Development of the enteric nervous system

Innervation of the Gastrointestinal Tract

Volumn , Issue , 2003, Pages 469-525

  Gershon, Michael D ^a  

^a College of Physicians and Surgeons ^*  (United States)

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EID: 85056507665     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (299)

1. Adler, R., Landa, K.B., Manthorpe, M. and Varon, S. (1979). Cholinergic neuronotrophic factors: intraocular distribution of trophic activity for ciliary neurons. Science, 204, 1434-1436.
2. Allan, I.J. and Newgreen, D.F. (1980). The origin and differentiation of enteric neurons of the intestine of the fowl embryo. American Journal of Anatomy, 157, 137-154.
3. Anderson, D.J. (1989). The neural crest cell lineage problem: neuropoiesis? Neuron, 3, 1-12.
4. Anderson, D.J., Carnahan, J.F., Michelsohn, A. and Patterson, P.H. (1991). Antibody markers identify a common progenitor to sympathetic neurons and chromaffin cells in vivo and reveal the timing of commitment to neuronal differentiation in the sympathoadrenal lineage. Journal of Neuroscience, 11, 3507-3519.
5. Angrist, M., Bolk, S., Thiel, B., Puffenberger, E.G., Hofstra, R.M., Buys, C.H. et al. (1995). Mutation analysis of the RET receptor tyrosine kinase in Hirschsprung disease. Human Molecular Genetics, 4, 821-830.
6. Baetge, G. and Gershon, M.D. (1989). Transient catecholaminergic (TC) cells in the vagus nerves and bowel of fetal mice: relationship to the development of enteric neurons. Developmental Biology, 132, 189-211.
7. Baetge, G., Pintar, J.E. and Gershon, M.D. (1990). Transiently catecholaminergic (TC) cells in the bowel of the fetal rat: precursors of noncatecholaminergic enteric neurons. Developmental Biology, 141, 353-380.
8. Baetge, G., Schneider, K.A. and Gershon, M.D. (1990). Development and persistence of catecholaminergic neurons in cultured explants of fetal murine vagus nerves and bowel. Development, 110, 689-701.
9. Barbacid, M. (1993). The trk family of neurotrophin receptors: molecular characterisation and oncogenic activation in human tumors. In Molecular Genetics of Nervous System Tumors, edited by A.J. Levine and H.H. Schmidek, pp. 123-135. New York: Wiley and Sons.
10. Baroffio, A., Dupin, E. and Le Douarin, N.M. (1988). Clone-forming ability and differentiation potential of migratory neural crest cells. Proceedings of the National Academy of Sciences of the USA, 85, 5325-5329.
11. Bayliss, W.M. and Starling, E.H. (1899). The movements and innervation of the small intestine. Journal of Physiology (London), 24, 99-143.
12. Bayliss, W.M. and Starling, E.H. (1900). The movements and the innervation of the large intestine. Journal of Physiology (London), 26, 107-118.
13. Baynash, A.G., Hosoda, K., Giaid, A., Richardson, J.A., Emoto, N., Hammer, R.E. et al. (1994). Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons. Cell, 79, 1277-1285.
14. Berthoud, H.R., Jedrzejewska, A. and Powley, T.L. (1990). Simultaneous labeling of vagal innervation of the gut and afferent projections from the visceral forebrain with dil injected into the dorsal vagal complex in the rat. Journal of Comparative Neurology, 301, 65-79.
15. Berthoud, H.R. and Powley, T.L. (1992). Vagal afferent innervation of the rat fundic stomach: morphological characterization of the gastric tension receptor. Journal of Comparative Neurology, 319, 261-276.
16. Besmer, P. (1991). The kit ligand encoded at the murine Steel locus: a pleiotropic growth and differentiation factor. Current Opinion in Cell Biology, 3, 939-946.
17. Bilozur, M.E. and Hay, E.D. (1988). Neural crest migration in 3D extracellular matrix utilizes laminin, fibronectin, or collagen. Developmental Biology, 125, 19-33.
18. Birren, S.J., Lo, L. and Anderson, D.J. (1993). Sympathetic neuroblasts undergo a developmental switch in trophic dependence. Development, 119, 597-610.
19. Black, I.B. (1978). Regulation of autonomic development. Annual Review of Neuroscience, 1, 183-214.
20. Blaugrund, E., Pham, T.D., Tennyson, V.M., Lo, L., Sommer, L., Anderson, D.J. et al. (1996). Distinct subpopulations of enteric neuronal progenitors defined by time of development, sympathoadrenal lineage markers and mash-1-dependence. Development, 122, 309-320.
21. Bodeker, D., Turck, O., Loven, E., Wieberneit, D. and Wegner, W. (1995). Pathophysiological and functional aspects of the megacolon-syndrome of homozygous spotted rabbits. Zentralblatt Fur Veterinarmedizin -Reihe A, 42, 549-559.
22. Bolande, R.P. (1975). Hirschsprung’s disease, aganglionic or hypoganglionic megacolon. Animal model: aganglionic megacolon in piebald and spotted mutant mouse strains. American Journal of Pathology, 79, 189-192.
23. Bornstein, J.C. and Furness, J.B. (1988). Correlated electrophysiological and histochemical studies of submucous neurons and their contribution to understanding enteric neural circuits. Journal of the Autonomic Nervous System, 25, 1-13.
24. Bornstein, J.C. and Furness, J.B. (1992). Enteric neurons and their chemical coding. In Advances in the Innervation of the Gastrointestinal Tract, edited by G.E. Holle and J.D. Wood, pp. 101-114. New York: Elsevier Science B.V.
25. Bornstein, J.C., Furness, J.B. and Kunze, W.A.A. (1994). Electrophysiological characterization of myenteric neurons -how do classification schemes relate? Journal of the Autonomic Nervous System, 48, 1-15.
26. Borrello, M.G., Smith, D.P., Pasini, B., Bongarzone, I., Greco, A., Lorenzo, M.J. et al. (1995). RET activation by germline MEN2A and MEN2B mutations. Oncogene, 11, 2419-2427.
27. Bothwell, M. (1996). p75NTR: a receptor after all. Science, 272, 506-507.
28. Bresalier, R.S., Schwartz, B., Kim, Y.S., Duh, Q.Y., Kleinman, H.K. and Sullam, P.M. (1995). The laminin α1 chain Ile-Lys-Val-Ala-Val (IKVAV)-containing peptide promotes liver colonization by human colon cancer cells. Cancer Research, 55, 2476-2480.
29. Bronner-Fraser, M. (1985). Alterations in neural crest migration by a monoclonal antibody that affects cell adhesion. Journal of Cell Biology, 101, 610-617.
30. Bronner-Fraser, M. (1986). An antibody to a receptor for fibronectin and laminin perturbs cranial neural crest development in vivo. Developmental Biology, 117, 528-536.
31. Bronner-Fraser, M. and Fraser, S.E. (1988). Cell lineage analysis reveals multipotency of some avian neural crest cells. Nature, 335, 161-164.
32. Bronner-Fraser, M. and Fraser, S. (1989). Developmental potential of avian trunk neural crest cells in situ. Neuron, 3, 755-766.
33. Bronner-Fraser, M. and Lallier, T. (1988). A monoclonal antibody against a laminin-heparan sulfate proteoglycan complex perturbs cranial neural crest migration in vivo. Journal of Cell Biology, 106, 1321-1329.
34. Brookes, S.J.H. and Costa, M. (1990). Identification of enteric motor neurones which innervate the circular muscle of the guinea pig small intestine. Neuroscience Letters, 118, 227-230.
35. Brookes, S.J.H., Mayo, R. and Costa, M. (1992). The neuronal basis of motor activity in the guinea-pig small intestine: a computer model. Gastroenterology, 102, A431 [Abstract].
36. Brookes, S.J.H., Song, Z.M., Steele, P.A. and Costa, M. (1992). Identification of motor neurons to the longitudinal muscle of the guinea pig ileum. Gastroenterology, 103, 961-973.
37. Brookes, S.J.H., Steele, P.A. and Costa, M. (1991a). Calretinin immunoreactivity in cholinergic motor neurones, interneurones and vasomotor neurones in the guinea-pig small intestine. Cell and Tissue Research, 263, 471-481.
38. Brookes, S.J.H., Steele, P.A. and Costa, M. (1991b). Identification and immunohistochemistry of cholinergic and non-cholinergic circular muscle motor neurons in the guinea-pig small intestine. Neuroscience, 42, 863-878.
39. Bülbring, E. and Gershon, M.D. (1967). 5-Hydroxytryptamine participation in the vagal inhibitory innervation of the stomach. Journal of Physiology (London), 192, 823-846.
