Consumption of iron-biofortified beans positively affects cognitive performance in 18-to 27-Year-Old Rwandan female college students in an 18-week randomized controlled efficacy trial

Journal of Nutrition

Volumn 147, Issue 11, 2017, Pages 2109-2117

  Murray Kolb, Laura E ^a   Wenger, Michael J ^b,c   Scott, Samuel P ^a   Rhoten, Stephanie E ^b   Lung'aho, Mercy G ^d   Haas, Jere D ^c  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF OKLAHOMA   (United States)

^c Cornell University ^*  (United States)

^d CIAT Rwanda   (Rwanda)

Author keywords

Biofortification; Cognition; Iron; Rwanda; Women of reproductive age

Indexed keywords

C REACTIVE PROTEIN; FERRITIN; HEMOGLOBIN; IRON; OROSOMUCOID; TRANSFERRIN RECEPTOR;

ADULT; ARTICLE; BEAN; BIOFORTIFICATION; CLINICAL ASSESSMENT; COGNITION; COMPARATIVE STUDY; CONTROLLED STUDY; DIETARY INTAKE; DOUBLE BLIND PROCEDURE; FEMALE; FERRITIN BLOOD LEVEL; FOOD CROP; FOOD INTAKE; HUMAN; IRON DEFICIENCY; IRON THERAPY; MAJOR CLINICAL STUDY; RANDOMIZED CONTROLLED TRIAL; RWANDAN; THERAPY EFFECT; ADMINISTRATION AND DOSAGE; ADOLESCENT; BLOOD; BODY MASS; CHEMISTRY; DEFICIENCY; DIET THERAPY; FABACEAE; FORTIFIED FOOD; IRON DEFICIENCY ANEMIA; IRON INTAKE; NUTRITIONAL ASSESSMENT; NUTRITIONAL STATUS; PREVALENCE; RWANDA; TREATMENT OUTCOME; YOUNG ADULT;

ADOLESCENT; ADULT; ANEMIA, IRON-DEFICIENCY; BODY MASS INDEX; COGNITION; DOUBLE-BLIND METHOD; FABACEAE; FEMALE; FERRITINS; FOOD, FORTIFIED; HUMANS; IRON; IRON, DIETARY; NUTRITION ASSESSMENT; NUTRITIONAL STATUS; PREVALENCE; RECEPTORS, TRANSFERRIN; RWANDA; TREATMENT OUTCOME; YOUNG ADULT;

EID: 85032731139     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.117.255356     Document Type: Article

References (45)

