Chloroquine inhibits endosomal viral RNA release and autophagy-dependent viral replication and effectively prevents maternal to fetal transmission of Zika virus

Antiviral Research

Volumn 169, Issue , 2019, Pages

  Zhang, Shengnan ^a,b   Yi, Changhua ^b   Li, Chufang ^c   Zhang, Fan ^b   Peng, Jiaojiao ^c   Wang, Qian ^b   Liu, Xinglong ^b   Ye, Xianmiao ^b   Li, Pingchao ^b   Wu, Min ^b   Yan, Qihong ^b   Guo, Wenjing ^b   Niu, Xuefeng ^c   Feng, Liqiang ^b   Pan, Weiqi ^c   Chen, Ling ^b,c   Qu, Linbing ^b  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^b GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

^c Guangzhou Eighth People's Hospital   (China)

Author keywords

Autophagy; Chloroquine; Viral RNA release; Zika virus

Indexed keywords

CHLOROQUINE; LAMIN B; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; VIRUS RNA; ANTIMALARIAL AGENT;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CELL ISOLATION; CONTROLLED STUDY; CYTOPLASM; ENDOSOME; FEMALE; FETUS; FETUS BRAIN; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LYSOSOME; MICROCEPHALY; MOUSE; NONHUMAN; PLACENTA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA EXTRACTION; RNA REPLICATION; SCID BEIGE MOUSE; TITRIMETRY; VERO CELL LINE; VERTICAL TRANSMISSION; VIREMIA; VIRUS INHIBITION; VIRUS LOAD; VIRUS REPLICATION; VIRUS TRANSMISSION; ZIKA FEVER; ANIMAL; CELL LINE; CHLOROCEBUS AETHIOPS; DISEASE MODEL; DISEASE TRANSMISSION; DRUG EFFECT; PREGNANCY; PREVENTION AND CONTROL; SCID MOUSE; VIRUS ENTRY; ZIKA VIRUS;

ANIMALS; ANTIMALARIALS; AUTOPHAGY; CELL LINE; CHLOROCEBUS AETHIOPS; CHLOROQUINE; DISEASE MODELS, ANIMAL; DISEASE TRANSMISSION, INFECTIOUS; ENDOSOMES; FEMALE; FETUS; HUMANS; MICE; MICE, SCID; PLACENTA; PREGNANCY; RNA, VIRAL; VERO CELLS; VIREMIA; VIRUS INTERNALIZATION; VIRUS REPLICATION; ZIKA VIRUS; ZIKA VIRUS INFECTION;

EID: 85068129078     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2019.104547     Document Type: Article

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