Cellular and Network Effects of Transcranial Direct Current Stimulation: Insights from Animal Models and Brain Slice

Transcranial Brain Stimulation

Volumn , Issue , 2012, Pages 55-91

  Bikson, Marom ^a   Reato, Davide ^a   Rahman, Asif ^a  

^a CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85074198999     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1201/b14174-8     Document Type: Chapter

References (121)

1. Alexander, J. K., B. Fuss, and R. J. Colello. 2006. Electric field-induced astrocyte alignment directs neurite outgrowth. Neuron Glia Biol 2 (2):93-103.
2. An, J. H., Y. Su, T. Radman, and M. Bikson. 2008. Effects of glucose and glutamine concentration in the formulation of the artificial cerebrospinal fluid (ACSF). Brain Res 1218:77-86.
3. Anastassiou, C. A., S. M. Montgomery, M. Barahona, G. Buzsaki, and C. Koch. 2010. The effect of spatially inhomogeneous extracellular electric fields on neurons. J Neurosci 30 (5):1925-1936.
4. Andreasen, M. and S. Nedergaard. 1996. Dendritic electrogenesis in rat hippocampal CA1 pyramidal neurons: Functional aspects of Na+ and Ca2+ currents in apical dendrites. Hippocampus 6 (1):79-95.
5. Antal, A., E. T. Varga, T. Z. Kincses, M. A. Nitsche, and W. Paulus. 2004. Oscillatory brain activity and transcranial direct current stimulation in humans. Neuroreport 15 (8):1307-1310.
6. Ardolino, G., B. Bossi, S. Barbieri, and A. Priori. 2005. Non-synaptic mechanisms underlie the after-effects of cathodal transcutaneous direct current stimulation of the human brain. J Physiol (Lond) 568 (2):653-663.
7. Artola, A., S. Brocher, and W. Singer. 1990. Different voltage-dependent thresholds for inducing long-term depression and long-term potentiation in slices of rat visual cortex. Nature 347 (6288):69-72.
8. Awatramani, G. B., G. D. Price, and L. O. Trussell. 2005. Modulation of transmitter release by presynaptic resting potential and background calcium levels. Neuron 48 (1):109-121.
9. Berliner, M. N. 1997. Skin microcirculation during tapwater iontophoresis in humans: Cathode stimulates more than anode. Microvasc Res 54 (1):74-80.
10. Bikson, M., P. Bulow, J. W. Stiller, A. Datta, F. Battaglia, S. V. Karnup, and T. T. Postolache. 2008. Transcranial direct current stimulation for major depression: A general system for quantifying transcranial electrotherapy dosage. Curr Treat Options Neurol 10 (5):377-385.
11. Bikson, M., A. Datta, and M. Elwassif. 2009. Establishing safety limits for transcranial direct current stimulation. Clin Neurophysiol 120 (6):1033-1034.
12. Bikson, M., A. Datta, A. Rahman, and J. Scaturro. 2010. Electrode montages for tDCS and weak transcranial electrical stimulation: Role of “return” electrode’s position and size. Clin Neurophysiol 121 (12):1976-1978.
13. Bikson, M., R. S. Ghai, S. C. Baraban, and D. M. Durand. 1999. Modulation of burst frequency, duration, and amplitude in the zero-Ca2+ model of epileptiform activity. J Neurophysiol 82 (5):2262-2270.
14. Bikson, M., M. Inoue, H. Akiyama, J. K. Deans, J. E. Fox, H. Miyakawa, and J. G. Jefferys. 2004. Effects of uniform extracellular DC electric fields on excitability in rat hippocampal slices in vitro. J Physiol 557 (Pt 1):175-190.
15. Bikson, M., T. Radman, and A. Datta. 2006. Rational modulation of neuronal processing with applied electric fields. Conf Proc IEEE Eng Med Biol Soc 1:1616-1629.
16. Bindman, L. J., O. C. Lippold, and J. W. Redfearn. 1962. Long-lasting changes in the level of the electrical activity of the cerebral cortex produced bypolarizing currents. Nature 196:584-585.
