Collusion between neutralizing antibodies and other immune factions in the destruction of adenoviral vectors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 115, Issue 41, 2018, Pages 10201-10203

  Klasse, P J ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ALPHA INTERFERON; NEUTRALIZING ANTIBODY; TRIPARTITE MOTIF PROTEIN; TRIPARTITE MOTIF PROTEIN 21; UNCLASSIFIED DRUG; VIRUS ANTIBODY;

ADAPTIVE IMMUNITY; ANTIGEN ANTIBODY REACTION; CYTOSOL; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; IMMUNE RESPONSE; INFECTION PREVENTION; INNATE IMMUNITY; NONHUMAN; NOTE; PRIORITY JOURNAL; PROGENY; PROTEIN EXPRESSION; VIRION; VIRUS ENTRY; VIRUS INFECTION; VIRUS NEUTRALIZATION; VIRUS PARTICLE; VIRUS REPLICATION; ADENOVIRIDAE; GENE VECTOR; GENETICS;

ADENOVIRIDAE; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; GENETIC THERAPY; GENETIC VECTORS;

EID: 85054753027     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1814275115     Document Type: Note

References (17)

1. Crystal RG (2014) Adenovirus: The first effective in vivo gene delivery vector. Hum Gene Ther 25:3-11.
2. Barouch DH, Picker LJ (2014) Novel vaccine vectors for HIV-1. Nat Rev Microbiol 12:765-771.
3. McEwan WA, James LC (2015) TRIM21-dependent intracellular antibody neutralization of virus infection. Prog Mol Biol Transl Sci 129:167-187.
4. Mallery DL, et al. (2010) Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21). Proc Natl Acad Sci USA 107:19985-19990.
5. Bottermann M (2018) TRIM21 mediates antibody inhibition of adenovirus-based gene delivery and vaccination. Proc Natl Acad Sci USA 115:10440-10445.
6. McEwan WA, et al. (2013) Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21. Nat Immunol 14:327-336.
7. Watkinson RE, McEwan WA, Tam JC, Vaysburd M, James LC (2015) TRIM21 promotes cGAS and RIG-I sensing of viral genomes during infection by antibodyopsonized virus. PLoS Pathog 11:e1005253.
8. Hauler F, Mallery DL, McEwan WA, Bidgood SR, James LC (2012) AAA ATPase p97/VCP is essential for TRIM21-mediated virus neutralization. Proc Natl Acad Sci USA 109:19733-19738.
9. Fletcher AJ, Mallery DL, Watkinson RE, Dickson CF, James LC (2015) Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21. Proc Natl Acad Sci USA 112:10014-10019.
10. McEwan WA, et al. (2012) Regulation of virus neutralization and the persistent fraction by TRIM21. J Virol 86:8482-8491.
11. Klasse PJ (2014) Neutralization of virus infectivity by antibodies: Old problems in new perspectives. Adv Biol 2014:157895.
12. Greber UF (2016) Virus and host mechanics support membrane penetration and cell entry. J Virol 90:3802-3805.
13. Panjwani A, et al. (2014) Capsid protein VP4 of human rhinovirus induces membrane permeability by the formation of a size-selective multimeric pore. PLoS Pathog 10:e1004294.
14. Fuchs R, Blaas D (2012) Productive entry pathways of human rhinoviruses. Adv Virol 2012:826301.
15. Wiethoff CM, Wodrich H, Gerace L, Nemerow GR (2005) Adenovirus protein VI mediates membrane disruption following capsid disassembly. J Virol 79:1992-2000.
16. Anghelina D, Lam E, Falck-Pedersen E (2016) Diminished innate antiviral response to adenovirus vectors in cGAS/STING-deficient mice minimally impacts adaptive immunity. J Virol 90:5915-5927.
17. Corti D, Lanzavecchia A (2013) Broadly neutralizing antiviral antibodies. Annu Rev Immunol 31:705-742.