Anemia and adverse outcomes in the elderly: A detrimental inflammatory loop?

Haematologica

Volumn 104, Issue 3, 2019, Pages 417-419

  Girelli, Domenico ^a   Busti, Fabiana ^a  

^a UNIVERSITY HOSPITAL OF VERONA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; DNA METHYLTRANSFERASE 3A; ERYTHROPOIETIN; HEMOGLOBIN; JANUS KINASE 2; PEPTIDES AND PROTEINS; TET METHYLCYTOSINE DIOXYGENASE 2; UNCLASSIFIED DRUG;

ADVERSE OUTCOME; ANDROGEN DEFICIENCY; ANEMIA; BLEEDING; COGNITIVE DEFECT; DISEASE EXACERBATION; EDITORIAL; ERYTHROPOIESIS; FALL RISK; FRACTURE; GENE MUTATION; HEMATOPOIESIS; IRON DEFICIENCY; MALABSORPTION; MALNUTRITION; MORTALITY; MYELOMA; PHYSICAL PERFORMANCE; PREVALENCE; QUALITY OF LIFE; SURVIVAL; UPREGULATION; VITAMIN D DEFICIENCY; AGED; COHORT ANALYSIS; HUMAN;

AGED; ANEMIA; COHORT STUDIES; HUMANS; QUALITY OF LIFE;

EID: 85063871408     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2018.208066     Document Type: Editorial

References (20)

1. Mannino RG, Myers DR, Tyburski EA, et al. Smartphone app for non-invasive detection of anemia using only patient-sourced photos. Nat Commun. 2018;9(1):4924.
2. Girelli D, Marchi G, Camaschella C. Anemia in the elderly. HemaSphere. 2018;2(3):e40.
3. Erikson GA, Bodian DL, Rueda M, et al. Whole-genome sequencing of a healthy aging cohort. Cell. 2016;165(4):1002-1011.
4. Wouters H, van der Klauw MM, de Witte T, et al. Association of anemia with health-related quality of life and survival: a large population-based cohort study. Haematologica. 2019;104(3):468-476.
5. Barnett K, Mercer SW, Norbury M, Watt G, Wyke S, Guthrie B. Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. Lancet. 2012;380(9836):37-43.
6. Busti F, Campostrini N, Martinelli N, Girelli D. Iron deficiency in the elderly population, revisited in the hepcidin era. Front Pharmacol. 2014;5:83.
7. Weiss G, Ganz T, Goodnough LT. Anemia of inflammation. Blood. 2018 Nov 6 [Epub ahead of print].
8. Shavelle RM, MacKenzie R, Paculdo DR. Anemia and mortality in older persons: does the type of anemia affect survival¿ Int J Hematol. 2012;95(3):248-256.
9. Steensma DP. Clinical consequences of clonal hematopoiesis of indeterminate potential. Blood Adv. 2018;2(22):3404-3410.
10. Jaiswal S, Natarajan P, Silver AJ, et al. Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease. N Engl J Med. 2017;377(2):111-121.
11. Libby P, Ebert BL. CHIP (clonal hematopoiesis of indeterminate potential). Circulation. 2018;138(7):666-668.
12. Franceschi C, Bonafe M, Valensin S, et al. Inflamm-aging. An evolu-evolu- tionary perspective on immunosenescence. Ann N Y Acad Sci. 2000;908:244-254. tionary
13. Youm YH, Grant RW, McCabe LR, et al. Canonical Nlrp3 inflamma-some links systemic low-grade inflammation to functional decline in aging. Cell Metab. 2013;18(4):519-532.
14. Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell. 2010;140(6):883-899.
15. Qu X, Zhang S, Wang S, et al. TET2 deficiency leads to stem cell fac-tor-dependent clonal expansion of dysfunctional erythroid progenitors. Blood. 2018;132(22):2406-2417.
16. Malcovati L, Galli A, Travaglino E, et al. Clinical significance of somatic mutation in unexplained blood cytopenia. Blood. 2017;129(25):3371-3378.
17. Crielaard BJ, Lammers T, Rivella S. Targeting iron metabolism in drug discovery and delivery. Nat Rev Drug Discov. 2017;16(6):400-423.
18. Girelli D, Ugolini S, Busti F, Marchi G, Castagna A. Modern iron replacement therapy: clinical and pathophysiological insights. Int J Hematol. 2018;107(1):16-30.
19. Platzbecker U, Germing U, Gotze KS, et al. Luspatercept for the treatment of anaemia in patients with lower-risk myelodysplastic syndromes (PACE-MDS): a multicentre, open-label phase 2 dose-finding study with long-term extension study. Lancet Oncol. 2017;18(10):1338-1347.
20. Gupta N, Wish JB. Hypoxia-inducible factor prolyl hydroxylase inhibitors: a potential new treatment for anemia in patients with CKD. Am J Kidney Dis. 2017;69(6):815-826.