Large-scale Artemisinin-Piperaquine Mass Drug Administration with or Without Primaquine Dramatically Reduces Malaria in a Highly Endemic Region of Africa

Clinical Infectious Diseases

Volumn 67, Issue 11, 2018, Pages 1670-1676

  Deng, Changsheng ^a   Huang, Bo ^a   Wang, Qi ^a   Wu, Wanting ^a   Zheng, Shaoqin ^a   Zhang, Hongying ^a   Li, Di ^a   Feng, Danghong ^a   Li, Guoming ^a   Xue, Linlu ^a   Yang, Tao ^a   Tuo, Fei ^a   Mohadji, Fouad ^b   Su, Xin Zhuan ^c   Xu, Qin ^a   Wu, Zhibing ^d   Lin, Li ^d   Zhou, Jiuyao ^a   Yan, Hong ^a   Bacar, Affane ^e   Abdallah, Kamal Said ^e   Kéké, Rachadi A ^e   Mliva, Ahamada Msa ^b   Mohamed, Moussa ^b   Wang, Xinhua ^f   Huang, Shiguang ^g   Oithik, Fatihou ^b   Li, Xiao Bo ^a   Lu, Fangli ^h,i   Fay, Michael P ^c   Liu, Xiao Hong ^a   Wellems, Thomas E ^c   Song, Jianping ^a   more..

^a GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

^b Ministry of Health   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d First Affiliated Hospital   (China)

^e National Malaria Control Programme   (China)

^f GUANGZHOU MEDICAL UNIVERSITY   (China)

^g UNIVERSITY OF JINAN   (China)

^h SUN YAT SEN UNIVERSITY   (China)

ⁱ SUN YAT SEN UNIVERSITY   (China)

Author keywords

artemisinin based combination therapy; Comoros Islands; malaria control; PfK13 Kelch propeller gene; Plasmodium falciparum

Indexed keywords

ARTEMISININ; PIPERAQUINE; PRIMAQUINE; ANTIMALARIAL AGENT; ARTEMISININ DERIVATIVE; PROTOZOAL DNA; QUINOLINE DERIVATIVE;

ADOLESCENT; ARTICLE; CHILD; COMOROS; DNA POLYMORPHISM; DRUG EFFICACY; GENE; HUMAN; MAJOR CLINICAL STUDY; MALARIA; MORTALITY; NONHUMAN; PFK13 GENE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; ADULT; COMBINATION DRUG THERAPY; ENDEMIC DISEASE; FEMALE; GENETIC POLYMORPHISM; GENETICS; INFANT; MALARIA FALCIPARUM; MALE; MASS DRUG ADMINISTRATION; PARASITEMIA; PRESCHOOL CHILD; TREATMENT OUTCOME; YOUNG ADULT;

ADOLESCENT; ADULT; ANTIMALARIALS; ARTEMISININS; CHILD; CHILD, PRESCHOOL; COMOROS; DNA, PROTOZOAN; DRUG THERAPY, COMBINATION; ENDEMIC DISEASES; FEMALE; HUMANS; INFANT; MALARIA, FALCIPARUM; MALE; MASS DRUG ADMINISTRATION; PARASITEMIA; PLASMODIUM FALCIPARUM; POLYMORPHISM, GENETIC; PRIMAQUINE; QUINOLINES; TREATMENT OUTCOME; YOUNG ADULT;

EID: 85056509233     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/ciy364     Document Type: Article

References (41)

