Personalized expression of bitter 'taste' receptors in human skin

PLoS ONE

Volumn 13, Issue 10, 2018, Pages

  Shaw, Lauren ^a   Mansfield, Corrine ^a   Colquitt, Lauren ^a   Lin, Cailu ^a   Ferreira, Jaime ^b   Emmetsberger, Jaime ^b   Reed, Danielle R ^a  

^a MONELL CHEMICAL SENSES CENTER   (United States)

^b Estee Lauder Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; MESSENGER RNA; TAS2R14 PROTEIN; TAS2R3 PROTEIN; TAS2R30 PROTEIN; TAS2R4 PROTEIN; TAS2R42 PROTEIN; TAS2R60 PROTEIN; TAS2R8 PROTEIN; TAS2R9 PROTEIN; TASTE RECEPTOR TYPE 2; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; TAS2R8 PROTEIN, HUMAN; TASTE RECEPTORS, TYPE 2;

ADULT; AGED; ARTICLE; AUTOPSY; BITTER TASTE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE LOCATION; GENETIC PROCEDURES; GENOTYPE; HUMAN; HUMAN TISSUE; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; QUANTITATIVE ANALYSIS; SKIN BIOPSY; SUN EXPOSURE; TAS2R GENE; TAS2R14 GENE; TAS2R3 GENE; TAS2R30 GENE; TAS2R4 GENE; TAS2R42 GENE; TAS2R5 GENE; TAS2R60 GENE; TAS2R8 GENE; TAS2R9 GENE; TASTE BUD; YOUNG ADULT; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; INTEGUMENTARY SYSTEM; METABOLISM; SKIN; TASTE; VERY ELDERLY;

AGED; AGED, 80 AND OVER; FEMALE; GENE EXPRESSION REGULATION; GENOTYPE; HEK293 CELLS; HUMANS; INTEGUMENTARY SYSTEM; MALE; MIDDLE AGED; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; RNA, MESSENGER; SKIN; TASTE; TASTE BUDS;

EID: 85055037724     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0205322     Document Type: Article

References (21)

