High-Sensitivity Cardiac Troponin Concentration and Risk of First-Ever Cardiovascular Outcomes in 154,052 Participants

Journal of the American College of Cardiology

Volumn 70, Issue 5, 2017, Pages 558-568

  Willeit, Peter ^a,b   Welsh, Paul ^c   Evans, Jonathan D W ^b,d   Tschiderer, Lena ^a   Boachie, Charles ^c   Jukema, J Wouter ^e   Ford, Ian ^c   Trompet, Stella ^e   Stott, David J ^c   Kearney, Patricia M ^f   Mooijaart, Simon P ^e   Kiechl, Stefan ^a   Di Angelantonio, Emanuele ^b,g   Sattar, Naveed ^c  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d PAPWORTH HOSPITAL   (United Kingdom)

^e LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^f UNIVERSITY COLLEGE CORK   (Ireland)

^g NHS BLOOD AND TRANSPLANT   (United Kingdom)

Author keywords

biomarker; cardiovascular disease; coronary heart disease; primary prevention; stroke; systematic review

Indexed keywords

TROPONIN I; TROPONIN T; BIOLOGICAL MARKER; TROPONIN;

ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CEREBROVASCULAR ACCIDENT; CLINICAL OUTCOME; CLINICAL STUDY; CONFIDENCE INTERVAL; DATA BASE; HEART MUSCLE INJURY; HUMAN; ISCHEMIC HEART DISEASE; NORTH AMERICAN; PRIMARY PREVENTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RISK FACTOR; BLOOD; CARDIOVASCULAR DISEASES; GLOBAL HEALTH; INCIDENCE; META ANALYSIS; PROCEDURES; RISK ASSESSMENT;

BIOMARKERS; CARDIOVASCULAR DISEASES; GLOBAL HEALTH; HUMANS; INCIDENCE; RISK ASSESSMENT; TROPONIN;

EID: 85028586215     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2017.05.062     Document Type: Article

References (52)