17. Bindman, L. J., O. C. Lippold, and J. W. Redfearn. 1964. The action of brief polarizing currents on the cerebral cortex of the rat (1) during current flow and (2) in the production of long-lasting after-effects. J Physiol 172:369-382.
18. Bishop, G. H. and J. Erlanger. 1926. The effects of polarization upon the activity of vertebrate nerve. Am J Physiol 78:630-657.
19. Bishop, G. H. and J. L. O’Leary. 1950. The effects of polarizing currents on cell potentials and their significance in the interpretation of central nervous system activity. Electroencephalogr Clin Neurophysiol 2 (4):401-416.
20. Bliss, T. V. and T. Lomo. 1973. Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J Physiol 232 (2):331-356.
21. Bolognini, N., F. Fregni, C. Casati, E. Olgiati, and G. Vallar. 2010. Brain polarization of parietal cortex augments training-induced improvement of visual exploratory and attentional skills. Brain Res 1349:76-89.
22. Brunoni, A. R., F. Fregni, and R. L. Pagano. 2011. Translational research in transcranial direct current stimulation (tDCS): A systematic review of studies in animals. Rev Neurosci 22 (4):471-481.
23. Bullock, T. H. and S. Hagiwara. 1957. Intracellular recording from the giant synapse of the squid. J Gen Physiol 40 (4):565-577.
24. Cambiaghi, M., L. Teneud, S. Velikova, J. J. Gonzalez-Rosa, M. Cursi, G. Comi, and L. Leocani. 2011. Flash visual evoked potentials in mice can be modulated by transcranial direct current stimulation. Neuroscience 185:161-165.
25. Cambiaghi, M., S. Velikova, J. J. Gonzalez-Rosa, M. Cursi, G. Comi, and L. Leocani. 2010. Brain transcranial direct current stimulation modulates motor excitability in mice. Eur J Neurosci 31 (4):704-709.
26. Carandini, M. and D. Ferster. 2000. Membrane potential and firing rate in cat primary visual cortex. J Neurosci 20 (1):470-484.
27. Carlson, C. and O. Devinsky. 2009. The excitable cerebral cortex Fritsch G, Hitzig E. Uber die elektrische Erregbarkeit des Grosshirns. Arch Anat Physiol Wissen, 1870 (37):300-332. Epilepsy Behav 15 (2):131-132.
28. Chan, C. Y., J. Hounsgaard, and C. Nicholson. 1988. Effects of electric fields on transmembrane potential and excitability of turtle cerebellar Purkinje cells in vitro. J Physiol 402:751-771.
29. Chan, C. Y. and C. Nicholson. 1986. Modulation by applied electric fields of Purkinje and stellate cell activity in the isolated turtle cerebellum. J Physiol 371:89-114.
30. Cosentino, G., B. Fierro, P. Paladino, S. Talamanca, S. Vigneri, A. Palermo, G. Giglia, and F. Brighina. 2012. Transcranial direct current stimulation preconditioning modulates the effect of high-frequency repetitive transcranial magnetic stimulation in the human motor cortex. Eur J Neurosci 35 (1):119-124.
31. Costain, R., J. W. Redfearn, and O. C. Lippold. 1964. A controlled trial of the therapeutic effect of polarization of the brain in depressive illness. Br J Psychiatry 110:786-799.
32. Creutzfeldt, O. D., G. H. Fromm, and H. Kapp. 1962. Influence of transcortical d-c currents on cortical neuronal activity. Exp Neurol 5:436-452.
33. Datta, A., V. Bansal, J. Diaz, J. Patel, D. Reato, and M. Bikson. 2009. Gyri-precise head model of transcranial direct current stimulation: Improved spatial focality using a ring electrode versus conventional rectangular pad. Brain Stimul 2 (4):201-207.
34. Datta, A., M. Bikson, and F. Fregni. 2010. Transcranial direct current stimulation in patients with skull defects and skull plates: High-resolution computational FEM study of factors altering cortical current flow. Neuroimage 52 (4):1268-1278.
