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Volumn 108, Issue 4, 2018, Pages 803-813

Production of asymmetric oxidative metabolites of [13C]-β-carotene during digestion in the gastrointestinal lumen of healthy men

Author keywords

asymmetric metabolites; digestion; duodenum; gastrointestinal lumen; metabolism; stomach; 13C carotene

Indexed keywords

ALPHA CAROTENE; BETA CAROTENE C 13; CAROTENE; RETINOID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; BETA CAROTENE; BETA-APO-13-CAROTENONE; BETA-APO-8'-CAROTENAL; CAROTENOIC ACID; CAROTENOID; LIPOPROTEIN; LIPOPROTEIN TRIGLYCERIDE; PROVITAMIN;

EID: 85055070954     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.1093/ajcn/nqy183     Document Type: Article
Times cited : (15)

References (53)
  • 1
    • 0013770246 scopus 로고
    • The biosynthesis and metabolism of carotenoids and retinol (Vitamin A)
    • Olson JA. The biosynthesis and metabolism of carotenoids and retinol (Vitamin A). J Lipid Res 1964;5:281-99.
    • (1964) J Lipid Res , vol.5 , pp. 281-299
    • Olson, J.A.1
  • 2
    • 0043138166 scopus 로고
    • Mechanism of conversion of β-carotene into Vitamin A-central cleavage versus random cleavage
    • Ganguly J, Sastry PS. Mechanism of conversion of β-carotene into Vitamin A-central cleavage versus random cleavage. Biochim Biophys Acta 1985;45:198-220.
    • (1985) Biochim Biophys Acta , vol.45 , pp. 198-220
    • Ganguly, J.1    Sastry, P.S.2
  • 3
    • 0001295972 scopus 로고
    • The conversion of β-carotene into Vitamin A
    • Glover J. The conversion of β-carotene into Vitamin A. Vitam Horm 1960;18:371-86.
    • (1960) Vitam Horm , vol.18 , pp. 371-386
    • Glover, J.1
  • 4
    • 0034697178 scopus 로고    scopus 로고
    • Filling the gap in Vitamin A research: Molecular identification of an enzyme cleaving β-carotene to retinal
    • von Lintig J, Vogt K. Filling the gap in Vitamin A research: molecular identification of an enzyme cleaving β-carotene to retinal. J Biol Chem 2000;275:11915-20.
    • (2000) J Biol Chem , vol.275 , pp. 11915-11920
    • Von Lintig, J.1    Vogt, K.2
  • 7
    • 0035957943 scopus 로고    scopus 로고
    • Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of proVitamin A
    • Keifer C, Hessel S, Lampert JM, Vogt K, Lederer MO, Breithoupt DE, von Lintig J. Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of proVitamin A. J Biol Chem 2001;276:14110-6.
    • (2001) J Biol Chem , vol.276 , pp. 14110-14116
    • Keifer, C.1    Hessel, S.2    Lampert, J.M.3    Vogt, K.4    Lederer, M.O.5    Breithoupt, D.E.6    Von Lintig, J.7
  • 9
    • 0019422226 scopus 로고
    • Can dietary β-carotene materially reduce human cancer rates?
    • Peto R, Doll R, Buckley JD, Sporn MB. Can dietary β-carotene materially reduce human cancer rates? Nature 1981;290:201-8.
    • (1981) Nature , vol.290 , pp. 201-208
    • Peto, R.1    Doll, R.2    Buckley, J.D.3    Sporn, M.B.4
  • 10
    • 0025637021 scopus 로고
    • Carotenoids, tocopherols and thiols as biological singlet molecular oxygen quenchers
    • Di Mascio P, Devasagayam TPA, Kaiser S, Sies H. Carotenoids, tocopherols and thiols as biological singlet molecular oxygen quenchers. Biochem Soc Trans 1990;18:1054-6.
    • (1990) Biochem Soc Trans , vol.18 , pp. 1054-1056
    • Di Mascio, P.1    Devasagayam, T.P.A.2    Kaiser, S.3    Sies, H.4
  • 11
    • 0026020970 scopus 로고
    • Antioxidant defense systems: The role of carotenoids, tocopherols, and thiols
    • Di Mascio P, Murphy ME, Sies H. Antioxidant defense systems: the role of carotenoids, tocopherols, and thiols. Am J Clin Nutr 1991;53:194S-200S.
    • (1991) Am J Clin Nutr , vol.53 , pp. 194S-200S
    • Di Mascio, P.1    Murphy, M.E.2    Sies, H.3
  • 12
    • 0142216401 scopus 로고    scopus 로고
    • Antioxidant activity of carotenoids
    • StahlW, Sies H. Antioxidant activity of carotenoids. Mol Aspects Med 2003;24:345-51.
    • (2003) Mol Aspects Med , vol.24 , pp. 345-351
    • Stahl, W.1    Sies, H.2
