Higher physical activity is associated with increased androgens, low interleukin 6 and less aortic calcification in peripheral obese elderly women

Journal of Endocrinology

Volumn 199, Issue 1, 2008, Pages 61-68

  Straub, Rainer H ^a   Tanko L B ^b   Christiansen, C ^b   Larsen, P J ^a   Jessop, D S ^c  

^a UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^b CENTER FOR CLINICAL AND BASIC RESEARCH   (Denmark)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROSTENEDIONE; HORMONE; HYDROCORTISONE; HYDROXYPROGESTERONE; INTERLEUKIN 6; PRASTERONE;

ADULT; AGED; AORTA CALCIFICATION; AORTA DISEASE; ARTICLE; BODY FAT; BODY FAT DISTRIBUTION; DUAL ENERGY X RAY ABSORPTIOMETRY; ELDERLY CARE; FEMALE; HORMONE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; HYDROCORTISONE BLOOD LEVEL; LUMBAR VERTEBRA; NORMAL HUMAN; OBESITY; PHYSICAL ACTIVITY; PRIORITY JOURNAL;

17-ALPHA-HYDROXYPROGESTERONE; ABSORPTIOMETRY, PHOTON; AGED; AGED, 80 AND OVER; ANDROSTENEDIONE; AORTIC VALVE; CALCINOSIS; COHORT STUDIES; DEHYDROEPIANDROSTERONE; FEMALE; HUMANS; HYDROCORTISONE; INTERLEUKIN-6; MIDDLE AGED; MOTOR ACTIVITY; OBESITY;

EID: 55049090968     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-08-0319     Document Type: Article

References (38)

