The association between serum sodium concentration, hypertension and primary cardiovascular events: a retrospective cohort study

Journal of Human Hypertension

Volumn 33, Issue 1, 2019, Pages 69-77

  Cole, Nicholas I ^a   Suckling, Rebecca J ^a   Swift, Pauline A ^a   He, Feng J ^b   MacGregor, Graham A ^b   Hinton, William ^c   van Vlymen, Jeremy ^c   Hayward, Nicholas ^c   Jones, Simon ^c,d   de Lusignan, Simon ^c  

^a EPSOM AND ST HELIER UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY OF SURREY   (United Kingdom)

^d NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ELECTROLYTE; SODIUM; BIOLOGICAL MARKER;

ACUTE CORONARY SYNDROME; ADULT; AGED; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CEREBROVASCULAR ACCIDENT; CHRONIC KIDNEY FAILURE; COHORT ANALYSIS; DIABETES MELLITUS; DISEASE ASSOCIATION; ELECTROLYTE BLOOD LEVEL; FEMALE; HEART FAILURE; HEART INFARCTION; HEART MUSCLE REVASCULARIZATION; HUMAN; HYPERTENSION; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; PRIMARY MEDICAL CARE; RETROSPECTIVE STUDY; RISK FACTOR; SODIUM BLOOD LEVEL; TRANSIENT ISCHEMIC ATTACK; BLOOD; BLOOD PRESSURE; CLINICAL TRIAL; ENGLAND; FOLLOW UP; INCIDENCE; MIDDLE AGED; MULTICENTER STUDY; PATHOPHYSIOLOGY; PHYSIOLOGY; SURVIVAL RATE; TIME FACTOR; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BIOMARKERS; BLOOD PRESSURE; CARDIOVASCULAR DISEASES; ENGLAND; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYPERTENSION; INCIDENCE; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; RISK FACTORS; SODIUM; SURVIVAL RATE; TIME FACTORS;

EID: 85053825093     PISSN: 09509240     EISSN: 14765527     Source Type: Journal    
DOI: 10.1038/s41371-018-0115-5     Document Type: Article

References (35)

