Study Protocol on Hormonal Mediation of Exercise on Cognition, Stress and Immunity (PRO-HMECSI): Effects of Different Exercise Programmes in Institutionalized Elders

Frontiers in Public Health

Volumn 4, Issue , 2016, Pages

  Teixeira, Ana Maria ^a   Ferreira, José Pedro ^a   Hogervorst, Eef ^b   Braga, Margarida Ferreira ^c   Bandelow, Stephan ^b   Rama, Luís ^a   Figueiredo, António ^a   Campos, Maria João ^a   Furtado, Guilherme Eustáquio ^a,d   Chupel, Matheus Uba ^a,d   Pedrosa, Filipa Martins ^a  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b LOUGHBOROUGH UNIVERSITY   (United Kingdom)

^c University of Porto   (Portugal)

^d MINISTRY OF EDUCATION OF BRAZIL   (Brazil)

Author keywords

cognition; exercise; immunity; mental health; older women

Indexed keywords

EID: 85068056035     PISSN: None     EISSN: 22962565     Source Type: Journal    
DOI: 10.3389/fpubh.2016.00133     Document Type: Article

References (96)

1. Mungas D. In-office mental status testing: a practical guide. Geriatrics (1991) 46(7):54–8.2060803
2. Doi T, Shimada H, Park H, Makizako H, Tsutsumimoto K, Uemura K, et al. Cognitive function and falling among older adults with mild cognitive impairment and slow gait. Geriatr Gerontol Int (2015) 15(8):1073–8.10.1111/ggi.12407
3. Panza F, Seripa D, Solfrizzi V, Tortelli R, Greco A, Pilotto A, et al. Targeting cognitive frailty: clinical and neurobiological roadmap for a single complex phenotype. J Alzheimers Dis (2015) 47(4):793–813.10.3233/JAD-15035826401761
4. Han ES, Lee Y, Kim J. Association of cognitive impairment with frailty in community-dwelling older adults. Int Psychogeriatr (2014) 26(1):155–63.10.1017/S104161021300184124153029
5. Panza F, Solfrizzi V, Barulli MR, Santamato A, Seripa D, Pilotto A, et al. Cognitive frailty: a systematic review of epidemiological and neurobiological evidence of an age-related clinical condition. Rejuvenation Res (2015) 18(5):389–412.10.1089/rej.2014.163725808052
6. Chong MS, Tay L, Chan M, Lim WS, Ye R, Tan EK, et al. Prospective longitudinal study of frailty transitions in a community-dwelling cohort of older adults with cognitive impairment. BMC Geriatr (2015) 15:175.10.1186/s12877-015-0174-126715536
7. Robertson DA, Savva GM, Kenny RA. Frailty and cognitive impairment – a review of the evidence and causal mechanisms. Ageing Res Rev (2013) 12(4):840–51.10.1016/j.arr.2013.06.004
8. Bilotta C, Bergamaschini L, Nicolini P, Casè A, Pina G, Rossi SV, et al. Frailty syndrome diagnosed according to the study of osteoporotic fractures criteria and mortality in older outpatients suffering from Alzheimer’s disease: a one-year prospective cohort study. Aging Ment Health (2012) 16(3):273–80.10.1080/13607863.2011.609534
9. Lee JSW, Auyeung T-W, Leung J, Kwok T, Woo J. Transitions in frailty states among community-living older adults and their associated factors. J Am Med Dir Assoc (2014) 15(4):281–6.10.1016/j.jamda.2013.12.00224534517
10. Walsh NP, Gleeson M, Shephard RJ, Gleeson M, Woods A, Bishop NC, et al. Position statement. Part one: immune function and exercise. Exerc Immunol Rev (2011) 17:6–63.21446352
11. Gruver AL, Hudson LL, Sempowski GD. Immunosenescence of ageing. J Pathol (2007) 211(2):144–56.10.1002/path.210417200946
12. Sato S, Kiyono H, Fujihashi K. Mucosal immunosenescence in the gastrointestinal tract: a mini-review. Gerontology (2015) 61(4):336–42.10.1159/00036889725531743