40. Bult, H., Boeckxstaens, G.E., Pelckmans, P.A., Jordaens, F.H., Van Maercke, Y.M. and Herman, A.G. (1990). Nitric oxide as an inhibitory non-adrenergic non-cholinergic neurotransmitter. Nature, 345, 346-347.
41. Calof, A.L. and Reichardt, L.F. (1985). Response of purified chick motoneurons to myotube conditioned medium: laminin is essential for the substratum-binding, neurite outgrowth-promoting activity. Neuroscience Letters, 59, 183-189.
42. Carnahan, J.F., Anderson, D.J. and Patterson, P.H. (1991). Evidence that enteric neurons may derive from the sympathoadrenal lineage. Developmental Biology, 148, 552-561.
43. Carter, B.D., Kaltschmidt, C., Kaltschmidt, B., Offenhauser, N., Bohm-Matthaei, R., Baeuerle, P.A. et al. (1996). Selective activation of NF-κB by nerve growth factor through the neurotrophin receptor p75. Science, 272, 542-545.
44. Ceccherini, I., Zhang, A.L., Matera, I., Yang, G., Devoto, M., Romeo, G. et al. (1995). Interstitial deletion of the endothelin-B receptor gene in the spotting lethal (sl) rat. Human Molecular Genetics, 4, 2089-2096.
45. Chalazonitis, A. (1996). Neurotrophin-3 as an essential signal for the developing nervous system. Molecular Neurobiology, 12, 39-53.
46. Chalazonitis, A., Rothman, T.P., Chen, J., Lamballe, F., Barbacid, M. and Gershon, M.D. (1994). Neurotrophin-3 induces neural crest-derived cells from fetal rat gut to develop in vitro as neurons or glia. Journal of Neuroscience, 14, 6571-6584.
47. Chalazonitis, A., Rothman, T.P., Chen, J., Vinson, E.N., MacLennan, A.J. and Gershon, M.D. (1998). Promotion of the development of enteric neurons and glia by neuropoietic cytokines: interactions with neurotrophin-3. Developmental Biology, 198, 343-365.
48. Chalazonitis, A., Rothman, T.P. and Gershon, M.D. (1995). Ciliary neurotrophic factor (CNTF). and neurotrophin-3 (NT-3) potentiate one another in promoting the enteric neuronal development. Neuroscience, 25, 1545 [Abstract].
49. Chalazonitis, A., Tennyson, V.M., Kibbey, M.C., Rothman, T.P. and Gershon, M.D. (1997). The α1 subunit of laminin-1 promotes the development of neurons by interacting with LBP110 expressed by neural crestderived cells immunoselected from the fetal mouse gut. Journal of Neurobiology, 33, 118-138.
50. Chalazonitis, A., Tennyson, V.M., Rothman, T.P. and Gershon, M.D. (1992). Selective isolation of neural and glial precursors from the developing murine bowel with antibodies to a 110 kDa cell surface laminin binding protein[Abstract]. Neuroscience, 18, 1109.
51. Chalazonitis, A., Pham, T.D., Rothman, T.P., Distephano, P.S., Bothwell, M., Blair-Flynn, J., Tessarollo, L. and Gershon, M.D. (2001). Neurotrophin-3 is required for the survival differention of subsets of developing enteric neurons. J. Neuroscience, 21, 5620-5636.
52. Chao, M.V. and Hempstead, B.L. (1995). p75 and Trk: a two-receptor system. Trends in Neurosciences, 18, 321-326.
53. Choi-Lundberg, D.L. and Bohn, M.C. (1995). Ontogeny and distribution of glial cell line-derived neurotrophic factor (GDNF) mRNA in rat. Brain Research. Developmental Brain Research, 85, 80-88.
54. Cochard, P., Goldstein, M. and Black, I.B. (1978). Ontogenetic appearance and disappearance of tyrosine hydroxylase and catecholamines in the rat embryo. Proceedings of the National Academy of Sciences of the USA, 75, 2986-2990.
55. Colamarino, S.A. and Tessier-Lavigne, M. (1995). The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons. Cell, 81, 621-629.
56. Cook, R.D. and Burnstock, G. (1976). The ultrastructure of Auerbach’s plexus in the guinea-pig. II. Non-neuronal elements. Journal of Neurocytology, 5, 195-206.
57. Cooke, H.J. (1989). Role of the “little brain” in the gut in water and electrolyte homeostasis. FASEB Journal, 3, 127-138.
58. Corcoran, M.L., Kibbey, M.C., Kleinman, H.K. and Wahl, L.M. (1995). Laminin SIKVAV peptide induction of monocyte/macrophage prostaglandin E2 and matrix metalloproteinases. Journal of Biological Chemistry, 270, 10365-10368.
59. Costa, M., Brookes, S.J.H., Steele, P.A., Gibbins, I., Burcher, E. and Kandiah, C.J. (1996). Neurochemical classification of myenteric neurons in the guinea-pig ileum. Neuroscience, 75, 949-967.
60. Costa, M. and Furness, J.B. (1979). On the possibility that an indoleamine is a neurotransmitter in the gastrointestinal tract. Biochemical Pharmacology, 28, 565-571.
61. Costa, M., Furness, J.B., Cuello, A.C.U., Verhofstad, A.A., Steinbusch, H.W. and Elde, R.P. (1982). Neurons with 5-hydroxytryptamine-like immunoreactivity in the enteric nervous system: their visualization and reactions to drug treatment. Neuroscience, 7, 351-363.
62. Costa, M., Furness, J.B., Pompolo, S., Brookes, S.J.H., Bornstein, J.C., Bredt, D.S. et al. (1992). Projections and chemical coding of neurons with immunoreactivity for nitric oxide synthase in the guinea-pig small intestine. Neuroscience Letters, 148, 121-125.
63. Coulter, H.D., Gershon, M.D. and Rothman, T.P. (1988). Neural and glial phenotypic expression by neural crest cells in culture: effects of control and presumptive aganglionic bowel from ls/ls mice. Journal of Neurobiology, 19, 507-531.
64. Coventry, S., Yost, C., Palmiter, R.D. and Kapur, R.P. (1994). Migration of ganglion cell precursors in the ileoceca of normal and lethal spotted embryos, a murine model for Hirschsprung disease. Laboratory Investigation, 71, 82-93.
65. Crowcroft, P.J., Holman, M.E. and Szurszewski, J.H. (1971). Excitatory input from the distal colon to the inferior mesenteric ganglion in the guinea-pig. Journal of Physiology, 219, 443-461.
66. Dalsgaard, C.J., Hokfelt, T., Schultzberg, M., Lundberg, J.M., Terenius, L., Dockray, G.J. et al. (1983). Origin of peptide-containing fibers in the inferior mesenteric ganglion of the guinea-pig: immunohistochemical studies with antisera to substance P, enkephalin, vasoactive intestinal polypeptide, cholecystokinin and bombesin. Neuroscience, 9, 191-211.
67. Davis, S., Aldrich, T.H., Stahl, N., Pan, L., Taga, T., Kishimoto, T. et al. (1993). LIFRβ and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor. Science, 260, 1805-1808.
68. Davis, S., Aldrich, T.H., Valenzuela, D.M., Wong, V.V., Furth, M.E., Squinto, S.P. et al. (1991). The receptor for ciliary neurotrophic factor. Science, 253, 59-63.
69. DeChiara, T.M., Vejsada, R., Poueymirou, W.T., Acheson, A., Suri, C., Conover, J.C. et al. (1995). Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth. Cell, 83, 313-322.
70. DiCicco-Bloom, E., Friedman, W.J. and Black, I.B. (1993). NT-3 stimulates sympathetic neuroblast proliferation by promoting precursor survival. Neuron, 11, 1101-1111.
71. Dogiel, A.S. (1899). Über den bau ganglien in den gerflechten des darmes und der gallenblase des menschen und der säugetiere. Archiv für Anatomie und Physiologie Leipzig, Anatomische Abteilung Jahrgang 1899, 130-158.
72. Douville, P.J., Harvey, W.J. and Carbonetto, S. (1988). Isolation and partial characterization of high affinity laminin receptors in neural cells. Journal of Biological Chemistry, 263, 14964-14969.
73. Dreyfus, C.F. and Bornstein, M.B. (1977). Synthesis of serotonin by neurons of the myenteric plexus in situ and in organotypic tissue culture. Brain Research, 128, 125-139.
74. Dreyfus, C.F., Sherman, D.L. and Gershon, M.D. (1977). Uptake of serotonin by intrinsic neurons of the myenteric plexus grown in organotypic tissue culture. Brain Research, 128, 109-123.
