Cognitive performance in Indian school-going adolescents is positively affected by consumption of iron-biofortified pearl millet: A 6-month randomized controlled efficacy trial

Journal of Nutrition

Volumn 148, Issue 9, 2018, Pages 1462-1471

  Scott, Samuel P ^a   Murray Kolb, Laura E ^a   Wenger, Michael J ^b,c   Udipi, Shobha A ^d   Ghugre, Padmini S ^d   Boy, Erick ^e   Haas, Jere D ^c  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF OKLAHOMA   (United States)

^c Cornell University ^*  (United States)

^d SNDT WOMEN S UNIVERSITY   (India)

^e INTERNATIONAL FOOD POLICY RESEARCH INSTITUTE   (United States)

Author keywords

Adolescent; Biofortification; Cognition; India; Iron

Indexed keywords

FERRITIN; HEMOGLOBIN; IRON; TRANSFERRIN RECEPTOR;

ADOLESCENT; ARTICLE; ATTENTION; ATTENTIONAL NETWORK TASK; BIOFORTIFICATION; CLINICAL EFFECTIVENESS; COGNITION; COMPOSITE FACE EFFECT TASK; CONTROLLED STUDY; CUED RECOGNITION TASK; DOUBLE BLIND PROCEDURE; FEMALE; FOOD INTAKE; GO NO GO TASK; HUMAN; INDIA; INTENTION TO TREAT ANALYSIS; IRON INTAKE; MAJOR CLINICAL STUDY; MALE; MEMORY; OUTCOME ASSESSMENT; PEARL MILLET; RANDOMIZED CONTROLLED TRIAL; SIMPLE REACTION TIME; STATISTICAL ANALYSIS; STUDENT; TASK PERFORMANCE; BLOOD; CHILD; DEFICIENCY; FORTIFIED FOOD; IRON DEFICIENCY ANEMIA; NUTRITIONAL STATUS; PENNISETUM; PHYSIOLOGY;

ADOLESCENT; ANEMIA, IRON-DEFICIENCY; ATTENTION; CHILD; COGNITION; DOUBLE-BLIND METHOD; FEMALE; FERRITINS; FOOD, FORTIFIED; HEMOGLOBINS; HUMANS; INDIA; IRON; MALE; MEMORY; NUTRITIONAL STATUS; PENNISETUM; RECEPTORS, TRANSFERRIN; STUDENTS;

EID: 85055583836     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/nxy113     Document Type: Article

References (40)

