Innate immune activation and depressive and anxious symptoms across the peripartum: An exploratory study

Psychoneuroendocrinology

Volumn 99, Issue , 2019, Pages 80-86

  Osborne, Lauren M ^a   Yenokyan, Gayane ^b   Fei, Kezhen ^c   Kraus, Thomas ^c   Moran, Thomas ^c   Monk, Catherine ^d,e   Sperling, Rhoda ^c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d NewYork Presbyterian Hospital   (United States)

^e NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

Anxiety; Cytokine; Depression; Immunity; Inflammation; Pregnancy

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 15; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; BIOLOGICAL MARKER; CYTOKINE;

ADULT; AFRICAN AMERICAN; ANXIETY DISORDER; ARTICLE; BECK DEPRESSION INVENTORY; CONTROLLED STUDY; DEPRESSION; ETHNIC DIFFERENCE; EXPLORATORY RESEARCH; FEMALE; HISPANIC; HUMAN; IMMUNOSTIMULATION; INFLAMMATION; INNATE IMMUNITY; MAJOR CLINICAL STUDY; OBESITY; PERINATAL PERIOD; PRIORITY JOURNAL; PUERPERIUM; RACE DIFFERENCE; STATE TRAIT ANXIETY INVENTORY; THIRD TRIMESTER PREGNANCY; AFFECT; ANXIETY; BLOOD; IMMUNOLOGY; LONGITUDINAL STUDY; PATHOPHYSIOLOGY; PHYSIOLOGY; POSTNATAL DEPRESSION; PREGNANCY; PSYCHOLOGICAL RATING SCALE; PSYCHOLOGY;

ADULT; AFFECT; ANXIETY; ANXIETY DISORDERS; BIOMARKERS; CYTOKINES; DEPRESSION; DEPRESSION, POSTPARTUM; FEMALE; HUMANS; IMMUNITY, INNATE; LONGITUDINAL STUDIES; PERIPARTUM PERIOD; PREGNANCY; PREGNANCY TRIMESTER, THIRD; PSYCHIATRIC STATUS RATING SCALES;

EID: 85052875444     PISSN: 03064530     EISSN: 18733360     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2018.08.038     Document Type: Article

References (44)