75. Duff, R.S., Langtimm, C.J., Richardson, M.K. and Sieber-Blum, M. (1991). In vitro clonal analysis of progenitor cell patterns in dorsal root and sympathetic ganglia of the quail embryo. Developmental Biology, 147, 451-459.
76. Durbec, P.L., Larssonblomberg, L.B., Schuchardt, A., Costantini, F. and Pachnis, V. (1996a). Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts. Development, 122, 349-358.
77. Durbec, P., Marcos-Gutierrez, C.V., Kilkenny, C., Grigoriou, M., Wartiowaara, K., Suvanto, P. et al. (1996b). GDNF signalling through the Ret receptor tyrosine kinase. Nature, 381, 789-793.
78. Edery, P., Attie, T., Amiel, J., Pelet, A., Eng, C., Hofstra, R.M. et al. (1996). Mutation of the endothelin-3 gene in the Waardenburg-Hirschsprung disease (Shah-Waardenburg syndrome). Nature Genetics, 12, 442-444.
79. Edery, P., Lyonnet, S., Mulligan, L.M., Pelet, A., Dow, E., Abel, L. et al. (1994). Mutations of the RET protooncogene in Hirschsprung’s disease. Nature, 367, 378-380.
80. El Shamy, W.M., Linnarsson, S., Lee, K.F., Jaenisch, R. and Ernfors, P. (1996). Prenatal and postnatal requirements of NT-3 for sympathetic neuroblast survival and innervation of specific targets. Development, 122, 491-500.
81. Engvall, E., Davis, G.E., Dickerson, K., Ruoslahti, E., Varon, S. and Manthorpe, M. (1986). Mapping of domains in human laminin using monoclonal antibodies: localization of the neurite-promoting site. Journal of Cell Biology, 103, 2457-2465.
82. Epstein, M.L., Mikawa, T., Brown, A.M. and McFarlin, D.R. (1994). Mapping the origin of the avian enteric nervous system with a retroviral marker. Developmental Dynamics, 201, 236-244.
83. Erickson, C.A., Loring, J.F. and Lester, S.M. (1989). Migratory pathways of HNK-1-immunoreactive neural crest cells in the rat embryo. Developmental Biology, 134, 112-118.
84. Erickson, C.A., Duong, T.D. and Tosney, K.W. (1992). Descriptive and experimental analysis of the dispersion of neural crest cells along the dorsolateral path and their entry into ectoderm in the chick embryo. Developmental Biology, 151, 251-272.
85. Ernfors, P., Lee, K.F., Kucera, J. and Jaenisch, R. (1994). Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents. Cell, 77, 503-512.
86. Ernsberger, U., Sendtner, M. and Rohrer, H. (1989). Proliferation and differentiation of embryonic chick sympathetic neurons: effects of ciliary neurotrophic factor. Neuron, 2, 1275-1284.
87. Escandon, E., Soppet, D., Rosenthal, A., Mendoza-Ramirez, J.L., Szonyi, E., Burton, L.E. et al. (1994). Regulation of neurotrophin receptor expression during embryonic and postnatal development. Journal of Neuroscience, 14, 2054-2068.
88. Farinas, I., Jones, K.R., Backus, C., Wang, X.Y. and Reichardt, L.F. (1994). Severe sensory and sympathetic deficits in mice lacking neurotrophin-3. Nature, 369, 658-661.
89. Faussone-Pellegrini, M.S. (1985). Cytodifferentiation of the interstitial cells of Cajal related to the myenteric plexus of mouse intestinal muscle coat. An E.M. study from foetal to adult life. Anatomy & Embryology, 171, 163-169.
90. Fontaine-Perus, J., Chanconie, M. and Le Douarin, N.M. (1988). Developmental potentialities in the nonneuronal population of quail sensory ganglia. Developmental Biology, 128, 359-375.
91. Fox, E.A. and Powley, T.L. (1992). Morphology of identified preganglionic neurons in the dorsal motor nucleus of the vagus. Journal of Comparative Neurology, 322, 79-98.
92. Fraser, S.E. and Bronner-Fraser, M. (1991). Migrating neural crest cells in the trunk of the avian embryo are multipotent. Development, 112, 913-920.
93. Fujimoto, T., Hata, J., Yokoyama, S. and Mitomi, T. (1989). A study of the extracellular matrix protein as the migration pathway of neural crest cells in the gut: analysis in human embryos with special reference to the pathogenesis of Hirschsprung’s disease. Journal of Pediatric Surgery, 24, 550-556.
94. Furness, J.B. and Costa, M. (1982). Neurons with 5-hydroxytryptamine-like immunoreactivity in the enteric nervous system: their projections in the guinea-pig small intestine. Neuroscience, 7, 341-349.
95. Furness, J.B. and Costa, M. (1987). The Enteric Nervous System. Edinburgh: Churchill-Livingstone.
96. Furness, J.B., Morris, J.L., Gibbins, I.L. and Costa, M. (1989). Chemical coding of neurons and plurichemical transmission. Annual Review of Pharmacology and Toxicology, 29, 289-306.
97. Gabella, G. (1971). Glial cells in the myenteric plexus. Zeitschrift für Naturforschung, 26B, 244-245.
98. Gabella, G. (1972). Fine structure of the myenteric plexus in the guinea-pig ileum. Journal of Anatomy, 111, 69-97.
99. Gabella, G. and Trigg, P. (1984). Size of neurons and glial cells in the enteric ganglia of mice, guinea-pigs, rabbits and sheep. Journal of Neurocytology, 13, 49-71.
100. Gariepy, C.E., Cass, D.T. and Yanagisawa, M. (1996). Null mutation of endothelin receptor type B gene in spotting lethal rats causes aganglionic megacolon and white coat color. Proceedings of the National Academy of Sciences of the USA, 93, 867-872.
101. Gearing, D.P., Thut, C.J., VandeBos, T., Gimpel, S.D., Delaney, P.B., King, J. et al. (1991). Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. EMBO Journal, 10, 2839-2848.
102. Gearing, D.P., Comeau, M.R., Friend, D.J., Gimpel, S.D., Thut, C.J., McGourty, J. et al. (1992). The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor. Science, 255, 1434-1437.
103. Gershon, M.D., Chalazonitis, A., Blaugrund, E., Tennson, V.M. and Rothman, T.P. (1993). Laminin and neurotrophin-3 (NT-3) in the formation of the enteric nervous system. Anatomical Record (Suppl. 1), 54.
104. Gershon, M.D., Chalazonitis, A. and Rothman, T.P. (1993). From neural crest to bowel: development of the enteric nervous system. Journal of Neurobiology, 24, 199-214.
105. Gershon, M.D., Drakontides, A.B. and Ross, L.L. (1965). Serotonin: synthesis and release from the myenteric plexus of the mouse intestine. Science, 149, 197-199.
106. Gershon, M.D., Kirchgessner, A.L. and Wade, P.R. (1994). Functional Anatomy of the Enteric Nervous System. In Physiology of the Gastrointestinal Tract, edited by L.R. Johnson, pp. 381-422. New York: Raven Press.
107. Gershon, M.D. and Ross, L.L. (1966a). Location of sites of 5-hydroxytryptamine storage and metabolism by radioautography. Journal of Physiology (London), 186, 477-492.
108. Gershon, M.D. and Ross, L.L. (1966b). Radioisotopic studies of the binding, exchange, and distribution of 5-hydroxytryptamine synthesised from its radioactive precursor. Journal of Physiology (London), 186, 451-476.
109. Gershon, M.D. and Rothman, T.P. (1991). Enteric glia. Glia, 4, 195-204.
110. Gershon, M.D., Rothman, T.P., Joh, T.H. and Teitelman, G.N. (1984). Transient and differential expression of aspects of the catecholaminergic phenotype during development of the fetal bowel of rats and mice. Journal of Neuroscience, 4, 2269-2280.
111. Gershon, M.D., Rothman, T.P., Sherman, D. and Johnson, E.M. (1983). Effect of prenatal exposure to anti-NGF on the enteric nervous system (ENS) of the guinea pig. Anatomical Record, 205, 62A.
112. Gotz, R., Koster, R., Winkler, C., Raulf, F., Lottspeich, F., Schartl, M. et al. (1994). Neurotrophin-6 is a new member of the nerve growth factor family. Nature, 372, 266-269.
113. Guillemot, F. and Joyner, A.L. (1993). Dynamic expression of the murine Achaete-Scute homologue mash-1 in the developing nervous system. Mechanisms of Development, 42, 171-185.