1. Stoltzfus R. Defining iron-deficiency anemia in public health terms: a time for reflection. J Nutr 2001;131:565S-7S
2. Kassebaum NJ, Jasrasaria R, Naghavi M, Wulf SK, Johns N, Lozano R, Regan M, Weatherall D, Chou DP, Eisele TP, et al. A systematic analysis of global anemia burden from 1990 to 2010. Blood 2014;123:615-24
3. Stevens GA, Finucane MM, De-Regil LM, Paciorek CJ, Flaxman SR, Branca F, Peña-Rosas JP, Bhutta ZA, Ezzati M; Nutrition Impact Model Study Group (Anaemia). Global, regional, and national trends in haemoglobin concentration and prevalence of total and severe anaemia in children and pregnant and non-pregnant women for 1995-2011: a systematic analysis of population-representative data. Lancet Glob Health 2013;1:e16-25
4. Rwanda-Demographic andHealth Survey 2014-2015 [Internet].Washington (DC): TheWorld Bank; 2016 Jun 3 [updated 2017 Jun 7; cited 2016 Jun 8]. Available from: http://microdata.worldbank.org/index.php/catalog/2597
5. Petry N, Olofin I, Hurrell RF, Boy E, Wirth JP, Moursi M, Donahue AM, Rohner F. The proportion of anemia associated with iron deficiency in low, medium, and high human development index countries: a systematic analysis of national surveys. Nutrients 2016;8. pii: E693
6. McClung JP, Murray-Kolb LE. Iron nutrition and premenopausal women: effects of poor iron status on physical and neuropsychological performance. Annu Rev Nutr 2013;33:271-88
7. Murray-Kolb LE. Iron and brain functions. Curr Opin Clin Nutr Metab Care 2013;16:703-7
8. Daugherty AM, Haacke EM, Raz N. Striatal iron content predicts its shrinkage and changes in verbal working memory after two years in healthy adults. J Neurosci 2015;35:6731-43
9. Blanton CA, GreenMW, KretschMJ. Body iron is associated with cognitive executive planning function in college women. Br J Nutr 2013;109:906-13
10. Scott SP, Murray-Kolb LE. Iron status is associated with performance on executive functioning tasks in nonanemic young women. J Nutr 2016;146:30-7
11. Scott SP, De Souza MJ, Koehler K, Murray-Kolb LE. Combined iron deficiency and low aerobic fitness doubly burden academic performance among women attending university. J Nutr 2017;147:104-9
12. Foley D, Hay DA, Mitchell RJ. Specific cognitive effects of mild iron deficiency and associations with blood polymorphisms in young adults. Ann Hum Biol 1986;13:417-25
13. Groner JA, Holtzman NA, Charney E, Mellits ED. A randomized trial of oral iron on tests of short-term memory and attention span in young pregnant women. J Adolesc Health Care 1986;7:44-8
14. Bruner AB, Joffe A, Duggan AK, Casella JF, Brandt J. Randomised study of cognitive effects of iron supplementation in non-anaemic irondeficient adolescent girls. Lancet 1996;348:992-6
15. Murray-Kolb LE, Beard JL. Iron treatment normalizes cognitive functioning in young women. Am J Clin Nutr 2007;85:778-87
16. Khedr E, Hamed SA, Elbeih E, El-Shereef H, Ahmad Y, Ahmed S. Iron states and cognitive abilities in young adults: neuropsychological and neurophysiological assessment. Eur Arch Psychiatry Clin Neurosci 2008;258:489-96
17. Falkingham M, Abdelhamid A, Curtis P, Fairweather-Tait S, Dye L, Hooper L. The effects of oral iron supplementation on cognition in older children and adults: a systematic review and meta-analysis. Nutr J 2010;9:4
18. Saltzman A, Birol E, Bouis H, Boy E, De Moura F, Islam Y, Pfeiffer WH. Biofortification: progress toward a more nourishing future. Glob Food Secur 2013;2:9-17
19. Haas JD, Beard JL, Murray-Kolb LE, del Mundo A, Felix A, Gregorio G. Iron-biofortified rice improves iron stores of non-anemic Filipino women. J Nutr 2005;135:2823-30
20. Finkelstein JL, Mehta S, Udipi S, Ghugre P, Luna SV, Wenger MJ, Murray-Kolb LE, Przybyszewski E, Haas JD. A randomized trial of iron-biofortified pearl millet in school children in India. J Nutr 2015;145:1576-81
21. Finkelstein JL, Haas JD, Mehta S. Iron-biofortified staple food crops for improving iron status: a review of the current evidence. Curr Opin Biotechnol 2017;44:138-45
