A Controlled Trial of Mass Drug Administration to Interrupt Transmission of Multidrug-Resistant Falciparum Malaria in Cambodian Villages

Clinical Infectious Diseases

Volumn 67, Issue 6, 2018, Pages 817-826

  Tripura, Rupam ^a,b,c   Peto, Thomas J ^a,b   Chea, Nguon ^d   Chan, Davoeung ^e   Mukaka, Mavuto ^a,b   Sirithiranont, Pasathorn ^a   Dhorda, Mehul ^a,b,f   Promnarate, Cholrawee ^f   Imwong, Mallika ^a   Von Seidlein, Lorenz ^a,b   Duanguppama, Jureeporn ^a   Patumrat, Krittaya ^a   Huy, Rekol ^d   Grobusch, Martin P ^c   Day, Nicholas P J ^a,b   White, Nicholas J ^a,b   Dondorp, Arjen M ^a,b  

^a MAHIDOL UNIVERSITY   (Thailand)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d National Center for Parasitology Entomology and Malaria Control   (Cambodia)

^e Provincial Health Department   (Cambodia)

^f MAHIDOL UNIVERSITY   (Thailand)

Author keywords

dihydroartemisinin piperaquine; malaria elimination; mass drug administration; Southeast Asia; subclinical malaria

Indexed keywords

ANTIMALARIAL AGENT; ARTEMISININ DERIVATIVE; DIHYDROARTEMISININ; PIPERAQUINE; QUINOLINE DERIVATIVE;

ADOLESCENT; ADULT; CAMBODIA; CHILD; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; HUMAN; INCIDENCE; ISOLATION AND PURIFICATION; MALARIA FALCIPARUM; MALE; MASS DRUG ADMINISTRATION; MIDDLE AGED; MULTIDRUG RESISTANCE; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PRESCHOOL CHILD; PREVALENCE; RANDOMIZED CONTROLLED TRIAL; YOUNG ADULT;

ADOLESCENT; ADULT; ANTIMALARIALS; ARTEMISININS; CAMBODIA; CHILD; CHILD, PRESCHOOL; CROSS-SECTIONAL STUDIES; DRUG RESISTANCE, MULTIPLE; FEMALE; HUMANS; INCIDENCE; MALARIA, FALCIPARUM; MALE; MASS DRUG ADMINISTRATION; MIDDLE AGED; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PREVALENCE; QUINOLINES; YOUNG ADULT;

EID: 85054981328     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/ciy196     Document Type: Article

References (36)