114. Guillemot, F., Lo, L.C., Johnson, J.E., Auerbach, A., Anderson, D.J. and Joyner, A.L. (1993). Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons. Cell, 75, 463-476.
115. Haralabopoulos, G.C., Grant, D.S., Kleinman, H.K., Lelkes, P.I., Papaioannou, S.P. and Maragoudakis, M.E. (1994). Inhibitors of basement membrane collagen synthesis prevent endothelial cell alignment in matrigel in vitro and angiogenesis in vivo. Laboratory Investigation, 71, 575-582.
116. Henderson, C.E. (1996). Role of neurotrophic factors in neuronal development. Current Opinion in Neurobiology, 6, 64-70.
117. Hofstra, R.M., Osinga, J., Tan-Sindhunata, G., Wu, Y., Kamsteeg, E.J., Stulp, R.P. et al. (1996). A homozygous mutation in the endothelin-3 gene associated with a combined Waardenburg type 2 and Hirschsprung phenotype (Shah-Waardenburg syndrome). Nature Genetics, 12, 445-447.
118. Holschneider, A.M., Meier-Ruge, W. and Ure, B.M. (1994). Hirschsprung’s disease and allied disorders -a review. European Journal of Pediatric Surgery, 4, 260-266.
119. Hosoda, K., Hammer, R.E., Richardson, J.A., Baynash, A.G., Cheung, J.C., Giaid, A. et al. (1994). Targeted and natural (piebald-lethal) mutations of endothelin-b receptor gene produce megacolon associated with spotted coat color in mice. Cell, 79, 1267-1276.
120. Huizinga, J.D., Thuneberg, L., Kluppel, M., Malysz, J., Mikkelsen, H.B. and Bernstein, A. (1995). W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity. Nature, 373, 347-349.
121. Ip, N.Y., McClain, J., Barrezueta, N.X., Aldrich, T.H., Pan, L., Li, Y. et al. (1993). The alpha component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development. Neuron, 10, 89-102.
122. Ip, N.Y., Nye, S.H., Boulton, T.G., Davis, S., Taga, T., Li, Y., et al. (1992). CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130. Cell, 69, 1121-1132.
123. Ito, K., Morita, T. and Sieber-Blum, M. (1993). In vitro clonal analysis of mouse neural crest development. Developmental Biology, 157, 517-525.
124. Jacobs Cohen, R.J., Payette, R.F., Gershon, M.D. and Rothman, T.P. (1987). Inability of neural crest cells to colonize the presumptive aganglionic bowel of ls/ls mutant mice: requirement for a permissive microenvironment. Journal of Comparative Neurology, 255, 425-438.
125. Jessen, K.R. and Mirsky, R. (1980). Glial cells in the enteric nervous system contain glial fibrillary acidic protein. Nature, 286, 736-737.
126. Jing, S., Wen, D., Yu, Y., Holst, P.L., Luo, Y., Fang, M. et al. (1996). GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-α, a novel receptor for GDNF. Cell, 85, 1113-1124.
127. Johnson, Jr. E.M., Osborne, P.A., Rydel, R.E., Schmidt, R.E. and Pearson, J. (1983). Characterization of the effects of autoimmune nerve growth factor deprivation in the developing guinea-pig. Neuroscience, 8, 631-642.
128. Johnson, J.E., Birren, S.J., Saito, T. and Anderson, D.J. (1992). DNA binding and transcriptional regulatory activity of mammalian achaete-scute homologous (MASH) proteins revealed by interaction with a muscle-specific enhancer. Proceedings of the National Academy of Sciences of the USA, 89, 3596-3600.
129. Jonakait, G.M., Rosenthal, M. and Morrell, J.I. (1989). Regulation of tyrosine hydroxylase mRNA in catecholaminergic cells of embryonic rat: analysis by in situ hybridisation. Journal of Histochemistry & Cytochemistry, 37, 1-5.
130. Jonakait, G.M., Wolf, J., Cochard, P., Goldstein, M. and Black, I.B. (1979). Selective loss of noradrenergic phenotypic characters in neuroblasts of the rat embryo. Proceedings of the National Academy of Sciences of the USA, 76, 4683-4686.
131. Jucker, M., Kleinman, H.K., Walker, L.C., Bialobok, P., Williams, L.R. and Ingram, D.K. (1991). Localization and characterization of a 110 KD laminin binding protein immunoreactivity in adult and lesioned brain [Abstract]. Neuroscience, 17, 207.
132. Kalcheim, C., Carmeli, C. and Rosenthal, A. (1992). Neurotrophin 3 is a mitogen for cultured neural crest cells. Proceedings of the National Academy of Sciences of the USA, 89, 1661-1665.
133. Kapur, R.P., Yost, C. and Palmiter, R.D. (1992). A transgenic model for studying development of the enteric nervous system in normal and aganglionic mice. Development, 116, 167-175.
134. Kapur, R.P., Yost, C. and Palmiter, R.D. (1993). Aggregation chimeras demonstrate that the primary defect responsible for aganglionic megacolon in lethal spotted mice is not neuroblast autonomous. Development, 117, 993-999.
135. Kapur, R.P., Sweetser, D.A., Doggett, B., Siebert, J.R. and Palmiter, R.D. (1995). Intercellular signals downstream of endothelin receptor-B mediate colonization of the large intestine by enteric neuroblasts. Development, 121, 3787-3795.
136. Kapur, R.P., Livingston, R., Doggett, B., Sweetser, D.A., Siebert, J.R. and Palmiter, R.D. (1996). Abnormal microenvironmental signals underlie intestinal aganglionosis in dominant megacolon mutant mice. Developmental Biology, 174, 360-369.
137. Karaki, H., Mitsui-Saito, M., Takimoto, M., Oda, K., Okada, T., Ozaki, T. et al. (1996). Lack of endothelin ETB receptor binding and function in the rat with a mutant ETB receptor gene. Biochemical & Biophysical Research Communications, 222, 139-143.
138. Kennedy, T.E., Serafini, T., de la Torre, J.R. and Tessier-Lavigne, M. (1994). Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord. Cell, 78, 425-435.
139. Keynes, R.J., Johnson, A.R., Picart, C.J., Dunin-Borkowski, O.M. and Cook, G.M.W. (1990). A glycoprotein fraction from adult chicken grey matter causes collapse of CNS and PNS growth cones in vitro [Abstract]. Neuroscience, 16, 169.
140. Kibbey, M.C., Corcoran, M.L., Wahl, L.M. and Kleinman, H.K. (1994). Laminin SIKVAV peptide-induced angiogenesis in vivo is potentiated by neutrophils. Journal of Cellular Physiology, 160, 185-193.
141. Kibbey, M.C., Jucker, M., Weeks, B.S., Neve, R.L., Van Nostrand, W.E. and Kleinman, H.K. (1993). β-Amyloid precursor protein binds to the neurite-promoting IKVAV site of laminin. Proceedings of the National Academy of Sciences of the USA, 90, 10150-10153.
142. Kirchgessner, A.L. and Gershon, M.D. (1989). Identification of vagal efferent fibers and putative target neurons in the enteric nervous system of the rat. Journal of Comparative Neurology, 285, 38-53.
143. Kirchgessner, A.L. and Gershon, M.D. (1990). Innervation of the pancreas by neurons in the gut. Journal of Neuroscience, 10, 1626-1642.
144. Kirchgessner, A.L. and Gershon, M.D. (1995). Presynaptic inhibition by serotonin of nerve-mediated secretion of pancreatic amylase. American Journal of Physiology, 268, G339-G345.
145. Kirchgessner, A.L., Liu, M.T. and Gershon, M.D. (1996). In situ identification and visualization of neurons that mediate enteric and enteropancreatic reflexes. Journal of Comparative Neurology, 371, 270-286.
146. Kirchgessner, A.L., Tamir, H. and Gershon, M.D. (1992). Identification and stimulation by serotonin of intrinsic sensory neurons of the submucosal plexus of the guinea pig gut: activity-induced expression of Fos immunoreactivity. Journal of Neuroscience, 12, 235-248.
147. Kishimoto, T., Taga, T. and Akira, S. (1994). Cytokine signal transduction. Cell, 76, 253-262.
148. Klein, R., Silos-Santiago, I., Smeyne, R.J., Lira, S.A., Brambilla, R. Bryant, S. et al. (1994). Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements. Nature, 368, 249-251.
149. Kleinman, H.K. and Weeks, B.S. (1989). Laminin: structure, functions and receptors. Current Opinion in Cell Biology, 1, 964-967.
