High donor age for liver transplantation: Tackling organ scarcity in Germany;Hohes Spenderalter bei Lebertransplantation: Wie begegnen wir dem Organmangel in Deutschland?

Chirurg

Volumn 90, Issue 9, 2019, Pages 744-751

  Moosburner, S ^a   Ritschl, P V ^a,b   Wiering, L ^a   Gassner, J M G V ^a   Ollinger R ^a   Pratschke, J ^a   Sauer, I M ^a   Raschzok, N ^a,b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b BERLIN INSTITUTE OF HEALTH   (Germany)

Author keywords

Aged, 80 and over; Donor selection; Liver transplantation; Population dynamics; Resource allocation

Indexed keywords

AGE; DONOR; GERMANY; GRAFT SURVIVAL; HUMAN; LIVER TRANSPLANTATION; LIVER TUMOR; MIDDLE AGED; RETROSPECTIVE STUDY; TREATMENT OUTCOME; VERY ELDERLY;

AGE FACTORS; AGED, 80 AND OVER; BERLIN; GERMANY; GRAFT SURVIVAL; HUMANS; LIVER NEOPLASMS; LIVER TRANSPLANTATION; MIDDLE AGED; RETROSPECTIVE STUDIES; TISSUE DONORS; TREATMENT OUTCOME;

EID: 85060911365     PISSN: 00094722     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00104-019-0801-z     Document Type: Article

References (36)

