Upadacitinib Versus Placebo or Adalimumab in Patients With Rheumatoid Arthritis and an Inadequate Response to Methotrexate: Results of a Phase III, Double-Blind, Randomized Controlled Trial

Arthritis and Rheumatology

Volumn 71, Issue 11, 2019, Pages 1788-1800

  Fleischmann, Roy ^a   Pangan, Aileen L ^b   Song, In Ho ^b   Mysler, Eduardo ^c   Bessette, Louis ^d   Peterfy, Charles ^e   Durez, Patrick ^f   Ostor, Andrew J ^g   Li, Yihan ^b   Zhou, Yijie ^b   Othman, Ahmed A ^b   Genovese, Mark C ^h  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b ABBVIE INC   (United States)

^c Organización Médica de Investigación   (Argentina)

^d UNIVERSITÉ LAVAL   (Canada)

^e Spire Sciences Inc   (United States)

^f Hôpital Saint Luc   (Belgium)

^g CABRINI INSTITUTE   (Australia)

^h STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADALIMUMAB; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; C REACTIVE PROTEIN; CREATINE KINASE; CREATININE; HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METHOTREXATE; PLACEBO; UPADACITINIB; ANTIRHEUMATIC AGENT; FUSED HETEROCYCLIC RINGS; JANUS KINASE INHIBITOR;

ADULT; ADVERSE OUTCOME; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CARDIOVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; CLINICAL OUTCOME; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; CREATININE BLOOD LEVEL; DAS28; DEATH; DEEP VEIN THROMBOSIS; DIGESTIVE SYSTEM PERFORATION; DISABILITY; DISEASE ACTIVITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; FEMALE; HEALTH ASSESSMENT QUESTIONNAIRE; HEALTH ASSESSMENT QUESTIONNAIRE DISABILITY INDEX; HEMOGLOBIN BLOOD LEVEL; HERPES ZOSTER; HUMAN; INFECTION; LATENT TUBERCULOSIS; LIVER DISEASE; LUNG EMBOLISM; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NEUTROPHIL COUNT; NON MELANOMA SKIN CANCER; NON-INFERIORITY TRIAL; OPPORTUNISTIC INFECTION; PAIN SEVERITY; PHASE 3 CLINICAL TRIAL; PLATELET COUNT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REMISSION; RHEUMATOID ARTHRITIS; SIDE EFFECT; TREATMENT RESPONSE; AGED; CLINICAL TRIAL; COMBINATION DRUG THERAPY; DIAGNOSTIC IMAGING; METABOLISM; PATHOPHYSIOLOGY; SEVERITY OF ILLNESS INDEX; VENOUS THROMBOEMBOLISM;

ADALIMUMAB; ADULT; AGED; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; CREATINE KINASE; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; HERPES ZOSTER; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; INFECTIONS; JANUS KINASE INHIBITORS; MALE; METHOTREXATE; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; VENOUS THROMBOEMBOLISM;

EID: 85070771516     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.41032     Document Type: Article

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