35. Datta, A., M. Elwassif, F. Battaglia, and M. Bikson. 2008. Transcranial current stimulation focality using disc and ring electrode configurations: FEM analysis. J Neural Eng 5 (2):163-174.
36. Datta, A., M. Elwassif, and M. Bikson. 2009. Bio-heat transfer model of transcranial DC stimulation: Comparison of conventional pad versus ring electrode. Conf Proc IEEE Eng Med Biol Soc 2009:670-673.
37. Deans, J. K., A. D. Powell, and J. G. Jefferys. 2007. Sensitivity of coherent oscillations in rat hippocampus to AC electric fields. J Physiol 583 (Pt 2):555-565.
38. Del Castillo, J. and B. Katz. 1954. Changes in end-plate activity produced by presynaptic polarization. J Physiol 124 (3):586-604.
39. Delgado-Lezama, R., J. F. Perrier, and J. Hounsgaard. 1999. Local facilitation of plateau potentials in dendrites of turtle motoneurones by synaptic activation of metabotropic receptors. J Physiol 515 (Pt 1):203-207.
40. Di Castro, M. A., J. Chuquet, N. Liaudet, K. Bhaukaurally, M. Santello, D. Bouvier, P. Tiret, and A. Volterra. 2011. Local Ca2+ detection and modulation of synaptic release by astrocytes. Nat Neurosci 14 (10):1276-1284.
41. Dubner, H. H. and R. W. Gerard. 1939. Factors controlling brain potentials in the cat. J Neurophysiol 2 (2):142-152.
42. Durand, D. M. and M. Bikson. 2001. Suppression and control of epileptiform activity by electrical stimulation: A review. Proc IEEE 89 (7):1065-1082.
43. Francis, J. T., B. J. Gluckman, and S. J. Schiff. 2003. Sensitivity of neurons to weak electric fields. J Neurosci 23 (19):7255-7261.
44. Fregni, F., P. S. Boggio, M. Nitsche, F. Bermpohl, A. Antal, E. Feredoes, M. A. Marcolin et al. 2005. Anodal transcranial direct current stimulation of prefrontal cortex enhances working memory. Exp Brain Res 166 (1):23-30.
45. Fregni, F., D. Liebetanz, K. K. Monte-Silva, M. B. Oliveira, A. A. Santos, M. A. Nitsche, A. Pascual-Leone, and R. C. Guedes. 2007. Effects of transcranial direct current stimulation coupled with repetitive electrical stimulation on cortical spreading depression. Exp Neurol 204 (1):462-466.
46. Freund, T. F. and G. Buzsaki. 1996. Interneurons of the hippocampus. Hippocampus 6 (4):347-470.
47. Fritsch G. T. and Hitzig E. 1870. On the electrical excitability of the cerebrum. In: Von Bonin G. (1960) trans. Some Papers on the Cerebral Cortex, Charles C. Thomas, Springfield, IL.
48. Fritsch, B., J. Reis, K. Martinowich, H. M. Schambra, Y. Ji, L. G. Cohen, and B. Lu. 2010. Direct current stimulation promotes BDNF-dependent synaptic plasticity: Potential implications for motor learning. Neuron 66 (2):198-204.
49. Frohlich, F. and D. A. McCormick. 2010. Endogenous electric fields may guide neocortical network activity. Neuron 67 (1):129-143.
50. Gardner-Medwin, A. R. 1983. A study of the mechanisms by which potassium moves through brain tissue in the rat. J Physiol 335:353-374.
51. Gartside, I. B. 1968a. Mechanisms of sustained increases of firing rate of neurones in the rat cerebral cortex after polarization: Reverberating circuits or modification of synaptic conductance? Nature 220 (5165):382-383.
52. Gartside, I. B. 1968b. Mechanisms of sustained increases of firing rate of neurones in the rat cerebral cortex after polarization: Role of protein synthesis. Nature 220 (5165):383-384.