1. World Health Organization Global Malaria Programme. World malaria report 2015. Geneva (Switzerland): WHO; 2015. Report No.: 978 92 4 156483 0.
2. Ouledi A. Epidemiology and control of malaria in the Federal Islamic Republic of Comoros. Sante 1995; 5:368-71.
3. Union of Comoros Ministry of Health Solidarity and Promotion of Gender. National health development plan 2010-2014. Available at: http://www.nation-alplanningcycles.org/sites/default/files/country_docs/Comoros/pnds_05_ mai_2010_documentvf_en.pdf. Accessed 14 July 2016.
4. Ouédraogo AL, Bousema T, Schneider P, et al. Substantial contribution of submi-croscopical Plasmodium falciparum gametocyte carriage to the infectious reservoir in an area of seasonal transmission. PLoS One 2009; 4:e8410.
5. Okell LC, Ghani AC, Lyons E, Drakeley CJ. Submicroscopic infection in Plasmodium falciparum-endemic populations: a systematic review and meta-anal-ysis. J Infect Dis 2009; 200:1509-17.
6. White NJ. Primaquine to prevent transmission of falciparum malaria. Lancet Infect Dis 2013; 13:175-81.
7. Maude RJ, Socheat D, Nguon C, et al. Optimising strategies for Plasmodium falci-parum malaria elimination in Cambodia: primaquine, mass drug administration and artemisinin resistance. PLoS One 2012; 7:e37166.
8. Song J, Socheat D, Tan B, et al. Rapid and effective malaria control in Cambodia through mass administration of artemisinin-piperaquine. Malar J 2010; 9:57.
9. Gosling RD, Okell L, Mosha J, Chandramohan D. The role of antimalarial treatment in the elimination of malaria. Clin Microbiol Infect 2011; 17:1617-23.
10. Ariey F, Witkowski B, Amaratunga C, et al. A molecular marker of artemisi-nin-resistant Plasmodium falciparum malaria. Nature 2014; 505:50-5.
11. Blanchy S, Julvez J, Mouchet J. Epidemiological stratification of malaria in the Comoro archipelago. Bull Soc Pathol Exot 1999; 92:177-84.
12. Chakir I, Said AI, Affane B, Jambou R. Control of malaria in the Comoro Islands over the past century. Malar J 2017; 16:387.
13. Papa Mze N, Ahouidi AD, Diedhiou CK, et al. Distribution of Plasmodium species on the island of Grande Comore on the basis of DNA extracted from rapid diagnostic tests. Parasite 2016; 23:34.
14. Diallo DA, Doumbo OK, Plowe CV, Wellems TE, Emanuel EJ, Hurst SA. Community permission for medical research in developing countries. Clin Infect Dis 2005; 41:255-9.
15. Dicko A, Brown JM, Diawara H, et al. Primaquine to reduce transmission of Plasmodium falciparum malaria in Mali: a single-blind, dose-ranging, adaptive randomised phase 2 trial. Lancet Infect Dis 2016; 16:674-84.
16. Greenwood B, Tine R. Primaquine to stop transmission of falciparum malaria. Lancet Infect Dis 2016; 16:623-4.
17. World Health Organization. Policy brief on single dose primaquine as a gameto-cytocide in Plasmodium falciparum malaria. Geneva (Switzerland): WHO; 2015. Available at: http://www.who.int/malaria/publications/atoz/policy-brief-sin-gle-dose-primaquine-pf/en/. Accessed 29 August 2016.
18. Gonçalves BP, Tiono AB, Ouédraogo A, et al. Single low dose primaquine to reduce gametocyte carriage and Plasmodium falciparum transmission after arte-mether-lumefantrine in children with asymptomatic infection: a randomised, double-blind, placebo-controlled trial. BMC Med 2016; 14:40.
19. Okebe J, Bousema T, Affara M, et al. The gametocytocidal efficacy of different single doses of primaquine with dihydroartemisinin-piperaquine in asymptomatic parasite carriers in The Gambia: a randomized controlled trial. EBioMedicine 2016; 13:348-55.
20. Eziefula AC, Bousema T, Yeung S, et al. Single dose primaquine for clearance of Plasmodium falciparum gametocytes in children with uncomplicated malaria in Uganda: a randomised, controlled, double-blind, dose-ranging trial. Lancet Infect Dis 2014; 14:130-9.
21. El-Sayed B, El-Zaki SE, Babiker H, et al. A randomized open-label trial of artesu-nate-sulfadoxine-pyrimethamine with or without primaquine for elimination of sub-microscopic P. falciparum parasitaemia and gametocyte carriage in eastern Sudan. PLoS One 2007; 2:e1311.
