, Wang T, Tran DQ, Rhoads JM, Liu Y. Protective effect of lactobacillus reuteri DSM 17938 against experimental necrotizing enterocolitis is mediated by toll-like receptor 2. Am J Physiol Gastrointest Liver Physiol. 2018;315(2):231-40. https://doi.org/10.1152/ajpgi.00084.2017.
32. Hunter C, Dimaguila MAV, Gal P, Wimmer JE, Ransom JL, Carlos RQ, et al. Effect of routine probiotic, lactobacillus reuteri DSM 17938, use on rates of necrotizing enterocolitis in neonates with birthweight< 1000 grams: a sequential analysis. BMC Pediatr. 2012;12(1):142. https://doi.org/10.1186/1471-2431-12-142.