1. Apple, F.S., Collinson, P.O., IFCC Task Force on Clinical Applications of Cardiac Biomarkers. Analytical characteristics of high-sensitivity cardiac troponin assays. Clin Chem 58 (2012), 54–61.
2. Jesse, R.L., On the relative value of an assay versus that of a test: a history of troponin for the diagnosis of myocardial infarction. J Am Coll Cardiol 55 (2010), 2125–2128.
3. Reichlin, T., Hochholzer, W., Bassetti, S., et al. Early diagnosis of myocardial infarction with sensitive cardiac troponin assays. N Engl J Med 361 (2009), 858–867.
4. Iribarren, C., Chandra, M., Rana, J.S., et al. High-sensitivity cardiac troponin I and incident coronary heart disease among asymptomatic older adults. Heart 102 (2016), 1177–1182.
5. Thorsteinsdottir, I., Aspelund, T., Gudmundsson, E., et al. High-sensitivity cardiac troponin I is a strong predictor of cardiovascular events and mortality in the AGES-Reykjavik community-based cohort of older individuals. Clin Chem 62 (2016), 623–630.
6. Oluleye, O.W., Folsom, A.R., Nambi, V., Lutsey, P.L., Ballantyne, C.M., Troponin T, B-type natriuretic peptide, C-reactive protein, and cause-specific mortality. Ann Epidemiol 23 (2013), 66–73.
7. Saunders, J.T., Nambi, V., de Lemos, J.A., et al. Cardiac troponin T measured by a highly sensitive assay predicts coronary heart disease, heart failure, and mortality in the Atherosclerosis Risk in Communities Study. Circulation 123 (2011), 1367–1376.
8. Folsom, A.R., Nambi, V., Bell, E.J., et al. Troponin T, N-terminal pro-B-type natriuretic peptide, and incidence of stroke: the Atherosclerosis Risk in Communities Study. Stroke 44 (2013), 961–967.
9. Nambi, V., Virani, S.S., Couper, D., et al. Biomarkers’ association with incident cardiovascular events is not modified by presence/severity of sub clinical carotid atherosclerosis: the Atherosclerosis Risk in Communities (ARIC) Study. Circulation, 128(Suppl 22), 2016, A14810 (abstr).
10. Welsh, P., Hart, C., Papacosta, O., et al. Prediction of cardiovascular disease risk by cardiac biomarkers in 2 United Kingdom cohort studies: does utility depend on risk thresholds for treatment?. Hypertension 67 (2016), 309–315.
11. Blankenberg, S., Salomaa, V., Makarova, N., et al. Troponin I and cardiovascular risk prediction in the general population: the BiomarCaRE consortium. Eur Heart J 37 (2016), 2428–2437.
12. deFilippi, C.R., de Lemos, J.A., Christenson, R.H., et al. Association of serial measures of cardiac troponin T using a sensitive assay with incident heart failure and cardiovascular mortality in older adults. JAMA 304 (2010), 2494–2502.
13. Elkind, M., Bartz, T., Gottdiener, J., et al. Serum cardiac biomarkers independently predict risk of stroke in older adults: the Cardiovascular Health Study. Neurology, 80(Suppl 7), 2013 S09.001 (abstr).
14. Imano, H., Yamagishi, K., Okada, T., Kitamura, A., Iso, H., High-sensitivity cardiac troponin t is an independent predictor for coronary artery disease in Japanese population: the Circulatory Risk in Communities Study. Circulation, 133(Suppl 1), 2016, AP020 (abstr).
15. de Lemos, J.A., Drazner, M.H., Omland, T., et al. Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population. JAMA 304 (2010), 2503–2512.
16. Wang, T.J., Wollert, K.C., Larson, M.G., et al. Prognostic utility of novel biomarkers of cardiovascular stress: the Framingham Heart Study. Circulation 126 (2012), 1596–1604.
17. Neumann, J.T., Havulinna, A.S., Zeller, T., et al. Comparison of three troponins as predictors of future cardiovascular events—prospective results from the FINRISK and BiomaCaRE studies. PLoS One, 9, 2014, e90063.
18. Omland, T., de Lemos, J.A., Holmen, O.L., et al. Impact of sex on the prognostic value of high-sensitivity cardiac troponin I in the general population: the HUNT study. Clin Chem 61 (2015), 646–656.
19. Lyngbakken, M.N., Rosjo, H., Holmen, O.L., et al. Gender, high-sensitivity troponin I, and the risk of cardiovascular events (from the Nord-Trondelag Health Study). Am J Cardiol 118 (2016), 816–821.
20. Everett, B.M., Zeller, T., Glynn, R.J., Ridker, P.M., Blankenberg, S., High sensitivity cardiac troponin I and B-type natriuretic peptide as predictors of vascular events in primary prevention: impact of statin therapy. Circulation 131 (2015), 1851–1860.
21. Koenig, W., Zierer, A., Karakas, M., et al. Ultra-sensitive troponin I strongly predicts incident coronary heart disease in the general population. Results from the MONICA/KORA Augsburg Case-Cohort study. Eur Heart J 35:Suppl 1 (2014), 204–205 (abstr).
22. Apple, F.S., Steffen, L.M., Pearce, L.A., Murakami, M.M., Luepker, R.V., Increased cardiac troponin I as measured by a high-sensitivity assay is associated with high odds of cardiovascular death: the Minnesota Heart Survey. Clin Chem 58 (2012), 930–935.
23. Eggers, K.M., Johnston, N., Lind, L., Venge, P., Lindahl, B., Cardiac troponin I levels in an elderly population from the community—the implications of sex. Clin Biochem 48 (2015), 751–756.
24. Eggers, K.M., Venge, P., Lindahl, B., Lind, L., Cardiac troponin I levels measured with a high-sensitive assay increase over time and are strong predictors of mortality in an elderly population. J Am Coll Cardiol 61 (2013), 1906–1913.