150. Kleinman, H.K., Ogle, R.C., Cannon, F.B., Little, C.D., Sweeney, T.M. and Luckenbill-Edds, L. (1988). Laminin receptors for neurite formation. Proceedings of the National Academy of Sciences of the USA, 85, 1282-1286.
151. Kleinman, H.K., Weeks, B.S., Cannon, F.B., Sweeney, T.M., Sephel, G.C., Clement, B. et al. (1991). Identification of a 110-kDa nonintegrin cell surface laminin-binding protein which recognises an A chain neuritepromoting peptide. Archives of Biochemistry and Biophysics, 290, 320-325.
152. Kobayashi, S., Furness, J.B., Smith, T.K. and Pompolo, S. (1989). Histological identification of the interstitial cells of Cajal in the guinea-pig small intestine. Arch ives of Histology and Cytology, 52, 267-286.
153. Kolodkin, A.L. (1995). Semaphorins: mediators of repulsive growth cone guidance. Trends in Cell Biology, 61, 15-22.
154. Konturek, S.J., Bilski, J., Konturek, P.K., Cieszkowski, M. and Pawlik, W. (1993). Role of endogenous nitric oxide in the control of canine pancreatic secretion and blood flow. Gastroenterology, 104, 896-902.
155. Kreulen, D.L. and Szurszewski, J.H. (1979). Reflex pathways in the abdominal prevertebral ganglia: evidence for a colo-colonic inhibitory reflex. Journal of Physiology (London), 295, 21-32.
156. Kuntz, A. (1913). On the innervation of the digestive tube. Journal of Comparative Neurology, 23, 173-192.
157. Kuntz, A. (1953). The autonomic Nervous System. Philadelphia: Lee and Febiger.
158. Kunze, W.A.A., Furness, J.B. and Bornstein, J.C. (1993). Simultaneous intracellular recordings from enteric neurons reveal that myenteric AH neurons transmit via slow excitatory postsynaptic potentials. Neuroscience, 55, 685-694.
159. Kunze, W.A., Bornstein, J.C. and Furness, J.B. (1995). Identification of sensory nerve cells in a peripheral organ (the intestine) of a mammal. Neuroscience, 66, 1-4.
160. Kurihara, Y., Kurihara, H., Suzuki, H., Kodama, T., Maemura, K., Nagai, R. et al. (1994). Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1. Nature, 368, 703-710.
161. Lahav, R., Ziller, C., Dupin, E. and Le Douarin, N.M. (1996). Endothelin 3 promotes neural crest cell proliferation and mediates a vast increase in melanocyte number in culture. Proceedings of the National Academy of Sciences of the USA, 93, 3892-3897.
162. Lallier, T. and Bronner-Fraser, M. (1991). Avian neural crest cell attachment to laminin: involvement of divalent cation dependent and independent integrins. Development, 113, 1069-1084.
163. Lallier, T., Deutzmann, R., Perris, R. and Bronner-Fraser, M. (1994). Neural crest cell interactions with laminin: structural requirements and localization of the binding site for alpha 1 beta 1 integrin. Developmental Biology, 162, 451-464.
164. Lamballe, F., Smeyne, R.J. and Barbacid, M. (1994). Developmental expression of TrkC, the neurotrophin-3 receptor, in the mammalian nervous system. Journal of Neuroscience, 14, 14-28.
165. Lander, A.D., Fujii, D.K. and Reichardt, L.F. (1985). Laminin is associated with the “neurite outgrowth-promoting factors” found in conditioned media. Proceedings of the National Academy of Sciences of the USA, 82, 2183-2187.
166. Lane, P.W. (1966). Association of megacolon with two recessive spotting genes in the mouse. Journal of Heredity, 57, 29-31.
167. Langley, J.N. (1921). The autonomic nervous system. Cambridge: Heffer.
168. Lecoin, L., Gabella, G. and Le Douarin, N. (1996). Origin of the c-kit-positive interstitial cells in the avian bowel. Development, 122, 725-733.
169. Le Douarin, N.M. (1986). Cell line segregation during peripheral nervous system ontogeny. Science, 231, 1515-1522.
170. Le Douarin, N.M. and Dupin, E. (1993). Cell lineage analysis in neural crest ontogeny. Journal of Neurobiology, 24, 146-161.
171. Le Douarin, N.M. and Teillet, M.A. (1973). The migration of neural crest cells to the wall of the digestive tract in avian embryo. Journal of Embryology and Experimental Morphology, 30, 31-48.
172. Le Douarin, N.M. and Teillet, M.A. (1974). Experimental analysis of the migration and differentiation of neuroblasts of the autonomic nervous system and of neurectodermal mesenchymal derivatives, using a biological cell marking technique. Developmental Biology, 41, 162-184.
173. Lee, K.F., Li, E., Huber, L.J., Landis, S.C., Sharpe, A.H., Chao, M.V. et al. (1992). Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Cell, 69, 737-749.
174. Liesi, P., Narvanen, A., Soos, J., Sariola, H. and Snounou, G. (1989). Identification of a neurite outgrowthpromoting domain of laminin using synthetic peptides. FEBS Letters, 244, 141-148.
175. Lin, L.F., Doherty, D.H., Lile, J.D., Bektesh, S. and Collins, F. (1993). GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science, 260, 1130-1132.
176. Lindsay, R.M., Wiegand, S.J., Altar, C.A. and DiStefano, P.S. (1994). Neurotrophic factors: from molecule to man. Trends in the Neurosciences, 17, 182-190.
177. Lo, L. and Anderson, D.J. (1995). Postmigratory neural crest cells expressing c-RET display restricted developmental and proliferative capacities. Neuron, 15, 527-539.
178. Lo, L.C., Johnson, J.E., Wuenschell, C.W., Saito, T. and Anderson, D.J. (1991). Mammalian achaete-scute homolog 1 is transiently expressed by spatially restricted subsets of early neuroepithelial and neural crest cells. Genes and Development, 5, 1524-1537.
179. Luo, Y., Raible, D. and Raper, J.A. (1993). Collapsin: a protein in brain that induces the collapse and paralysis of neuronal growth cones. Cell, 75, 217-227.
180. Mackey, H.M., Payette, R.F. and Gershon, M.D. (1988). Tissue effects on the expression of serotonin, tyrosine hydroxylase and GABA in cultures of neurogenic cells from the neuraxis and branchial arches. Development, 104, 205-217.
181. Maeda, H., Yamagata, A., Nishikawa, S., Yoshinaga, K., Kobayashi, S. and Nishi, K. (1992). Requirement of c-kit for development of intestinal pacemaker system. Development, 116, 369-375.
182. Manthorpe, M., Engvall, E., Ruoslahti, E., Longo, F.M., Davis, G.E. and Varon, S. (1983). Laminin promotes neuritic regeneration from cultured peripheral and central neurons. Journal of Cell Biology, 97, 1882-1890.
183. Martins-Green, M. and Erickson, C.A. (1987). Basal lamina is not a barrier to neural crest cell emigration: documentation by TEM and by immunofluorescent and immunogold labelling. Development, 101, 517-533.
184. Masu, Y., Wolf, E., Holtmann, B., Sendtner, M., Brem, G. and Thoenen, H. (1993). Disruption of the CNTF gene results in motor neuron degeneration. Nature, 365, 27-32.
185. Mawe, G.M. and Gershon, M.D. (1989). Relationship of gallbladder ganglia to the enteric nervous ystemt: strucutre, putative neurotransmitters and direct neural connections. In Proceedings of the 50th Falk Symposium. Titisee: Kluwer Academic Publishers.
186. Messersmith, E.K., Leonardo, E.D., Shatz, C.J., Tessier-Lavigne, M., Goodman, C.S. and Kolodkin, A.L. (1995). Semaphorin III can function as a selective chemorepellent to pattern sensory projections in the spinal cord. Neuron, 14, 949-959.
187. Miura, H., Ohi, R., Tseng, S.W. and Takahashi, T. (1996). The structure of the transitional and aganglionic zones of Auerbach’s plexus in patients with Hirschsprung’s disease: a computer-assisted three-dimensional reconstruction study. Journal of Pediatric Surgery, 31, 420-426.
188. Miyazawa, K., Williams, D.A., Gotoh, A., Nishimaki, J., Broxmeyer, H.E. and Toyama, K. (1995). Membranebound Steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit geneencoded protein than its soluble form. Blood, 85, 641-649.
189. Moore, M.W., Klein, R.D., Farinas, I., Sauer, H., Armanini, M., Phillips, H. et al. (1996). Renal and neuronal abnormalities in mice lacking GDNF. Nature, 382, 76-79.