1. Abbasi A, Duthie EH Jr, Sheldahl L, Wilson C, Sasse E, Rudman I & Mattson DE 1998 Association of dehydroepiandrosterone sulfate, body composition, and physical fitness in independent community-dwelling older men and women. Journal of the American Geriatrics Society 46 263-273.
2. Anderson DC & Yen SS 1976 Effects of estrogens on adrenal 3 beta-hydroxysteroid dehydrogenase in ovariectomized women. Journal of Clinical Endocrinology and Metabolism 43 561-570.
3. Barone KM, Shamonki IM, Siiteri PK & Judd HL 1979 Inhibition of peripheral aromatization of androstenedione to estrone in postmenopausal women with breast cancer using delta 1-testololactone. Journal of Clinical Endocrinology and Metabolism 49 672-676.
4. Colbert LH, Visser M, Simonsick EM, Tracy RP, Newman AB, Kritchevsky SB, Pahor M, Taaffe DR, Brach J, Rubin S et al. 2004 Physical activity, exercise, and inflammatory markers in older adults: findings from the Health, Aging and Body Composition Study. Journal of the American Geriatrics Society 52 1098-1104.
5. Cumming DC, Brunsting LA III, Strich G, Ries AL & Rebar RW 1986 Reproductive hormone increases in response to acute exercise in men. Medicine and Science in Sports and Exercise 18 369-373.
6. Ehrhart-Bornstein M, Hinson JP, Bornstein SR, Scherbaum WA & Vinson GP 1998 Intraadrenal interactions in the regulation of adrenocortical steroidogenesis. Endocrine Reviews 19 101-143.
7. Fernandez-Real JM & Ricart W 2003 Insulin resistance and chronic cardiovascular inflammatory syndrome. Endocrine Reviews 24 278-301.
8. Ferreira I, Snijder MB, Twisk JW, van MW Kemper HC, Seidell JC & Stehouwer CD 2004 Central fat mass versus peripheral fat and lean mass: opposite (adverse versus favorable) associations with arterial stiffness? The Amsterdam Growth and Health Longitudinal Study Journal of Clinical Endocrinology and Metabolism 89 2632-2639.
9. Gordon CM, LeBoff MS & Glowacki J 2001 Adrenal and gonadal steroids inhibit IL-6 secretion by human marrow cells. Cytokine 16 178-186.
10. Grant RW & Meigs JB 2004 Should the insulin resistance syndrome be treated in the elderly? Drugs & Aging 21 141-151.
11. Hakkinen K, Pakarinen A, Kraemer WJ, Newton RU & Alen M 2000 Basal concentrations and acute responses ofserum hormones and strength development during heavy resistance training in middle-aged and elderly men and women. Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 55 1395-13105.
12. Hautanen A, Manttari M, Manninen V, Tenkanen L, Hurtunen JK, Frick MH & Adlercreutz H 1994 Adrenal androgens and testosterone as coronary risk factors in the Helsinki Heart Study. Atherosclerosis 105 191-200.
13. Hersey WC III, Graves JE, Pollock ML, Gingerich R, Shireman RB, Heath GW, Spierto F, McCole SD & Hagberg JM 1994 Endurance exercise training improves body composition and plasma insulin responses in 70- to 79-year-old men and women. Metabolism 43 847-854.
14. Jankord R & Jemiolo B 2004 Influence of physical activity on serum IL-6 and IL-10 levels in healthy older men. Medicine and Science in Sports and Exercise 36 960-964.
15. Kauppila LI, Polak JF, Cupples LA, Hannan MT, Kiel DP & Wilson PW 1997 New indices to classify location, severity and progression of calcific lesions in the abdominal aorta: a 25-year follow-up study. Atherosclerosis 132 245-250.
16. Keizer HA, Kuipers H, de HJ, Beckers E & Habets L 1987 Multiple hormonal responses to physical exercise in eumenorrheic trained and untrained women. International Journal of Sports Medicine 8 139-150.
17. Keller C, Steensberg A, Hansen AK, Fischer CF, Plomgaard P & Pedersen BK 2005 Effect of exercise, training, and glycogen availability on IL-6 receptor expression in human skeletal muscle. Journal of Applied Physiology 99 2075-2079.
18. Kim SK, Shin MS, Jung BK, Shim JY, Won HS, Lee PR & Kim A 2006 Effect of dehydroepiandrosterone on lipopolysaccharide-induced interleukin-6 production in DH82 cultured canine macrophage cells. Journal of Reproductive Immunology 70 71-81.
19. Kipper-Galperin M, Galilly R, Danenberg HD & Brenner T 1999 Dehydroepiandrosterone selectively inhibits production of tumor necrosis factor alpha and interleukin-6 correction of interlukin-6 in astrocytes. International Journal of Developmental Neuroscience 17 765-775.
20. Kizildere S, Glück T, Zietz B, Schölmerich J & Straub RH 2003 During a corticotropin-releasing hormone test in healthy subjects, administration of a beta-adrenergic antagonist induced secretion of cortisol and dehydroepiandrosterone sulfate and inhibited secretion of ACTH. European Journal of Endocrinology 148 45-53.
21. Kohut ML, McCann DA, Russell DW, Konopka DN, Cunnick JE, Franke WD, Castillo MC, Reighard AE & Vanderah E 2006 Aerobic exercise, but not flexibiliry/resistance exercise, reduces serum IL-18, CRP, and IL-6 independent of beta-blockers, BMI, and psychosocial factors in older adults. Brain, Behavior, and Immunity 20 201-209.
22. Laukkanen JA, Kurl S & Salonen JT 2002 Cardiorespiratory fitness and physical activity as risk predictors of future atherosclerotic cardiovascular diseases. Current Atherosclerosis Reports 4 468-476.
23. Malarkey WB, Hall JC, Rice RR Jr, O'Toole ML, Douglas PS, Demers LM & Glaser R 1993 The influence of age on endocrine responses to ultraendurance stress. Journal of Gerontology 48 M134-M139.
24. Milani RV, Lavie CJ, Barbee RW & Littman AB 1995 Lack of effect of exercise training on dehydroepiandrosterone-sulfate. American Journal of the Medical Sciences 310 242-246.
25. Nestler JE, Clore JN & Blackard WG 1992 Dehydroepiandrosterone: the 'missing link' between hyperinsulinemia and atherosclerosis? FASEB Journal 6 3073-3075.
26. Pedersen BK, Steensberg A & Schjerling P 2001 Muscle-derived interleukin-6: possible biological effects. Journal of Physiology 536 329-337.
27. Phillips GB, Pinkernell BH & Jing TY 1997 Relationship between serum sex hormones and coronary artery disease in postmenopausal women. Arteriosclerosis, Thrombosis, and Vascular Biology 17 695-701.
28. Raji A & Plutzky J 2002 Insulin resistance, diabetes, and atherosclerosis: thiazolidinediones as therapeutic interventions. Current Cardiology Reports 4 514-521.
29. Ryan AS & Nicklas BJ 2004 Reductions in plasma cytokine levels with weight loss improve insulin sensitivity in overweight and obese postmenopausal women. Diabetes Care 27 1699-1705.
30. Snijder MB, Henry RM, Visser M, Dekker JM, Seidell JC, Ferreira I, Bouter LM, Yudkin JS, Westerhof N & Stehouwer CD 2004 Regional body composition as a determinant of arterial stiffness in the elderly: the Hoorn Study. Journal of Hypertension 22 2339-2347.
31. Straub RH, Konecna L, Hrach S, Rothe G, Kreutz M, Schölmerich J, Falk W & Lang B 1998 Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence. Journal of Clinical Endocrinology and Metabolism 83 2012-2017.
32. Straub RH, Pongratz G, Schölmerich J, Kees F, Schaible TF, Antoni C, Kalden JR & Lorenz HM 2003 Long-term anti-tumor necrosis factor antibody therapy in rheumatoid arthritis patients sensitizes the pituitary gland and favors adrenal androgen secretion. Arthritis and Rheumatism 48 1504-1512.
33. Tanko LB, Bagger YZ, Alexandersen P, Larsen PJ & Christiansen C 2003 Peripheral adiposity exhibits an independent dominant antiatherogenic effect in elderly women. Circulation 107 1626-1631.
34. Tanko LB, Bruun JM, Alexandersen P, Bagger YZ, Richelsen B, Christiansen C & Larsen PJ 2004 Novel associations between bioavailable estradiol and adipokines in elderly women with different phenotypes of obesity: implications for atherogenesis. Circulation 110 2246-2252.
35. Tanko LB, Bagger YZ, Qin G, Alexandersen P, Larsen PJ & Christiansen C 2005 Enlarged waist combined with elevated triglycerides is a strong predictor of accelerated atherogenesis and related cardiovascular mortality in postmenopausal women. Circulation 111 1883-1890.
36. Vicennati V & Pasquali R 2000 Abnormalities of the hypothalamic-pituitary-adrenal axis in nondepressed women with abdominal obesity and relations with insulin resistance: evidence for a central and a peripheral alteration. Journal of Clinical Endocrinology and Metabolism 85 4093-4098.
37. Wilson PW, Kauppila LI, O'Donnell CJ, Kiel DP, Hannan M, Polak JM & Cupples LA 2001 Abdominal aortic calcific deposits are an important predictor of vascular morbidity and mortality. Circulation 103 1529-1534.
38. Wu FC & von EA 2003 Androgens and coronary artery disease. Endocrine Reviews 24 183-217.