Digestive stability, micellarization, and uptake of β-carotene isomers by Caco-2 human intestinal cells

Journal of Agricultural and Food Chemistry

Volumn 54, Issue 7, 2006, Pages 2780-2785

  Ferruzzi, Mario G ^a   Lumpkin, John L ^b   Schwartz, Steven J ^c   Failla, Mark ^c  

^a PURDUE UNIVERSITY   (United States)

^b UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

carotene; Caco 2 intestinal cells; Carotenoids; cis isomers; Electrochemical detection; HPLC; In vitro digestion

Indexed keywords

DUNALIELLA SALINA; ZEA MAYS;

BETA CAROTENE;

ARTICLE; CELL STRAIN CACO 2; DIET SUPPLEMENTATION; DIGESTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN VITRO STUDY; INTESTINE; ISOMERISM; METABOLISM; MICELLE;

BETA CAROTENE; CACO-2 CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIETARY SUPPLEMENTS; DIGESTION; HUMANS; INTESTINES; ISOMERISM; MICELLES;

EID: 33645990883     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf0530603     Document Type: Article

References (31)

1. Chandler, L. A.; Schwartz, S. J. Isomerization and losses trans-β-carotene in sweet potatoes as affected by processing treatments. J. Agric. Food Chem. 1988, 39, 129-133.
2. Lessin, W. J.; Catigani, G. L.; Schwartz, S. J. Quantification of cis-trans isomers of provitamin A carotenoids in fresh and processed fruits and vegetables. J. Agric. Food Chem. 1997, 45, 3728-3732.
3. Nguyen, M.; Francis, D.; Schwartz, S. Thermal isomerization susceptibility of carotenoids in different tomato varieties. J. Sci. Food Agric. 2001, 81, 910-917.
4. Heyman, R. A.; Mangelsdorf, D. J.; Dyck, J. A.; Stein, R. B.; Eichele, G.; Evans, R. M.; Thaller, C. 9-cis Retinoic acid is a high affinity ligand for the retinoid X receptor. Cell 1992, 68, 397-406.
5. Levin, A. A.; Sturzenbecker, L. J.; Kazmer, S.; Bosakowski, T.; Huselton, C.; Allenby, G.; Speck, J.; Kratzeisen, C.; Rosenberger, M.; Lovey, A.; Grippo, J. F. 9-cis Retinoic acid stereoisomer binds and activates the nuclear receptor RXR alpha. Nature 1992, 355, 359-361.
6. You, C.-S.; Parker, R. S.; Goodman, K. J.; Swanson, J. E.; Corso, T. N. Evidence of cis-trans isomerization of 9-cis-β-carotene during absorption in humans. Am. J. Clin. Nutr. 1996, 64, 177-183.
7. Furr, H. C.; Clark, R. M. Intestinal absorption and tissue distribution of carotenoids. J. Nutr. Biochem. 1997, 8, 364-377.
8. Yeum, K.-J.; Russell, R. M. Carotenoid bioavailability and bioconversion. Annu. Rev. Nutr. 2002, 22, 483-504.
9. Stahl, W.; Schwarz, W.; von Laar, J.; Sies, H. All-trans β-carotene preferentially accumulates in human chylomicrons and very low-density lipoproteins compared with the 9-cis geometrical isomer. J. Nutr. 1995, 125, 2128-2133.
10. Deming, D. M.; Teixeira, S. R.; Erdman, J. W., Jr. All-trans beta-carotene appears to be more bioavailable than 9-cis or 13-cis beta-carotene in gerbils given single oral doses of each isomer. J. Nutr. 2002, 132, 2700-2708.
11. During, A.; Hussain, M. M.; Morel, D. W.; Harrison, E. H. Carotenoid uptake and secretion by CaCo-2 cells: Beta-carotene isomer selectivity and carotenoid interactions. J. Lipid Res. 2002, 43, 1086-1095.
12. During, A.; Dawson, H. D.; Harrison, E. H. Carotenoid transport is decreased and expression of the lipid transporters SR-BI, NPC1L1 and ABCA1 is down-regulated in CACO-2 cells treated with ezetimibe. J. Nutr. 2005, 135, 2305-2312.
13. Reboul, E.; Abou, L.; Mikal, C.; Ghiringhelli, O.; Andre, M.; Portugal, H.; Jourdheuil-Rahmani, D.; Amiot, M. J.; Lairon, D.; Borel, P. Lutein transport by Caco-2 TC-7 cells occurs partly by a facilitated process involving the scavenger receptor class B type I (SR-BI). Biochem. J. 2005, 387, 455-461.
