Mendelian Randomization Analysis Identifies Body Mass Index and Fasting Insulin as Potential Causal Risk Factors for Pancreatic Cancer Risk

Journal of the National Cancer Institute

Volumn 109, Issue 9, 2017, Pages

  Tsilidis, Konstantinos K ^a,b   Dai, James Y ^c   Peters, Ulrike ^c,d  

^a UNIVERSITY OF IOANNINA   (Greece)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c USA   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; INSULIN;

BODY MASS; CANCER RISK; CHOLESTEROL BLOOD LEVEL; EDITORIAL; ENVIRONMENTAL EXPOSURE; FASTING BLOOD GLUCOSE LEVEL; FASTING INSULIN LEVEL; GENETIC RISK; GENETIC VARIABILITY; GENOME-WIDE ASSOCIATION STUDY; HIP CIRCUMFERENCE; HUMAN; HYPERINSULINEMIA; INSULIN RESISTANCE; MENDELIAN RANDOMIZATION ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS CANCER; PLEIOTROPY; RISK FACTOR; WAIST CIRCUMFERENCE; DIET RESTRICTION; GENETICS; PANCREAS TUMOR; SINGLE NUCLEOTIDE POLYMORPHISM;

BODY MASS INDEX; FASTING; HUMANS; INSULIN; MENDELIAN RANDOMIZATION ANALYSIS; PANCREATIC NEOPLASMS; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 85054078043     PISSN: 00278874     EISSN: 14602105     Source Type: Journal    
DOI: 10.1093/jnci/djx043     Document Type: Editorial

References (15)

1. Carreras-Torres R, Johansson M, Gaborieau V, et al. The role of obesity, type 2 diabetes and metabolic factors in pancreatic cancer: A Mendelian randomization study. J Natl Cancer Inst. 2017;109(9): djx012.
2. Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359–E386.
3. Ilic M, Ilic I. Epidemiology of pancreatic cancer. World J Gastroenterol. 2016; 22(44):9694–9705.
4. Haycock PC, Burgess S, Wade KH, et al. Best (but oft-forgotten) practices: The design, analysis, and interpretation of Mendelian randomization studies. Am J Clin Nutr. 2016;103(4):965–978.
5. 0: Can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol. 2003;32(1):1–22.
6. Carreras-Torres R, Haycock PC, Relton CL, et al. The causal relevance of body mass index in different histological types of lung cancer: A Mendelian randomization study. Sci Rep. 2016;6:31121.
7. Dixon SC, Nagle CM, Thrift AP, et al. Adult body mass index and risk of ovarian cancer by subtype: A Mendelian randomization study. Int J Epidemiol. 2016;45(3):884–895.
8. Gao C, Patel CJ, Michailidou K, et al. Mendelian randomization study of adiposity-related traits and risk of breast, ovarian, prostate, lung and colorectal cancer. Int J Epidemiol. 2016;45(3):896–908.
9. Guo Y, Warren Andersen S, Shu XO, et al. Genetically predicted body mass index and breast cancer risk: Mendelian randomization analyses of data from 145,000 women of European descent. PLoS Med. 2016;13(8):e1002105.
10. Tsilidis KK, Kasimis JC, Lopez DS, et al. Type 2 diabetes and cancer: Umbrella review of meta-analyses of observational studies. BMJ. 2015;350:g7607.
11. Kyrgiou M, Kalliala I, Markozannes G, et al. Adiposity and cancer at all anatomic sites: An umbrella review of the literature. BMJ. 2017;356:j477.
12. Bowden J, Davey Smith G, Burgess S. Mendelian randomization with invalid instruments: Effect estimation and bias detection through Egger regression. Int J Epidemiol. 2015;44(2):512–525.
13. Bowden J, Davey Smith G, Haycock PC, et al. Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator. Genet Epidemiol. 2016;40(4):304–314.
14. Ben Q, Xu M, Ning X, et al. Diabetes mellitus and risk of pancreatic cancer: A meta-analysis of cohort studies. Eur J Cancer. 2011;47(13):1928–1937.
15. Elena JW, Steplowski E, Yu K, et al. Diabetes and risk of pancreatic cancer: A pooled analysis from the pancreatic cancer cohort consortium. Cancer Causes Control. 2013;24(1):13–25.