1. Angele MK, Rentsch M, Hartl WH et al (2008) Effect of graft steatosis on liver function and organ survival after liver transplantation. Am J Surg 195:214–220. 10.1016/j.amjsurg.2007.02.023
2. De Boer JD, Koopman JJE, Metselaar HJ et al (2017) Liver transplantation with geriatric liver allografts: the current situation in Eurotransplant. Transpl Int 30:432–433. 10.1111/tri.12914
3. Branger P, Samuel U (2018) Eurotransplant International Foundation Annual Report 2017. Eurotransplant Statistics Report Library, Leiden
4. Cohen B, Persijn GG (2004) Eurotransplant International Foundation Annual Report 2004. Eurotransplant Statistics Report Library, Leiden
5. Kan C, Ungelenk L, Lupp A et al (2018) Ischemia-Reperfusion Injury in Aged Livers – The Energy Metabolism, Inflammatory Response, and Autophagy. 102:368–377 10.1097/TP.0000000000001999
6. Deutsche Stiftung Organstransplantation (2011) Organspende und Transplantation in Deutschland 2010. Deutsche Stiftung Organstransplantation, Frankfurt/Main
7. Deutsche Stiftung Organstransplantation (2017) Organspende und Transplantation in Deutschland 2017. Deutsche Stiftung Organstransplantation, Frankfurt/Main
8. Die Bundesregierung der Bundesrepublik Deutschland (2018) Zweites Gesetz zur Änderung des Transplantationsgesetzes – Verbesserung der Zusammenarbeit und der Strukturen bei der Organspende. Die Bundesregierung der Bundesrepublik Deutschland, Berlin
9. Dudek K, Kornasiewicz O, Remiszewski P et al (2014) Results of liver transplantation from old donors. Transplant Proc. 10.1016/j.transproceed.2014.09.022
10. Dutkowski P, Schlegel A, Slankamenac K et al (2012) The use of fatty liver grafts in modern allocation systems: risk assessment by the balance of risk (BAR) score. Ann Surg 256:861–869. 10.1097/SLA.0b013e318272dea2
11. Eurotransplant (2018) Deceased donors used in All ET, by year, by age group. Eurotransplant Statistics Report Library. Eurotransplant, Leiden
12. Feng S, Goodrich NP, Bragg-Gresham JI et al (2006) Characteristics associated with liver graft failure: the concept of a donor risk index. Am J Transplant 6:783–790. 10.1111/j.1600-6143.2006.01242.x
13. Gao Q, Mulvihill MS, Scheuermann U et al (2018) Improvement in liver transplant outcomes from older donors. Ann Surg. 10.1097/SLA.0000000000002876
14. Ghinolfi D, Lai Q, Pezzati D et al (2018) Use of Elderly Donors in Liver Transplantation: A Paired-match Analysis at a Single Center. Ann Surg 268:325–331. 10.1097/SLA.0000000000002305
15. Ghinolfi D, Marti J, De Simone P et al (2014) Use of octogenarian donors for liver transplantation: a survival analysis. Am J Transplant 14:2062–2071. 10.1111/ajt.12843
16. Ghinolfi D, De Simone P, Tincani G et al (2016) Beyond the limit: Approaching systematic use of nonagenarian donors in liver transplantation. Transplantation 100:e37–e38. 10.1097/TP.0000000000001207
17. de Graaf EL, Kench J, Dilworth P et al (2012) Grade of deceased donor liver macrovesicular steatosis impacts graft and recipient outcomes more than the Donor Risk Index. J Gastroenterol Hepatol 27:540–546. 10.1111/j.1440-1746.2011.06844.x
18. Habka D, Mann D, Landes R, Soto-Gutierrez A (2015) Future economics of liver transplantation: a 20-year cost modeling forecast and the prospect of bioengineering autologous liver grafts. PLoS ONE 10:e131764. 10.1371/journal.pone.0131764
19. Halldorson JB, Bakthavatsalam R, Fix O et al (2009) D‑MELD, a simple predictor of post liver transplant mortality for optimization of donor/recipient matching. Am J Transplant 9:318–326. 10.1111/j.1600-6143.2008.02491.x
20. Han JH, Kim DG, Na GH et al (2015) Effect of donor-recipient age matching in living donor liver transplantation. Transplant Proc. 10.1016/j.transproceed.2015.01.022
21. Jiménez-Romero C, Caso Maestro O, Cambra Molero F et al (2014) Using old liver grafts for liver transplantation: where are the limits? World J Gastroenterol 20:10691–10702. 10.3748/wjg.v20.i31.10691
22. Kamo N, Kaido T, Hammad A et al (2015) Impact of elderly donors for liver transplantation: a single-center experience. Liver Transplant. 10.1002/lt.24086
23. Kubota T, Hata K, Sozu T et al (2018) Impact of Donor Age on Recipient Survival in Adult-to-Adult Living-donor Liver Transplantation. Ann Surg 267:1126–1133. 10.1097/SLA.0000000000002194
24. Kulik U, Lehner F, Klempnauer J, Borlak J (2017) Primary non-function is frequently associated with fatty liver allografts and high mortality after re-transplantation. Liver Int 37:1219–1228. 10.1111/liv.13404
25. Nasralla D, Coussios CC, Mergental H et al (2018) A randomized trial of normothermic preservation in liver transplantation * for the consortium for Organ Preservation in Europe 10.1038/s41586-018-0047-9
26. Orman ES, Mayorga ME, Wheeler SB et al (2015) Declining liver graft quality threatens the future of liver transplantation in the United States. Liver Transpl 21:1040–1050. 10.1002/lt.24160
27. Piardi T, Lhuaire M, Bruno O et al (2016) Vascular complications following liver transplantation: a literature review of advances in 2015. World J Hepatol 8:36–57. 10.4254/wjh.v8.i1.36
28. Pötzsch O, Rößger F (2015) 13. koordinierte Bevölkerungsvorausberechnung. Statistisches Bundesamt, Wiesbaden
29. Pratschke S, Bender A, Boesch F et al (2018) Association between donor age and risk of graft failure after liver transplantation: an analysis of the Eurotransplant database – a retrospective cohort study. Transpl Int. 10.1111/tri.13357
30. Richter-Hulmann E (2018) Organspende: Politik erkennt Handlungsbedarf. Dtsch Arztebl Int 115:A-1311
31. Sass DA, Reich DJ (2011) Liver transplantation in the 21st century: expanding the donor options. Gastroenterol Clin North Am 40:641–658. 10.1016/j.gtc.2011.06.007
32. Schulte K, Kunzendorf U, Feldkamp T et al (2018) Rückgang der Organspenden in Deutschland. Dtsch Arztebl Int 115:463–468. 10.3238/arztebl.2018.0463
33. Silberhumer GR, Rahmel A, Karam V et al (2013) The difficulty in defining extended donor criteria for liver grafts: the Eurotransplant experience. Transpl Int 26:990–998. 10.1111/tri.12156
34. Spitzer AL, Lao OB, Dick AA et al (2010) The biopsied donor liver: incorporating macrosteatosis into high-risk donor assessment. Liver Transpl 16:874–884. 10.1002/lt.22085
35. Tacke F, Kroy DC, Barreiros AP, Neumann UP (2016) Liver transplantation in Germany. Liver Transpl 22:1136–1142. 10.1002/lt.24461
36. Yazdanyar A, Newman AB (2009) The burden of cardiovascular disease in the elderly: morbidity, mortality, and costs. Clin Geriatr Med 25:563–577. 10.1016/j.cger.2009.07.007