Effects of montelukast sodium and bacterial lysates on airway remodeling and expression of transforming growth factor-β1 and Smad7 in Guinea pigs with bronchial asthma

Chinese Journal of Contemporary Pediatrics

Volumn 20, Issue 12, 2018, Pages 1063-1069

  Liao, Jia Yi ^a   Zhang, Tao ^a  

^a Guangzhou Children's Hospital of Yuexiu District   (China)

Author keywords

Airway remodeling; Bacterial lysates; Bronchial asthma; Guinea pigs; Montelukast sodium; Smad7; Transforming growth factor 1

Indexed keywords

BACTERIUM LYSATE; MONTELUKAST; OVALBUMIN; SMAD7 PROTEIN; SODIUM CHLORIDE; TRANSFORMING GROWTH FACTOR BETA1; ACETIC ACID; BRONCHO-VAXOM; CELL EXTRACT; QUINOLINE DERIVATIVE;

AEROSOL; AIRWAY REMODELING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BASEMENT MEMBRANE; BRONCHUS MUSCLE; COMBINATION DRUG THERAPY; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFICACY; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; LUNG ALVEOLUS WALL; LUNG LAVAGE; MALE; MONOTHERAPY; NONHUMAN; PROTEIN EXPRESSION; SENSITIZATION; THORAX WALL; ANIMAL; GUINEA PIG; LUNG;

ACETATES; AIRWAY REMODELING; ANIMALS; ASTHMA; CELL EXTRACTS; GUINEA PIGS; LUNG; MALE; OVALBUMIN; QUINOLINES; TRANSFORMING GROWTH FACTOR BETA1;

EID: 85058888907     PISSN: 10088830     EISSN: None     Source Type: Journal    
DOI: 10.7499/j.issn.1008-8830.2018.12.016     Document Type: Article

References (19)

1. Trevor JL, Chipps BE. Severe asthma in primary care: identification and management[J]. Am J Med, 2018, 131(5): 484-491.
2. The GINA Board of Directors, The GINA Science Committee. 2018 GINA report, global strategy for asthma management and prevention[EB/OL]. (2018-03-06). http://ginasthma.org/2018gina-report-global-strategy-for-asthma-management-and-prevention.
3. Matsumoto H. Serum periostin: a novel biomarker for asthma management[J]. Allergol Int, 2014, 63(2): 153-160.
4. Carlstrom L, Castro M. Severe asthma: what makes it so hard to manage?[J]. Curr Allergy Asthma Rep, 2009, 9(5): 393-400.
5. Lee HY, Kim IK, Yoon HK, et al. Inhibitory effects of resveratrol on airway remodeling by transforming growth factor-β/Smad signaling pathway in chronic asthma model[J]. Allergy Asthma Immunol Res, 2017, 9(1): 25-34.
6. Groneberg DA, Witt H, Adcock IM, et al. Smads as intracellular mediators of airway inflammation[J]. Exp Lung Res, 2004, 30(3): 223-250.
7. Nakao A, Sagara H, Setoguchi Y, et al. Expression of Smad7 in bronchial epithelial cells is inversely correlated to basement membrane thickness and airway hyperresponsiveness in patients with asthma[J]. J Allergy Clin Immuno, 2002, 110(6): 873-878.
8. Ohki Y, Tokuyama K, Sato A, et al. Maturational changes in airway remodeling after chronic exposure to ovalbumin in sensitized guinea pigs: role of cell renewal of airway resident cells[J]. Pediatr Res, 2002, 52(4): 525-532.
9. Bessler WG, Vor dem Esche U, Masihi N. The bacterial extract OM-85BV protects mice against influenza and Salmonella infection[J]. Int Immunopharmacol, 2010, 10(9): 1086-1090.
10. Cho JY. Recent advances in mechanisms and treatments of airway remodeling in asthma: a message from the bench side to the clinic[J]. Korean J Intern Med, 2011, 26(4): 367-383.
11. Thompson-Souza GA, Gropillo I, Neves JS. Cysteinyl leukotrienes in eosinophil biology: functional roles and therapeutic perspectives in eosinophilic disorders[J]. Front Med (Lausanne), 2017, 4: 106.
12. Hosoki K, Kainuma K, Toda M, et al. Montelukast suppresses epithelial to mesenchymal transition of bronchial epithelial cells induced by eosinophils[J]. Biochem Biophys Res Commun, 2014, 449(3): 351-356.
13. Shin IS, Jeon WY, Shin HK, et al. Effects of montelukast on subepithelial/peribronchial fibrosis in a murine model of ovalbumin induced chronic asthma[J]. Int Immunopharmacol, 2013, 17(3): 867-873.
14. Han RF, Li HY, Wang JW, et al. Study on clinical effect and immunologic mechanism of infants capillary bronchitis secondary bronchial asthma treated with bacterial lysates Broncho-Vaxom[J]. Eur Rev Med Pharmacol Sci, 2016, 20(10): 2151-2155.
15. Fu R, Li J, Zhong H, et al. Broncho-Vaxom attenuates allergic airway inflammation by restoring GSK3β-related T regulatory cell insufficiency[J]. PLoS One, 2014, 9(3): e92912.
16. Kearney SC, Dziekiewicz M, Feleszko W. Immunoregulatory and immunostimulatory responses of bacterial lysates in respiratory infections and asthma[J]. Ann Allergy Asthma Immunol, 2015, 114(5): 364-369.
17. Alyanakian MA, Grela F, Aumeunier A, et al. Transforming growth factor-beta and natural killer T-cells are involved in the protective effect of a bacterial extract on type 1 diabetes[J]. Diabetes, 2006, 55(1): 179-185.
18. Polla BS, Baladi S, Fuller K, et al. Presence of hsp65 in bacterial extracts (OM-89): a possible mediator of orally-induced tolerance?[J]. Experientia, 1995, 51(8): 775-779.
19. Bowman LM, Holt PG. Selective enhancement of systemic Th1 immunity in immunologically immature rats with an orally administered bacterial extract[J]. Infect Immun, 2001, 69(6): 3719-3727.