The molecular adsorbent recirculating system in posthepatectomy liver failure: Results from a prospective phase I study

Hepatology Communications

Volumn 2, Issue 4, 2018, Pages 445-454

  Gilg, Stefan ^a,b   Sparrelid, Ernesto ^a,b   Saraste, Lars ^b   Nowak, Greg ^a,b   Wahlin, Staffan ^a,b   Strömberg, Cecilia ^a,b   Lundell, Lars ^a,b   Isaksson, Bengt ^a,c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; AMMONIA; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; C REACTIVE PROTEIN; CREATININE;

ADULT; AGED; ARTICLE; BLOOD CLOTTING; CLINICAL ARTICLE; DISEASE FREE SURVIVAL; EXTRACORPOREAL THERAPY; FEASIBILITY STUDY; FEMALE; HUMAN; HYPERBILIRUBINEMIA; INTERNATIONAL NORMALIZED RATIO; LIVER FAILURE; LIVER FUNCTION; LIVER RESECTION; LONG TERM SURVIVAL; MALE; MIDDLE AGED; MODEL FOR END STAGE LIVER DISEASE SCORE; MORTALITY RATE; PATIENT SAFETY; PHASE 1 CLINICAL TRIAL; POSTHEPATECTOMY LIVER FAILURE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RECURRENCE RISK; SURVIVAL RATE; TREATMENT OUTCOME; VASCULAR ACCESS;

EID: 85055531308     PISSN: None     EISSN: 2471254X     Source Type: Journal    
DOI: 10.1002/hep4.1167     Document Type: Article

References (40)