190. Nomizu, M., Weeks, B.S., Weston, C.A., Kim, W.H., Kleinman, H.K. and Yamada, Y. (1995). Structure-activity study of a laminin alpha 1 chain active peptide segment Ile-Lys-Val-Ala-Val (IKVAV). FEBS Letters, 365, 227-231.
191. Norris, W.E., Stern, C.D. and Keynes, R.J. (1989). Molecular differences between the rostral and caudal halves of the sclerotome in the chick embryo. Development, 105, 541-548.
192. Oakley, R.A. and Tosney, K.W. (1991). Peanut agglutinin and chondroitin-6-sulfate are molecular markers for tissues that act as barriers to axon advance in the avian embryo. Developmental Biology, 147, 187-206.
193. Oakley, R.A., Lasky, C.J., Erickson, C.A. and Tosney, K.W. (1994). Glycoconjugates mark a transient barrier to neural crest migration in the chicken embryo. Development, 120, 103-114.
194. Ockel, M., Lewin, G.R. and Barde, Y.A. (1996). In vivo effects of neurotrophin-3 during sensory neurogenesis. Development, 122, 301-307.
195. Okabe, H., Chijiiwa, Y., Nakamura, K., Yoshinaga, M., Akiho, H., Harada, N. et al. (1995). Two endothelin receptors (ETA and ETB) expressed on circular smooth muscle cells of guinea pig cecum. Gastroenterology, 108, 51-57.
196. Pachnis, V., Mankoo, B. and Costantini, F. (1993). Expression of the c-ret proto-oncogene during mouse embryogenesis. Development, 119, 1005-1017.
197. Parikh, D.H., Leibl, M., Tam, P.K. and Edgar, D. (1995). Abnormal expression and distribution of nidogen in Hirschsprung’s disease. Journal of Pediatric Surgery, 30, 1687-1693.
198. Parikh, D.H., Tam, P.K., Van Velzen, D. and Edgar, D. (1992). Abnormalities in the distribution of laminin and collagen type IV in Hirschsprung’s disease. Gastroenterology, 102, 1236-1241.
199. Pasini, B., Borrello, M.G., Greco, A., Bongarzone, I., Luo, Y., Mondellini, P. et al. (1995). Loss of function effect of RET mutations causing Hirschsprung disease. Nature Genetics, 10, 35-40.
200. Payette, R.F., Bennett, G.S. and Gershon, M.D. (1984). Neurofilament expression in vagal neural crest-derived precursors of enteric neurons. Developmental Biology, 105, 273-287.
201. Payette, R.F., Tennyson, V.M., Pham, T.D., Mawe, G.M., Pomeranz, H.D., Rothman, T.P. et al. (1987). Origin and morphology of nerve fibers in the aganglionic colon of the lethal spotted (ls/ls) mutant mouse. Journal of Comparative Neurology, 257, 237-252.
202. Payette, R.F., Tennyson, V.M., Pomeranz, H.D., Pham, T.D., Rothman, T.P. and Gershon, M.D. (1988). Accumulation of components of basal laminae: association with the failure of neural crest cells to colonize the presumptive aganglionic bowel of ls/ls mutant mice. Developmental Biology, 125, 341-360.
203. Pearson, J., Johnson, E.M. and Brandeis, L. (1983). Effects of antibodies to nerve growth factor on intrauterine development of derivatives of cranial neural crest and placode in the guinea pig. Developmental Biology, 96, 32-36.
204. Pennica, D., Shaw, K.J., Swanson, T.A., Moore, M.W., Shelton, D.L., Zioncheck, K.A. et al. (1995). Cardiotrophin-1. Biological activities and binding to the leukemia inhibitory factor receptor/gp130 signaling complex. Journal of Biological Chemistry, 270, 10915-10922.
205. Perris, R., Paulsson, M. and Bronner-Fraser, M. (1989). Molecular mechanisms of avian neural crest cell migration on fibronectin and laminin. Developmental Biology, 136, 222-238.
206. Pettway, Z., Guillory, G. and Bronner-Fraser, M. (1990). Absence of neural crest cells from the region surrounding implanted notochords in situ. Developmental Biology, 142, 335-345.
207. Pham, T.D., Gershon, M.D. and Rothman, T.P. (1991). Time of origin of neurons in the murine enteric nervous system: sequence in relation to phenotype. Journal of Comparative Neurology, 314, 789-798.
208. Pham, T., Wade, A., Chalazonitis, A., Skirboll, S.L., Bothwell, M. and Gershon, M.D. (1996). Increased numbers of myenteric neurons arise in transgenic mice that overexpress neurotrophin-3 (NT-3) directed to the enteric nervous system (ENS) by the dopamin beta-hydroxylase promoter. Neuroscience, 12, 999 [Abstract].
209. Pichel, J.G., Shen, L., Sheng, H.Z., Granholm, A.C., Drago, J., Grinberg, A. et al. (1996). Defects in enteric innervation and kidney development in mice lacking GDNF. Nature, 382, 73-76.
210. Pinco, O., Carmeli, C., Rosenthal, A. and Kalcheim, C. (1993). Neurotrophin-3 affects proliferation and differentiation of distinct neural crest cells and is present in the early neural tube of avian embryos. Journal of Neurobiology, 24, 1626-1641.
211. Pomeranz, H.D. and Gershon, M.D. (1990). Colonization of the avian hindgut by cells derived from the sacral neural crest. Developmental Biology, 137, 378-394.
212. Pomeranz, H.D., Rothman, T.P. and Gershon, M.D. (1991). Colonization of the post-umbilical bowel by cells derived from the sacral neural crest: direct tracing of cell migration using an intercalating probe and a replication-deficient retrovirus. Development, 111, 647-655.
213. Pomeranz, H.D., Sherman, D.L., Smalheiser, N.R., Tennyson, V.M. and Gershon, M.D. (1991). Expression of a neurally related laminin binding protein by neural crest-derived cells that colonize the gut: relationship to the formation of enteric ganglia. Journal of Comparative Neurology, 313, 625-642.
214. Pomeranz, H.D., Rothman, T.P., Chalazonitis, A., Tennyson, V.M. and Gershon, M.D. (1993). Neural crestderived cells isolated from the gut by immunoselection develop neuronal and glial phenotypes when cultured on laminin. Developmental Biology, 156, 341-361.
215. Powley, T.L., Holst, M.C., Boyd, D.B. and Kelly, J.B. (1994). Three-dimensional reconstructions of autonomic projections to the gastrointestinal tract. Microscopy Research & Technique, 29, 297-309.
216. Puffenberger, E.G., Hosoda, K., Washington, S.S., Nakao, K., deWit, D., Yanagisawa, M. et al. (1994). A missense mutation of the endothelin-B receptor gene in multigenic Hirschsprung’s disease. Cell, 79, 1257-1266.
217. Puliti, A., Poirier, V., Goossens, M. and Simonneau, M. (1996). Neuronal defects in genotyped dominant megacolon (Dom) mouse embryos, a model for Hirschsprung disease. Neuroreport, 7, 489-492.
218. Rickmann, M., Fawcett, J.W. and Keynes, R.J. (1985). The migration of neural crest cells and the growth of motor axons through the rostral half of the chick somite. Journal of Embryology & Experimental Morphology, 90, 437-455.
219. Romeo, G., Ronchetto, P., Luo, Y., Barone, V., Seri, M., Ceccherini, I., et al. (1994). Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung’s disease. Nature, 367, 377-378.
220. Rothman, T.P. and Gershon, M.D. (1982). Phenotypic expression in the developing murine enteric nervous system. Journal of Neuroscience, 2, 381-393.
221. Rothman, T.P. and Gershon, M.D. (1984). Regionally defective colonization of the terminal bowel by the precursors of enteric neurons in lethal spotted mutant mice. Neuroscience, 12, 1293-1311.
222. Rothman, T.P., Ross, L.L. and Gershon, M.D. (1976). Separately developing axonal uptake of 5-hydroxytryptamine and noepinephrine in the fetal ileum of the rabbit. Brain Research, 115, 437-456.
223. Rothman, T.P., Specht, L.A., Gershon, M.D., Joh, T.H., Teitelman, G., Pickel, V.M. et al. (1980). Catecholamine biosynthetic enzymes are expressed in replicating cells of the peripheral but not the central nervous system. Proceedings of the National Academy of Sciences of the USA, 77, 6221-6225.
224. Rothman, T.P., Tennyson, V.M. and Gershon, M.D. (1986). Colonization of the bowel by the precursors of enteric glia: studies of normal and congenitally aganglionic mutant mice. Journal of Comparative Neurology, 252, 493-506.
225. Rothman, T.P., Sherman, D., Cochard, P. and Gershon, M.D. (1986). Development of the monoaminergic innervation of the avian gut: transient and permanent expression of phenotypic markers. Developmental Biology, 116, 357-380.