22. Haas JD, Luna SV, Lung'aho MG, Wenger MJ, Murray-Kolb LE, Beebe S, Gahutu JB, Egli IM. Consuming iron biofortified beans increases iron status in Rwandan women after 128 days in a randomized controlled feeding trial. J Nutr 2016;146:1586-92
23. French MT, Homer JF, Popovici I, Robins PK. What you do in high school matters: high school GPA, educational attainment, and labor market earnings as a young adult. East Econ J 2015;41:370-86
24. Sulastri A, Handoko M, Janssens JMAM. Grade point average and biographical data in personal resumes: predictors of finding employment. Int J Adolesc Youth 2015;20:306-16
25. Erhardt JG, Estes JE, Pfeiffer CM, Biesalski HK, Craft NE. Combined measurement of ferritin, soluble transferrin receptor, retinol binding protein, and C-reactive protein by an inexpensive, sensitive, and simple sandwich enzyme-linked immunosorbent assay technique. J Nutr 2004;134:3127-32
26. Cook JD, Flowers CH, Skikne BS. The quantitative assessment of body iron. Blood 2003;101:3359-64
27. Forster KI, Forster JC. DMDX: a windows display program with millisecond accuracy. Behav Res Methods Instrum Comput 2003; 35:116-24
28. Wickens CD, Lee J, Liu Y, Becker SG. An introduction to human factors engineering. 2nd ed. Upper Saddle River (NJ): Pearson Education; 2004
29. Fan J, McCandliss BD, Sommer T, Raz A, Posner MI. Testing the efficiency and independence of attentional networks. J Cogn Neurosci 2002;14:340-7
30. Wenger MK, Negash S, Petersen RC, Petersen L. Modeling and estimating recall processing capacity: sensitivity and diagnostic utility in application to mild cognitive impairment. J Math Psychol 2010;54:73-89
31. Ebbinghaus H. Uber das Gedachtnis: Untersuchungen zur experimentellen Psychologie. Leipzig; Duncker and Humblot; 1885
32. Sternberg S. High-speed scanning in human memory. Science 1966; 153:652-4
33. Zar JH. Biostatistical analysis. 4th ed. Upper Saddle River (NJ): Prentice-Hall; 1999
34. Thurnham DI, Mccabe LD, Haldar S, Wieringa FT, Northrop-Clewes CA, McCabe GP. Adjusting plasma ferritin concentrations to remove the effects of subclinical inflammation in the assessment of iron deficiency: a meta-analysis. Am J Clin Nutr 2010;92:546-55
35. Beard JL, Hendricks MK, Perez EM, Murray-Kolb LE, Berg A, Vernon-Feagans L, Irlam J, Isaacs W, Sive A, Tomlinson M. Maternal iron deficiency anemia affects postpartum emotions and cognition. J Nutr 2005;135:267-72
36. Kretsch MJ, Fong AK, Green MW, Johnson HL. Cognitive function, iron status, and hemoglobin concentration in obese dieting women. Eur J Clin Nutr 1998;52:512-8
37. Blanton C. Improvements in iron status and cognitive function in young women consuming beef or non-beef lunches. Nutrients 2014;6:90-110
38. Salthouse TA. The processing-speed theory of adult age differences in cognition. Psychol Rev 1996;103:403
39. Kail R. Development of processing speed in childhood and adolescence. Adv Child Dev Behav 1991;23:151-85
40. Unger EL, Hurst AR, GeorgieffMK, Schallert T, Rao R, Connor JR, Kaciroti N, LozoffB. Behavior and monoamine deficits in prenatal and perinatal iron deficiency are not corrected by early postnatal moderateiron or high-iron diets in rats. J Nutr 2012;142:2040-9
41. Rao R, Tkac I, Schmidt AT, GeorgieffMK. Fetal and neonatal iron deficiency causes volume loss and alters the neurochemical profile of the adult rat hippocampus. Nutr Neurosci 2011;14:59-65
42. Youdim MB, Ben-Shachar D, Yehuda S. Putative biological mechanisms of the effect of iron deficiency on brain biochemistry and behavior. Am J Clin Nutr 1989;50:607-15; discussion 615-7
43. Unger EL, Wiesinger JA, Hao L, Beard JL. Dopamine D2 receptor expression is altered by changes in cellular iron levels in PC12 cells and rat brain tissue. J Nutr 2008;138:2487-94
44. Ashby FG, O'Brien JB. Category learning and multiple memory systems. Trends Cogn Sci 2005;9:83-9
45. Sowell ER, Thompson PM, Holmes CJ, Jernigan TL, Toga AW. In vivo evidence for post-adolescent brain maturation in frontal and striatal regions. Nat Neurosci 1999;2:859-61