13. Wullems JA, Verschueren SMP, Degens H, Morse CI, Onambélé GL. A review of the assessment and prevalence of sedentarism in older adults, its physiology/health impact and non-exercise mobility counter-measures. Biogerontology (2016) 17(3):547–65.10.1007/s10522-016-9640-126972899
14. Williams JW, Plassman BL, Burke J, Benjamin S. Preventing Alzheimer’s disease and cognitive decline. Evid Rep Technol Assess (Full Rep) (2010) (193):1–727.
15. Erickson KI, Kramer AF. Aerobic exercise effects on cognitive and neural plasticity in older adults. Br J Sports Med (2009) 43(1):22–4.10.1136/bjsm.2008.052498
16. Middleton LE, Mitnitski A, Fallah N, Kirkland SA, Rockwood K. Changes in cognition and mortality in relation to exercise in late life: a population based study. PLoS One (2008) 3(9):e3124.10.1371/journal.pone.000312418769616
17. Blazer DG. Depression in late life: review and commentary. J Gerontol A Biol Sci Med Sci (2003) 58(3):249–65.10.1093/gerona/58.3.M24912634292
18. Koenig AM, Bhalla RK, Butters MA. Cognitive functioning and late-life depression. J Int Neuropsychol Soc (2014) 20(5):461–7.10.1017/S135561771400019824685173
19. Leonard BE, Myint A. Changes in the immune system in depression and dementia: causal or coincidental effects? Dialogues Clin Neurosci (2006) 8(2):163–74.16889103
20. Allison DJ, Ditor DS. The common inflammatory etiology of depression and cognitive impairment: a therapeutic target. J Neuroinflammation (2014) 11(1):151.10.1186/s12974-014-0151-125178630
21. Conn VS. Depressive symptom outcomes of physical activity interventions: meta-analysis findings. Ann Behav Med (2010) 39(2):128–38.10.1007/s12160-010-9172-x20422333
22. Sjösten N, Kivelä S-L. The effects of physical exercise on depressive symptoms among the aged: a systematic review. Int J Geriatr Psychiatry (2006) 21(5):410–8.10.1002/gps.149416676285
23. Chodzko-Zajko W, Schwingel A. Successful aging: the role of physical activity. Am J Lifestyle Med (2008) 3(1):20–8.10.1177/1559827608325456
24. Papacosta E, Nassis GP. Saliva as a tool for monitoring steroid, peptide and immune markers in sport and exercise science. J Sci Med Sport (2011) 14(5):424–34.10.1016/j.jsams.2011.03.00421474377
25. van Stegeren AH, Wolf OT, Kindt M. Salivary alpha amylase and cortisol responses to different stress tasks: impact of sex. Int J Psychophysiol (2008) 69(1):33–40.10.1016/j.ijpsycho.2008.02.00818417235
26. Scannapieco FA, Solomon L, Wadenya RO. Emergence in human dental plaque and host distribution of amylase-binding streptococci. J Dent Res (1994) 73(10):1627–35.7523468
27. Beauchet O. Testosterone and cognitive function: current clinical evidence of a relationship. Eur J Endocrinol (2006) 155(6):773–81.10.1530/eje.1.0230617132744
28. Maninger N, Wolkowitz OM, Reus VI, Epel ES, Mellon SH. Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS). Front Neuroendocrinol (2009) 30(1):65–91.10.1016/j.yfrne.2008.11.00219063914
29. Straub RH, Tankó LB, Christiansen C, Larsen PJ, Jessop DS. Higher physical activity is associated with increased androgens, low interleukin 6 and less aortic calcification in peripheral obese elderly women. J Endocrinol (2008) 199(1):61–8.10.1677/JOE-08-031918617605
30. Guerreiro RJ, Santana I, Brás JM, Santiago B, Paiva A, Oliveira C. Peripheral inflammatory cytokines as biomarkers in Alzheimer’s disease and mild cognitive impairment. Neurodegener Dis (2007) 4(6):406–12.10.1159/000107700
