Cognitive flexibility predicts PTSD symptoms: Observational and interventional studies

Frontiers in Psychiatry

Volumn 9, Issue OCT, 2018, Pages

  Ben Zion, Ziv ^a,b   Fine, Naomi B ^a,b,c   Keynan, Nimrod Jackob ^a,b   Admon, Roee ^d   Green, Nili ^a,b   Halevi, Mor ^a,b   Fonzo, Greg A ^e,f   Achituv, Michal ^c   Merin, Ofer ^c,g   Sharon, Haggai ^a,b,h   Halpern, Pinchas ^a   Liberzon, Israel ⁱ   Etkin, Amit ^e,f   Hendler, Talma ^a,b   Shalev, Arieh Y ^j  

^a TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c SHAARE ZEDEK MEDICAL CENTER   (Israel)

^d UNIVERSITY OF HAIFA   (Israel)

^e STANFORD UNIVERSITY   (United States)

^f VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^g HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^h GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

ⁱ UNIVERSITY OF MICHIGAN   (United States)

^j NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

more..

Author keywords

Cognitive flexibility; Cognitive training intervention; Neurocognitive functioning; Post Traumatic Stress Disorder (PTSD); Resilience factors; Risk factors

Indexed keywords

EID: 85055128353     PISSN: None     EISSN: 16640640     Source Type: Journal    
DOI: 10.3389/fpsyt.2018.00477     Document Type: Article

References (42)

