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Volumn , Issue , 2016, Pages 442-464

Enabling the large-scale analysis of quantitative high-throughput screening data

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EID: 85051691015     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter
Times cited : (20)

References (36)
  • 1
    • 17744409919 scopus 로고    scopus 로고
    • Application of high-throughput screening techniques to drug discovery
    • Cox B, Denyer JC, Binnie A, et al. Application of high-throughput screening techniques to drug discovery. Prog Med Chem 2000; 37: 83-133.
    • (2000) Prog Med Chem , vol.37 , pp. 83-133
    • Cox, B.1    Denyer, J.C.2    Binnie, A.3
  • 2
    • 0032401982 scopus 로고    scopus 로고
    • High-throughput screening of historic collections: Observations on file size, biological targets, and file diversity
    • Spencer RW. High-throughput screening of historic collections: Observations on file size, biological targets, and file diversity. Biotechnol Bioeng 1998; 61(1): 61-67.
    • (1998) Biotechnol Bioeng , vol.61 , Issue.1 , pp. 61-67
    • Spencer, R.W.1
  • 3
    • 0034680641 scopus 로고    scopus 로고
    • Virtual screening for bioactive molecules by evolutionary De Novo design
    • Schneider G, Clement-Chomienne O, Hilfiger L, et al. Virtual screening for bioactive molecules by evolutionary De Novo design. Angew Chem Int Ed Engl 2000; 39(22): 4130-4133.
    • (2000) Angew Chem Int Ed Engl , vol.39 , Issue.22 , pp. 4130-4133
    • Schneider, G.1    Clement-Chomienne, O.2    Hilfiger, L.3
  • 4
    • 0033606951 scopus 로고    scopus 로고
    • Lead generation using pharmacophore mapping and three-dimensional database searching: Application to muscarinic M(3) receptor antagonists
    • Marriott DP, Dougall IG, Meghani P, et al. Lead generation using pharmacophore mapping and three-dimensional database searching: Application to muscarinic M(3) receptor antagonists. J Med Chem 1999; 42(17): 3210-3216.
    • (1999) J Med Chem , vol.42 , Issue.17 , pp. 3210-3216
    • Marriott, D.P.1    Dougall, I.G.2    Meghani, P.3
  • 5
  • 6
    • 0033915982 scopus 로고    scopus 로고
    • Recent advances in structure-based rational drug design
    • Gane PJ, Dean PM. Recent advances in structure-based rational drug design. Curr Opin Struct Biol 2000; 10(4): 401-404.
    • (2000) Curr Opin Struct Biol , vol.10 , Issue.4 , pp. 401-404
    • Gane, P.J.1    Dean, P.M.2
  • 7
    • 34249040810 scopus 로고    scopus 로고
    • Physics-based methods for studying protein-ligand interactions
    • Huang N, Jacobson MP. Physics-based methods for studying protein-ligand interactions. Curr Opin Drug Discov Dev 2007; 10(3): 325-331.
    • (2007) Curr Opin Drug Discov Dev , vol.10 , Issue.3 , pp. 325-331
    • Huang, N.1    Jacobson, M.P.2
  • 8
    • 33749449880 scopus 로고    scopus 로고
    • Docking and scoring-theoretically easy, practically impossible?
    • Coupez B, Lewis, RA. Docking and scoring-theoretically easy, practically impossible? Curr Med Chem 2006; 13(25): 2995-3003.
    • (2006) Curr Med Chem , vol.13 , Issue.25 , pp. 2995-3003
    • Coupez, B.1    Lewis, R.A.2
  • 9
    • 42349100173 scopus 로고    scopus 로고
    • The chemical genomic portrait of yeast: Uncovering a phenotype for all genes
    • Hillenmeyer ME, Fung E,Wildenhain J, et al. The chemical genomic portrait of yeast: Uncovering a phenotype for all genes. Science 2008; 320(5874): 362-365.