226. Rothman, T.P., Le, D.N., Fontaine, P.J. and Gershon, M.D. (1990). Developmental potential of neural crest-derived cells migrating from segments of developing quail bowel back-grafted into younger chick host embryos. Development, 109, 411-423.
227. Rothman, T.P., Goldowitz, D. and Gershon, M.D. (1993). Inhibition of migration of neural crest-derived cells by the abnormal mesenchyme of the presumptive aganglionic bowel of ls/ls mice: analysis with aggregation and interspecies chimeras. Developmental Biology, 159, 559-573.
228. Rothman, T.P., Le, D.N., Fontaine, P.J. and Gershon, M.D. (1993). Colonization of the bowel by neural crest-derived cells re-migrating from foregut backtransplanted to vagal or sacral regions of host embryos. Developmental Dynamics, 196, 217-233.
229. Rothman, T.P., Chen, J. and Gershon, M.D. (1994). Microenvironmental factors in the differentiation of enteric neurons from neural crest-derived precursors. Neuroscience, 20, 1492 [Abstract].
230. Rothman, T.P., Chen, J., Howard, M.J., Costantini, F., Schuchardt, A., Pachnis, V. and Gershon, M.D. (1996). Increased expression of laminin-1 and collagen (IV) subunits in the aganglionic bowel of ls/ls, but not c-ret-/-mice. Developmental Biology, 178, 498-513.
231. Rubanyi, G.M. and Polokoff, M.A. (1994). Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology. Pharmacological Reviews, 46, 325-415.
232. Saadat, S., Sendtner, M. and Rohrer, H. (1989). Ciliary neurotrophic factor induces cholinergic differentiation of rat sympathetic neurons in culture. Journal of Cell Biology, 108, 1807-1816.
233. Sakamoto, A., Yanagisawa, M., Sawamura, T., Enoki, T., Ohtani, T., Sakurai, T. et al. (1993). Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB-selective agonists. Journal of Biological Chemistry, 268, 8547-8553.
234. Sanchez, M.P., Silos-Santiago, I., Frisen, J., He, B., Lira, S.A. and Barbacid, M. (1996). Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature, 382, 70-73.
235. Sanders, K.M. (1996). A case for interstitial cells of Cajal as pacemakers and mediators of neurotransmission in the gastrointestinal tract. Gastroenterology, 111, 492-515.
236. Sang, Q. and Young, H.M. (1996). Chemical coding of neurons in the myenteric plexus and external muscle of the small and large intestine of the mouse. Cell and Tissue Research, 284, 39-53.
237. Schemann, M. and Grundy, D. (1992). Electrophysiological identification of vagally innervated enteric neurons in guinea pig stomach. American Journal of Physiology, 263, G709-G718.
238. Schemann, M., Schaaf, C. and Mader, M. (1995). Neurochemical coding of enteric neurons in the guinea pig stomach. Journal of Comparative Neurology, 353, 161-178.
239. Schuchardt, A., D’Agati, V., Larsson-Blomberg, L., Costantini, F. and Pachnis, V. (1994). Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Nature, 367, 380-383.
240. Sendtner, M., Carroll, P., Holtmann, B., Hughes, R.A. and Thoenen, H. (1994). Ciliary neurotrophic factor. Journal of Neurobiology, 25, 1436-1453.
241. Sephel, G.C., Tashiro, K., Sasaki, M., Kandel, S., Yamada, Y. and Kleinman, H.K. (1989a). A laminin-pepsin fragment with cell attachment and neurite outgrowth activity at distinct sites. Developmental Biology, 135, 172-181.
242. Sephel, G.C., Tashiro, K.I., Sasaki, M., Greatorex, D., Martin, G.R., Yamada, Y. et al. (1989b). Laminin A chain synthetic peptide which supports neurite outgrowth. Biochemical & Biophysical Research Communications, 162, 821-829.
243. Serafini, T., Kennedy, T.E., Galko, M.J., Mirzayan, C., Jessell, T.M. and Tessier-Lavigne, M. (1994). The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell, 78, 409-424.
244. Serbedzija, G.N., Burgan, S., Fraser, S.E. and Bronner, F.M. (1991). Vital dye labelling demonstrates a sacral neural crest contribution to the enteric nervous system of chick and mouse embryos. Development, 111, 857-866.
245. Sextier-Sainte-Claire Deville, F., Ziller, C. and Le Douarin, N.M. (1992). Developmental potentialities of cells derived from the truncal neural crest in clonal cultures. Brain Research Developmental Brain Research, 66, 1-10.
246. Sextier-Sainte-Claire Deville, F., Ziller, C. and Le Douarin, N.M. (1994). Developmental potentials of enteric neural crest-derived cells in clonal and mass cultures. Developmental Biology, 163, 141-151.
247. Sieber-Blum, M. and Cohen, A.M. (1980). Clonal analysis of quail neural crest cells: they are pluripotent and differentiate in vitro in the absence of noncrest cells. Developmental Biology, 80, 96-106.
248. Simo, P., Simon-Assmann, P., Bouziges, F., Leberquier, C., Kedinger, M., Ekblom, P., et al. (1991). Changes in the expression of laminin during intestinal development. Development, 112, 477-487.
249. Song, Z.M., Brookes, S.J. and Costa, M. (1991). Identification of myenteric neurons which project to the mucosa of the guinea-pig small intestine. Neuroscience Letters, 129, 294-298.
250. Song, Z.M., Brookes, S.J.H. and Costa, M. (1994). All calbindin-immunoreactive myenteric neurons project to the mucosa of the guinea-pig small intestine. Neuroscience Letters, 180, 219-222.
251. Song, Z.M., Brookes, S.J.H. and Costa, M. (1996). Projections of specific morphological types of neurons within the myenteric plexus of the small intestine of the guinea-pig. Cell and Tissue Research, 285, 149-156.
252. Stahl, N., Boulton, T.G., Farruggella, T., Ip, N.Y., Davis, S., Witthuhn, B.A. et al. (1994). Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6β receptor components. Science, 263, 92-95.
253. Stark, M.E., Bauer, A.J. and Szurszewski, J.H. (1991). Effect of nitric oxide on circular muscle of the canine small intestine. Journal of Physiology (London), 444, 743-761.
254. Stemple, D.L. and Anderson, D.J. (1992). Isolation of a stem cell for neurons and glia from the mammalian neural crest. Cell, 71, 973-985.
255. Stemple, D.L. and Anderson, D.J. (1993). Lineage diversification of the neural crest: in vitro investigations. Developmental Biology, 159, 12-23.
256. Szurszewski, J.H. (1981). Physiology of mammalian prevertebral ganglia. Annual Review of Physiology, 43, 53-68.
257. Takahashi, R., Yokoji, H., Misawa, H., Hayashi, M., Hu, J. and Deguchi, T. (1994). A null mutation in the human CNTF gene is not causally related to neurological diseases. Nature Genetics, 7, 79-84.
258. Tam, P.K. and Lister, J. (1986). Development profile of neuron-specific enolase in human gut and its implications in Hirschsprung’s disease. Gastroenterology, 90, 1901-1906.
259. Teitelman, G., Joh, T.H. and Reis, D.J. (1978). Transient expression of a noradrenergic phenotype in cells of the rat embryoinic gut. Brain Research, 158, 229-234.
260. Teitelman, G., Gershon, M.D., Rothman, T.P., Joh, T.H. and Reis, D.J. (1981). Proliferation and distribution of cells that transiently express a catecholaminergic phenotype during development in mice and rats. Developmental Biology, 86, 348-355.
261. Tennyson, V.M., Payette, R.F., Rothman, T.P. and Gershon, M.D. (1990). Distribution of hyaluronic acid and chondroitin sulfate proteoglycans in the presumptive aganglionic terminal bowel of ls/ls fetal mice: an ultrastructural analysis. Journal of Comparative Neurology, 291, 345-362.
262. Tennyson, V.M., Chalazonitis, A., Kibbey, M.C. and Gershon, M.D. (1995). Laminin-1 stimulates a cell surface receptor (LBP 110). to promote the differentiation of enteric neurons in vitro independently of its role as an adhesion molecule. Neuroscience, 21, 788 [Absract].
263. Teramoto, M., Domoto, T., Tanigawa, K., Yasui, Y. and Tamura, K. (1996). Distribution of nitric oxide synthase-containing nerves in the aganglionic intestine of mutant rats: a histochemical study. Journal of Gastroenterology, 31, 214-223.