1. Kessler RC, Sonnega A, Bromet E, Hughes M, Nelson CB. Posttraumatic stress disorder in the National Comorbidity Survey. Arch Gen Psychiatry (1995) 52:1048-60. doi: 10.1128/AAC.03728-14
2. Kessler RC. Posttraumatic stress disorder: the burden to the individual and to society. J Clin Psychiatry (2000) 61(Suppl. 5):4-12; discussion 13-4. doi: 10.1002/(ISSN)1097-4679
3. Galatzer-Levy IR, Ankri Y, Freedman S, Israeli-Shalev Y, Roitman P, Gilad M, et al. Early PTSD symptom trajectories: persistence, recovery, and response to treatment: results from the jerusalem trauma outreach and prevention study (J-TOPS). PLoS ONE (2013) 8:e70084. doi: 10.1371/journal.pone.0070084
4. Koren D, Arnon I, Klein E. Long term course of chronic posttraumatic stress disorder in traffic accident victims: a three-year prospective follow-up study. Behav Res Ther. (2001) 39:1449-58. doi: 10.1016/S0005-7967(01)00025-0
5. Perkonigg A, Pfister H, Stein MB, Höfler M, Lieb R, Maercker A, et al. longitudinal course of posttraumatic stress disorder and posttraumatic stress disorder symptoms in a community sample of adolescents and young adults. Am J Psychiatry (2005) 162:1320-7. doi: 10.1176/appi.ajp.162.7.1320
6. Galatzer-Levy IR, Karstoft KI, Statnikov A, Shalev AY. Quantitative forecasting of PTSD from early trauma responses: a machine learning application. J Psychiatr Res. (2014) 59:68-76. doi: 10.1016/j.jpsychires.2014.08.017
7. Stein DJ, Karam EG, Shahly V, Hill ED, King A, Petukhova M, et al. Post-traumatic stress disorder associated with life-threatening motor vehicle collisions in the WHO World Mental Health Surveys. BMC Psychiatry (2016) 16:257. doi: 10.1186/s12888-016-0957-8
8. Galatzer-Levy IR, Bonanno GA, Bush DEA, Le Doux JE. Heterogeneity in threat extinction learning: substantive and methodological considerations for identifying individual difference in response to stress. Front Behav Neurosci. (2013) 7:55. doi: 10.3389/fnbeh.2013.00055
9. Ursano RJ, Fullerton CS, Epstein RS, Crowley B, Kao TC, Vance K, et al. Acute and chronic posttraumatic stress disorder in motor vehicle accident victims. Am J Psychiatry (1999) 156:589-95. doi: 10.1176/ajp.156.4.589
10. Shalev AY, Ankri Y, Israeli-Shalev Y, Peleg T, Adessky R, Freedman S. Prevention of posttraumatic stress disorder by early treatment. Arch Gen Psychiatry (2012) 69:166-76. doi: 10.1001/archgenpsychiatry.2011.127
11. Shalev AY, Ankri YLE, Peleg T, Israeli-Shalev Y, Freedman S. Barriers to receiving early care for PTSD: results from the jerusalem trauma outreach and prevention study. Psychiatric Serv. (2011) 62:765-73. doi: 10.1176/ps.62.7.pss6207-0765
12. Shalev A, Liberzon I, Marmar C. Post-traumatic stress disorder. New Engl J Med. (2017) 376:2459-69. doi: 10.1056/NEJMra1612499
13. Scott JC, Matt GE, Wrocklage KM, Crnich C, Jordan J, Southwick SM, et al. A quantitative meta-analysis of neurocognitive functioning in posttraumatic stress disorder. Psychol Bull. (2015) 141:105-40. doi: 10.1037/a0038039
14. Johnsen GE, Asbjørnsen AE. Consistent impaired verbal memory in PTSD: a meta-analysis. J Affect Disord. (2008) 111:74-82. doi: 10.1016/j.jad.2008.02.007
15. Samuelson KW. Post-traumatic stress disorder and declarative memory functioning: A review. Dialog Clin Neurosci. (2011) 13:346-51. doi: 10.1016/j.tics.2006.04.007
16. Aupperle RL, Melrose AJ, Paulus MP. Executive function and PTSD: disengaging from trauma. Neuropharmacology (2012) 62:686-94. doi: 10.1016/J.NEUROPHARM.2011.02.008
17. Polak AR, Witteveen AB, Reitsma JB, Olff M. The role of executive function in posttraumatic stress disorder: a systematic review. J Affect Dis. (2012) 141:11-21. doi: 10.1016/j.jad.2012.01.001
18. Casada JH, Roache JD. Behavioral inhibition and activation in posttraumatic stress disorder. J Nerv Mental Dis. (2005) 193:102-9. doi: 10.1097/01.nmd.0000152809.20938.37
19. Hart RP, Bagrodia R, Rahman N, Bryant RA, Titcombe-Parekh R, Marmar CR, et al. Neuropsychological Predictors of Trauma Centrality in OIF/OEF Veterans. Front Psychol. (2017) 8:1120. doi: 10.3389/fpsyg.2017.01120
20. Koenen KC, Driver KL, Oscar-Berman M, Wolfe J, Folsom S, Huang MT, et al. Measures of prefrontal system dysfunction in posttraumatic stress disorder. Brain Cogn. (2001) 45:64-78. doi: 10.1006/BRCG.2000.1256