  • 15
    • 0010607277 scopus 로고
    • The effect of Vitamin E and β-carotene on the incidence of lung cancer and other cancers in Male smokers
    • Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group
    • Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of Vitamin E and β-carotene on the incidence of lung cancer and other cancers in Male smokers. N Engl J Med 1994;330:1029-35.
    • (1994) N Engl J Med , vol.330 , pp. 1029-1035
  • 16
    • 0027275148 scopus 로고
    • Nutrition intervention trials in Linxian, China: Supplementation with specific Vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population
    • Blot WJ, Li JY, Taylor PR, Guo W, Dawsey S, Wang GQ, Yang CS, Zheng SF, Gail M, Li GY. Nutrition intervention trials in Linxian, China: supplementation with specific Vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J Natl Cancer Inst 1993;85:1483-92.
    • (1993) J Natl Cancer Inst , vol.85 , pp. 1483-1492
    • Blot, W.J.1    Li, J.Y.2    Taylor, P.R.3    Guo, W.4    Dawsey, S.5    Wang, G.Q.6    Yang, C.S.7    Zheng, S.F.8    Gail, M.9    Li, G.Y.10
  • 19
    • 21444438990 scopus 로고    scopus 로고
    • Vitamin E in the primary prevention of cardiovascular disease and cancer: The Women's Health Study: A randomized controlled trial
    • Lee I-M, Cook NR, Gaziano JM, Gordon D, Ridker PM, Manson JE, Hennekens CH, Buring JE. Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial. JAMA 2005;294:56-65.
    • (2005) JAMA , vol.294 , pp. 56-65
    • Lee, I.-M.1    Cook, N.R.2    Gaziano, J.M.3    Gordon, D.4    Ridker, P.M.5    Manson, J.E.6    Hennekens, C.H.7    Buring, J.E.8
  • 21
    • 1542316996 scopus 로고    scopus 로고
    • β-Carotene and β-apo-14-carotenoic acid prevent the reduction of retinoic acid receptor β in benzo[a]pyrene-treated normal human bronchial epithelial cells
    • Prakash P, Liu C, Hu K-Q, Krinsky NI, Russell RM, Wang XD. β-Carotene and β-apo-14-carotenoic acid prevent the reduction of retinoic acid receptor β in benzo[a]pyrene-treated normal human bronchial epithelial cells. J Nutr 2004;134:667-73.
    • (2004) J Nutr , vol.134 , pp. 667-673
    • Prakash, P.1    Liu, C.2    Hu, K.-Q.3    Krinsky, N.I.4    Russell, R.M.5    Wang, X.D.6
  • 23
    • 0033528079 scopus 로고    scopus 로고
    • Retinoid signaling and activator protein-1 expression in ferrets given beta-carotene supplements and exposed to tobacco smoke
    • Wang XD, Liu C, Bronson RT, Smith DE, Krinsky NI, Russell M. Retinoid signaling and activator protein-1 expression in ferrets given beta-carotene supplements and exposed to tobacco smoke. JNatl Cancer Inst 1999;91:60-6.
    • (1999) JNatl Cancer Inst , vol.91 , pp. 60-66
    • Wang, X.D.1    Liu, C.2    Bronson, R.T.3    Smith, D.E.4    Krinsky, N.I.5    Russell, M.6
  • 24
    • 0942290532 scopus 로고    scopus 로고
    • α-Tocopherol and ascorbic acid decrease the production of β-apo-carotenals and increase the formation of retinoids from β-carotene in the lung tissues of cigarette smoke-exposed ferrets in vitro
    • Liu C, Russell RM, Wang X-D. α-Tocopherol and ascorbic acid decrease the production of β-apo-carotenals and increase the formation of retinoids from β-carotene in the lung tissues of cigarette smoke-exposed ferrets in vitro. J Nutr 2004;134:426-30.
    • (2004) J Nutr , vol.134 , pp. 426-430
    • Liu, C.1    Russell, R.M.2    Wang, X.-D.3
  • 25
    • 79955678970 scopus 로고    scopus 로고
    • Carotene and novel apocarotenoid concentrations in orange-fleshed Cucumis melo melons: Determinations of β-carotene bioaccessibility and bioavailability
    • Fleshman MK, Lester GE, Riedl KM, Kopec RE, Narayanasamy S, Curley RW, Schwartz SJ, Harrison EH. Carotene and novel apocarotenoid concentrations in orange-fleshed Cucumis melo melons: determinations of β-carotene bioaccessibility and bioavailability. J Agric Food Chem 2011;59:4448-54.
    • (2011) J Agric Food Chem , vol.59 , pp. 4448-4454