1. He FJ, MacGregor GA. Salt reduction lowers cardiovascular risk: meta-analysis of outcome trials. Lancet. 2011;378:380–2
2. He FJ, Li J, Macgregor GA. Effect of longer term modest salt reduction on blood pressure: Cochrane systematic review and meta-analysis of randomised trials. BMJ. 2013;346:f1325
3. He FJ, Markandu ND, Sagnella GA, de Wardener HE, MacGregor GA. Plasma sodium: ignored and underestimated. Hypertension. 2005;45:98–102
4. de Wardener HE, He FJ, MacGregor GA. Plasma sodium and hypertension. Kidney Int. 2004;66:2454–66
5. Suckling RJ, He FJ, Markandu ND, MacGregor GA. Dietary salt influences postprandial plasma sodium concentration and systolic blood pressure. Kidney Int. 2012;81:407–11
6. Bulpitt CJ, Shipley MJ, Semmence A. Blood pressure and plasma sodium and potassium. Clin Sci (Lond). 1981;61(suppl 7):85s–7s
7. Komiya I, Yamada T, Takasu N, Asawa T, Akamine H, Yagi N, et al. An abnormal sodium metabolism in Japanese patients with essential hypertension, judged by serum sodium distribution, renal function and the renin-aldosterone system. J Hypertens. 1997;15:65–72
8. He FJ, Fan S, MacGregor GA, Yaqoob MM. Plasma sodium and blood pressure in individuals on haemodialysis. J Hum Hypertens. 2013;27:85–9
9. Norman RA Jr., Coleman TG, Wiley TL Jr., Manning RD Jr., Guyton AC. Separate roles of sodium ion concentration and fluid volumes in salt-loading hypertension in sheep. Am J Physiol. 1975;229:1068–72
10. Friedman SM, McIndoe RA, Tanaka M. The relation of blood sodium concentration to blood pressure in the rat. J Hypertens. 1990;8:61–6
11. Suckling RJ, Swift PA, He FJ, Markandu ND, MacGregor GA. Altering plasma sodium concentration rapidly changes blood pressure during haemodialysis. Nephrol Dial Transplant. 2013;28:2181–6
12. Oberleithner H, Riethmuller C, Schillers H, MacGregor GA, de Wardener HE, Hausberg M. Plasma sodium stiffens vascular endothelium and reduces nitric oxide release. Proc Natl Acad Sci USA. 2007;104:16281–86
13. Gu JW, Anand V, Shek EW, Moore MC, Brady AL, Kelly WC, et al. Sodium induces hypertrophy of cultured myocardial myoblasts and vascular smooth muscle cells. Hypertension. 1998;31:1083–87
14. Gheorghiade M, Abraham WT, Albert NM, Gattis Stough W, Greenberg BH, O’Connor CM, et al. Relationship between admission serum sodium concentration and clinical outcomes in patients hospitalized for heart failure: an analysis from the OPTIMIZE-HF registry. Eur Heart J. 2007;28:980–8
15. Rusinaru D, Tribouilloy C, Berry C, Richards AM, Whalley GA, Earle N, et al. Relationship of serum sodium concentration to mortality in a wide spectrum of heart failure patients with preserved and with reduced ejection fraction: an individual patient data meta-analysis(dagger): meta-analysis global group in chronic heart failure (MAGGIC). Eur J Heart Fail. 2012;14:1139–46
16. Goldberg A, Hammerman H, Petcherski S, Zdorovyak A, Yalonetsky S, Kapeliovich M, et al. Prognostic importance of hyponatremia in acute ST-elevation myocardial infarction. Am J Med. 2004;117:242–8
17. Rodrigues B, Staff I, Fortunato G, McCullough LD. Hyponatremia in the prognosis of acute ischemic stroke. J Stroke Cerebrovasc Dis. 2014;23:850–4
18. Dmitrieva NI, Burg MB. Elevated sodium and dehydration stimulate inflammatory signaling in endothelial cells and promote atherosclerosis. PLoS ONE. 2015;10:e0128870
19. Wang AYM, Lu Y, Cheung S, Chan IHS, Lam CWK. Plasma sodium and subclinical left atrial enlargement in chronic kidney disease. Nephrol Dial Transplant. 2013;28:2319–28
20. Wannamethee SG, Shaper AG, Lennon L, Papacosta O, Whincup P. Mild hyponatremia, hypernatremia and incident cardiovascular disease and mortality in older men: a population-based cohort study. Nutr Metab Cardiovasc Dis. 2016;26:12–9
21. Hippisley-Cox J, Coupland C, Vinogradova Y, Robson J, Minhas R, Sheikh A, et al. Predicting cardiovascular risk in England and Wales: prospective derivation and validation of QRISK2. BMJ. 2008;336:1475
22. Department for Communities and Local Government. English indices of deprivation. https://www.gov.uk/government/collections/english-indices-of-deprivation. Accessed 19 Sept 2018
23. Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150:604–12
24. Harrell Jr FE. Regression modelling strategies with applications to linear models, logistic regression, and survival analysis. 1st ed. New York: Springer-Verlag Publishers; 2001
25. Zhang Z, Duckart J, Slatore CG, Fu Y, Petrik AF, Thorp ML, et al. Individuality of the plasma sodium concentration. Am J Physiol Ren Physiol. 2014;306:F1534–43
26. Gao S, Xiangqin C, Wang X, Burg MB, Dmitrieva NI. Cross-sectional positive association of serum lipids and blood pressure with serum sodium within the normal reference range of 135-145 mmol/L. Arterioscler Thromb Vasc Biol. 2017;37:598–606
27. Millett C, Laverty AA, Stylianou N, Bibbins-Domingo K, Pape UJ. Impacts of a national strategy to reduce population salt intake in England: serial cross sectional study. PLoS ONE. 2012;7:e29836
28. Public Health England. National Diet and Nutrition Survey: assessment of dietary sodium. Adults (19 to 64 years) in England, 2014. https://www.gov.uk/government/statistics/national-diet-and-nutrition-survey-assessment-of-dietary-sodium-in-adults-in-england-2014. Accessed 19 Sept 2018
29. Alsanjari ON, de Lusignan S, van Vlymen J, Gallagher H, Millett C, Harris J, et al. Trends and transient change in end-digit preference in blood pressure recording: studies of sequential and longitudinal collected primary care data. Int J Clin Pract. 2012;66:37–43
30. Dmitrieva NI, Burg MB. Secretion of von Willebrand factor by endothelial cells links sodium to hypercoagulability and thrombosis. Proc Natl Acad Sci USA. 2014;111:6485–90
31. Wild J, Soehnlein O, Dietel B, Urschel K, Garlichs CD, Cicha I. Rubbing salt into wounded endothelium: sodium potentiates proatherogenic effects of TNF-alpha under non-uniform shear stress. Thromb Haemost. 2014;112:183–195
32. Lilly LS, Dzau VJ, Williams GH, Rydstedt L, Hollenberg NK. Hyponatremia in congestive heart failure: implications for neurohumoral activation and responses to orthostasis. J Clin Endocrinol Metab. 1984;59:924–30
33. Lee WH, Packer M. Prognostic importance of serum sodium concentration and its modification by converting-enzyme inhibition in patients with severe chronic heart failure. Circulation. 1986;73:257–67
34. O’Donnell M, Mente A, Rangarajan S, McQueen MJ, Wang X, Liu L, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014;371:612–23
35. De Bacquer D, De Backer G, De Buyzere M, Kornitzer M. Is low serum chloride level a risk factor for cardiovascular mortality? J Cardiovasc Risk. 1998;5:177–84