Efficacy and safety of tranexamic acid in pediatric patients undergoing cardiac surgery: A single-center experience

Frontiers in Pediatrics

Volumn 7, Issue MAY, 2019, Pages

  Zhang, Yu ^a   Zhang, Xue ^a   Wang, Yang ^a   Shi, Jia ^a   Yuan, Su ^a   Duan, Fujian ^a   Wang, Yuefu ^a   Zhang, Zhe ^a   Jia, Yuan ^a   Gong, Junsong ^a   Li, Lihuan ^a   Yan, Fuxia ^a  

^a FUWAI HOSPITAL   (China)

Author keywords

Blood loss; Congenital heart disease; Cyanosis; Infant; Safety; Tranexamic acid

Indexed keywords

CREATININE; HEMOGLOBIN; TRANEXAMIC ACID;

ARTICLE; BLOOD TRANSFUSION; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; CYANOSIS; DRUG EFFICACY; DRUG SAFETY; FALLOT TETRALOGY; FEMALE; HEART ATRIUM SEPTUM DEFECT; HEART SURGERY; HEART VENTRICLE SEPTUM DEFECT; HOSPITAL MORTALITY; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MULTIPLE ORGAN FAILURE; PEDIATRIC PATIENT; POSTOPERATIVE HEMORRHAGE; REOPERATION; RETROSPECTIVE STUDY;

EID: 85067505447     PISSN: None     EISSN: 22962360     Source Type: Journal    
DOI: 10.3389/fped.2019.00181     Document Type: Article

References (22)