    • (2008) Science , vol.320 , Issue.5874 , pp. 362-365
    • Hillenmeyer, M.E.1    Fung, E.2    Wildenhain, J.3
  • 10
    • 33746789921 scopus 로고    scopus 로고
    • Quantitative high-throughput screening: A titration-based approach that efficiently identifies biological activities in large chemical libraries
    • Inglese J, Auld DS, Jadhav A, et al. Quantitative high-throughput screening: A titration-based approach that efficiently identifies biological activities in large chemical libraries. Proc Natl Acad Sci U S A 2006; 103(31): 11473-11478.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.31 , pp. 11473-11478
    • Inglese, J.1    Auld, D.S.2    Jadhav, A.3
  • 11
    • 34548636526 scopus 로고    scopus 로고
    • New LSD therapies unfolding
    • Kozarich JW. New LSD therapies unfolding. Chem Biol 2007; 14(9): 976-977.
    • (2007) Chem Biol , vol.14 , Issue.9 , pp. 976-977
    • Kozarich, J.W.1
  • 12
    • 34147214417 scopus 로고    scopus 로고
    • A cellular assay for IκBα stabilization using a two-color dual luciferase-based sensor
    • Davis RE, Zhang Y-Q, Southall N, et al. A cellular assay for IκBα stabilization using a two-color dual luciferase-based sensor. Assay Drug Dev Technol 2007; 5: 85-103.
    • (2007) Assay Drug Dev Technol , vol.5 , pp. 85-103
    • Davis, R.E.1    Zhang, Y.-Q.2    Southall, N.3
  • 13
    • 43049109870 scopus 로고    scopus 로고
    • Fluorescence spectroscopic profiling of compound libraries
    • Simeonov A, Jadhav A, Thomas CJ, et al. Fluorescence spectroscopic profiling of compound libraries. J Med Chem 2008; 51(8): 2363-2371.
    • (2008) J Med Chem , vol.51 , Issue.8 , pp. 2363-2371
    • Simeonov, A.1    Jadhav, A.2    Thomas, C.J.3
  • 14
    • 40849137783 scopus 로고    scopus 로고
    • Compound cytotoxicity profiling using quantitative high-throughput screening
    • Xia M, Huang R, Witt KL, et al. Compound cytotoxicity profiling using quantitative high-throughput screening. Environ Health Perspect 2008, 116(3): 284-291.
    • (2008) Environ Health Perspect , vol.116 , Issue.3 , pp. 284-291
    • Xia, M.1    Huang, R.2    Witt, K.L.3
  • 15
    • 41849099259 scopus 로고    scopus 로고
    • Characterization of diversity in toxicity mechanism using in vitro cytotoxicity assays in quantitative high throughput screening
    • Huang R, Southall N, Cho MH, et al. Characterization of diversity in toxicity mechanism using in vitro cytotoxicity assays in quantitative high throughput screening. Chem Res Toxicol 2008; 21(3): 659-667.
    • (2008) Chem Res Toxicol , vol.21 , Issue.3 , pp. 659-667
    • Huang, R.1    Southall, N.2    Cho, M.H.3
  • 16
    • 85051689017 scopus 로고    scopus 로고
    • IkB Signaling qHTS Assay
    • PubChem, IkB Signaling qHTS Assay. http://pubchem.ncbi.nlm.nih.gov/assay /assay.cgi?aid=445.
  • 17
    • 40149087853 scopus 로고    scopus 로고
    • Compound management for quantitative highthroughput screening
    • Yasgar A, Shinn P, Jadhav A, et al. Compound management for quantitative highthroughput screening. JALA 2008; 13(2): 79-89.
    • (2008) JALA , vol.13 , Issue.2 , pp. 79-89
    • Yasgar, A.1    Shinn, P.2    Jadhav, A.3
  • 18
    • 45149129386 scopus 로고    scopus 로고
    • NCGC, Eli Lilly and Company. Assay Guidance Manual. http://www.ncgc.nih.gov /guidance/index.html.
    • Assay Guidance Manual
  • 19
    • 32344448950 scopus 로고    scopus 로고
    • Statistical practice in high-throughput screening data analysis
    • Malo N, Hanley JA, Cerquozzi S, et al. Statistical practice in high-throughput screening data analysis. Nat Biotechnol 2006; 24(2): 167-175.
    • (2006) Nat Biotechnol , vol.24 , Issue.2 , pp. 167-175
    • Malo, N.1    Hanley, J.A.2    Cerquozzi, S.3
  • 20
    • 23844517718 scopus 로고    scopus 로고
    • Quantifying bioactivity on a large scale: quality assurance and analysis of multiparametric ultra-HTS data
    • Heyse S, Brodte A, Bruttger O, et al. Quantifying bioactivity on a large scale: quality assurance and analysis of multiparametric ultra-HTS data. JALA 2005; 10(4): 207-212.
