Microbiota of Children with Complex Appendicitis: Different Composition and Diversity of the Microbiota in Children with Complex Compared with Simple Appendicitis

Pediatric Infectious Disease Journal

Volumn 38, Issue 10, 2019, Pages 1054-1060

  The, Sarah May M L ^a   Bakx, Roel ^a   Budding, Andries E ^b   De Meij, Tim G J ^b   Van Der Lee, Johanna H ^a,c   Bunders, Madeleine J ^d,e,f   Poort, Linda ^g   Heij, Hugo A ^a   Van Heurn, L W Ernst ^a   Gorter, Ramon R ^a  

^a EMMA CHILDREN S HOSPITAL   (Netherlands)

^b Department of Medical Microbiology and Infection Control ^*  (Netherlands)

^c Paediatric Clinical Research Office   (Netherlands)

^d Utrecht   (Netherlands)

^e ACADEMIC MEDICAL CENTER   (Netherlands)

^f LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

^g InBiome BV   (Netherlands)

Author keywords

bacterial infection; complex appendicitis; intestinal microbiota; pediatric surgery; simple appendicitis

Indexed keywords

BACTERIAL DNA; DNA 16S; DNA 23S; RIBOSOME DNA; RNA 16S; RNA 23S;

ACTINOBACTERIA; ADOLESCENT; ALISTIPES; APPENDECTOMY; APPENDICITIS; APPENDIX; ARTICLE; BACTEROIDES FRAGILIS; BACTEROIDES VULGATUS; BACTEROIDETES; CHILD; CLINICAL ARTICLE; CLUSTER ANALYSIS; COHORT ANALYSIS; ESCHERICHIA COLI; FAECALIBACTERIUM PRAUSNITZII; FEMALE; FIRMICUTES; FISHER EXACT TEST; FUSOBACTERIA; FUSOBACTERIUM NUCLEATUM; HUMAN; HUMAN TISSUE; MALE; MICROBIAL DIVERSITY; MICROFLORA; NONHUMAN; PARVIMONAS MICRA; PHENOTYPE; PILOT STUDY; PREVOTELLA; PREVOTELLA INTERMEDIA; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEOBACTERIA; RUMINOCOCCUS; STAPHYLOCOCCUS AUREUS; VERRUCOMICROBIA; BACTERIUM; CHEMISTRY; CLASSIFICATION; COMPARATIVE STUDY; DNA SEQUENCE; GENETICS; INFANT; MICROBIOLOGY; NEWBORN; PATHOLOGY; PHYLOGENY; PRESCHOOL CHILD;

ADOLESCENT; APPENDECTOMY; APPENDICITIS; APPENDIX; BACTERIA; CHILD; CHILD, PRESCHOOL; CLUSTER ANALYSIS; DNA, BACTERIAL; DNA, RIBOSOMAL; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; MALE; MICROBIOTA; PHYLOGENY; PILOT PROJECTS; PROSPECTIVE STUDIES; RNA, RIBOSOMAL, 16S; RNA, RIBOSOMAL, 23S; SEQUENCE ANALYSIS, DNA;

EID: 85072771873     PISSN: 08913668     EISSN: 15320987     Source Type: Journal    
DOI: 10.1097/INF.0000000000002434     Document Type: Article

References (39)

