Simvastatin Modulates Interaction between Vascular Smooth Muscle Cell/Macrophage and TNF-α–Activated Endothelial Cell

Journal of Cardiovascular Pharmacology

Volumn 71, Issue 5, 2018, Pages 268-274

  Chu, Fujiang ^a   Wang, Min ^a   Ma, Hongyan ^a   Zhu, Jiayong ^a  

^a GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

endothelial cell; macrophage; simvastatin; vascular smooth muscle cell

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CD11B ANTIGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 6; PLATELET ENDOTHELIAL CELL ADHESION MOLECULE 1; SIMVASTATIN; TUMOR NECROSIS FACTOR; VASCULOTROPIN; ANTIINFLAMMATORY AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IL6 PROTEIN, RAT; VASCULAR ENDOTHELIAL GROWTH FACTOR A, RAT; VASCULOTROPIN A;

ABDOMINAL AORTA; ADIPOSE TISSUE; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS ASSAY; ARTICLE; ATHEROSCLEROSIS; BONE MARROW DERIVED MACROPHAGE; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL VIABILITY; COCULTURE; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; EC50; ENDOTHELIUM; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE OVEREXPRESSION; HEMODIALYSIS; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INFLAMMATION; LEUKOCYTE; MACROPHAGE; MACROPHAGE FUNCTION; MALE; NONHUMAN; PLACENTA; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; THORACIC AORTA; UPREGULATION; VASCULAR SMOOTH MUSCLE CELL; ANIMAL; APOPTOSIS; CELL COMMUNICATION; CELL CULTURE; DRUG EFFECT; METABOLISM; SMOOTH MUSCLE CELL; SPRAGUE DAWLEY RAT; VASCULAR SMOOTH MUSCLE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; CELL COMMUNICATION; CELL PROLIFERATION; CELLS, CULTURED; COCULTURE TECHNIQUES; ENDOTHELIAL CELLS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INTERLEUKIN-6; MACROPHAGES; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SIMVASTATIN; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 85055319949     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0000000000000567     Document Type: Article

References (41)