31. Satizabal CL, Zhu YC, Mazoyer B, Dufouil C, Tzourio C. Circulating IL-6 and CRP are associated with MRI findings in the elderly: the 3C-Dijon study. Neurology (2012) 78(10):720–7.10.1212/WNL.0b013e318248e50f22357713
32. Sudheimer DKD, O’Hara R, Spiegel D, Powers B, Kraemer CHC, Neri E, et al. Cortisol, cytokines, and hippocampal volume interactions in the elderly. Front Aging Neurosci (2014) 6:1–7.10.3389/fnagi.2014.0015325071562
33. Gomez-Pinilla F, Hillman C. The influence of exercise on cognitive abilities. Compr Physiol (2013) 3(1):403–28.10.1002/cphy.c11006323720292
34. Vaughan S, Morris N, Shum D, O’Dwyer S, Polit D. Study protocol: a randomised controlled trial of the effects of a multi-modal exercise program on cognition and physical functioning in older women. BMC Geriatr (2012) 12(1):60.10.1186/1471-2318-12-6023009189
35. De Jager CA, Hogervorst E, Combrinck M, Budge MM. Sensitivity and specificity of neuropsychological tests for mild cognitive impairment, vascular cognitive impairment and Alzheimer’s disease. Psychol Med (2003) 33(6):1039–50.10.1017/S0033291703008031
36. Kocabas NA, Antonijevic I, Faghel C, Forray C, Kasper S, Lecrubier Y, et al. Brain-derived neurotrophic factor gene polymorphisms: influence on treatment response phenotypes of major depressive disorder. Int Clin Psychopharmacol (2011) 26(1):1–10.10.1097/YIC.0b013e32833d18f821188787
37. Shimizu E, Hashimoto K, Okamura N, Koike K, Komatsu N, Kumakiri C, et al. Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiatry (2003):70–5.10.1016/S0006-3223(03)00181-1
38. Verdelho A, Madureira S, Moleiro C, Santos CO, Ferro JM, Erkinjuntti T, et al. Self-perceived memory complaints predict progression to Alzheimer disease. The LADIS study. J Alzheimers Dis (2011) 27(3):491–8.10.3233/JAD-2011-110494
39. Braga R. Ética na publicação de trabalhos científicos. Rev Port Med Geral e Fam (2013) 29(6):354–6.
40. Shephard RJ. Ethics in exercise science research. Sports Med (2002) 32(3):169–83.10.2165/00007256-200232030-00002
41. Petrini C. Helsinki 50 years on. Clin Ter (2014) 165(4):179–81.10.7417/CT.2014.1729
42. Bischoff HA, Stähelin HB, Monsch AU, Iversen MD, Weyh A, von Dechend M, et al. Identifying a cut-off point for normal mobility: a comparison of the timed “up and go” test in community-dwelling and institutionalised elderly women. Age Ageing (2003) 32(3):315–20.10.1093/ageing/32.3.315
43. Jensen CS, Hasselbalch SG, Waldemar G, Simonsen AH. Biochemical markers of physical exercise on mild cognitive impairment and dementia: systematic review and perspectives. Front Neurol (2015) 6:187.10.3389/fneur.2015.0018726379621
44. González-Vaca J, de la Rica-Escuín M, Silva-Iglesias M, Arjonilla-García MD, Varela-Pérez R, Oliver-Carbonell JL, et al. Frailty in INstitutionalized older adults from ALbacete. The FINAL study: rationale, design, methodology, prevalence and attributes. Maturitas (2014) 77(1):78–84.10.1016/j.maturitas.2013.10.00524189222
45. Faul F, Erdfelder E, Lang A-G, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods (2007) 39(2):175–91.10.3758/BF0319314617695343
46. Faul F, Erdfelder E, Buchner A, Lang A-G. Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods (2009) 41(4):1149–60.10.3758/BRM.41.4.114919897823