53. Gasca, F., L. Richter, and A. Schweikard. 2010. Simulation of a conductive shield plate for the focalization of transcranial magnetic stimulation in the rat. Conf Proc IEEE Eng Med Biol Soc 2010:1593-1596.
54. Ghai, R. S., M. Bikson, and D. M. Durand. 2000. Effects of applied electric fields on low-calcium epileptiform activity in the CA1 region of rat hippocampal slices. J Neurophysiol 84 (1):274-280.
55. Gluckman, B. J., E. J. Neel, T. I. Netoff, W. L. Ditto, M. L. Spano, and S. J. Schiff. 1996. Electric field suppression of epileptiform activity in hippocampal slices. J Neurophysiol 76 (6):4202-4205.
56. Hattori, Y., A. Moriwaki, and Y. Hori. 1990. Biphasic effects of polarizing current on adenosine-sensitive generation of cyclic AMP in rat cerebral cortex. Neurosci Lett 116 (3):320-324.
57. Hayashi, Y., Y. Hattori, A. Moriwaki, H. Asaki, and Y. Hori. 1988. Effects of prolonged weak anodal direct current on electrocorticogram in awake rabbit. Acta Med Okayama 42 (5):293-296.
58. Haydon, P. G. and G. Carmignoto. 2006. Astrocyte control of synaptic transmission and neurovascular coupling. Physiol Rev 86 (3):1009-1031.
59. Hess, G. and J. P. Donoghue. 1999. Facilitation of long-term potentiation in layer II/III horizontal connections of rat motor cortex following layer I stimulation: Route of effect and cholinergic contributions. Exp Brain Res 127 (3):279-290.
60. Hubbard, J. I. and W. D. Willis. 1962a. Hyperpolarization of mammalian motor nerve terminals. J Physiol 163:115-137.
61. Hubbard, J. I. and W. D. Willis. 1962b. Mobilization of transmitter by hyperpolarization. Nature 193:174-175.
62. Islam, N., M. Aftabuddin, A. Moriwaki, Y. Hattori, and Y. Hori. 1995. Increase in the calcium level following anodal polarization in the rat brain. Brain Res 684 (2):206-208.
63. Islam, N., A. Moriwaki, Y. Hattori, and Y. Hori. 1994. Anodal polarization induces protein kinase C gamma (PKC gamma)-like immunoreactivity in the rat cerebral cortex. Neurosci Res 21 (2):169-172.
64. Islam, N., A. Moriwaki, and Y. Hori. 1995. Co-localization of c-fos protein and protein kinase C gamma in the rat brain following anodal polarization. Indian J Physiol Pharmacol 39 (3):209-215.
65. Jefferys, J. G. 1981. Influence of electric fields on the excitability of granule cells in guineapig hippocampal slices. J Physiol 319:143-152.
66. Jefferys, J. G. R., J. Deans, M. Bikson, and J. Fox. 2003. Effects of weak electric fields on the activity of neurons and neuronal networks. Radiat Prot Dosimetry 106 (4):321-323.
67. Joucla, S. and B. Yvert. 2009. The “mirror” estimate: An intuitive predictor of membrane polarization during extracellular stimulation. Biophys J 96 (9):3495-3508.
68. Kabakov, A. Y., P. A. Muller, A. Pascual-Leone, F. E. Jensen, and A. Rotenberg. 2012. Contribution of axonal orientation to pathway-dependent modulation of excitatory transmission by direct current stimulation in isolated rat hippocampus. J Neurophysiol 107 (7):1881-1889.
69. Kotnik, T. and D. Miklavcic. 2000. Analytical description of transmembrane voltage induced by electric fields on spheroidal cells. Biophys J 79 (2):670-679.
70. Ledger, P. W. 1992. Skin biological issues in electrically enhanced transdermal delivery. Adv Drug Deliv Rev 9:289-307.
71. Li, L., Y. H. El-Hayek, B. Liu, Y. Chen, E. Gomez, X. Wu, K. Ning et al. 2008. Directcurrent electrical field guides neuronal stem/progenitor cell migration. Stem Cells 26 (8):2193-2200.
