Organ-specific dietary fatty acid uptake in humans using positron emission tomography coupled to computed tomography

American Journal of Physiology - Endocrinology and Metabolism

Volumn 300, Issue 3, 2011, Pages

  Labbé, Sébastien M ^a   Grenier Larouche, Thomas ^a   Croteau, Etienne ^a   Normand Lauzière, François ^a   Frisch, Frédérique ^a   Ouellet, René ^a   Guérin, Brigitte ^a   Turcotte, Eric E ^a   Carpentier, André C ^a  

^a UNIVERSITÉ DE SHERBROOKE   (Canada)

Author keywords

Food metabolism

Indexed keywords

CHYLOMICRON; FLUORO 6 THIAHEPTADECANOIC ACID F 18; GLUCOSE; INSULIN; RADIOPHARMACEUTICAL AGENT; TRIACYLGLYCEROL; TRIOLEIN; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY SPECIFICITY; ARTICLE; CONTROLLED STUDY; DRUG UPTAKE; FAT INTAKE; FATTY ACID TRANSPORT; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; LIPID METABOLISM; LIPOTOXICITY; MALE; NON INVASIVE PROCEDURE; NONHUMAN; NORMAL HUMAN; PORTAL VEIN; PRIORITY JOURNAL; QUADRICEPS FEMORIS MUSCLE; RADIOACTIVITY; RAT; SUBCUTANEOUS FAT; THORACIC DUCT; WHOLE BODY CT; WHOLE BODY PET;

ADOLESCENT; ADULT; ANIMALS; BLOOD GLUCOSE; CHYLOMICRONS; DIABETES MELLITUS, TYPE 2; DIETARY FATS; FATTY ACIDS; FATTY ACIDS, NONESTERIFIED; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; MIDDLE AGED; PALMITATES; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RATS; RATS, WISTAR; TOMOGRAPHY, EMISSION-COMPUTED; TRIAZOLES; TRIGLYCERIDES; WHOLE-BODY COUNTING; YOUNG ADULT;

EID: 79952150629     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00579.2010     Document Type: Article

References (37)