1. Addiss DG, Shaffer N, Fowler BS,. The epidemiology of appendicitis and appendectomy in the United States. Am J Epidemiol. 1990; 132: 910-925.
2. Andersson RE,. The natural history and traditional management of appendicitis revisited: spontaneous resolution and predominance of prehospital perforations imply that a correct diagnosis is more important than an early diagnosis. World J Surg. 2007; 31: 86-92.
3. Livingston EH, Woodward WA, Sarosi GA,. Disconnect between incidence of nonperforated and perforated appendicitis: implications for pathophysiology and management. Ann Surg. 2007; 245: 886-892.
4. Cobben LP, de Van Otterloo AM, Puylaert JB,. Spontaneously resolving appendicitis: frequency and natural history in 60 patients. Radiology. 2000; 215: 349-352.
5. Bröker ME, van Lieshout EM, van der Elst M,. Discriminating between simple and perforated appendicitis. J Surg Res. 2012; 176: 79-83.
6. Williams RF, Blakely ML, Fischer PE,. Diagnosing ruptured appendicitis preoperatively in pediatric patients. J Am Coll Surg. 2009; 208: 819-25; discussion 826.
7. Peng YS, Lee HC, Yeung CY,. Clinical criteria for diagnosing perforated appendix in pediatric patients. Pediatr Emerg Care. 2006; 22: 475-479.
8. Oliak D, Yamini D, Udani VM,. Can perforated appendicitis Be diagnosed preoperatively based on admission factors? J Gastrointest Surg. 2000; 4: 470-474.
9. Rubér M, Berg A, Ekerfelt C,. Different cytokine profiles in patients with a history of gangrenous or phlegmonous appendicitis. Clin Exp Immunol. 2006; 143: 117-124.
10. Rubér M, Andersson M, Petersson BF,. Systemic Th17-like cytokine pattern in gangrenous appendicitis but not in phlegmonous appendicitis. Surgery. 2010; 147: 366-372.
11. Gorter RR, The SML, Gorter-Stam MAW,. Systematic review of nonoperative versus operative treatment of uncomplicated appendicitis. J Pediatr Surg. 2017; 52: 1219-1227.
12. Salminen P, Tuominen R, Paajanen H,. Five-Year follow-up of antibiotic therapy for uncomplicated acute appendicitis in the APPAC randomized clinical trial. JAMA. 2018; 320: 1259-1265.
13. Gorter RR, van den Boom AL, Heij HA,. A scoring system to predict the severity of appendicitis in children. J Surg Res. 2016; 200: 452-459.
14. Atema JJ, van Rossem CC, Leeuwenburgh MM,. Scoring system to distinguish uncomplicated from complicated acute appendicitis. Br J Surg. 2015; 102: 979-990.
15. Carr NJ,. The pathology of acute appendicitis. Ann Diagn Pathol. 2000; 4: 46-58.
16. Swidsinski A, Dörffel Y, Loening-Baucke V,. Acute appendicitis is characterised by local invasion with Fusobacterium nucleatum/necrophorum. Gut. 2011; 60: 34-40.
17. Rogers MB, Brower-Sinning R, Firek B,. Acute appendicitis in children is associated with a local expansion of fusobacteria. Clin Infect Dis. 2016; 63: 71-78.
18. Jackson HT, Mongodin EF, Davenport KP,. Culture-independent evaluation of the appendix and rectum microbiomes in children with and without appendicitis. PLoS One. 2014; 9: e95414.
19. Zhong D, Brower-Sinning R, Firek B,. Acute appendicitis in children is associated with an abundance of bacteria from the phylum fusobacteria. J Pediatr Surg. 2014; 49: 441-446.
20. Guinane CM, Tadrous A, Fouhy F,. Microbial composition of human appendices from patients following appendectomy. MBio. 2013; 4: e00366-12.
21. Salö M, Marungruang N, Roth B,. Evaluation of the microbiome in children's appendicitis. Int J Colorectal Dis. 2017; 32: 19-28.
22. Bakker OJ, Go PM, Puylaert JB,. Richtlijn voor diagnostiek en behandeling van acute appendicitis [Guideline on diagnosis and treatment of acute appendicitis]. Beeldvorming voor appendectomie aanbevolen. Ned Tijdschr Geneeskd. 2010; 154: A303
23. Budding AE, Grasman ME, Lin F,. IS-pro: high-throughput molecular fingerprinting of the intestinal microbiota. FASEB J. 2010; 24: 4556-4564.
24. Michener CD, Sokal RR,. A quantitative approach to a problem in classification. Evolution (N Y). 1957; 11: 130-162.
25. Obinwa O, Casidy M, Flynn J,. The microbiology of bacterial peritonitis due to appendicitis in children. Ir J Med Sci. 2014; 183: 585-591.
26. Brook I,. Bacterial studies of peritoneal cavity and postoperative surgical wound drainage following perforated appendix in children. Ann Surg. 1980; 192: 208-212.
27. Chan KW, Lee KH, Mou JW,. Evidence-based adjustment of antibiotic in pediatric complicated appendicitis in the era of antibiotic resistance. Pediatr Surg Int. 2010; 26: 157-160.
28. Guillet-Caruba C, Cheikhelard A, Guillet M,. Bacteriologic epidemiology and empirical treatment of pediatric complicated appendicitis. Diagn Microbiol Infect Dis. 2011; 69: 376-381.
29. Troy EB, Kasper DL,. Beneficial effects of Bacteroides fragilis polysaccharides on the immune system. Front Biosci (Landmark Ed. 2010; 15: 25-34.
30. Prindiville TP, Sheikh RA, Cohen SH,. Bacteroides fragilis enterotoxin gene sequences in patients with inflammatory bowel disease. Emerg Infect Dis. 2000; 6: 171-174.
31. Hiippala K, Kainulainen V, Kalliomäki M,. Mucosal Prevalence and Interactions with the Epithelium Indicate Commensalism of Sutterella spp. Front Microbiol. 2016; 7: 1706.
32. Gaboriau-Routhiau V, Rakotobe S, Lécuyer E,. The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity. 2009; 31: 677-689.
33. Ivanov II, Honda K,. Intestinal commensal microbes as immune modulators. Cell Host Microbe. 2012; 12: 496-508.
34. Atarashi K, Tanoue T, Ando M,. Th17 cell induction by adhesion of microbes to intestinal epithelial cells. Cell. 2015; 163: 367-380.
35. Ott SJ, Musfeldt M, Wenderoth DF,. Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease. Gut. 2004; 53: 685-693.
36. Chang JY, Antonopoulos DA, Kalra A,. Decreased diversity of the fecal microbiome in recurrent Clostridium difficile-associated diarrhea. J Infect Dis. 2008; 197: 435-438.
37. Daniels L, Budding AE, de Korte N,. Fecal microbiome analysis as a diagnostic test for diverticulitis. Eur J Clin Microbiol Infect Dis. 2014; 33: 1927-1936.
38. de Meij TG, Budding AE, de Groot EF,. Composition and stability of intestinal microbiota of healthy children within a Dutch population. FASEB J. 2016; 30: 1512-1522.
39. De Meij TGJ, Van Der Schee MPC, Berkhout DJC,. Early detection of necrotizing enterocolitis by fecal volatile organic compounds analysis. J Pediatr. 2015; 167: 562-567.e1.