47. Picorelli AMA, Pereira LSM, Pereira DS, Felício D, Sherrington C. Adherence to exercise programs for older people is influenced by program characteristics and personal factors: a systematic review. J Physiother (2014) 60(3):151–6.10.1016/j.jphys.2014.06.01225092418
48. Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res (1975) 12(3):189–98.10.1016/0022-3956(75)90026-6
49. de Melo DM, Barbosa AJG. [Use of the mini-mental state examination in research on the elderly in Brazil: a systematic review]. Cien Saude Colet (2015) 20(12):3865–76.10.1590/1413-812320152012.0603201526691810
50. Hogervorst E, Clifford A. Exercise to prevent cognitive decline and Alzheimer’s disease: for whom, when, what, and (most importantly) how much? J Alzheimers Dis Park (2012) 02(03):2–4.10.4172/2161-0460.1000e117
51. Dellagi L, Ben Azouz O, Johnson I, Kebir O, Amado I, Tabbane K. [Tunisian adaptation of Hopkins verbal learning test, form 1]. La Tunisie médicale (2009) 87(10):670–3.20187355
52. Rieu D, Bachoud-Lévi A-C, Laurent A, Jurion E, Dalla Barba G. [French adaptation of the Hopkins verbal learning test]. Rev Neurol (Paris) (2006) 162(6–7):721–8.10.1016/S0035-3787(06)75069-X
53. Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis (1987) 40(5):373–83.10.1016/0021-9681(87)90171-8
54. Charlson M, Szatrowski TP, Peterson J, Gold J. Validation of a combined comorbidity index. J Clin Epidemiol (1994) 47(11):1245–51.10.1016/0895-4356(94)90129-57722560
55. Quan H, Li B, Couris CM, Fushimi K, Graham P, Hider P, et al. Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries. Am J Epidemiol (2011) 173(6):676–82.10.1093/aje/kwq43321330339
56. Rikli R, Jones C. Senior Fitness Test Manual. 2nd ed. Champaign, IL: Human Kinetics (2013).
57. Savva GM, Donoghue OA, Horgan F, O’Regan C, Cronin H, Kenny RA. Using timed up-and-go to identify frail members of the older population. J Gerontol A Biol Sci Med Sci (2013) 68(4):441–6.10.1093/gerona/gls19022987796
58. Greene BR, Doheny EP, O’Halloran A, Anne Kenny R. Frailty status can be accurately assessed using inertial sensors and the TUG test. Age Ageing (2014) 43(3):406–11.10.1093/ageing/aft17624212918
59. Hogervorst E, Clifford A, Stock J, Xin X, Bandelow S. Exercise to prevent cognitive decline and Alzheimer’s disease: for whom, when, what, and (most importantly) how much? J Alzheimers Dis Park (2012) 2(3):1000e117.10.4172/2161-0460.1000e117
60. Alice M, Pimenta DM, Baradel RR, Fonseca RP, Pereira N, Carthery-Goulart MT. Evolution of language assessment in patients with acquired neurological disorders in Brazil. Dementia e Neuropsychologia (2014) 8(3):196–206.10.1590/S1980-57642014DN83000002
61. Ardila A, Ostrosky-Solís F, Bernal B. Cognitive testing toward the future: the example of semantic verbal fluency (ANIMALS). Int J Psychol (2006) 41(5):324–32.10.1080/00207590500345542
62. Lortie JJ, Remington R, Hoffmann H, Shea TB. Lack of correlation of WAIS digit span with clox 1 and the dementia rating scale in MCI. Int J Alzheimers Dis (2012) 2012:829743.10.1155/2012/82974322577593
63. Berrigan LI, Fisk JD, Walker LAS, Wojtowicz M, Rees LM, Freedman MS, et al. Reliability of regression-based normative data for the oral symbol digit modalities test: an evaluation of demographic influences, construct validity, and impairment classification rates in multiple sclerosis samples. Clin Neuropsychol (2014) 28(2):281–99.10.1080/13854046.2013.87133724438521
