Comparison between high-sensitivity cardiac troponin T and cardiac troponin I in a large general population cohort

Clinical Chemistry

Volumn 64, Issue 11, 2018, Pages 1607-1616

  Welsh, Paul ^a   Preiss, David ^b   Shah, Anoop S V ^c   Mcallister, David ^a   Briggs, Andrew ^a   Boachie, Charles ^a   McConnachie, Alex ^a   Hayward, Caroline ^d   Padmanabhan, Sandosh ^a   Welsh, Claire ^a   Woodward, Mark ^b,e,f   Campbell, Archie ^g   Porteous, David ^g   Mills, Nicholas L ^c   Sattar, Naveed ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

^e UNIVERSITY OF NEW SOUTH WALES   (Australia)

^f JOHNS HOPKINS UNIVERSITY   (United States)

^g UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; CREATININE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TROPONIN I; TROPONIN T; BIOLOGICAL MARKER;

ADULT; AGED; ARTICLE; BLOOD PRESSURE; BODY MASS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CLINICAL EVALUATION; COHORT ANALYSIS; COMPARATIVE STUDY; DIABETES MELLITUS; DRUG THERAPY; FEMALE; GROUPS BY AGE; HUMAN; LIMIT OF DETECTION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; POPULATION; RISK ASSESSMENT; SENSITIVITY ANALYSIS; SEX; SMOKING; SYSTOLIC BLOOD PRESSURE; AGE; BLOOD; MASS SCREENING; REFERENCE VALUE; RISK FACTOR; SCOTLAND; SEX FACTOR;

ADULT; AGE FACTORS; AGED; BIOMARKERS; CARDIOVASCULAR DISEASES; COHORT STUDIES; FEMALE; HUMANS; MALE; MASS SCREENING; MIDDLE AGED; REFERENCE VALUES; RISK FACTORS; SCOTLAND; SEX FACTORS; TROPONIN I; TROPONIN T;

EID: 85055658030     PISSN: 00099147     EISSN: 15308561     Source Type: Journal    
DOI: 10.1373/clinchem.2018.292086     Document Type: Article

References (30)