1. Kyu HH, Pinho C, Wagner JA, Brown JC, Bertozzi-Villa A, Charlson FJ, Coffeng LE, Dandona L, Erskine HE, Ferrari AJ, et al. Global and national burden of diseases and injuries among children and adolescents between 1990 and 2013: findings from the Global Burden of Disease 2013 study. JAMA Pediatr 2016;170:267-87.
2. WHO. Prevention of iron deficiency anaemia in adolescents: role of weekly iron and folic acid supplementation. SEA-CAH-02. [Internet]. 2011. http://apps.who.int/iris/handle/10665/205656 (accessed January 1, 2018).
3. Bureau NNM. Diet and nutritional status of rural population. Indian Council of Medical Research; 2002. (Technical report no. 21.) National Nutrition Monitoring Bureau, Jamai-Osmania PO, Hyderabad
4. International Institute for Population Sciences. National Family Health Survey 4 (NFHS-4), 2015-2016. 2017. International Institute for Population Sciences, Deonar, Mumbai. http://rchiips.org/NFHS/NFHS4Reports/India.pdf (accessed January 1, 2018).
5. International Institute for Population Sciences (IIPS) and Macro International. 2007. National Family Health Survey (NFHS-3), 2005-06: India: Volume I. Mumbai: IIPS. http://rchiips.org/NFHS/NFHS3%20Data/VOL-1/India_volume_I_corrected_17oct08.pdf (accessed January 1, 2018).
6. Ahankari AS, Myles PR, Fogarty AW, Dixit JV, Tata LJ. Prevalence of iron-deficiency anaemia and risk factors in 1010 adolescent girls from rural Maharashtra, India: a cross-sectional survey. Public Health 2017;142:159-66.
7. Petry N, Olofin I, Hurrell R, Boy E, Wirth J, Moursi M, Donahue Angel M, Rohner F. The proportion of anemia associated with iron deficiency in low, medium, and high human development index countries: a systematic analysis of national surveys. Nutrients 2016;8:693.
8. Kassebaum NJ, Jasrasaria R, Naghavi M, Wulf SK, Johns N, Lozano R, Regan M, Weatherall D, Chou DP, Eisele TP, et al. A systematic analysis of global anemia burden from 1990 to 2010. Blood 2014;123:615-24.
9. Murray-Kolb LE. Iron and brain functions. Curr Opin Clin Nutr Metab Care 2013;16:703-7.
10. Keshavan MS, Giedd J, Lau JYF, Lewis DA, Paus T. Changes in the adolescent brain and the pathophysiology of psychotic disorders. Lancet Psychiatr 2014;1:549-58.
11. Murray-Kolb LE, Beard JL. Iron deficiency and child and maternal health. Am J Clin Nutr 2009;89(Suppl):946S-50S.
12. Falkingham M, Abdelhamid A, Curtis P, Fairweather-Tait S, Dye L, Hooper L. The effects of oral iron supplementation on cognition in older children and adults: a systematic review and meta-analysis. Nutr J 2010;9:4.
13. Wenger MJ, Murray-Kolb LE, Nevins JE, Venkatramanan S, Reinhart GA, Wesley A, Haas JD. Consumption of a double-fortified salt affects perceptual, attentional, and mnemonic functioning in women in a randomized controlled trial in India. J Nutr 2017;147:2297-308.
14. Murray-Kolb LE, Wenger MJ, Scott SP, Rhoten SE, Lung'aho MG, Haas JD. Consumption of iron-biofortified beans positively affects cognitive performance in 18- to 27-year-old Rwandan female college students in an 18-week randomized controlled efficacy trial. J Nutr 2017;147:2109-2117.
15. Bouhouch RR, El-Fadeli S, Andersson M, Aboussad A, Chabaa L, Zeder C, Kippler M, Baumgartner J, Sedki A, Zimmermann MB. Effects of wheat-flour biscuits fortified with iron and EDTA, alone and in combination, on blood lead concentration, iron status, and cognition in children: a double-blind randomized controlled trial. Am J Clin Nutr 2016;104:1318-26.
16. Bouis HE, Hotz C, McClafferty B, Meenakshi JV, Pfeiffer WH. Biofortification: a new tool to reduce micronutrient malnutrition. Food Nutr Bull 2011;32:S31-40.
17. Vasconcelos MW, Gruissem W, Bhullar NK. Iron biofortification in the 21st century: setting realistic targets, overcoming obstacles, and new strategies for healthy nutrition. Curr Opin Biotechnol 2017;44:8-15.
18. Haas JD, Luna SV, Lung'aho MG, Wenger MJ, Murray-Kolb LE, Beebe S, Gahutu J-B, Egli IM. Consuming iron biofortified beans increases iron status in Rwandan women after 128 days in a randomized controlled feeding trial. J Nutr 2016;146:1586-92.
19. Finkelstein JL, Mehta S, Udipi SA, Ghugre PS, Luna SV, Wenger MJ, Murray-Kolb LE, Przybyszewski EM, Haas JD. A randomized trial of iron-biofortified pearl millet in school children in India. J Nutr 2015;145:1576-81.
20. Murray-Kolb LE, Beard JL. Iron treatment normalizes cognitive functioning in young women. Am J Clin Nutr 2007;85:778-87.
21. Cook JD, Flowers CH, Skikne BS. The quantitative assessment of body iron. Blood 2003;101:3359-63.
22. Forster KI, Forster JC. DMDX: a windows display program with millisecond accuracy. Behav Res Methods Instrum Comput 2003;35:116-24.
23. Eriksen CW. The flankers task and response competition: a useful tool for investigating a variety of cognitive problems. Vis Cogn 1995;2:101-18.
24. Fan J, McCandliss BD, Sommer T, Raz A, Posner MI. Testing the efficiency and independence of attentional networks. J Cogn Neurosci 2002;14:340-7.
25. Wenger MK, Negash S, Petersen RC, Petersen L. Modeling and estimating recall processing capacity: sensitivity and diagnostic utility in application to mild cognitive impairment. J Math Psychol 2010;54:73-89.
26. Salam RA, Hooda M, Das JK, Arshad A, Lassi ZS, Middleton P, Bhutta ZA. Interventions to improve adolescent nutrition: a systematic review and meta-analysis. J Adolesc Heal 2016;59:S29-39.
27. Sheehan P, Sweeny K, Rasmussen B, Wils A, Friedman HS, Mahon J, Patton GC, Sawyer SM, Howard E, Symons J, et al. Building the foundations for sustainable development: a case for global investment in the capabilities of adolescents. Lancet 2017;390:1792-806.
28. Bruner AB, Joffe A, Duggan AK, Casella JF, Brandt J. Randomised study of cognitive effects of iron supplementation in non-anaemic iron-deficient adolescent girls. Lancet 1996;348:992-6.
29. Lambert A, Knaggs K, Scragg R, Metcalf P, Schaaf D. Effects of iron treatment on cognitive performance and working memory in non-anaemic, iron-deficient girls. NZ J Psychol 2002;31:19-28.
30. Kashyap P, Gopaldas T. Impact of hematinic supplementation on cognitive function in underprivileged school girls (8-15 yrs of age). Nutr Res 1987;7:1117-26.
31. Youdim MB, Ben-Shachar D, Yehuda S. Putative biological mechanisms of the effect of iron deficiency on brain biochemistry and behavior. Am J Clin Nutr 1989;50:607-615.
32. Kim J, Wessling-Resnick M. Iron and mechanisms of emotional behavior. J Nutr Biochem 2014;25:1101-7.
33. Malcolm GL, Rattinger M, Shomstein S. Intrusive effects of semantic information on visual selective attention. Atten Percept Psychophys 2016;78:2066-78.
34. Scott SP, De Souza MJ, Koehler K, Murray-Kolb LE. Combined iron deficiency and low aerobic fitness doubly burden academic performance among women attending university. J Nutr 2017;147:104-9.
35. Cambridge Cognition. CANTAB Cognitive assessment softw are. [Internet]. 2017. http://www.cambridgecognition.com/cantab/ (accessed January 1, 2018).
36. Weiss LG. WAIS-IV clinical use and interpretation: scientist-practitioner perspectives. Academic Press, London, UK; 2010.
37. Rahman MT. Dietary zinc and the brain. In: Preedy Victor R., Watson Ronald Ross, Martin Colin R., editors, Handbook of behavior, food and nutrition. New York: Springer; 2011. p. 2357-73.
38. Wieringa F, Dijkhuizen M, Fiorentino M, Laillou A, Berger J. Determination of zinc status in humans: which indicator should we use? Nutrients 2015;7:3252-63.
39. Pasricha S-R, Low M, Thompson J, Farrell A, De-Regil L-M. Iron supplementation benefits physical performance in women of reproductive age: a systematic review and meta-analysis. J Nutr 2014;144:906-14.
40. Gomez-Pinilla F, Hillman C. The influence of exercise on cognitive abilities. Compr Physiol 2013;3:403-28.