25. Scheven, L., de Jong, P.E., Hillege, H.L., et al. High-sensitive troponin T and N-terminal pro-B type natriuretic peptide are associated with cardiovascular events despite the cross-sectional association with albuminuria and glomerular filtration rate. Eur Heart J 33 (2012), 2272–2281.
26. Eggers, K.M., Al-Shakarchi, J., Berglund, L., et al. High-sensitive cardiac troponin T and its relations to cardiovascular risk factors, morbidity, and mortality in elderly men. Am Heart J 166 (2013), 541–548.
27. Everett, B.M., Cook, N.R., Magnone, M.C., et al. Sensitive cardiac troponin T assay and the risk of incident cardiovascular disease in women with and without diabetes mellitus: the Women's Health Study. Circulation 123 (2011), 2811–2818.
28. Ford, I., Shah, A.S.V., Zhang, R., et al. High-sensitivity cardiac troponin, statin therapy, and risk of coronary heart disease. J Am Coll Cardiol 68 (2016), 2719–2728.
29. Zeller, T., Tunstall-Pedoe, H., Saarela, O., et al. High population prevalence of cardiac troponin I measured by a high-sensitivity assay and cardiovascular risk estimation: the MORGAM Biomarker Project Scottish Cohort. Eur Heart J 35 (2014), 271–281.
30. Leistner, D.M., Klotsche, J., Pieper, L., et al. Circulating troponin as measured by a sensitive assay for cardiovascular risk assessment in primary prevention. Clin Chem 58 (2012), 200–208.
31. Willeit, P., Kiechl, S., Kronenberg, F., et al. Discrimination and net reclassification of cardiovascular risk with lipoprotein(a): prospective 15-year outcomes in the Bruneck Study. J Am Coll Cardiol 64 (2014), 851–860.
32. Shamseer, L., Moher, D., Clarke, M., et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ, 349, 2015, g7647.
33. Shepherd, J., Blauw, G.J., Murphy, M.B., et al. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial. Lancet 360 (2002), 1623–1630.
34. Shepherd, J., Blauw, G.J., Murphy, M.B., et al. The design of a prospective study of Pravastatin in the Elderly at Risk (PROSPER). PROSPER Study Group. PROspective Study of Pravastatin in the Elderly at Risk. Am J Cardiol 84 (1999), 1192–1197.
35. Pencina, M.J., D'Agostino, S.R., D'Agostino, J.R., Vasan, R.S., Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Stat Med 27 (2008), 157–172.
36. Pencina, M.J., D'Agostino, S.R., Steyerberg, E.W., Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers. Stat Med 30 (2011), 11–21.
37. Chêne, G., Thompson, S.G., Methods for summarizing the risk associations of quantitative variables in epidemiologic studies in a consistent form. Am J Epidemiol 144 (1996), 610–621.
38. Higgins, J.P., Thompson, S.G., Deeks, J.J., Altman, D.G., Measuring inconsistency in meta-analyses. BMJ 327 (2003), 557–560.
39. Higgins, J.P., Thompson, S.G., Controlling the risk of spurious findings from meta-regression. Stat Med 23 (2004), 1663–1682.
40. Egger, M., Smith, G.D., Schneider, M., Minder, C., Bias in meta-analysis detected by a simple, graphical test. BMJ 315 (1997), 629–634.
41. McCarthy, C.P., Yousuf, O., Alonso, A., Selvin, E., Calkins, H., McEvoy, J.W., High-sensitivity troponin as a biomarker in heart rhythm disease. Am J Cardiol 119 (2017), 1407–1413.
42. Wrigley, P., Khoury, J., Eckerle, B., et al. Prevalence of positive troponin and echocardiogram findings and association with mortality in acute ischemic stroke. Stroke 48 (2017), 1226–1232.
43. Parwani, A.S., Boldt, L.H., Huemer, M., et al. Atrial fibrillation-induced cardiac troponin I release. Int J Cardiol 168 (2013), 2734–2737.
44. Seliger, S.L., Hong, S.N., Christenson, R.H., et al. High-sensitive cardiac troponin T as an early biochemical signature for clinical and subclinical heart failure: MESA (Multi-Ethnic Study of Atherosclerosis). Circulation 135 (2017), 1494–1505.
45. Caselli, C., Prontera, C., Liga, R., et al. Effect of coronary atherosclerosis and myocardial ischemia on plasma levels of high-sensitivity troponin T and NT-proBNP in patients with stable angina. Arterioscler Thromb Vasc Biol 36 (2016), 757–764.
46. Korosoglou, G., Lehrke, S., Mueller, D., et al. Determinants of troponin release in patients with stable coronary artery disease: insights from CT angiography characteristics of atherosclerotic plaque. Heart 97 (2011), 823–831.
47. Pastormerlo, L.E., Agazio, A., Benelli, E., et al. Usefulness of high-sensitive troponin elevation after effort stress to unveil vulnerable myocardium in patients with heart failure. Am J Cardiol 116 (2015), 567–572.
48. Willeit, P., Kaptoge, S., Welsh, P., et al. Natriuretic peptides and integrated risk assessment for cardiovascular disease: an individual-participant-data meta-analysis. Lancet Diabetes Endocrinol 4 (2016), 840–849.
49. Klinkenberg, L.J., van Dijk, J.W., Tan, F.E., van Loon, L.J., van Dieijen-Visser, M.P., Meex, S.J., Circulating cardiac troponin T exhibits a diurnal rhythm. J Am Coll Cardiol 63 (2014), 1788–1795.
50. Nordenskjold, A.M., Ahlstrom, H., Eggers, K.M., et al. Short- and long-term individual variation in cardiac troponin in patients with stable coronary artery disease. Clin Chem 59 (2013), 401–409.
51. McEvoy, J.W., Chen, Y., Ndumele, C.E., et al. Six-year change in high-sensitivity cardiac troponin T and risk of subsequent coronary heart disease, heart failure, and death. JAMA Cardiol 1 (2016), 519–528.
52. Danesh, J., Collins, R., Appleby, P., Peto, R., Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies. JAMA 279 (1998), 1477–1482.