1. Gilg S, Sparrelid E, Isaksson B, Lundell L, Nowak G, Stromberg C. Mortality-related risk factors and long-term survival after 4460 liver resections in Sweden-a population-based study. Langenbecks Arch Surg 2017;402:105-113.
2. Farges O, Goutte N, Bendersky N, Falissard B. Incidence and risks of liver resection: an all-inclusive French nationwide study. Ann Surg 2012;256:697-704.
3. Hammond JS, Guha IN, Beckingham IJ, Lobo DN. Prediction, prevention and management of postresection liver failure. Br J Surg 2011;98:1188-1200.
4. Helling TS. Liver failure following partial hepatectomy. HPB (Oxford) 2006;8:165-174.
5. van Mierlo KM, Schaap FG, Dejong CH, Olde Damink SW. Liver resection for cancer: New developments in prediction, prevention and management of postresectional liver failure. J Hepatol 2016;65:1217-1231.
6. Lafaro K, Buettner S, Maqsood H, Wagner D, Bagante F, Spolverato G, et al. Defining post hepatectomy liver insufficiency: where do we stand? J Gastrointest Surg 2015;19:2079-2092.
7. Qadan M, Garden OJ, Corvera CU, Visser BC. Management of postoperative hepatic failure. J Am Coll Surg 2016;222:195-208.
8. Nevens F, Laleman W. Artificial liver support devices as treatment option for liver failure. Best Pract Res Clin Gastroenterol 2012;26:17-26.
9. Catalina MV, Barrio J, Anaya F, Salcedo M, Rincon D, Clemente G, et al. Hepatic and systemic haemodynamic changes after MARS in patients with acute on chronic liver failure. Liver Int 2003;23(Suppl. 3):39-43.
10. Donati G, La Manna G, Cianciolo G, Grandinetti V, Carretta E, Cappuccilli M, et al. Extracorporeal detoxification for hepatic failure using molecular adsorbent recirculating system: depurative efficiency and clinical results in a long-term follow-up. Artif Organs 2014;38:125-134.
11. Mitzner SR, Stange J, Klammt S, Peszynski P, Schmidt R, Noldge-Schomburg G. Extracorporeal detoxification using the molecular adsorbent recirculating system for critically ill patients with liver failure. J Am Soc Nephrol 2001;12(Suppl. 17):S75-S82.
12. Schmidt LE, Wang LP, Hansen BA, Larsen FS. Systemic hemodynamic effects of treatment with the molecular adsorbents recirculating system in patients with hyperacute liver failure: a prospective controlled trial. Liver Transpl 2003;9:290-297.
13. Heemann U, Treichel U, Loock J, Philipp T, Gerken G, Malago M, et al. Albumin dialysis in cirrhosis with superimposed acute liver injury: a prospective, controlled study. Hepatology 2002;36:949-958.
14. Banares R, Nevens F, Larsen FS, Jalan R, Albillos A, Dollinger M, et al.; RELIEF study group. Extracorporeal albumin dialysis with the molecular adsorbent recirculating system in acute-on-chronic liver failure: the RELIEF trial. Hepatology 2013;57:1153-1162.
15. Saliba F, Camus C, Durand F, Mathurin P, Letierce A, Delafosse B, et al. Albumin dialysis with a noncell artificial liver support device in patients with acute liver failure: a randomized, controlled trial. Ann Intern Med 2013;159:522-531.
16. Kellersmann R, Gassel HJ, Buhler C, Thiede A, Timmermann W. Application of Molecular Adsorbent Recirculating System in patients with severe liver failure after hepatic resection or transplantation: initial single-centre experiences. Liver 2002;22(Suppl. 2):56-58.
17. van de Kerkhove MP, de Jong KP, Rijken AM, de Pont AC, van Gulik TM. MARS treatment in posthepatectomy liver failure. Liver Int 2003;23(Suppl. 3):44-51.
18. Rittler P, Ketscher C, Inthorn D, Jauch KW, Hartl WH. Use of the molecular adsorbent recycling system in the treatment of postoperative hepatic failure and septic multiple organ dysfunction--preliminary results. Liver Int 2004;24:136-141.
19. Inderbitzin D, Muggli B, Ringger A, Beldi G, Gass M, Gloor B, et al. Molecular absorbent recirculating system for the treatment of acute liver failure in surgical patients. J Gastrointest Surg 2005;9:1155-1161.
20. Chiu A, Chan LMY, Fan ST. Molecular adsorbent recirculating system treatment for patients with liver failure: the Hong Kong experience. Liver Int 2006;26:695-702.
21. Gilg S, Escorsell A, Fernandez J, Garcia Valdecasas JC, Saraste L, Wahlin S, et al. Albumin dialysis with mars in post-hepatectomy liver failure (PHLF): experiences from two HPB centers. Surgery Curr Res 2015;5:252.
22. Balzan S, Belghiti J, Farges O, Ogata S, Sauvanet A, Delefosse D, et al. The “50-50 criteria” on postoperative day 5: an accurate predictor of liver failure and death after hepatectomy. Ann Surg 2005;242:824-828.
23. Meijers B, Laleman W, Vermeersch P, Nevens F, Wilmer A, Evenepoel P. A prospective randomized open-label crossover trial of regional citrate anticoagulation vs. anticoagulation free liver dialysis by the Molecular Adsorbents Recirculating System. Crit Care 2012;16:R20.
24. Van Den Broek MA, Olde Damink SW, Dejong CH, Lang H, Malagó M, Jalan R, et al. Liver failure after partial hepatic resection: definition, pathophysiology, risk factors and treatment. Liver Int 2008;28:767-780.
25. Ferenci P, Lockwood A, Mullen K, Tarter R, Weissenborn K, Blei AT. Hepatic encephalopathy--definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998. Hepatology 2002;35:716-721.
26. Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 2004;240:205-213.
27. Chun YS, Ribero D, Abdalla EK, Madoff DC, Mortenson MM, Wei SH, et al. Comparison of two methods of future liver remnant volume measurement. J Gastrointest Surg 2008;12:123-128.
28. Sparrelid E, Gilg S, Brismar TB, Lundell L, Isaksson B. Rescue ALPPS is efficient and safe after failed portal vein occlusion in patients with colorectal liver metastases. Langenbecks Arch Surg 2017;402:69-75.
29. Truant S, El Amrani M, Skrzypczyk C, Boleslawski E, Sergent G, Hebbar M, et al. Factors associated with fatal liver failure after extended hepatectomy. HPB (Oxford). 2017;19:682-687.
30. Michalopoulos GK. Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas. Am J Pathol 2010;176:2-13.
31. Siu J, McCall J, Connor S. Systematic review of pathophysiological changes following hepatic resection. HPB (Oxford). 2014;16:407-421.
32. Bernal W, Wendon J. Acute liver failure. N Engl J Med 2013;369:2525-2534.
33. Sen S, Williams R, Jalan R. The pathophysiological basis of acute-on-chronic liver failure. Liver 2002;22(Suppl. 2):5-13.
34. Quinlan GJ, Martin GS, Evans TW. Albumin: biochemical properties and therapeutic potential. Hepatology 2005;41:1211-1219.
35. Beyer TA, Xu W, Teupser D, auf dem Keller U, Bugnon P, Hildt E, et al. Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance. EMBO J 2008;27:212-223.
36. Allard MA, Adam R, Bucur PO, Termos S, Cunha AS, Bismuth H, et al. Posthepatectomy portal vein pressure predicts liver failure and mortality after major liver resection on noncirrhotic liver. Ann Surg 2013;258:822-829.
37. Tucker ON, Heaton N. The ‘small for size’ liver syndrome. Curr Opin Crit Care 2005;11:150-155.
38. Kim HJ, Kim CY, Park EK, Hur YH, Koh YS, Kim HJ, et al. Volumetric analysis and indocyanine green retention rate at 15 min as predictors of post-hepatectomy liver failure. HPB (Oxford) 2015;17:159-167.
39. Camus C, Lavoue S, Gacouin A, Compagnon P, Boudjema K, Jacquelinet C, et al. Liver transplantation avoided in patients with fulminant hepatic failure who received albumin dialysis with the molecular adsorbent recirculating system while on the waiting list: impact of the duration of therapy. Ther Apher Dial 2009;13:549-555.
40. Hassanein T, Oliver D, Stange J, Steiner C. Albumin dialysis in cirrhosis with superimposed acute liver injury: possible impact of albumin dialysis on hospitalization costs. Liver Int 2003;23(Suppl. 3):61-65.