1. Aalto, A.M., Elovaino, M., Kivimaki, M., Uutela, A., Pirkola, S., The Beck Depression Inventory and General Health Questionnaire as measures of depression in the general population: a validation study using the Composite International Diagnostic Interview as the gold standard. Psychiatry Res. 197 (2012), 163–171.
2. Baba, T., Mukaida, N., Role of macrophage inflammatory protein (MIP)-1α/CCL3 in leukemogenesis. Mol. Cell. Oncol., 1(1), 2014, e29899.
3. Bastard, J.-P., Maachi, M., Lagathu, C., Kim, M.J., Caron, M., Vidal, H., Capeau, J., Feve, B., Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur. Cytokine Netw. 17:1 (2006), 4–12.
4. Becher, B., Tugues, S., Greter, M., GM-CSF: from growth factor to central mediator of tissue inflammation. Immunity 45:5 (2016), 963–973.
5. Beck, A.T., Steer, R.A., Manual for the Beck Depression Inventory. 1993 edition, 1993, The Psychological Corporation, San Antonio (TX).
6. Beck, A.T., Ward, C.G., Mendelson, M., Mock, J., Erbaugh, J., An inventory for measuring depression. Arch. Gen. Psychiatry 4 (1961), 53–63.
7. Bianco-Miatto, T., Craig, J.M., Gasser, Y.P., van Dijk, S.J., Ozanne, S.E., Epigenetics and DOHaD: from basics to birth and beyond. J. Dev. Orig. Health Dis. 8:5 (2017), 513–519.
8. Bloch, M., Schmidt, P.J., Danaceau, M., Murphy, J., Nieman, L., Rubinow, D.R., Effects of gonadal steroids in women with a history of postpartum depression. Am. J. Psychiatry 157 (2000), 924–930.
9. Bränn, E., Papadopoulos, F., Fransson, E., White, R., Edvinsson, Å., Hellgren, C., Kamali-Moghaddam, M., Boström, A., Schiöth, H.B., Sundström-Poromaa, I., Skalkidou, A., Inflammatory markers in late pregnancy in association with postpartum depression-A nested case-control study. Psychoneuroendocrinology 79 (2017), 146–159.
10. Cassidy-Bushrow, A.E., Peters, R.M., Johnson, D.A., Templin, T.N., Association of depressive symptoms with inflammatory biomarkers among pregnant African-American women. J. Reprod. Immunol. 94 (2012), 202–209.
11. Chen, S.-J., Liu, Y.-L., Sytwu, H.-K., Immunologic regulation in pregnancy: from mechanism to therapeutic strategy for immunomodulation. Clin. Dev. Immunol., 2012, 2012, 258391.
12. Chen, T., Guo, M., Gao, Y., Chen, F., Guo, J., Liu, T., Wu, D., Jiang, X., A comparative study on the levels of serum cytokines and cortisol among post-traumatic stress disorder patients of Li and Han ethnicities in Hainan. Chin. Med. J. (Engl.) 127:15 (2014), 2771–2774.
13. Christian, L.M., Franco, A., Glaser, R., Iams, J.D., Depressive symptoms are associated with elevated serum proinflammatory cytokines among pregnant women. Brain Behav. Immun. 23 (2012), 750–754.
14. Christian, L.M., Kowalsky, J.M., Mitchell, A.M., Porter, K., Associations of postpartum sleep, stress, and depressive symptoms with LPS-stimulated cytokine production among African American and white women. J. Neuroimmunol. 15:316 (2018), 98–106.
15. Eder, K., Baffy, N., Falus, A., Fulop, A.K., The major inflammatory mediator interleukin-6 and obesity. Inflamm. Res. 58:11 (2009), 727–736.
16. Edvinsson, Å., Bränn, E., Hellgren, C., Freyhult, E., White, R., Kamali-Moghaddam, M., Olivier, J., Bergquist, J., Boström, A.E., Schiöth, H.B., Skalkidou, A., Cunningham, J.L., Sundström-Poromaa, I., Lower inflammatory markers in women with antenatal depression brings the M1/M2 balance into focus from a new direction. Psychoneuroendocrinology 28:80 (2017), 15–25.
17. Eftekhar, M., Naghshineh, E., Khani, P., Role of granulocyte colony-stimulating factor in human reproduction. J. Res. Med. Sci., 29(23), 2018, 7.
18. Francisco-Cruz, A., Aguilar-Santelises, M., Ramos-Espinosa, O., Mata-Espinosa, D., Marquina-Castillo, B., Barrios-Payan, J., Hernandez-Pando, R., Granulocyte–macrophage colony-stimulating factor: not just another haematopoietic growth factor. Med. Oncol., 31, 2014, 774.
19. Gaynes, B.N., Gavin, N., Meltzer-Brody, S., Lohr, K.N., Swinson, T., Gartlehner, G., Brody, S., Miller, W.C., Perinatal depression: prevalence, screening accuracy, and screening outcomes. Evid. Rep. Technol. Assess. (Summ.) 119 (2005), 1–8.
20. Gold, P.W., Chrousos, G.P., Organization of the stress system and its dysregulation in melancholid and atypical depression: high vs. Low CRH/NE states. Mol. Psychiatry 7 (2002), 254–275.
21. Guo, Y., Luan, L., Patil, N.K., Sherwood, E.R., Immunobiology of the IL-15/IL-15Rα complex as an antitumor and antiviral agent. Cytokine Growth Factor Rev. 38 (2017), 10–21.
22. Ha, H., Debnath, B., Neamati, N., Role of the CXCL8-CXCR1/2 Axis in Cancer and inflammatory diseases. Theranostics 7:6 (2017), 1543–1588.