14. van Bennekum, A.; Werder, M.; Thuahnai, S. T.; Han, C.-H.; Duong, P.; Williams, D. L.; Wettstein, P.; Schulthess, G.; Phillips, M. C.; Hauser, H. Class B scavenger receptor-mediated intestinal absorption of dietary β-carotene and cholesterol. Biochemistry 2005, 44, 4517-4525.
15. Garrett, D. A.; Failla, M. L.; Sarama, R. J. Development of an in vitro digestion method to assess carotenoid bioavailability from meals. J. Agric. Food Chem. 1999, 47, 4301-4309.
16. Garrett, D. A.; Failla, M. L.; Sarama, R. J. Estimation of carotenoid bioavailability from fresh stir-fried vegetables using an in vitro digestion/Caco-2 cell culture model. J. Nutr. Biochem. 2000, 11, 574-580.
17. Ferruzzi, M. G.; Failla, M. L.; Schwartz, S. J. Assessment of degradation and intestinal cell uptake of chlorophyll derivatives from spinach puree using an in vitro digestion and Caco-2 human cell model. J. Agric. Food Chem. 2001, 16, 123-134.
18. Han, O.; Failla, M. L.; Hill, A. D.; Morris, E. R.; Smith, J. C., Jr. Inositol phosphates inhibit uptake and transport of iron and zinc by a human intestinal cell line. J. Nutr. 1994, 124, 580-587.
19. Ferruzzi, M. G.; Sander, L. C.; Rock, C. L.; Schwartz, S. J. Carotenoid determination in biological microsamples using liquid chromatography with a coulometric electrochemical array detector. Anal. Biochem. 1998, 256, 74-81.
20. Faulks, R. M.; Hart, D. J.; Wilson, P. D. G.; Scott, K. J.; Southon, S. Absorption of all-trans and 9-cis β-carotene in human ileostomy volunteers. Clin. Sci. 1997, 93, 585-591.
21. Ben-Amotz, A.; Lers, A.; Avron, M. Stereoisomers of β-carotene and phytoene in the alga Dunaliella bardawil. Plant Physiol. 1988, 86, 7147-7153.
22. van het Hof, K. H.; West, C. E.; Weststrate, J. A.; Hautvast, J. G. A. J. Dietary factors that affect bioavailability of carotenoids. J. Nutr. 2000, 503-506.
23. Levin, G.; Mokady, S. Incorporation of all-trans- or 9-cis-β-carotene into mixed micelles in vitro. Lipids 1995, 30, 177-179.
24. Ben-Amotz, A.; Mokady, S.; Edelstein, S.; Avron, M. Bioavailability of a natural isomer mixture as compared with synthetic all-trans-β-carotene in rats and chicks. J. Nutr. 1989, 119, 1013-1019.
25. Moore, A. C.; Gugger, E. T.; Erdman, J. W., Jr. Brush border membrane vesicles from rats and gerbils can be utilized to evaluate the intestinal uptake of all-trans and 9-cis beta-carotene. J. Nutr. 1996, 126, 2904-2912.
26. Hebuterne, X.; Wang, X. D.; Johnson, E. J.; Krinsky, N. I.; Russell, R. M. Intestinal absorption and metabolism of 9-cis-beta-carotene in vivo: Biosynthesis of 9-cis-retinoic acid. J. Lipid Res. 1995, 36, 1264-1273.
27. El-Gorab, M. I.; Underwood, B. A.; Loerch, J. D. The roles of bile salts in the uptake of beta-carotene and retinol by rat everted gut sacs. Biochim. Biophys. Acta. 1975, 401 (2), 265-277.
28. Stahl, W.; Schwarz, W.; Sies, H. Human serum concentrations of all-trans β-and α-carotene but not 9-cis β-carotene increase upon ingestion of a natural isomer mixture obtained from Dunaliella salina (Betatene). J. Nutr. 1993, 123, 847-851.
29. Chitchumroonchokchai, C.; Schwanz, S. J.; Failla, M. L. Assessment of lutein bioavailability from meals and supplements using simulated digestion and Caco-2 human intestinal cells. J. Nutr. 2004, 134, 2280-2286.
30. Xu, X.; Wang, Y.; Constantinou, A. I.; Stacewicz-Sapuntzakis, M.; Bowen, P. E.; van Breemen, R. B. Solubilization and stabilization of carotenoids using micelles: Delivery of lycopene to cells in culture. Lipids 1999, 34, 1031-1036.
31. Garrett, D. A.; Failla, M. L.; Sarama, R. J.; Craft, N. Accumulation and retention of micellar beta-carotene and lutein by Caco-2 human intestinal cells. J. Nutr. Biochem. 1999, 10, 573-581.