    • Fleshman, M.K.1    Lester, G.E.2    Riedl, K.M.3    Kopec, R.E.4    Narayanasamy, S.5    Curley, R.W.6    Schwartz, S.J.7    Harrison, E.H.8
  • 27
    • 33751158346 scopus 로고
    • Occurrence of cis-isomers of proVitamin A in brazilian fruits
    • Godoy HT, Rodriguez-Amaya DB. Occurrence of cis-isomers of proVitamin A in brazilian fruits. J Agric Food Chem 1994;42:1306-13.
    • (1994) J Agric Food Chem , vol.42 , pp. 1306-1313
    • Godoy, H.T.1    Rodriguez-Amaya, D.B.2
  • 29
    • 85025688227 scopus 로고    scopus 로고
    • Scientific Opinion on the re-evaluation of β-apo-8-carotenal (E 160e) as a food additive: Re-evaluation of β-apo-8-carotenal (E 160e) as a food additive
    • EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS)
    • EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS). Scientific Opinion on the re-evaluation of β-apo-8-carotenal (E 160e) as a food additive: re-evaluation of β-apo-8-carotenal (E 160e) as a food additive. EFSA Journal 2012;10:2499.
    • (2012) EFSA Journal , vol.10 , pp. 2499
  • 30
    • 85025155271 scopus 로고    scopus 로고
    • Safety and efficacy of ethyl ester of β-apo-8-carotenoic acid
    • European Commission
    • European Commission. Safety and efficacy of ethyl ester of β-apo-8-carotenoic acid. EFSA Journal 2016;14:4439-43.
    • (2016) EFSA Journal , vol.14 , pp. 4439-4443
  • 31
    • 84893762328 scopus 로고    scopus 로고
    • Enzymology of the carotenoid cleavage dioxygenases: Reaction mechanisms, inhibition and biochemical roles
    • Harrison PJ, Bugg TDH. Enzymology of the carotenoid cleavage dioxygenases: reaction mechanisms, inhibition and biochemical roles. Arch Biochem Biophys 2014;544:105-11.
    • (2014) Arch Biochem Biophys , vol.544 , pp. 105-111
    • Harrison, P.J.1    Bugg, T.D.H.2
  • 32
    • 85055315301 scopus 로고    scopus 로고
    • Nutrition C for FS and A.cited 2018 Feb 10
    • Nutrition C for FS and A. Color Additive Inventories-Color Additive Status List [Internet]. [ cited 2018 Feb 10]. Available from: https://www.fda.gov/ForIndustry/ColorAdditives/ColorAdditive Inventories/ucm106626.htm.
    • Color Additive Inventories-Color Additive Status List [Internet]
  • 33
    • 19044379578 scopus 로고    scopus 로고
    • Inhibition of the metmyoglobin-induced peroxidation of linoleic acid by dietary antioxidants: Action in the aqueous vs lipid phase
    • Vulcain E, Goupy P, Caris-Veyrat C, Dangles O. Inhibition of the metmyoglobin-induced peroxidation of linoleic acid by dietary antioxidants: Action in the aqueous vs. lipid phase. Free Radic Res 2005;39:547-63.
    • (2005) Free Radic Res , vol.39 , pp. 547-563
    • Vulcain, E.1    Goupy, P.2    Caris-Veyrat, C.3    Dangles, O.4
  • 34
    • 84879050401 scopus 로고    scopus 로고
    • Iron-induced oxidation of (all-E)-β-carotene under model gastric conditions: Kinetics, products, and mechanism
    • Sy C, Dangles O, Borel P, Caris-Veyrat C. Iron-induced oxidation of (all-E)-β-carotene under model gastric conditions: kinetics, products, and mechanism. Free Radic Biol Med 2013;63:195-206.
    • (2013) Free Radic Biol Med , vol.63 , pp. 195-206
    • Sy, C.1    Dangles, O.2    Borel, P.3    Caris-Veyrat, C.4
  • 35
    • 84877312269 scopus 로고    scopus 로고
    • Inhibition of iron-induced lipid peroxidation by newly identified bacterial carotenoids in model gastric conditions: Comparison with common carotenoids
    • Sy C, Caris-Veyrat C, Dufour C, Boutaleb M, Borel P, Dangles O. Inhibition of iron-induced lipid peroxidation by newly identified bacterial carotenoids in model gastric conditions: comparison with common carotenoids. Food Funct 2013;4:698-712.
    • (2013) Food Funct , vol.4 , pp. 698-712
    • Sy, C.1    Caris-Veyrat, C.2    Dufour, C.3    Boutaleb, M.4    Borel, P.5    Dangles, O.6
  • 36
    • 84907846178 scopus 로고    scopus 로고
    • Evidence for compartmentalization of mammalian carotenoid metabolism
    • Palczewski G, Amengual J, Hoppel CL, von Lintig J. Evidence for compartmentalization of mammalian carotenoid metabolism. FASEB J 2014;28:4457-69.