264. Tessarollo, L., Tsoulfas, P., Martin-Zanca, D., Gilbert, D.J., Jenkins, N.A., Copeland, N.G. et al. (1993). TrkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues. Development, 118, 463-475.
265. Tessier-Lavigne, M. (1994). Axon guidance by diffusible repellants and attractants. Current Opinion in Genetics and Development, 4, 596-601.
266. Tojo, H., Kaisho, Y., Nakata, M., Matsuoka, K., Kitagawa, M., Abe, T. et al. (1995). Targeted disruption of the neurotrophin-3 gene with lacz induces loss of trkC-positive neurons in sensory ganglia but not in spinal cords. Brain Research, 669, 163-175.
267. Torihashi, S., Kobayashi, S., Gerthoffer, W.T. and Sanders, K.M. (1993). Interstitial cells in deep muscular plexus of canine small intestine may be specialized smooth muscle cells. American Journal of Physiology, 265, G638-G645.
268. Torihashi, S., Ward, S.M., Nishikawa, S.I., Nishi, K., Kobayashi, S. and Sanders, K.M. (1995). C-kit-dependent development of interstitial cells and electrical activity in the murine gastrointestinal tract. Cell and Tissue Research, 280, 97-111.
269. Torihashi, S., Ward, S.M. and Sanders, K.M. (1997). Development of C-kit-positive cells and the onset of electrical rhythmicity in murine small intestine. Gastroenterology, 112, 144-155.
270. Toyohara, T., Nada, O., Nagasaki, A., Goto, S. and Ikeda, K. (1985). An immunohistochemical study of serotoninergic nerves in the colon and rectum of children with Hirschsprung’s disease. Acta Neuropathologica, 68, 306-310.
271. Treanor, J.J., Goodman, L., de Sauvage, F., Stone, D.M., Poulsen, K.T., Beck, C.D. et al. (1996). Characterization of a multicomponent receptor for GDNF. Nature, 382, 80-83.
272. Trendelenburg, P. (1917). Physiologische und pharmakologische Versuche Uber die Dunndarmperistaltik. Naunyn-Schmiedeberg Archiv fürExperimentale Pathologies und Pharmakologie, 81, 55-129.
273. Trupp, M., Arenas, E., Fainzilber, M., Nilsson, A.S., Sieber, B.A., Grigoriou, M. et al. (1996). Functional receptor for GDNF encoded by the c-ret proto-oncogene. Nature, 381, 785-789.
274. Trupp, M., Ryden, M., Jornvall, H., Funakoshi, H., Timmusk, T., Arenas, E. et al. (1995). Peripheral expression and biological activities of gdnf, a new neurotrophic factor for avian and mammalian peripheral neurons. Journal of Cell Biology, 130, 137-148.
275. Tsoulfas, P., Soppet, D., Escandon, E., Tessarollo, L., Mendoza-Ramirez, J.L., Rosenthal, A. et al. (1993). The rat TrkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells. Neuron, 10, 975-990.
276. Tsuzuki, T., Takahashi, M., Asai, N., Iwashita, T., Matsuyama, M. and Asai, J.P. (1995). Spatial and temporal expression of the ret proto-oncogene product in embryonic, infant and adult rat tissues. Oncogene, 10, 191-198.
277. Tucker, G.C., Ciment, G. and Thiery, J.P. (1986). Pathways of avian neural crest cell migration in the developing gut. Developmental Biology, 116, 439-450.
278. Vanderwinden, J.M., Rumessen, J.J., Liu, H., Descamps, D., Delaet, M.H. and Vanderhaeghen, J.J. (1996). Interstitial cells of cajal in human colon and in hirschsprungs disease. Gastroenterology, 111, 901-910.
279. Verdi, J.M. and Anderson, D.J. (1994). Neurotrophins regulate sequential changes in neurotrophin receptor expression by sympathetic neuroblasts. Neuron, 13, 1359-1372.
280. Ward, S.M., Burns, A.J., Torihashi, S., Harney, S.C. and Sanders, K.M. (1995). Impaired development of interstitial cells and intestinal electrical rhythmicity in steel mutants. American Journal of Physiology Cell Physiology, 38, C1577-C1585.
281. Ward, S.M., Burns, A.J., Torihashi, S. and Sanders, K.M. (1994). Mutation of the proto-oncogene c-kit blocks development of interstitial cells and electrical rhythmicity in murine intestine. Journal of Physiology, 480, 91-97.
282. Watanabe, Y., Ito, T., Harada, T., Kobayashi, S., Ozaki, T. and Nimura, Y. (1995a). Spatial distribution and pattern of extrinsic nerve strands in the aganglionic segment of congenital aganglionosis -stereoscopic analysis in spotting lethal rats. Journal of Pediatric Surgery, 30, 1471-1476.
283. Watanabe, Y., Ito, T., Harada, T., Takahashi, M., Kobayashi, S., Ozaki, T. et al. (1995b). Expression of ret protooncogene products in the hypoganglionic segment of the small intestine of congenital aganglionosis rats. Journal of Pediatric Surgery, 30, 641-645.
284. Weeks, B.S., Holloway, E., Klotman, P.E., Akiyama, S.K., Schnaper, H.W. and Kleinman, H.K. (1994). 12-O-tetradecanoylphorbol 13-acetate stimulates human T-lymphocyte adherence to the fibronectin RGD domain and the laminin IKVAV domain. Cellular Immunology, 153, 94-104.
285. Wehrle-Haller, B. and Weston, J.A. (1995). Soluble and cell-bound forms of steel factor activity play distinct roles in melanocyte precursor dispersal and survival on the lateral neural crest migration pathway. Development, 121, 731-742.
286. Wood, J.D. (1994). Physiology of the Enteric Nervous System. In Physiology of the Gastrointestinal Tract, edited by L.R. Johnson, D.H. Alpers, E.D. Jacobson and J.H. Walsh, pp. 423-482. New York: Raven Press.
287. Wu, J.J., Rothman, T.P. and Gershon, M.D. (1996). Development of the interstitial cells of cajal in the mouse gut: requirement for Kit ligand (KL) [Abstract]. Neuroscience, 22, 31.
288. Wu, J.J., Chen, J.-X., Rothman, T.P. and Gershon, M.D. (1999). Inhibition of in vitro enteric neuronal development by endothelin-3: mediation by endothelin B receptors. Development 126, 1161-1173.
289. Wyatt, S. and Davies, A.M. (1995). Regulation of nerve growth factor receptor gene expression in sympathetic neurons during development. Journal of Cell Biology, 130, 1435-1446.
290. Xu, D., Emoto, N., Giaid, A., Slaughter, C., Kaw, S., deWit, D., et al. (1994). ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1. Cell, 78, 473-485.
291. Yamataka, A., Kato, Y., Tibboel, D., Murata, Y., Sueyoshi, N., Fujimoto, T. et al. (1995). A lack of intestinal pacemaker (c-kit) in aganglionic bowel of patients with hirschsprungs disease. Journal of Pediatric Surgery, 30, 441-444.
292. Yanagisawa, M., Kurihara, H., Kimura, S., Tomobe, Y., Kobayashi, M., Mitsui, Y. et al. (1988). A novel potent peptide produced by vascular endothelial cells. Nature, 332, 411-415.
293. Yanagisawa, M. (1994). The endothelin system: a new target for therapeutic intervention. Circulation, 89, 1320-1322.
294. Yntema, C.L. and Hammond, W.S. (1954). The origin of intrinsic ganglia of trunk viscera from vagal neural crest in the chick embryo. Journal of Comparative Neurology, 101, 515-542.
295. Yntema, C.L. and Hammond, W.S. (1955). Experiments on the origin and development of the sacral autonomic nerves in the chick enbryo. Journal of Experimental Zoology, 129, 375-414.
296. Yoshinaga, M., Chijiiwa, Y., Misawa, T., Harada, N. and Nawata, H. (1992). Endothelin-B receptor on guinea pig small intestinal smooth muscle cells. American Journal of Physiology, 262, G308-G311.
297. Young, H.M., McConalogue, K., Furness, J.B. and Devente, J. (1993). Nitric oxide targets in the guinea-pig intestine identified by induction of cyclic GMP immunoreactivity. Neuroscience, 55, 583-596.
298. Zhang, J.M., Winslow, J.W. and Sieber-Blum, M. (1993). Role of neurotrophin-3 (NT-3) in the expression of the adrenergic phenotype by neural crest cells [Abstract]. Neuroscience, 19, 251.
299. Zhou, X.F. and Rush, R. (1995). Sympathetic neurons in neonatal rats require endogenous neurotrophin-3 for survival. Journal of Neuroscience, 15, 6521-6530.