23. Holtan, S.G., Chen, Y., Kaimal, R., Creedon, D.J., Enninga, E.A.I., Nevala, W.K., Markovic, S.N., Growth modeling of the maternal cytokine milieu throughout normal pregnancy: macrophage-derived chemokine decreases as inflammation/counterregulation increases. J. Immunol. Res., 2015, 2015, 952571.
24. Kammerer, M., Taylor, A., Glover, V., The HPA axis and perinatal depression: a hypothesis. Arch. Womens Ment. Health 9 (2006), 187–196.
25. Karlsson, L., Nousiainen, N., Scheinen, N.M., Maksimow, M., Salmi, M., Lehto, S.M., Tolvanen, M., Likkarinen, H., Karlsson, H., Cytokine profile and maternal depression and anxiety symptoms in mid-pregnancy – the FinnBrain Birth Cohort Study. Arch. Womens Mental Health 20 (2017), 39–48.
26. Kishimoto, T., The biology of interleukin-6. Blood 74:1 (1989), 1–10.
27. Knight, R.G., Wall-Manning, H., Spears, G.F., Some norms and reliability data for the state-trait anxiety inventory and the zung self-rating depression scale. Br. J. Clin. Psychol. 22 (1983), 245–249.
28. Kraus, T.A., Sperling, R.S., Engel, S.M., Lo, Y., Kellerman, L., Singh, T., Loubeau, M., Ge, Y., Garrido, J.L., Rodríguez-García, M., Moran, T.M., Peripheral blood cytokine profiling during pregnancy and postpartum periods. Am. J. Reprod. Immunol. 64 (2010), 411–426.
29. Kraus, T.A., Engel, S.M., Sperling, R.S., Kellerman, L., Lo, Y., Wallenstein, S., Escribese, M.M., Garrido, J.L., Singh, T., Loubeau, M., Moran, T.M., Characterizing the pregnancy immune phenotype: results of the viral imunity and pregnancy (VIP) study. J. Clin. Immunol. 32 (2012), 300–311.
30. Leff-Gelman, P., Mancilla-Herrera, I., Flores-Ramos, M., Cruz-Fuentes, C., Reyes-Grajeda, J.P., Garcia-Cuetara, Md.P., Bugnot-Perez, M.D., Pulido-Ascencio, D.E., The immune system and the role of inflammation in perinatal depression. Neurosci. Bull. 32:4 (2016), 398–420.
31. Maes, M., Anderson, G., Kubera, M., Berk, M., Targeting classical IL-6 signalling or Il-6 trans-signalling in depression?. Expert Opin. Ther. Targets 18:5 (2014), 495–512.
32. Miller, A.H., Maletic, V., Raison, C.L., Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol. Psychiatry 65 (2009), 732–741.
33. Mitchell, A.M., Porter, K., Christian, L.M., Examination of the role of obesity in the association between childhood trauma and inflammation during pregnancy. Health Psychol. 37:2 (2018), 114–124.
34. Osborne, L.M., Monk, C., Perinatal depression: the fourth inflammatory morbidity of pregnancy? Theory and literature review. Psychoneuroendocrinology 38 (2013), 1929–1952.
35. Osborne, L.M., Gispen, F., Sanyal, A., Yenokyan, G., Meilman, S., Payne, J.L., Lower allopregnanolone during pregnancy predicts postpartum depression: an exploratory study. Psychoneuroendocrinology 79 (2017), 116–121.
36. Pazos, M., Sperling, R.S., Moran, T.H.M., Kraus, T.A., The influence of pregnancy of systemic immunity. Immunol. Res. 54:1–3 (2012), 254–261.
37. Santangelo, G., Sacco, R., Siciliano, M., Bisecco, A., Muzzo, G., Docimo, R., De Stefano, M., Bonavita, S., Lavorgna, L., Tedeschi, G., Trojano, L., Gallo, A., Anxiety in Multiple Sclerosis: psychometric properties of the State-Trait Anxiety Inventory. Acta Neurol. Scand. 134 (2016), 458–466.
38. Sherer, M.L., Posillico, C.K., Schwarz, J.M., The psychoneuroimmunology of pregnancy. Front. Neuroendocrinol., 27, 2017 pii:S0091-3022(17)30066-3.
39. Skogen, J.C., Overland, S., The fetal origins of adult disease: a narrative review of the epidemiological literature. JRSM Short Rep., 3(8), 2012, 59.
40. Somogyi, A.A., Sia, A.T., Tan, E.-C., Coller, J.K., Hutchinson, M.R., Barratt, D.R., Ethnicity-dependent influence of innate immune genetic markers on morphine PCA requirements and adverse effects in postoperative pain. Pain 157 (2016), 2458–2466.
41. Spielberger, C.D., Gorsuch, R.L., Lushene, R., Vagg, P.R., Jacobs, G.A., Manual for the State-Trait Anxiety Inventory. 1983, Consulting Psychologists Press, Palo Alto, CA.
42. Tucker, P., Pfefferbaum, B., Nitiema, P., Khan, Q., Aggarwal, R., Walling, E.E., Possible link of Interleukin-6 and Interleukin-2 with psychiatric diagnosis, ethnicity, disaster or BMI. Cytokine 96 (2017), 247–252.
43. Unver, N., McAllister, F., IL-6 family cytokines: key inflammatory mediators as biomarkers and potential therapeutic targets. Cytokine Growth Factor Rev., 18, 2018 pii:S1359-6101(18)30045-5.
44. World Health Organization, Mental Health Aspects of Women's Reproductive Health: a Global Review of the Literature. 2009, World Health Organization, Geneva.