1. Noedl H, Se Y, Schaecher K, Smith BL, Socheat D, Fukuda MM; Artemisinin Resistance in Cambodia 1 (ARC1) Study Consortium. Evidence of artemisinin-resistant malaria in western Cambodia. N Engl J Med 2008; 359:2619-20.
2. Dondorp AM, Nosten F, Yi P, et al. Artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med 2009; 361:455-67.
3. Amaratunga C, Sreng S, Suon S, et al. Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate study. Lancet Infect Dis 2012; 12:851-8.
4. Amaratunga C, Lim P, Suon S, et al. Dihydroartemisinin-piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study. Lancet Infect Dis 2016; 16:357-65.
5. Maude RJ, Pontavornpinyo W, Saralamba S, et al. The last man standing is the most resistant: eliminating artemisinin-resistant malaria in Cambodia. Malar J 2009; 8:31.
6. Maude RJ, Socheat D, Nguon C, et al. Optimising strategies for Plasmodium falciparum malaria elimination in Cambodia: primaquine, mass drug administration and artemisinin resistance. PLoS One 2012; 7:e37166.
7. World Health Organization. Global plan for artemisinin resistance containment (GPARC). Geneva, Switzerland: WHO, 2011.
8. Thuy-Nhien N, von Seidlein L, Tuong-Vy N, et al. The persistence and oscillations of submicroscopic Plasmodium falciparum and vivax infections over time in Vietnam: an open cohort study. Lancet Infect Dis 2018. doi:10. 1016/ S473-3099(18)30046-X.
9. Poirot E, Skarbinski J, Sinclair D, Kachur SP, Slutsker L, Hwang J. Mass drug administration for malaria. Cochrane Database Syst Rev 2013; CD008846.
10. World Health Organization. Strategy for malaria elimination in the Greater Mekong subregion 2015-30. Geneva, Switzerland: WHO, 2015.
11. World Health Organization. Eliminating malaria in the Greater Mekong Subregion: united to end a deadly disease. Geneva, Switzerland: WHO, 2016.
12. Imwong M, Suwannasin K, Kunasol C, et al. The spread of artemisinin-resistant Plasmodium falciparum in the Greater Mekong subregion: a molecular epidemiology observational study. Lancet Infect Dis 2017; 17:491-7.
13. Tripura R, Peto TJ, Veugen CC, et al. Submicroscopic Plasmodium prevalence in relation to malaria incidence in 20 villages in western Cambodia. Malar J 2017; 16:56.
14. Roberts L. Malaria wars. Science 2016; 352:398-402, 404-5.
15. Roberts L. The village recruiter. Science 2016; 352:407.
16. Lim R, Peto TJ, Tripura R, Cheah PY. Village drama against malaria. Lancet 2016; 388:2990.
17. Imwong M, Hanchana S, Malleret B, Renia L, Day NP, Dondorp A. High throughput ultra-sensitive molecular techniques to quantity low density malaria parasitaemias. J Clin Microbiol 2014; 52:3303-9.
18. Valea I, Tinto H, Drabo MK, et al; FSP/MISAME Study Group. An analysis of timing and frequency of malaria infection during pregnancy in relation to the risk of low birth weight, anaemia and perinatal mortality in Burkina Faso. Malar J 2012; 11:71.
19. Medana IM, Day NP, Sachanonta N, et al. Coma in fatal adult human malaria is not caused by cerebral oedema. Malar J 2011; 10:267.
20. Kamau E, Tolbert LS, Kortepeter L, et al. Development of a highly sensitive genus-specific quantitative reverse transcriptase real-time PCR assay for detection and quantitation of Plasmodium by amplifying RNA and DNA of the 18S rRNA genes. J Clin Microbiol 2011; 49:2946-53.
21. Erhart A, Thang ND, Hung NQ, et al. Forest malaria in Vietnam: a challenge for control. Am J Trop Med Hyg 2004; 70:110-8.
22. Van Bortel W, Trung HD, Hoi le X, et al. Malaria transmission and vector behaviour in a forested malaria focus in central Vietnam and the implications for vector control. Malar J 2010; 9:373.
23. Thanh PV, Van Hong N, Van Van N, et al. Epidemiology of forest malaria in central Vietnam: the hidden parasite reservoir. Malar J 2015; 14:86.
24. Sanh NH, Van Dung N, Thanh NX, Trung TN, Van Co T, Cooper RD. Forest malaria in central Vietnam. Am J Trop Med Hyg 2008; 79:652-4.
25. Erhart A, Ngo DT, Phan VK, et al. Epidemiology of forest malaria in central Vietnam: a large scale cross-sectional survey. Malar J 2005; 4:58.
26. Abe T, Honda S, Nakazawa S, et al. Risk factors for malaria infection among ethnic minorities in Binh Phuoc, Vietnam. Southeast Asian J Trop Med Public Health 2009; 40:18-29.
27. von Seidlein L, Dondorp A. Fighting fire with fire: mass antimalarial drug administrations in an era of antimalarial resistance. Expert Rev Anti Infect Ther 2015; 13:715-30.
28. PREGACT Study Group. Four artemisinin-based treatments in African pregnant women with malaria. N Engl J Med 2016; 374:913-27.
29. Saunders DL, Vanachayangkul P, Lon C; US Army Military Malaria Research Program; National Center for Parasitology, Entomology, and Malaria Control (CNM); Royal Cambodian Armed Forces. Dihydroartemisinin-piperaquine failure in Cambodia. N Engl J Med 2014; 371:484-5.
30. Landier J, Kajeechiwa L, Thwin MM, et al. Safety and effectiveness of mass drug administration to accelerate elimination of artemisinin-resistant falciparum malaria: a pilot trial in four villages of eastern Myanmar. Wellcome Open Res 2017; 2:81.
31. Pell C, Tripura R, Nguon C, et al. Mass anti-malarial administration in western Cambodia: a qualitative study of factors affecting coverage. Malar J 2017; 16:206.
32. Landier J, Kajeechiwa L, Thwin MM, et al. Safety and effectiveness of mass drug administration to accelerate elimination of artemisinin-resistant falciparum malaria: a pilot trial in four villages of eastern Myanmar. Wellcome Open Res 2017; 2:81.
33. Kaneko A, Taleo G, Kalkoa M, Yamar S, Kobayakawa T, Bjorkman A. Malaria eradication on islands. Lancet 2000; 356:1560-4.
34. Newby G, Hwang J, Koita K, et al. Review of mass drug administration for malaria and its operational challenges. Am J Trop Med Hyg 2015; 93:125-34.
35. Brady OJ, Slater HC, Pemberton-Ross P, et al. Role of mass drug administration in elimination of Plasmodium falciparum malaria: a consensus modelling study. Lancet Glob Health 2017; 5:e680-7.
36. World Health Organization. Mass drug administration for falciparum malaria: a practical field manual. Geneva, Switzerland: WHO, 2017.