64. Fernandes HM, Vasconcelos-Raposo J, Pereira E, Ramalho J, Oliveira S. A influência da actividade física na saúde mental positiva de idosos. Motricidade Revista Motricidade/Edições Desafio Singular (2009) 5(1):33–50.10.6063/motricidade.5(1).186
65. McAuley E, Elavsky S, Motl RW, Konopack JF, Hu L, Marquez DX. Physical activity, self-efficacy, and self-esteem: longitudinal relationships in older adults. J Gerontol B Psychol Sci Soc Sci (2005) 60(5):268–75.10.1093/geronb/60.5.P26816131621
66. Barros F, Neto J. Satisfação com a vida: diferenças conforme a religião e a cultura. Psicol Educ e Cult (2004) VI(2):243–78.
67. Parker SJ, Strath SJ, Swartz AM. Physical activity measurement in older adults: relationships with mental health. J Aging Phys Act (2008) 16(4):369–80.19033599
68. Trigo M, Canudo N, Branco F, Silva D. Estudo das propriedades psicométricas da perceived stress scale (PSS) na população portuguesa. Phychologica (2010) 53:353–8.10.14195/1647-8606_53_17
69. Remor E. Psychometric properties of a European Spanish version of the perceived stress scale (PSS). Span J Psychol (2006) 9(1):86–93.10.1017/S113874160000600416673626
70. Pais-Ribeiro J, Silva I, Ferreira T, Martins A, Meneses R, Baltar M. Validation study of a Portuguese version of the hospital anxiety and depression scale. Psychol Health Med (2007) 12:225–35; quiz 235–7.10.1080/1354850050052408817365902
71. Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist (1969) 9(3):179–86.10.1093/geront/9.3_Part_1.179
72. Graf C. The Lawton instrumental activities of daily living scale. Am J Nurs (2008) 108(4):52–62; quiz 62–3.10.1097/01.NAJ.0000314810.46029.74
73. Katz S, Downs TD, Cash HR, Grotz RC. Progress in development of the index of ADL. Gerontologist (1970) 10(1):20–30.10.1093/geront/10.1_Part_1.20
74. Arik G, Varan HD, Yavuz BB, Karabulut E, Kara O, Kilic MK, et al. Validation of Katz index of independence in activities of daily living in Turkish older adults. Arch Gerontol Geriatr (2015) 61(3):344–50.10.1016/j.archger.2015.08.01926328478
75. Buurman BM, van Munster BC, Korevaar JC, de Haan RJ, de Rooij SE. Variability in measuring (instrumental) activities of daily living functioning and functional decline in hospitalized older medical patients: a systematic review. J Clin Epidemiol (2011) 64(6):619–27.10.1016/j.jclinepi.2010.07.00521074969
76. Tinetti ME, Richman D, Powell L. Falls efficacy as a measure of fear of falling. J Gerontol (1990) 45(6):239–43.10.1093/geronj/45.6.P2392229948
77. Morgan MT, Friscia LA, Whitney SL, Furman JM, Sparto PJ. Reliability and validity of the falls efficacy scale-international (FES-I) in individuals with dizziness and imbalance. Otol Neurotol (2013) 34(6):1104–8.10.1097/MAO.0b013e318281df5d23542134
78. Allgrove JE, Gomes E, Hough J, Gleeson M. Effects of exercise intensity on salivary antimicrobial proteins and markers of stress in active men. J Sports Sci (2008) 26(6):653–61.10.1080/0264041070171679018344136
79. Rikli RE, Jones CJ. Development and validation of criterion-referenced clinically relevant fitness standards for maintaining physical independence in later years. Gerontologist (2013) 53(2):255–67.10.1093/geront/gns07122613940
80. Chumlea W, Baumgartner N. Status of anthropometry in elderly subjects3 w composition data. Am J Clin Nutr (1989) 50:1158–66.