1. Reed DR, Knaapila A.Genetics of taste and smell: poisons and pleasures.Prog Mol Biol Transl Sci.2010; 94:213-40.Epub 2010/11/03.B978-0-12-375003-7.00008-X [pii] https://doi.org/10.1016/S1877-1173(10)94008-8 PMID: 21036327; PubMed Central PMCID: PMCPMC3342754.
2. Lee RJ, Cohen NA.Taste receptors in innate immunity.Cell Mol Life Sci.2015; 72(2):217-36.https://doi.org/10.1007/s00018-014-1736-7 PMID: 25323130; PubMed Central PMCID: PMCPMC4286424.
3. Zheng K, Lu P, Delpapa E, Bellve K, Deng R, Condon JC, et al.Bitter taste receptors as targets for toco-lytics in preterm labor therapy.FASEB J.2017; 31(9):4037-52.https://doi.org/10.1096/fj.201601323RR PMID: 28559440; PubMed Central PMCID: PMCPMC5572693.
4. Shah AS, Ben-Shahar Y, Moninger TO, Kline JN, Welsh MJ.Motile cilia of human airway epithelia are chemosensory.Science.2009; 325:1131-4.https://doi.org/10.1126/science.1173869 PMID: 19628819.
5. Janssen S, Laermans J, Verhulst PJ, Thijs T, Tack J, Depoortere I.Bitter taste receptors and -gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying.Proc Natl Acad Sci USA.2011.https://doi.org/10.1073/pnas.1011508108 PMID: 21245306
6. Foster SR, Porrello ER, Purdue B, Chan HW, Voigt A, Frenzel S, et al.Expression, regulation and putative nutrient-sensing function of taste GPCRs in the heart.PloS One.2013; 8(5):e64579.Epub 2013/ 05/23.https://doi.org/10.1371/journal.pone.0064579 PMID: 23696900; PubMed Central PMCID: PMC3655793.
7. Jang HJ, Kokrashvili Z, Theodorakis MJ, Carlson OD, Kim BJ, Zhou J, et al.Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.Proc Natl Acad Sci USA.2007; 104 (38):15069-74.https://doi.org/10.1073/pnas.0706890104 PMID: 17724330.
8. Lee RJ, Xiong G, Kofonow JM, Chen B, Lysenko A, Jiang P, et al.T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection.J Clin Invest.2012; 122(11):4145-59.Epub 2012/ 10/09.https://doi.org/10.1172/JCI64240 PMID: 23041624; PubMed Central PMCID: PMCPMC3484455.
9. Denda M.Newly discovered olfactory receptors in epidermal keratinocytes are associated with proliferation, migration, and re-epithelialization of keratinocytes.J Invest Dermatol.2014; 134(11):2677-9.https://doi.org/10.1038/jid.2014.229 PMID: 25318430.
10. Wolfle U, Elsholz FA, Kersten A, Haarhaus B, Muller WE, Schempp CM.Expression and functional activity of the bitter taste receptors TAS2R1 and TAS2R38 in human keratinocytes.Skin Pharmacol Physiol.2015; 28(3):137-46.https://doi.org/10.1159/000367631 PMID: 25573083.
11. Reszka E, Nowakowska-Swirta E, Kupczyk M, Dudek W, Swierczynska-Machura D, Wittczak T, et al.Expression of bitter taste receptors in the human skin in vitro.Journal of Clinical Research and Bioethics.2015; 6(2).
12. Lion T.Appropriate controls for RT-PCR.Leukemia.1996; 10(11):1843.PMID: 8892692.
13. Cottel WI, Proper S.Mohs' surgery, fresh-tissue technique.Our technique with a review.J Dermatol Surg Oncol.1982; 8(7):576-87.PMID: 6181110.
14. Edqvist PH, Fagerberg L, Hallstrom BM, Danielsson A, Edlund K, Uhlen M, et al.Expression of human skin-specific genes defined by transcriptomics and antibody-based profiling.J Histochem Cytochem.2015; 63(2):129-41.https://doi.org/10.1369/0022155414562646 PMID: 25411189; PubMed Central PMCID: PMCPMC4305515.
15. Tracy LE, Minasian RA, Caterson EJ.Extracellular matrix and dermal fibroblast function in the healing wound.Adv Wound Care (New Rochelle).2016; 5(3):119-36.https://doi.org/10.1089/wound.2014.0561 PMID: 26989578; PubMed Central PMCID: PMCPMC4779293.
16. Behrens M, Foerster S, Staehler F, Raguse JD, Meyerhof W.Gustatory expression pattern of the human TAS2R bitter receptor gene family reveals a heterogenous population of bitter responsive taste receptor cells.J Neurosci.2007; 27(46):12630-40.https://doi.org/10.1523/JNEUROSCI.1168-07.2007PMID: 18003842.
17. Lossow K, Hubner S, Roudnitzky N, Slack JP, Pollastro F, Behrens M, et al.Comprehensive analysis of mouse bitter taste receptors reveals different molecular receptive ranges for orthologous receptors in mice and humans.J Biol Chem.2016.https://doi.org/10.1074/jbc.M116.718544 PMID: 27226572.
18. Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, Bufe B, et al.The molecular receptive ranges of human TAS2R bitter taste receptors.Chem Senses.2010; 35(2):157-70.https://doi.org/10.1093/chemse/bjp092 PMID: 20022913.
19. Tizzano M, Gulbransen BD, Vandenbeuch A, Clapp TR, Herman JP, Sibhatu HM, et al.Nasal chemosensory cells use bitter taste signaling to detect irritants and bacterial signals.Proc Natl Acad Sci USA.2010; 107:3210-5.https://doi.org/10.1073/pnas.0911934107 PMID: 20133764.
20. Spielman AI, Pepino MY, Feldman R, Brand JG.Technique to collect fungiform (taste) papillae from human tongue.J Vis Exp.2010; 18(42):2201.Epub 2010/10/26.https://doi.org/10.3791/2201 PMID: 20972388; PubMed Central PMCID: PMC3168239.
21. Livak KJ, Schmittgen TD.Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.Methods.2001; 25(4):402-8.https://doi.org/10.1006/meth.2001.1262 PMID: 11846609.