21. Leskin LP, White PM. Attentional networks reveal executive function deficits in posttraumatic stress disorder. Neuropsychology (2007) 21:275-84. doi: 10.1037/0894-4105.21.3.275
22. Vasterling JJ, Constans JI, Brailey K, Sutker PB. Attention and memory dysfunction in posttraumatic stress disorder. Neuropsychology (1998) 12:125-33. doi: 10.1037/0894-4105.12.1.125
23. Pineles SL, Shipherd JC, Mostoufi SM, Abramovitz SM, Yovel I. Attentional biases in PTSD: More evidence for interference. Behav Res Ther. (2009) 47:1050-7. doi: 10.1016/J.BRAT.2009.08.001
24. Bryant RA, Felmingham KL, Kemp AH, Barton M, Peduto AS, Rennie C, et al. Neural networks of information processing in posttraumatic stress disorder: a functional magnetic resonance imaging study. Biol Psychiatry (2005) 58:111-8. doi: 10.1016/j.biopsych.2005.03.021
25. Falconer E, Bryant R, Felmingham KL, Kemp AH, Gordon E, Peduto A, et al. The neural networks of inhibitory control in posttraumatic stress disorder. J Psychiatry Neurosci. (2008) 33:413-22.
26. Kaplan Z, Weiser M, Reichenberg A, Rabinowitz J, Caspi A, Bodner E, et al. Motivation to serve in the military influences vulnerability to future posttraumatic stress disorder. Psychiatry Res. (2002) 109:45-9. doi: 10.1016/S0165-1781(01)00365-1
27. Scholz J, Klein MC, Behrens TEJ, Johansen-Berg H. Training induces changes in white-matter architecture. Nat Neurosci. (2009) 12:1370-1. doi: 10.1038/nn.2412
28. Takeuchi H, Sekiguchi A, Taki Y, Yokoyama S, Yomogida Y, Komuro N, et al. Training of working memory impacts structural connectivity. J Neurosci. (2010) 30:3297-303. doi: 10.1523/JNEUROSCI.4611-09.2010
29. Voss MW, Prakash RS, Erickson KI, Boot WR, Basak C, Neider MB, et al. Effects of training strategies implemented in a complex videogame on functional connectivity of attentional networks. NeuroImage (2012) 59:138-48. doi: 10.1016/j.neuroimage.2011.03.052
30. Bremner JD, Elzinga B, Schmahl C, Vermetten E. Structural and functional plasticity of the human brain in posttraumatic stress disorder. Progress Brain Res. (2008) 167:171-86. doi: 10.1016/S0079-6123(07)67012-5
31. Mahan AL, Ressler KJ. Fear conditioning, synaptic plasticity and the amygdala: Implications for posttraumatic stress disorder. Trends Neurosci. (2012) 35:24-35. doi: 10.1016/j.tins.2011.06.007
32. Olesen PJ, Westerberg H, Klingberg T. Increased prefrontal and parietal activity after training of working memory. Nat Neurosci. (2004) 7:75-9. doi: 10.1038/nn1165
33. Weathers FW, Bovin MJ, Lee DJ, Sloan DM, Schnurr PP, Kaloupek DG, et al. Psychological assessment the clinician-administered PTSD scale for DSM-5 (CAPS- 5): development and initial psychometric evaluation in military veterans. Psychol Assess. (2017) 30:383-95. doi: 10.1037/pas0000486
34. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders, Clinician Version (SCID-CV) for DSMIV. New York, NY: Columbia University Press (1997).
35. Silverstein SM, Berten S, Olson P, Paul R, Williams LM, Cooper N, et al. Development and validation of a World-Wide-Web-based neurocognitive assessment battery: WebNeuro. Behav Res Methods (2007) 39:940-9. doi: 10.3758/BF03192989
36. Stroop JR. Stroop color word test. J Exp Physiol. (1935) 643-62. doi: 10.1007/978-0-387-79948-3
37. Reitan R. Validity of the trail making test as an indicator of organic brain damage. Percept Motor Skil. (1958) 8:271-6. doi: 10.2466/PMS.8.7.271-276
38. Fine NB, Achituv M, Etkin A, Merin O, Shalev AY. Evaluating web-based cognitive-affective remediation in recent trauma survivors: study rationale and protocol. Eur J Psychotraumatol. (2018) 9:1442602. doi: 10.1080/20008198.2018.1442602
39. Scott WA. Cognitive complexity and cognitive flexibility. Sociometry (1962) 25:405. doi: 10.2307/2785779
40. Siegle GJ, Price RB, Jones NP, Ghinassi F, Painter T, Thase ME. You gotta work at it: Pupillary indices of task focus are prognostic for response to a neurocognitive intervention for rumination in depression. Clin Psychol Sci. (2014) 2:455-71. doi: 10.1177/2167702614536160
41. Medalia A, Saperstein AM. Does cognitive remediation for schizophrenia improve functional outcomes? Curr Opin Psychiatry (2013) 26:151-7. doi: 10.1097/YCO.0b013e32835dcbd4
42. Lezak MD, Howieson DB, Loring DW, Hannay HJ, Fischer JS. Neuropsychological Assessment. 4th ed. New York, NY: Oxford University Press (2004).