    • (2014) FASEB J , vol.28 , pp. 4457-4469
    • Palczewski, G.1    Amengual, J.2    Hoppel, C.L.3    Von Lintig, J.4
  • 40
    • 84903527424 scopus 로고    scopus 로고
    • Interindividual variability of lutein bioavailability in healthy men: Characterization, genetic variants involved, and relation with fasting plasma lutein concentration
    • Borel P, Desmarchelier C, Nowicki M, Bott R, Morange S, Lesavre N. Interindividual variability of lutein bioavailability in healthy men: characterization, genetic variants involved, and relation with fasting plasma lutein concentration. Am J Clin Nutr 2014;100: 168-75.
    • (2014) Am J Clin Nutr , vol.100 , pp. 168-175
    • Borel, P.1    Desmarchelier, C.2    Nowicki, M.3    Bott, R.4    Morange, S.5    Lesavre, N.6
  • 43
    • 0001119747 scopus 로고    scopus 로고
    • Separation of geometrical carotenoid isomers in biological extracts using a polymeric C30 column in reversed-phase liquid chromatography
    • Emenhiser C, Simunovic N, Sander LC, Schwartz SJ. Separation of geometrical carotenoid isomers in biological extracts using a polymeric C30 column in reversed-phase liquid chromatography. J Agric Food Chem 1996;44:3887-93.
    • (1996) J Agric Food Chem , vol.44 , pp. 3887-3893
    • Emenhiser, C.1    Simunovic, N.2    Sander, L.C.3    Schwartz, S.J.4
  • 44
    • 84863304598 scopus 로고    scopus 로고
    • R Core Team. R Foundation for Statistical Computing, Vienna, Austria. [ Internet]
    • R Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. [ Internet]. 2013. Available from: http://www.R-project.org/
    • (2013) R: A Language and Environment for Statistical Computing
  • 47
    • 33748293152 scopus 로고    scopus 로고
    • Formation of apocarotenals and epoxycarotenoids from β-carotene by chemical reactions and by autoxidation in model systems and processed foods
    • Rodriguez EB, Rodriguez-Amaya DB. Formation of apocarotenals and epoxycarotenoids from β-carotene by chemical reactions and by autoxidation in model systems and processed foods. Food Chem 2007;101:563-72.
    • (2007) Food Chem , vol.101 , pp. 563-572
    • Rodriguez, E.B.1    Rodriguez-Amaya, D.B.2
  • 48
    • 84929167163 scopus 로고    scopus 로고
    • Analytical tools for the analysis of β-carotene and its degradation products
    • Stutz H, Bresgen N, Eckl PM. Analytical tools for the analysis of β-carotene and its degradation products. Free Radic Res 2015;49: 650-80.
    • (2015) Free Radic Res , vol.49 , pp. 650-680
    • Stutz, H.1    Bresgen, N.2    Eckl, P.M.3
  • 51
    • 33645990883 scopus 로고    scopus 로고
    • Digestive stability, micellarization, and uptake of β-carotene isomers by Caco-2 human intestinal cells
    • Ferruzzi MG, Lumpkin JL, Schwartz SJ, Failla M. Digestive stability, micellarization, and uptake of β-carotene isomers by Caco-2 human intestinal cells. J Agric Food Chem 2006;54: 2780-5.
    • (2006) J Agric Food Chem , vol.54 , pp. 2780-2785
    • Ferruzzi, M.G.1    Lumpkin, J.L.2    Schwartz, S.J.3    Failla, M.4
  • 52
    • 0033213505 scopus 로고    scopus 로고
    • Development of an in vitro digestion method to assess carotenoid bioavailability from meals
    • Garrett DA, Failla ML, Sarama RJ. Development of an in vitro digestion method to assess carotenoid bioavailability from meals. J Agric Food Chem 1999;47:4301-9.
    • (1999) J Agric Food Chem , vol.47 , pp. 4301-4309
    • Garrett, D.A.1    Failla, M.L.2    Sarama, R.J.3
  • 53
    • 85052202631 scopus 로고    scopus 로고
    • Uptake and metabolism of dietary β-apocarotenoids by Caco-2 intestinal cells
    • Durojaye BO, Riedl KM, Curley RW, Harrison E. Uptake and metabolism of dietary β-apocarotenoids by Caco-2 intestinal cells. FASEB J 2017;31:635.18.
    • (2017) FASEB J , vol.31 , Issue.635 , pp. 18
    • Durojaye, B.O.1    Riedl, K.M.2    Curley, R.W.3    Harrison, E.4


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