    • (2005) JALA , vol.10 , Issue.4 , pp. 207-212
    • Heyse, S.1    Brodte, A.2    Bruttger, O.3
  • 21
    • 1542702936 scopus 로고    scopus 로고
    • A simple technique for reducing edge effect in cell-based assays
    • Lundholt BK, Scudder KM, Pagliaro L. A simple technique for reducing edge effect in cell-based assays. J Biomol Screen 2003; 8(5): 566-570.
    • (2003) J Biomol Screen , vol.8 , Issue.5 , pp. 566-570
    • Lundholt, B.K.1    Scudder, K.M.2    Pagliaro, L.3
  • 24
    • 43049089747 scopus 로고    scopus 로고
    • Identification of promiscuous small molecule activators in high-throughput enzyme activation screens
    • Goode DR, Totten RK, Heeres, JT, et al. Identification of promiscuous small molecule activators in high-throughput enzyme activation screens. JMed Chem 2008; 51(8): 2346-2349.
    • (2008) JMed Chem , vol.51 , Issue.8 , pp. 2346-2349
    • Goode, D.R.1    Totten, R.K.2    Heeres, J.T.3
  • 25
    • 0003043542 scopus 로고
    • The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves
    • Hill AV. The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves. J Physiol 1910; 40(Suppl): iv-vii.
    • (1910) J Physiol , vol.40 , pp. iv-vii
    • Hill, A.V.1
  • 26
    • 0030768931 scopus 로고    scopus 로고
    • The Hill equation revisited: uses and misuses
    • Weiss JN. The Hill equation revisited: uses and misuses. FASEB J 1997; 11(11): 835-841.
    • (1997) FASEB J , vol.11 , Issue.11 , pp. 835-841
    • Weiss, J.N.1
  • 28
    • 85051690052 scopus 로고    scopus 로고
    • GeneBLAzer® Technology Overview
    • Invitrogen, GeneBLAzer® Technology Overview. http://www.invitrogen.com /site/us/en/home/Products-and-Services/Applications/Drug-Discovery/Targetand-Lead-Identification-and-Validation/g-protein coupled html/GPCR-Cell-Based-Assays/GeneBLAzer-Theory.html.
  • 29
    • 28944449789 scopus 로고    scopus 로고
    • Novel statistical approach for primary high-throughput screening hit selection
    • Yan SF, Asatryan H, Li J, et al. Novel statistical approach for primary high-throughput screening hit selection. J Chem Inf Model 2005; 45(6): 1784-1790.
    • (2005) J Chem Inf Model , vol.45 , Issue.6 , pp. 1784-1790
    • Yan, S.F.1    Asatryan, H.2    Li, J.3
  • 30
    • 85051691382 scopus 로고    scopus 로고
    • Columbus, OH: Leadscope
    • Leadscope Leadscope, Columbus, OH: Leadscope.
  • 32
    • 0344741467 scopus 로고    scopus 로고
    • Expanded substrate screenings of human and Drosophila type 10 17beta-hydroxysteroid dehydrogenases (HSDs) reveal multiple specificities in bile acid and steroid hormone metabolism: Characterization ofmultifunctional 3alpha/7alpha/7beta/17beta/20beta/21-HSD
    • Shafqat N, Marschall HU, Filling C, et al. Expanded substrate screenings of human and Drosophila type 10 17beta-hydroxysteroid dehydrogenases (HSDs) reveal multiple specificities in bile acid and steroid hormone metabolism: Characterization ofmultifunctional 3alpha/7alpha/7beta/17beta/20beta/21-HSD. Biochem J 2003; 376(Pt 1): 49-60.
    • (2003) Biochem J , vol.376 , pp. 49-60
    • Shafqat, N.1    Marschall, H.U.2    Filling, C.3
  • 34
    • 85051688903 scopus 로고    scopus 로고
    • PubChem, Pyruvate Kinase. http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?.
    • Pyruvate Kinase
  • 36
    • 85051690683 scopus 로고    scopus 로고
    • GeneData GeneData Screener
    • GeneData AG, Basel, Switzerland
    • GeneData GeneData Screener, GeneData AG, Basel, Switzerland.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.