1. Barrows BR, Parks EJ. Contributions of different fatty acid sources to very low-density lipoprotein-triacylglycerol in the fasted and fed states. J Clin Endocrinol Metab 91: 1446-1452, 2006.
2. Barrows BR, Timlin MT, Parks EJ. Spillover of dietary fatty acids and use of serum nonesterified fatty acids for the synthesis of VLDL-triacylglycerol under two different feeding regimens. Diabetes 54: 2668-2673, 2005. (Pubitemid 41233589)
3. Bickerton AS, Roberts R, Fielding BA, Hodson L, Blaak EE, Wagenmakers AJ, Gilbert M, Karpe F, Frayn KN. Preferential uptake of dietary Fatty acids in adipose tissue and muscle in the postprandial period. Diabetes 56: 168-176, 2007.
4. Brassard P, Frisch F, Lavoie F, Cyr D, Bourbonnais A, Cunnane SC, Patterson BW, Drouin R, Baillargeon JP, Carpentier AC. Impaired plasma nonesterified fatty acid tolerance is an early defect in the natural history of type 2 diabetes. J Clin Endocrinol Metab 93: 837-844, 2008. (Pubitemid 351398561)
5. Cabré E, Hernández-Pérez JM, Fluvià L, Pastor C, Corominas A, Gassull MA. Absorption and transport of dietary long-chain fatty acids in cirrhosis: a stable-isotope-tracing study. Am J Clin Nutr 81: 692-701, 2005.
6. Carpentier AC, Frisch F, Cyr D, Généreux P, Patterson BW, Giguère R, Baillargeon JP. On the suppression of plasma nonesterified fatty acids by insulin during enhanced intravascular lipolysis in humans. Am J Physiol Endocrinol Metab 289: E849-E856, 2005. (Pubitemid 41504385)
7. Carpentier A, Taghibiglou C, Leung N, Szeto L, Van Iderstine SC, Uffelman KD, Buckingham R, Adeli K, Lewis GF. Ameliorated hepatic insulin resistance is associated with normalization of microsomal triglyceride transfer protein expression and reduction in very low density lipoprotein assembly and secretion in the fructose-fed hamster. J Biol Chem 277: 28795-28802, 2002.
8. Carpentier AC. Postprandial fatty acid metabolism in the development of lipotoxicity and type 2 diabetes. Diabetes Metab 34: 97-107, 2008.
9. Chavez JA, Summers SA. Lipid oversupply, selective insulin resistance, and lipotoxicity: molecular mechanisms. Biochim Biophys Acta 1801: 252-265, 2010.
10. Ci X, Frisch F, Lavoie F, Germain P, Lecomte R, van Lier JE, Bénard F, Carpentier AC. The effect of insulin on the intracellular distribution of 14(R,S)-[18F]Fluoro-6-thia-heptadecanoic acid in rats. Mol Imaging Biol 8: 237-244, 2006.
11. DeGrado TR, Coenen HH, Stocklin G. 14(R,S)-[18F]fluoro-6-thia- heptadecanoic acid (FTHA): evaluation in mouse of a new probe of myocardial utilization of long chain fatty acids. J Nucl Med 32: 1888-1896, 1991.
12. Hannukainen JC, Kalliokoski KK, Borra RJ, Viljanen AP, Janatuinen T, Kujala UM, Kaprio J, Heinonen OJ, Viljanen T, Haaparanta M, Iozzo P, Parkkola R, Nuutila P. Higher free fatty acid uptake in visceral than in abdominal subcutaneous fat tissue in men. Obesity (Silver Spring) 18: 261-265, 2010.
13. Havel RJ. Receptor and non-receptor mediated uptake of chylomicron remnants by the liver. Atherosclerosis 141, Suppl 1: S1-S7, 1998.
14. Hvid-Jacobsen K, Thomsen HS, Nielsen SL, Kamper AL, Vestbo J. Scintigraphic demonstration of the thoracic duct following oral ingestion of 123I-heptadecanoic acid. Gastrointest Radiol 14: 212-214, 1989. (Pubitemid 19129349)
15. Iozzo P, Turpeinen AK, Takala T, Oikonen V, Solin O, Ferrannini E, Nuutila P, Knuuti J. Liver uptake of free fatty acids in vivo in humans as determined with 14( R, S)-[18F]fluoro-6-thia-heptadecanoic acid and PET. Eur J Nucl Med Mol Imaging 30: 1160-1164, 2003. (Pubitemid 36988228)
16. Jensen MD, Sarr MG, Dumesic DA, Southorn PA, Levine JA. Regional uptake of meal fatty acids in humans. Am J Physiol Endocrinol Metab 285: E1282-E1288, 2003. (Pubitemid 37464379)
17. Knuuti J, Takala TO, Nagren K, Sipila H, Turpeinen AK, Uusitupa MI, Nuutila P. Myocardial fatty acid oxidation in patients with impaired glucose tolerance. Diabetologia 44: 184-187, 2001. (Pubitemid 32156202)
18. Li LO, Klett EL, Coleman RA. Acyl-CoA synthesis, lipid metabolism and lipotoxicity. Biochim Biophys Acta 1801: 246-251, 2010.
19. Maki MT, Haaparanta M, Nuutila P, Oikonen V, Luotolahti M, Eskola O, Knuuti JM. Free fatty acid uptake in the myocardium and skeletal muscle using fluorine-18-fluoro-6-thia-heptadecanoic acid. J Nucl Med 39: 1320-1327, 1998. (Pubitemid 28373549)