72. Lian, J., M. Bikson, C. Sciortino, W. C. Stacey, and D. M. Durand. 2003. Local suppression of epileptiform activity by electrical stimulation in rat hippocampus in vitro. J Physiol (Lond) 547 (2):427-434.
73. Liebetanz, D., F. Fregni, K. K. Monte-Silva, M. B. Oliveira, A. Amancio-dos-Santos, M. A. Nitsche, and R. C. Guedes. 2006a. After-effects of transcranial direct current stimulation (tDCS) on cortical spreading depression. Neurosci Lett 398 (1-2):85-90.
74. Liebetanz, D., F. Klinker, D. Hering, R. Koch, M. A. Nitsche, H. Potschka, W. Loscher, W. Paulus, and F. Tergau. 2006b. Anticonvulsant effects of transcranial directcurrent stimulation (tDCS) in the rat cortical ramp model of focal epilepsy. Epilepsia 47 (7):1216-1224.
75. Liebetanz, D., R. Koch, S. Mayenfels, F. Konig, W. Paulus, and M. A. Nitsche. 2009. Safety limits of cathodal transcranial direct current stimulation in rats. Clin Neurophysiol 120 (6):1161-1167.
76. Liebetanz, D., M. A. Nitsche, F. Tergau, and W. Paulus. 2002. Pharmacological approach to the mechanisms of transcranial DC-stimulation-induced after-effects of human motor cortex excitability. Brain 125 (Pt 10):2238-2247.
77. Lopez-Quintero, S. V., A. Datta, R. Amaya, M. Elwassif, M. Bikson, and J. M. Tarbell. 2010. DBS-relevant electric fields increase hydraulic conductivity of in vitro endothelial monolayers. J Neural Eng 7 (1):16005.
78. Malty, A. M. and J. Petrofsky. 2007. The effect of electrical stimulation on a normal skin blood flow in active young and older adults. Med Sci Monit 13 (4):CR147-CR155.
79. Marshall, L., H. Helgadottir, M. Molle, and J. Born. 2006. Boosting slow oscillations during sleep potentiates memory. Nature 444 (7119):610-613.
80. Marshall, L., R. Kirov, J. Brade, M. Molle, and J. Born. 2011. Transcranial electrical currents to probe EEG brain rhythms and memory consolidation during sleep in humans. PLoS One 6 (2):e16905.
81. Marshall, L., M. Molle, M. Hallschmid, and J. Born. 2004. Transcranial direct current stimulation during sleep improves declarative memory. J Neurosci 24 (44):9985-9992.
82. Márquez-Ruiz, J., R. Leal-Campanario, R. Sánchez-Campusano, B. Molaee-Ardekani, F. Wendling, P. C. Miranda, G. Ruffini, A. Gruart, and J. M. Delgado-Garcia. 2012. Transcranial direct-current stimulation modulates synaptic mechanisms involved in associative learning in behaving rabbits. Proc Natl Acad Sci USA 109 (17):6710-6715.
83. Merrill, D. R., M. Bikson, and J. G. R. Jefferys. 2005. Electrical stimulation of excitable tissue: design of efficacious and safe protocols. J Neurosci Methods 141 (2):171-198.
84. Minhas, P., V. Bansal, J. Patel, J. S. Ho, J. Diaz, A. Datta, and M. Bikson. 2010. Electrodes for high-definition transcutaneous DC stimulation for applications in drug delivery and electrotherapy, including tDCS. J Neurosci Methods 190 (2):188-197.
85. Minhas, P., A. Datta, and M. Bikson. 2011. Cutaneous perception during tDCS: Role of electrode shape and sponge salinity. Clin Neurophysiol 122 (4):637-638.
86. Miranda, P. C., L. Correia, R. Salvador, and P. J. Basser. 2007. The role of tissue heterogeneity in neural stimulation by applied electric fields. Conf Proc IEEE Eng Med Biol Soc 2007:1715-1718.
87. Miranda, P. C., M. Lomarev, and M. Hallett. 2006. Modeling the current distribution during transcranial direct current stimulation. Clin Neurophysiol 117 (7):1623-1629.