1. Siemens K, Sangaran DP, Hunt BJ, Murdoch IA, Tibby SM. Strategies for prevention and management of bleeding following pediatric cardiac surgery on cardiopulmonary bypass: a scoping review. Pediatr Crit Care Med. (2018) 19:40-7. doi: 10.1097/PCC.0000000000001387
2. Cholette JM, Faraoni D, Goobie SM, Ferraris V, Hassan N. Patient blood management in pediatric cardiac surgery: a review. Anesth Analg. (2018) 127:1002-16. doi: 10.1213/ANE.0000000000002504
3. Koster A, Faraoni D, Levy JH. Antifibrinolytic therapy for cardiac surgery: an update. Anesthesiology. (2015) 123:214-21. doi: 10.1097/ALN.0000000000000688
4. Kozek-Langenecker SA, Ahmed AB, Afshari A, Albaladejo P, Aldecoa C, Barauskas G, et al. Management of severe perioperative bleeding: guidelines from the European society of anaesthesiology: first update 2016. Eur J Anaesthesiol. (2017) 34:332-95. doi: 10.1097/EJA.0000000000000630
5. Pasquali SK, Li JS, He X, Jacobs ML, O'Brien SM, Hall M, et al. Comparative analysis of antifibrinolytic medications in pediatric heart surgery. J Thorac Cardiovasc Surg. (2012) 143:550-7. doi: 10.1016/j.jtcvs.2011.06.048
6. Koster A, Börgermann J, Zittermann A, Lueth JU, Gillis-Januszewski T, Schirmer U. Moderate dosage of tranexamic acid during cardiac surgery with cardiopulmonary bypass and convulsive seizures: incidence and clinical outcome. Br J Anaest. (2013) 110:34-40. doi: 10.1093/bja/aes310
7. Myles PS, Smith JA, Forbes A, Silbert B, Jayarajah M, Painter T, et al. Tranexamic acid in patients undergoing coronary-artery surgery. N Engl J Med. (2017) 376:136-48. doi: 10.1056/NEJMoa1606424
8. Takagi H, Ando T, Umemoto T. All-literature investigation of cardiovascular evidence (ALICE) group. Seizures associated with tranexamic acid for cardiac surgery:a meta-analysis of randomized and non-randomized studies. J Cardiovasc Surg. (2017) 58:633-41. doi: 10.23736/S0021-9509.17.09877-9
9. Martin K, Breuer T, Gertler R, Hapfelmeier A, Schreiber C, Lange R, et al. Tranexamic acid versus ε-aminocaproic acid: efficacy and safety in paediatric cardiac surgery. Eur J Cardiothorac Surg. (2011) 39:892-7. doi: 10.1016/j.ejcts.2010.09.041
10. Maeda T, Sasabuchi Y, Matsui H, Ohnishi Y, Miyata S, Yasunaga H. Safety of tranexamic acid in pediatric cardiac surgery: a nationwide database study. J Cardiothorac Vasc Anesth. (2017) 31:549-53. doi: 10.1053/j.jvca.2016.10.001
11. Naef N, Liamlahi R, Beck I, Bernet V, Dave H, Knirsch W, et al. Neurodevelopmental profiles of children with congenital heart disease at school age. J Pediatr. (2017) 188:75-81. doi: 10.1016/j.jpeds.2017.05.073
12. Zhou ZF, Zhang FJ, Huo YF, Yu YX, Yu LN, Sun K, et al. Intraoperative tranexamic acid is associated with postoperative stroke in patients undergoing cardiac surgery. PLoS ONE. (2017) 12:e0177011. doi: 10.1371/journal.pone.0177011
13. Kwiatkowski DM, Goldstein SL, Cooper DS, Nelson DP, Morales DL, Krawczeski CD. Peritoneal dialysis vs furosemide for prevention of fluid overload in infants after cardiac surgery: a randomized clinical trial. JAMA Pediatr. (2017) 171:357-64. doi: 10.1001/jamapediatrics.2016.4538
14. Wesley MC, Pereira LM, Scharp LA, Emani SM, McGowan FX, DiNardo JA. Pharmacokinetics of tranexamic acid in neonates, infants, and children undergoing cardiac surgery with cardiopulmonary bypass. Anesthesiology. (2015) 122:746-58. doi: 10.1097/ALN.0000000000000570
15. Nishijima DK, Monuteaux MC, Faraoni D, Goobie SM, Lee L, Galante J, et al. Tranexamic acid use in united states children's hospitals. J Emerg Med. (2016) 50:868-74. doi: 10.1016/j.jemermed.2016.02.004
16. Basta MN, Stricker PA, Taylor JA. A systematic review of the use of antifibrinolytic agents in pediatric surgery and implications for craniofacial use. Pediatr Surg Int. (2012) 28:1059-69. doi: 10.1007/s00383-012-3167-6
17. Faraoni D, Willems A, Melot C, De Hert S, Van der Linden P. Efficacy of tranexamic acid in paediatric cardiac surgery: a systematic review and meta-analysis. Eur J Cardiothorac Surg. (2012) 42:781-6. doi: 10.1093/ejcts/ezs127
18. Shimizu K, Toda Y, Iwasaki T, Takeuchi M, Morimatsu H, Egi M, et al. Effect of tranexamic acid on blood loss in pediatric cardiac surgery: a randomized trial. J Anesth. (2011) 25:823-30. doi: 10.1007/s00540-011-1235-z
19. Vida VL, Spiezia L, Bortolussi G, Marchetti ME, Campello E, Pittarello D, et al. The coagulative profile of cyanotic children undergoing cardiac surgery: the role of whole blood preoperative thromboelastometry on postoperative transfusion requirement. Artif Organs. (2016) 40:698-705. doi: 10.1111/aor.12629
20. Goobie SM. Tranexamic acid:still far to go. Br J Anaesth. (2017) 118:293-5. doi: 10.1093/bja/aew470
21. Later AF, Sitniakowsky LS, van Hilten JA, van de Watering L, Brand A, Smit NP, et al. Antifibrinolytics attenuate inflammatory gene Expression after cardiac surgery. J Thorac Cardiovasc Surg. (2013) 145:1611-6. doi: 10.1016/j.jtcvs.2012.11.042
22. Giordano R, Palma G, Poli V, Palumbo S, Russolillo V, Cioffi S, et al. Tranexamic acid therapy in pediatric cardiac surgery: a single-center study. Ann Thorac Surg. (2012) 94:1302-6. doi: 10.1016/j.athoracsur.2012.04.078