1. Ford I, Shah AS, Zhang R, McAllister DA, Strachan FE, Caslake M, et al. High-sensitivity cardiac troponin, statin therapy, and risk of coronary heart disease. J Am Coll Cardiol 2016;68:2719 -28.
2. Chin CWL, Shah ASV, McAllister DA, Cowell SJ, Alam S, Langrish JP, et al. High-sensitivity troponin I concentrations are a marker of an advanced hypertrophic response and adverse outcomes in patients with aortic stenosis. Eur Heart J 2014;35:2312-21.
3. Chapman AR, Lee KK, McAllister DA, Cowell SJ, Alam S, Langrish JP, et al. Association of high-sensitivity cardiac troponin I concentration with cardiac outcomes in patients with suspected acute coronary syndrome. JAMA 2017;318:1913.
4. Willeit P, Welsh P, Evans JDW, Tschiderer L, Boachie C, Jukema JW, et al. High-sensitivity cardiac troponin concentration and risk of first-ever cardiovascular outcomes in 154, 052 participants. J Am Coll Cardiol 2017;70: 558 - 68.
5. Wu AHB, Christenson RH, Greene DN, Jaffe AS, Kavsak PA, Ordonez-Llanos J, et al. Clinical laboratory practice recommendations for the use of cardiac troponin in acute coronary syndrome: expert opinion from the Academy of the American Association for Clinical Chemistry and the Task Force on Clinical Applications of Cardiac Bio-markers of the International Federation of Clinical Chemistry and Laboratory Medicine. Clin Chem 2018;64:645-55.
6. Apple FS, Collinson PO, IFCC Task Force on Clinical Applications of Cardiac Biomarkers. Analytical characteristics of high-sensitivity cardiac troponin assays. Clin Chem 2012;58:54 - 61.
7. Gore MO, Seliger SL, Defilippi CR, Nambi V, Christenson RH, Hashim IA, et al. Age- And sex-dependent upper reference limits for the high-sensitivity cardiac troponin T assay. J Am Coll Cardiol 2014;63:1441- 8.
8. Eggers KM, Lind L, Venge P, Lindahl B. Factors influencing the 99th percentile of cardiac troponin I evaluated in community-dwelling individuals at 70 and 75 years of age. Clin Chem 2013;59:1068 -73.
9. Eggers KM, Apple FS, Lind L, Lindahl B. The applied statistical approach highly influences the 99th percentile of cardiac troponin I. Clin Biochem 2016;49:1109 -12.
10. Gunsolus IL, Jaffe AS, Sexter A, Schulz K, Ler R, Lindgren B, et al. Sex-specific 99th percentiles derived from the AACC Universal Sample Bank for the Roche Gen 5 cTnT assay: comorbidities and statistical methods influence derivation of reference limits. Clin Biochem 2017;50: 1073-7.
11. Apple FS, Ler R, Murakami MM. Determination of 19 cardiac troponin I and T assay 99th percentile values from a common presumably healthy population. Clin Chem 2012;58:1574 - 81.
12. Dallmeier D, Denkinger M, Peter R, Rapp K, Jaffe AS, Koenig W, et al. Sex-specific associations of established and emerging cardiac biomarkers with all-cause mortality in older adults: The ActiFE study. Clin Chem 2015; 61:389 -99.
13. Scottish Government.The Scottish Index of Multiple Deprivation. http://www.gov.scot/Topics/Statistics/SIMD (Accessed April 2018).
14. Woodward M, Brindle P, Tunstall-Pedoe H. Adding social deprivation and family history to cardiovascular risk assessment: The ASSIGN score from the Scottish Heart Health Extended Cohort (SHHEC). Heart 2007;93: 172- 6.
15. Woodward M, Tunstall-Pedoe H. The ASSIGN score. http://assign-score.com/(Accessed April 2018).
16. Shah ASV, Griffiths M, Lee KK, McAllister DA, Hunter AL, Ferry AV, et al. High sensitivity cardiac troponin and the under-diagnosis of myocardial infarction in women: prospective cohort study. BMJ 2015;350:g7873.
17. Omland T, Pfeffer MA, Solomon SD, de Lemos JA, Rosjo H, Šaltyte? BJ, et al. Prognostic value of cardiac troponin I measured with a highly sensitive assay in patients with stable coronary artery disease. J Am Coll Cardiol 2013;61:1240 -9.
18. Sawyer N, Blennerhassett J, Lambert R, Sheehan P, Vasikaran SD. Outliers affecting cardiac troponin I measurement: comparison of a new high sensitivity assay with a contemporary assay on the Abbott ARCHITECT analyser. Ann Clin Biochem 2014;51:476 - 84.
19. Katrukha IA. Human cardiac troponin complex. Structure and functions. Biochem 2013;78:1447- 65.
20. Gimenez MR, Twerenbold R, Reichlin T, Wildi K, Haaf P, Schaefer M, et al. Direct comparison of high-sensitivitycardiac troponin I vs. T for the early diagnosis of acute myocardial infarction. Eur Heart J 2014;35:2303-11.
21. Klinkenberg LJJ, Luyten P, van der Linden N, Urgel K, Snijders DPC, Knackstedt C, et al. Cardiac troponin T and I release after a 30-km run.Am J Cardiol 2016;118: 281-7.
22. Bella JN, Devereux RB, Roman MJ, Urgel K, Snijders DP, Knackstedt C, et al. Relations of left ventricular mass to fat-free and adipose body mass: The strong heart study. The Strong Heart Study Investigators. Circulation 1998;98:2538 - 44.
23. de Lemos JA, Drazner MH, Omland T, Ayers CR, Khera A, Rohatgi A, et al. Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population. JAMA 2010;304: 2503.
24. Lyngbakken MN, Skranes JB, de Lemos JA, Nygard S, Dalen H, Hveem K, et al. Impact of smoking on circulating cardiac troponin I concentrations and cardiovascular events in the general population: The HUNT Study (Nord-Trondelag Health Study). Circulation 2016;134: 1962-72.
25. Nadruz W, Goncalves A, Claggett B, Querejeta Roca G, Shah AM, Cheng S, etal.Influenceofcigarettesmokingon cardiac biomarkers: The Atherosclerosis Risk in Communities (ARIC) Study. Eur J Heart Fail 2016;18:629-37.
26. Welsh P, Hart C, Papacosta O, Preiss D, McConnachie A, Murray H, et al. Prediction of cardiovascular disease risk by cardiac biomarkers in 2 United Kingdom cohort studies. Hypertension 2016;67:309 -15.
27. Shah ASV, Sandoval Y, Noaman A, Sexter A, Vaswani A, Smith SW. Patient selection for high sensitivity cardiac troponin testing and diagnosis of myocardial infarction: prospective cohort study. BMJ 2017;359:j4788.
28. Adamson PD, Hunter A, Madsen DM, Shah ASV, Mc- Allister DA, Pawade TA, et al. High-sensitivity cardiac troponin I and the diagnosis of coronary artery disease in patients with suspected angina pectoris. Circ Cardiovasc Qual Outcomes 2018;11:e004227.
29. Kimenai DM, Henry RM, van der Kallen CJ, Dagnelie PC, Schram MT, Stehouwer CD, et al. Direct comparison of clinical decision limits for cardiac troponin T and I. Heart 2016;102:610 - 6.
30. Wildi K, Gimenez MR, Twerenbold R, Reichlin T, Jaeger C, Heinzelmann A, et al. Misdiagnosis of myocardial infarction related to limitations of the current regulatory approach to define clinical decision values for cardiac troponin. Circulation 2015;131:2032- 40.