Association between donor age and risk of graft failure after liver transplantation: an analysis of the Eurotransplant database

Transplant International

Volumn 32, Issue 3, 2019, Pages 270-279

  Pratschke, Sebastian ^a   Bender, Andreas ^b   Boesch, Florian ^a   Andrassy, Joachim ^a   van Rosmalen, Marieke ^c   Samuel, Undine ^c   Rogiers, Xavier ^d   Meiser, Bruno ^a   Küchenhoff, Helmut ^b   Driesslein, David ^b   Werner, Jens ^a   Guba, Markus ^a   Angele, Martin K ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c EUROTRANSPLANT INTERNATIONAL FOUNDATION   (Netherlands)

^d GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

clinical liver transplantation; cox regression model; cutoff age; donor age; frailty terms; graft failure

Indexed keywords

AGE; AGED; ARTICLE; COHORT ANALYSIS; CORRELATIONAL STUDY; DATA BASE; FEMALE; GRAFT FAILURE; GRAFT SURVIVAL; HUMAN; LIVER DONOR; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PATIENT RISK; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK FACTOR; SURVIVAL RATE; VERY ELDERLY; ADULT; DONOR; FACTUAL DATABASE; MIDDLE AGED; PROPORTIONAL HAZARDS MODEL; RISK;

ADULT; AGE FACTORS; AGED; DATABASES, FACTUAL; FEMALE; GRAFT SURVIVAL; HUMANS; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; PROPORTIONAL HAZARDS MODELS; RISK; TISSUE DONORS;

EID: 85055895241     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/tri.13357     Document Type: Article

References (32)

1. Bertuzzo VR, Cescon M, Odaldi F, et al. Actual risk of using very aged donors for unselected liver transplant candidates: a European single-center experience in the meld era. Ann Surg 2017; 265: 388.
2. Chedid MF, Rosen CB, Nyberg SL, Heimbach JK. Excellent long-term patient and graft survival are possible with appropriate use of livers from deceased septuagenarian and octogenarian donors. HPB (Oxford) 2014; 16: 852.
3. Serrano MT, Garcia-Gil A, Arenas J, et al. Outcome of liver transplantation using donors older than 60 years of age. Clin Transplant 2010; 24: 543.
4. Eurotransplant. Eurotransplant manual chapter 5, et liver allocation system (elas), 2016;22-3.
5. Christensen K, Doblhammer G, Rau R, Vaupel JW. Ageing populations: the challenges ahead. Lancet 2009; 374: 1196.
6. Branger P, Samuel U. Annual report 2015 – eurotransplant international foundation, in Annual Reports, 2016: 1–164. http://www.eurotransplant.org/cms/index.php?page=annual_reports.
7. Pratschke S, Meimarakis G, Bruns CJ, et al. Temporary intraoperative porto-caval shunt: useless or beneficial in piggy back liver transplantation? Transpl Int 2013; 26: 90.
8. Simon N, Wood NP, Säfken B. Smoothing parameter and model selection for general smooth models. J Am Stat Assoc 2016; 111: 1548.
9. Cox DR. Regression models and life-tables. J R Stat Soc Series B Methodol 1972; 34: 187.
10. Eilers PHC, Marx BD. Flexible smoothing with b-splines and penalties. Stat Sci 1996; 11: 89.
11. Govindarajulu US, Lin H, Lunetta KL, D'Agostino RB Sr. Frailty models: applications to biomedical and genetic studies. Stat Med 2011; 30: 2754.
12. Blok JJ, Putter H, Rogiers X, et al. Combined effect of donor and recipient risk on outcome after liver transplantation: research of the Eurotransplant database. Liver Transpl 2015; 21: 1486.
13. Nemes B, Gaman G, Polak WG, et al. Extended-criteria donors in liver transplantation part II: reviewing the impact of extended-criteria donors on the complications and outcomes of liver transplantation. Expert Rev Gastroenterol Hepatol 2016; 10: 841.
14. Cescon M, Grazi GL, Cucchetti A, et al. Improving the outcome of liver transplantation with very old donors with updated selection and management criteria. Liver Transpl 2008; 14: 672.
15. Nemes B, Gaman G, Polak WG, et al. Extended criteria donors in liver transplantation part I: reviewing the impact of determining factors. Expert Rev Gastroenterol Hepatol 2016; 10: 827.
16. Nickkholgh A, Weitz J, Encke J, et al. Utilization of extended donor criteria in liver transplantation: a comprehensive review of the literature. Nephrol Dial Transplant 2007; 22(Suppl. 8): viii29.
17. Dasari BV, Mergental H, Isaac JR, Muiesan P, Mirza DF, Perera T. Systematic review and meta-analysis of liver transplantation using grafts from deceased donors aged over 70 years. Clin Transplant 2017; 31: e13139.
18. Fruhauf NR, Fischer-Frohlich CL, Kutschmann M, Schmidtmann I, Kirste G. Joint impact of donor and recipient parameters on the outcome of liver transplantation in Germany. Transplantation 2011; 92: 1378.
19. Ghinolfi D, Marti J, De Simone P, et al. Use of octogenarian donors for liver transplantation: a survival analysis. Am J Transplant 2014; 14: 2062.
20. Silberhumer GR, Pokorny H, Hetz H, et al. Combination of extended donor criteria and changes in the model for end-stage liver disease score predict patient survival and primary dysfunction in liver transplantation: a retrospective analysis. Transplantation 2007; 83: 588.
21. Adam R, Cailliez V, Majno P, et al. Normalised intrinsic mortality risk in liver transplantation: European liver transplant registry study. Lancet 2000; 356: 621.
22. Braat AE, Blok JJ, Putter H, et al. The Eurotransplant donor risk index in liver transplantation: ET-DRI. Am J Transplant 2012; 12: 2789.
23. Feng S, Goodrich NP, Bragg-Gresham JL, et al. Characteristics associated with liver graft failure: the concept of a donor risk index. Am J Transplant 2006; 6: 783.
24. Rana A, Hardy MA, Halazun KJ, et al. Survival outcomes following liver transplantation (soft) score: a novel method to predict patient survival following liver transplantation. Am J Transplant 2008; 8: 2537.
25. Ghobrial RM, Gornbein J, Steadman R, et al. Pretransplant model to predict posttransplant survival in liver transplant patients. Ann Surg 2002; 236: 315; discussion 22-3.
26. Halazun KJ, Rana AA, Fortune B, et al. No country for old livers? Examining and optimizing the utilization of elderly liver grafts Am J Transplant 2017; 18: 669.
27. Gao Q, Mulvihill MS, Scheuermann U, et al. Improvement in liver transplant outcomes from older donors: a us national analysis. Ann Surg 2018; https://doi.org/10.1097/SLA.0000000000002876. [Epub ahead of print]
28. Dopazo C, Bilbao I, Castells L, et al. Does matching donor-recipient age affect long-term survival in liver transplantation? Ann Transplant 2016; 21: 708.
29. Schmucker DL, Sanchez H. Liver regeneration and aging: a current perspective. Curr Gerontol Geriatr Res 2011; 2011: 526379.
30. Takubo K, Nakamura K, Izumiyama N, et al. Telomere shortening with aging in human liver. J Gerontol A Biol Sci Med Sci 2000; 55: B533.
31. O'Neil C. Weapons of Math Destruction: How Big Data Increases Inequality and Threatens Democracy. New York, NY: Broadway Books, 2016.
32. Team RC. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing, 2014.