88. Monte-Silva, K., M. F. Kuo, D. Liebetanz, W. Paulus, and M. A. Nitsche. 2010. Shaping the optimal repetition interval for cathodal transcranial direct current stimulation (tDCS). J Neurophysiol 103 (4):1735-1740.
89. Mozzachiodi, R. and J. H. Byrne. 2010. More than synaptic plasticity: Role of nonsynaptic plasticity in learning and memory. Trends Neurosci 33 (1):17-26.
90. Nitsche, M. A., K. Fricke, U. Henschke, A. Schlitterlau, D. Liebetanz, N. Lang, S. Henning, F. Tergau, and W. Paulus. 2003. Pharmacological modulation of cortical excitability shifts induced by transcranial direct current stimulation in humans. J Physiol 553 (Pt 1):293-301.
91. Nitsche, M. A. and W. Paulus. 2000. Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. J Physiol 527 (Pt 3):633-639.
92. Nitsche, M. A., A. Schauenburg, N. Lang, D. Liebetanz, C. Exner, W. Paulus, and F. Tergau. 2003. Facilitation of implicit motor learning by weak transcranial direct current stimulation of the primary motor cortex in the human. J Cogn Neurosci 15 (4):619-626.
93. Ozen, S., A. Sirota, M. A. Belluscio, C. A. Anastassiou, E. Stark, C. Koch, and G. Buzsaki. 2010. Transcranial electric stimulation entrains cortical neuronal populations in rats. J Neurosci 30 (34):11476-11485.
94. Panatier, A., J. Vallee, M. Haber, K. K. Murai, J. C. Lacaille, and R. Robitaille. 2011. Astrocytes are endogenous regulators of basal transmission at central synapses. Cell 146 (5):785-798.
95. Peterchev, A. V., T. A. Wagner, P. C. Miranda, M. A. Nitsche, W. Paulus, S. H. Lisanby, A. Pascual-Leone, and M. Bikson. 2011. Fundamentals of transcranial electric and magnetic stimulation dose: Definition, selection, and reporting practices. Brain Stimul. Nov 1 [Epub. ahead of print].
96. Prausnitz, M. R. 1996. The effects of electric current applied to skin: A review for transdermal drug delivery. Adv Drug Deliv Rev 18:395-425.
97. Purpura, D. P. and J. G. McMurtry. 1965a. Intracellular activities and evoked potential changes during polarization of motor cortex. J Neurophysiol 28 (1):166-185.
98. Purpura, D. P. and J. G. McMurtry. 1965b. Intracellular potentials of cortical neurons during applied transcortical polarizing currents. Electroen Clin Neuro 18 (2):203.
99. Purpura, D. P., J. G. McMurtry, and C. F. Leonard. 1966. Intracellular spike potentials of dendritic origin during hippocampal seizures induced by subiculum stimulation. Brain Res 1 (1):109-113.
100. Radman, T., A. Datta, and A. V. Peterchev. 2007a. In vitro modulation of endogenous rhythms by AC electric fields: Syncing with clinical brain stimulation. J Physiol 584 (Pt 2):369-370.
101. Radman, T., R. L. Ramos, J. C. Brumberg, and M. Bikson. 2009. Role of cortical cell type and morphology in subthreshold and suprathreshold uniform electric field stimulation in vitro. Brain Stimul 2 (4):215-228.
102. Radman, T., Y. Z. Su, J. H. An, L. C. Parra, and M. Bikson. 2007b. Spike timing amplifies the effect of electric fields on neurons: Implications for endogenous field effects. J Neurosci 27:3030-3036.
103. Ranieri, F., M. V. Podda, E. Riccardi, G. Frisullo, M. Dileone, P. Profice, F. Pilato, V. Di Lazzaro, and C. Grassi. 2012. Modulation of LTP at rat hippocampal CA3-CA1 synapses by direct current stimulation. J Neurophysiol 107 (7):1868-1880.