1. Davignon J, Ganz P. Role of endothelial dysfunction in atherosclerosis. Circulation. 2004;109(23 suppl 1):III27–III32.
2. Sena CM, Pereira AM, Seiça R. Endothelial dysfunction—a major mediator of diabetic vascular disease. Biochim Biophys Acta. 2013;1832: 2216–2231.
3. Steyers CM, Miller FJ. Endothelial dysfunction in chronic inflammatory diseases. Int J Mol Sci. 2014;15:11324–11349.
4. Zhang H, Park Y, Wu J, et al. Role of TNF-a in vascular dysfunction. Clin Sci. 2009;116:219–230.
5. Tuttolomondo A, Di Raimondo D, Pecoraro R, et al. Atherosclerosis as an inflammatory disease. Curr Pharm Des. 2012;18:4266–4288.
6. Zhou J, Li YS, Nguyen P, et al. Regulation of vascular smooth muscle cell turnover by endothelial cell–secreted microRNA-126 role of shear stress. Circ Res. 2013;113:40–51.
7. McGown CC, Brookes ZLS. Beneficial effects of statins on the micro-circulation during sepsis: the role of nitric oxide. Br J Anaesth. 2007;98: 163–175.
8. Dichtl W, Dulak J, Frick M, et al. HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells. Arteriosclerosis Thromb Vasc Biol. 2003;23:58–63.
9. Chu FJ, Jin XB, Xu YY, et al. Effect of lipopolysaccharide mediating early-and late-activated THP-1 macrophages on ECV304 endothelial cell dysfunction: dysregulation of secretion of VEGF and proliferation and migration of ECV304. Cell Physiol Biochem. 2013;31:400–407.
10. Chu F, Jin X, Ma H, et al. Effect of Musca domestic maggot polypeptide extract on HUVEC dysfunction induced by early-activated macrophages. Pharm Biol. 2016;54:572–575
11. Lau YS, Tian XY, Huang Y, et al. Boldine protects endothelial function in hyperglycemia-induced oxidative stress through an antioxidant mechanism. Biochem Pharmacol. 2013;85:367–375.
12. Zhuang Y, Mao JQ, Yu M, et al. Hyperlipidemia induces vascular smooth muscle cell proliferation involving Wnt/b-catenin signaling. Cell Biol Int. 2016;40:121–130.
13. Lacey DC, Achuthan A, Fleetwood AJ, et al. Defining GM-CSF–and macrophage-CSF–dependent macrophage responses by in vitro models. J Immunol. 2012;188:5752–5765.
14. Fong LY, Ng CT, Ahmad Z. Asiaticoside reduces TNF-a-induced increased soluble platelet endothelial cell adhesion molecule-1 (sPECAM-1) levels in human aortic endothelial cells. Planta Med. 2015;81:PW_115.
15. Wang DH, Zhang YJ, Zhang SB, et al. Geldanamycin mediates the apoptosis of gastric carcinoma cells through inhibition of EphA2 protein expression. Oncol Rep. 2014;32:2429–2436.
16. Yao S, Zong C, Zhang Y, et al. Activating transcription factor 6 mediates oxidized LDL-induced cholesterol accumulation and apoptosis in macrophages by up-regulating CHOP expression. J Atheroscler Thromb. 2013; 20:94–107.
17. Islam K, Timraz SBH, Nasser R, et al. Co-culture methods used to model atherosclerosis in vitro using endothelial, smooth muscle and monocyte cells. SM J Biomed Eng. 2016;2:1008.
18. Gabison E, Khayati F, Mourah S, et al. Cell membrane vesicles as a tool for the study of direct epithelial-stromal interaction: lessons from CD147. Methods Mol Biol. 2013;1066:103–111.
19. Ye D, Dawson KA, Lynch I. A TEM protocol for quality assurance of in vitro cellular barrier models and its application to the assessment of nanoparticle transport mechanisms across barriers. Analyst. 2015;140:83–97.
20. Vanhoutte PM. Regenerated endothelium and its senescent response to aggregating platelets. Circ J. 2016;80:783–790.
21. Hot A, Lavocat F, Lenief V, et al. Simvastatin inhibits the proinflammatory and pro-thrombotic effects of IL-17 and TNF-a on endothelial cells. Ann Rheum Dis. 2013;72:754–760.
22. Spillmann F, Van Linthout S, Miteva K, et al. LXR agonism improves TNF-a-induced endothelial dysfunction in the absence of its cholesterol-modulating effects. Atherosclerosis. 2014;232:1–9.
23. Cao Y, Roursgaard M, Jacobsen NR, et al. Monocyte adhesion induced by multi-walled carbon nanotubes and palmitic acid in endothelial cells and alveolar–endothelial co-cultures. Nanotoxicology. 2016;10: 235–244.
24. Li P, Liu Y, Yi B, et al. MicroRNA-638 is highly expressed in human vascular smooth muscle cells and inhibits PDGF-BB-induced cell proliferation and migration through targeting orphan nuclear receptor NOR1. Cardiovasc Res. 2013:cvt082.
25. Babelova A, Sedding DG, Brandes RP. Anti-atherosclerotic mechanisms of statin therapy. Curr Opin Pharmacol. 2013;13:260–264.
26. Mill C, Monk BA, Williams H, et al. Wnt5a-induced Wnt1-inducible secreted protein-1 suppresses vascular smooth muscle cell apoptosis induced by oxidative stress. Arteriosclerosis Thromb Vasc Biol. 2014; 34:2449–2456.
27. Silvestre-Roig C, de Winther MP, Weber C, et al. Atherosclerotic plaque destabilization mechanisms, models, and therapeutic strategies. Circ Res. 2014;114:214–226.
28. Harrison D, Griendling KK, Landmesser U, et al. Role of oxidative stress in atherosclerosis. Am J Cardiol. 2003;91:7–11.
29. Frey RS, Rahman A, Kefer JC, et al. PKCz regulates TNF-a–induced activation of NADPH oxidase in endothelial cells. Circ Res. 2002;90: 1012–1019.
30. Meng Z, Yan C, Deng Q, et al. Curcumin inhibits LPS-induced inflammation in rat vascular smooth muscle cells in vitro via ROS-relative TLR4-MAPK/NF-kB pathways. Acta Pharmacol Sin. 2013;34:901–911.
31. Mantovani A, Biswas SK, Galdiero MR, et al. Macrophage plasticity and polarization in tissue repair and remodelling. J Pathol. 2013;229:176–185.
32. Liu YC, Zou XB, Chai YF, et al. Macrophage polarization in inflammatory diseases. Int J Biol Sci. 2014;10:520–529.
33. Tsujimoto A, Takemura G, Mikami A, et al. A therapeutic dose of the lipophilic statin pitavastatin enhances oxidant-induced apoptosis in human vascular smooth muscle cells. J Cardiovasc Pharmacol. 2006; 48:160–165.
34. Erl W. Statin-induced vascular smooth muscle cell apoptosis: a possible role in the prevention of restenosis? Curr Drug Targets Cardiovasc Haematol Disord. 2005;5:135–144.
35. Wang D, Nie H, Ozhegov E, et al. Globally profiling sialylation status of macrophages upon statin treatment. Glycobiology. 2015;25:cwv038.
36. Sato K, Nuki T, Gomita K, et al. Statins reduce endothelial cell apoptosis via inhibition of TRAIL expression on activated CD4 T cells in acute coronary syndrome. Atherosclerosis. 2010;213:33–39.
37. Hergenreider E, Heydt S, Tréguer K, et al. Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. Nat Cel Biol. 2012;14:249–256.
38. Minichsdorfer C, Wasinger C, Hohenegger M. IL-6 primes melanoma cells from early stages to statin induced apoptosis. Cancer Res. 2014;74 (19 suppl): 336.
39. Lu P, Liu J, Pang X. Pravastatin inhibits fibrinogen-and FDP-induced inflammatory response via reducing the production of IL-6, TNF-a and iNOS in vascular smooth muscle cells. Mol Med Rep. 2015;12: 6145–6151.
40. Dworacka M, Krzyżagórska E, Wesołowska A, et al. Statins in low doses reduce VEGF and bFGF serum levels in patients with type 2 diabetes mellitus. Pharmacology. 2014;93:32–38.
41. Claude S, Boby C, Rodriguez-Mateos A, et al. Flavanol metabolites reduce monocyte adhesion to endothelial cells through modulation of expression of genes via p38-MAPK and p65-Nf-kB pathways. Mol Nutr Food Res. 2014;58:1016–1027.