20. Mansbach CM, Siddiqi SA. The biogenesis of chylomicrons. Annu Rev Physiol 72: 315-333, 2010.
21. Mårin P, Lönn L, Andersson B, Odén B, Olbe L, Bengtsson BA, Björntorp P. Assimilation of triglycerides in subcutaneous and intraabdominal adipose tissues in vivo in men: effects of testosterone. J Clin Endocrinol Metab 81: 1018-1022, 1996. (Pubitemid 26083964)
22. Menard SL, Ci X, Frisch F, Normand-Lauziere F, Cadorette J, Ouellet R, van Lier JE, Benard F, Bentourkia M, Lecomte R, Carpentier AC. Mechanism of reduced myocardial glucose utilization during acute hypertriglyceridemia in rats. Mol Imaging Biol 11: 6-14, 2009.
23. Ménard SL, Croteau E, Sarrhini O, Gélinas R, Brassard P, Ouellet R, Bentourkia M, van Lier JE, Des Rosiers C, Lecomte R, Carpentier AC. Abnormal in vivo myocardial energy substrate uptake in diet-induced type 2 diabetic cardiomyopathy in rats. Am J Physiol Endocrinol Metab 298: E1049-E1057, 2010.
24. Muoio DM. Intramuscular triacylglycerol and insulin resistance: guilty as charged or wrongly accused? Biochim Biophys Acta 1801: 281-288, 2010.
25. Nelson RH, Basu R, Johnson CM, Rizza RA, Miles JM. Splanchnic spillover of extracellular lipase-generated fatty acids in overweight and obese humans. Diabetes 56: 2878-2884, 2007. (Pubitemid 350223621)
26. Nelson RH, Prasad A, Lerman A, Miles JM. Myocardial uptake of circulating triglycerides in nondiabetic patients with heart disease. Diabetes 56: 527-530, 2007.
27. Normand-Lauzière F, Frisch F, Labbé SM, Bherer P, Gagnon R, Cunnane SC, Carpentier AC. Increased postprandial nonesterified fatty acid appearance and oxidation in type 2 diabetes is not fully established in offspring of diabetic subjects. PLoS One 5: e10956, 2010.
28. Park Y, Grellner WJ, Harris WS, Miles JM. A new method for the study of chylomicron kinetics in vivo. Am J Physiol Endocrinol Metab 279: E1258-E1263, 2000.
29. Ravikumar B, Carey PE, Snaar JE, Deelchand DK, Cook DB, Neely RD, English PT, Firbank MJ, Morris PG, Taylor R. Real-time assessment of postprandial fat storage in liver and skeletal muscle in health and type 2 diabetes. Am J Physiol Endocrinol Metab 288: E789-E797, 2005. (Pubitemid 40397216)
30. Roberts R, Bickerton AS, Fielding BA, Blaak EE, Wagenmakers AJ, Chong MF, Gilbert M, Karpe F, Frayn KN. Reduced oxidation of dietary fat after a short term high-carbohydrate diet. Am J Clin Nutr 87: 824-831, 2008. (Pubitemid 351549225)
31. St-Onge MP, Jones PJ. Physiological effects of medium-chain triglycerides: potential agents in the prevention of obesity. J Nutr 132: 329-332, 2002. (Pubitemid 34208728)
32. Takala TO, Nuutila P, Pulkki K, Oikonen V, Grönroos T, Savunen T, Vähäsilta T, Luotolahti M, Kallajoki M, Bergman J, Forsback S, Knuuti J. 14(R,S)-[18F]Fluoro-6-thia-heptadecanoic acid as a tracer of free fatty acid uptake and oxidation in myocardium and skeletal muscle. Eur J Nucl Med Mol Imaging 29: 1617-1622, 2002.
33. Turpeinen AK, Takala TO, Nuutila P, Axelin T, Luotolahti M, Haaparanta M, Bergman J, Hämäläinen H, Iida H, Mäki M, Uusitupa MI, Knuuti J. Impaired free fatty acid uptake in skeletal muscle but not in myocardium in patients with impaired glucose tolerance: studies with PET and 14(R,S)-[18F]fluoro-6-thia-heptadecanoic acid. Diabetes 48: 1245-1250, 1999. (Pubitemid 29241021)
34. Unger RH, Clark GO, Scherer PE, Orci L. Lipid homeostasis, lipotoxicity and the metabolic syndrome. Biochim Biophys Acta 1801: 209-214, 2010.
35. van Hees AM, Saris WH, Hul GB, Schaper NC, Timmerman BE, Lovegrove JA, Roche HM, Blaak EE. Effects of dietary fat modification on skeletal muscle fatty acid handling in the metabolic syndrome. Int J Obes (Lond) 34: 859-870, 2010.
36. Vistisen B, Mu H, Hoy CE. Recoveries of rat lymph FA after administration of specific structured 13C-TAG. Lipids 38: 903-911, 2003. (Pubitemid 37255276)
37. You YQ, Ling PR, Qu JZ, Bistrian BR. Effects of medium-chain triglycerides, long-chain triglycerides, or 2-monododecanoin on fatty acid composition in the portal vein, intestinal lymph, and systemic circulation in rats. JPEN J Parenter Enteral Nutr 32: 169-175, 2008. (Pubitemid 351464896)