104. Reato, D., A. Rahman, M. Bikson, and L. C. Parra. 2010. Low-intensity electrical stimulation affects network dynamics by modulating population rate and spike timing. J Neurosci 30 (45):15067-15079.
105. Redfearn, J. W., O. C. Lippold, and R. Costain. 1964. A preliminary account of the clinical effects of polarizing the brain in certain psychiatric disorders. Br J Psychiatry 110:773-785.
106. Rioult-Pedotti, M. S., D. Friedman, G. Hess, and J. P. Donoghue. 1998. Strengthening of horizontal cortical connections following skill learning. Nat Neurosci 1 (3):230-234.
107. Ruohonen, J. and J. Karhu. 2012. tDCS possibly stimulates glial cells. Clin Neurophysiol. Apr 3 [Epub. ahead of print].
108. Sadleir, R. J., T. D. Vannorsdall, D. J. Schretlen, and B. Gordon. 2010. Transcranial direct current stimulation (tDCS) in a realistic head model. Neuroimage 51 (4):1310-1318.
109. Salvador, R., A. Mekonnen, G. Ruffini, and P. C. Miranda. 2010. Modeling the electric field induced in a high resolution realistic head model during transcranial current stimulation. Conf Proc IEEE Eng Med Biol Soc 2010:2073-2076.
110. Stagg, C. J. and M. A. Nitsche. 2011. Physiological basis of transcranial direct current stimulation. Neuroscientist 17 (1):37-53.
111. Su, Y. Z., T. Radman, J. Vaynshteyn, L. C. Parra, and M. Bikson. 2008. Effects of highfrequency stimulation on epileptiform activity in vitro: ON/OFF control paradigm. Epilepsia 49 (9):1586-1593.
112. Sunderam, S., B. Gluckman, D. Reato, and M. Bikson. 2010. Toward rational design of electrical stimulation strategies for epilepsy control. Epilepsy Behav 17 (1):6-22.
113. Svirskis, G., A. Gutman, and J. Hounsgaard. 1997. Detection of a membrane shunt by DC field polarization during intracellular and whole cell recording. J Neurophysiol 77 (2):579-586.
114. Takeuchi, A. and N. Takeuchi. 1962. Electrical changes in pre- and postsynaptic axons of the giant synapse of Loligo. J Gen Physiol 45:1181-1193.
115. Terzuolo, C. A. and T. H. Bullock. 1956. Measurement of imposed voltage gradient adequate to modulate neuronal firing. Proc Natl Acad Sci USA 42 (9):687-694.
116. Toleikis, J. R., A. Sances, Jr. and S. J. Larson. 1974. Effects of diffuse transcerebral electrical currents on cortical unit potential activity. Anesth Analg 53 (1):48-55.
117. Turkeltaub, P. E., J. Benson, R. H. Hamilton, A. Datta, M. Bikson, and H. B. Coslett. 2011. Left lateralizing transcranial direct current stimulation improves reading efficiency. Brain Stimul.
118. Varga, E. T., D. Terney, M. D. Atkins, M. Nikanorova, D. S. Jeppesen, P. Uldall, H. Hjalgrim, and S. Beniczky. 2011. Transcranial direct current stimulation in refractory continuous spikes and waves during slow sleep: A controlled study. Epilepsy Res 97 (1-2):142-145.
119. Wachter, D., A. Wrede, W. Schulz-Schaeffer, A. Taghizadeh-Waghefi, M. A. Nitsche, A. Kutschenko, V. Rohde, and D. Liebetanz. 2011. Transcranial direct current stimulation induces polarity-specific changes of cortical blood perfusion in the rat. Exp Neurol 227 (2):322-327.
120. Wong, R. K. and M. Stewart. 1992. Different firing patterns generated in dendrites and somata of CA1 pyramidal neurones in guinea-pig hippocampus. J Physiol 457:675-687.
121. Yoon, K. J., B. M. Oh, and D. Y. Kim. 2012. Functional improvement and neuroplastic effects of anodal transcranial direct current stimulation (tDCS) delivered 1 day vs. 1 week after cerebral ischemia in rats. Brain Res. 1452:61-72.