81. Nelson ME, Rejeski WJ, Blair SN, Duncan PW, Judge JO, King AC, et al. Physical activity and public health in older adults: recommendation from the American College of Sports Medicine and the American Heart Association. Med Sci Sports Exerc (2007) 39(8):1435–45.10.1249/mss.0b013e3180616aa2
82. Robinson KR, Leighton P, Logan P, Gordon AL, Anthony K, Harwood RH, et al. Developing the principles of chair based exercise for older people: a modified Delphi study. BMC Geriatr (2014) 14(1):65.10.1186/1471-2318-14-6524884392
83. Anthony K, Robinson K, Logan P, Gordon AL, Harwood RH, Masud T. Chair-based exercises for frail older people: a systematic review. Biomed Res Int (2013) 2013:309506.10.1155/2013/30950624089670
84. Hars M, Herrmann FR, Gold G, Rizzoli R, Trombetti A. Effect of music-based multitask training on cognition and mood in older adults. Age Ageing (2014) 43(2):196–200.10.1093/ageing/aft16324212920
85. Nikolić G. Narrow capture beat. Heart Lung (2004) 33(3):194–5.10.1016/S0147-9563(03)00118-3
86. ® elastic bands. J Sports Sci Med (2014) 13(4):758–66.25435767
87. Patel NK, Newstead AH, Ferrer RL. The effects of yoga on physical functioning and health related quality of life in older adults: a systematic review and meta-analysis. J Altern Complement Med (2012) 18(10):902–17.10.1089/acm.2011.047322909385
88. Büssing A, Ostermann T, Lüdtke R, Michalsen A. Effects of yoga interventions on pain and pain-associated disability: a meta-analysis. J Pain (2012) 13(1):1–9.10.1016/j.jpain.2011.10.00122178433
89. Guderian B, Johnson A, Mathiowetz V. Impact of exercise frequency on hand strength of the elderly. Phys Occup Ther Geriatr (2013) 31(3):268–79.10.3109/02703181.2013.796583
90. Gillespie LD, Robertson MC, Gillespie WJ, Sherrington C, Gates S, Clemson LM, et al. Interventions for preventing falls in older people living in the community. Cochrane Database Syst Rev (2012) 9:CD007146.10.1002/14651858.CD007146.pub322972103
91. Robitaille A, Muniz G, Lindwall M, Piccinin AM, Hoffman L, Johansson B, et al. Physical activity and cognitive functioning in the oldest old: within- and between-person cognitive activity and psychosocial mediators. Eur J Ageing (2014) 11(4):333–47.10.1007/s10433-014-0314-z25598770
92. Hopkins WG, Marshall SW, Batterham AM, Hanin J. Progressive statistics for studies in sports medicine and exercise science. Med Sci Sports Exerc (2009) 41(1):3–12.10.1249/MSS.0b013e31818cb278
93. Carlson MC, Erickson KI, Kramer AF, Voss MW, Bolea N, Mielke M, et al. Evidence for neurocognitive plasticity in at-risk older adults: the experience corps program. J Gerontol A Biol Sci Med Sci (2009) 64(12):1275–82.10.1093/gerona/glp11719692672
94. Milte R, Crotty M. Musculoskeletal health, frailty and functional decline. Best Pract Res Clin Rheumatol (2014) 28(3):395–410.10.1016/j.berh.2014.07.00525481423
95. Macklai NS, Spagnoli J, Junod J, Santos-Eggimann B. Prospective association of the SHARE-operationalized frailty phenotype with adverse health outcomes: evidence from 60+ community-dwelling Europeans living in 11 countries. BMC Geriatr (2013) 13(1):3.10.1186/1471-2318-13-323286928
96. Uemura K, Shimada H, Makizako H, Doi T, Yoshida D, Tsutsumimoto K, et al. Cognitive function affects trainability for physical performance in exercise intervention among older adults with mild cognitive impairment. Clin Interv Aging (2013) 8:97–102.10.2147/CIA.S3943423390362