22. Gerardin J, Eckhoff P, Wenger EA. Mass campaigns with antimalarial drugs: a modelling comparison of artemether-lumefantrine and DHA-piperaquine with and without primaquine as tools for malaria control and elimination. BMC Infect Dis 2015; 15:144.
23. Song J, Duong S, Tan B, et al. A pilot project on fast eliminating malaria by eradicating source in a highly malaria endemic area. J Guangzhou Univ Tradit Chin Med 2006; 23:89-94.
24. Li G, Song J, Deng C, et al. One-year report on the Fast Elimination of Malaria by Source Eradication (FEMSE) project in Moheli Island of Comoros. J Guangzhou Univ Tradit Chin Med 2010; 27:90-8.
25. Tang L. Progress in malaria control in China. Chin Med J (Engl) 2000; 113:89-92.
26. Tang LH, Qian HL, Xu SH. Malaria and its control in the People's Republic of China. Southeast Asian J Trop Med Public Health 1991; 22:467-76.
27. Yip K. Antimalarial work in China: a historical perspective. Parassitologia 1998; 40:29-38.
28. Kassim SA, James PB, Alolga RN, et al. Major decline in malaria morbidity and mortality in the Union of Comoros between 2010 and 2014: the effect of a combination of prevention and control measures. S Afr Med J 2016; 106:709-14.
29. Baiden R, Oduro A, Halidou T, et al. Prospective observational study to evaluate the clinical safety of the fixed-dose artemisinin-based combination Eurartesim® (dihydroartemisinin/piperaquine), in public health facilities in Burkina Faso, Mozambique, Ghana, and Tanzania. Malar J 2015; 14:160.
30. Smithuis F, Kyaw MK, Phe O, et al. Effectiveness of five artemisinin combination regimens with or without primaquine in uncomplicated falciparum malaria: an open-label randomised trial. Lancet Infect Dis 2010; 10:673-81.
31. Saunders DL, Vanachayangkul P, Lon C; U.S. Army Military Malaria Research Program; National Center for Parasitology, Entomology, and Malaria Control (CNM); Royal Cambodian Armed Forces. Dihydroartemisinin-piperaquine failure in Cambodia. N Engl J Med 2014; 371:484-5.
32. Spring MD, Lin JT, Manning JE, et al. Dihydroartemisinin-piperaquine failure associated with a triple mutant including kelch13 C580Y in Cambodia: an obser-vational cohort study. Lancet Infect Dis 2015; 15:683-91.
33. Amaratunga C, Lim P, Suon S, et al. Dihydroartemisinin-piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study. Lancet Infect Dis 2016; 16:357-65.
34. von Seidlein L, Greenwood BM. Mass administrations of antimalarial drugs. Trends Parasitol 2003; 19:452-60.
35. World Health Organization Evidence Review Group. Mass drug administration, mass screening and treatment and focal screening and treatment for malaria. Geneva (Switzerland): WHO; 2015. Available at: http://www.who.int/malaria/mpac/mpac-sept2015-erg-mda-report.pdf. Accessed 13 July 2016.
36. White NJ. Does antimalarial mass drug administration increase or decrease the risk of resistance? Lancet Infect Dis 2017; 17:e15-20.
37. World Health Organization. Status report on artemisinin and ACT resistance. Geneva (Switzerland): WHO; 2015. Available at: http://www.who.int/malaria/publications/atoz/status-rep-artemisinin-resistance-sept2015.pdf. Accessed 25 August 2016.
38. Huang B, Deng C, Yang T, et al. Polymorphisms of the artemisinin resistant marker (K13) in Plasmodium falciparum parasite populations of Grande Comore Island 10 years after artemisinin combination therapy. Parasit Vectors 2015; 8:634.
39. Torrentino-Madamet M, Collet L, Lepere JF, et al. K13-propeller polymorphisms in Plasmodium falciparum isolates from patients in Mayotte in 2013 and 2014. Antimicrob Agents Chemother 2015; 59:7878-81.
40. Maillard O, Lernout T, Olivier S, et al. Major decrease in malaria transmission on Mayotte Island. Malar J 2015; 14:323.
41. Toyb M, Ouledi A, Gauzere BA, Aubry P. Malaria in the Comoros Archipelago in 2015: status after 15 years of fight. Bull Soc Pathol Exot 2016; 109:107-13.