Characteristics of depressive and bipolar disorder patients with mixed features

Acta Psychiatrica Scandinavica

Volumn 138, Issue 3, 2018, Pages 243-252

  Tondo, L ^a,b,c   Vazquez G H ^a,d   Pinna, M ^c   Vaccotto, P A ^e   Baldessarini, R J ^a,b  

^a MCLEAN HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Lucio Bini Mood Disorder Center   (Italy)

^d QUEEN S UNIVERSITY   (Canada)

^e Morra Foundation for the Progress of Psychiatry   (Argentina)

Author keywords

bipolar disorder; depression; hypomania; major depressive disorder; mania; mixed features

Indexed keywords

ANTIDEPRESSANT AGENT; MOOD STABILIZER; NEUROLEPTIC AGENT; TRANQUILIZER;

ADULT; AGITATION; ANXIETY DISORDER; ARTICLE; BIPOLAR DEPRESSION; BIPOLAR DISORDER; CLINICAL FEATURE; DIVORCE; FEMALE; FIRST-DEGREE RELATIVE; HOSPITALIZATION; HUMAN; HYPOMANIA; IRRITABILITY; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MANIA; MIDDLE AGED; MIXED MANIA AND DEPRESSION; PREVALENCE; PRIORITY JOURNAL; SELF CONCEPT; SEX DIFFERENCE; SUBSTANCE ABUSE; SUICIDAL BEHAVIOR; SUICIDE ATTEMPT; TEMPERAMENT; TEMPERAMENT EVALUATION OF MEMPHIS, PISA, PARIS AND SAN DIEGO; CLASSIFICATION; COMBINATION DRUG THERAPY; COMPARATIVE STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DRUG DEPENDENCE; ITALY; MOOD DISORDER; PROSPECTIVE STUDY; PSYCHOLOGY;

ADULT; ANTIDEPRESSIVE AGENTS; ANTIMANIC AGENTS; ANTIPSYCHOTIC AGENTS; BIPOLAR DISORDER; DEPRESSIVE DISORDER, MAJOR; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; IRRITABLE MOOD; ITALY; MALE; MIDDLE AGED; MOOD DISORDERS; PREVALENCE; PROSPECTIVE STUDIES; SUBSTANCE-RELATED DISORDERS; SUICIDE, ATTEMPTED;

EID: 85051643141     PISSN: 0001690X     EISSN: 16000447     Source Type: Journal    
DOI: 10.1111/acps.12911     Document Type: Article

References (37)

1. Baldessarini RJ, Pérez J, Salvatore P, Trede K, Maggini C. History of bipolar manic-depressive disorder. In: Yildiz A, Nemeroff C, Ruiz P, eds. The Bipolar Book: history, Neurobiology, and Treatment. New York City: Oxford University Press, 2015:3–20
2. Trede K, Salvatore P, Baethge C, Gerhard A, Maggini C, Baldessarini RJ. Manic-depressive illness: evolution in Kraepelin's Textbook, 1883-1926. Harv Rev Psychiatry 2005;13:155–178
3. Salvatore P, Baldessarini RJ, Centorrino F et al. Weygandt's on the mixed states of manic-depressive insanity: a translation and commentary on its significance in the evolution of the concept of bipolar disorder. Harv Rev Psychiatry 2002;10:255–275
4. Goldberg JF, Perlis RH, Bowden CL et al. Manic symptoms during depressive episodes in 1,380 patients with bipolar disorder: findings from the STEP-BD. Am J Psychiatry 2009;166:173–181
5. Baldessarini RJ, Salvatore P, Khalsa HK, Tohen M. Dissimilar morbidity following initial mania versus mixed-states in type-I bipolar disorder. J Affect Disord 2010;126:299–302
6. Miller S, Suppes T, Mintz J et al. Mixed depression in bipolar disorder: prevalence rate and clinical correlates during naturalistic follow-up in the Stanley bipolar network. Am J Psychiatry 2016;173:1015–1023
7. Swann AC. Mixed features: evolution of the concept, past and current definitions, and future prospects. CNS Spectr 2017;22:161–169
8. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 4th edn (DSM-IV). Arlington, VA: American Psychiatric Press, 1994
9. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 5th edn (DSM-5). Arlington, VA: American Psychiatric Press, 2013
10. Perugi G, Angst J, Azorin J-M et al. Mixed features in patients with a major depressive episode: the BRIDGE-II-MIX study. J Clin Psychiatry 2015;76:e351–e358
11. Koukopoulos A, Koukopoulos A. Agitated depression as a mixed state and the problem of melancholia. Psychiatr Clin North Am 1999;22:547–564
12. Benazzi F, Koukopoulos A, Akiskal HS. Toward a validation of a new definition of agitated depression as a bipolar mixed state (mixed depression). Eur Psychiatry 2004;19:85–90
13. Swann AC, Moeller FG, Steinberg JL, Schneider L, Barratt ES, Dougherty DM. Manic symptoms and impulsivity during bipolar depressive episodes. Bipolar Disord 2007;9:206–212
14. Judd LL, Schettler PJ, Akiskal H et al. Prevalence and clinical significance of subsyndromal manic symptoms, including irritability and psychomotor agitation, during bipolar major depressive episodes. J Affect Disord 2012;138:440–448
15. Koukopoulos A, Sani G, Ghaemi SN. Mixed features of depression: why DSM-5 is wrong (and so was DSM-IV). Br J Psychiatry 2013;203:3–5
16. Swann AC, Lafer B, Perugi G et al. Bipolar mixed states: an international society for bipolar disorders task force report of symptom structure, course of illness, and diagnosis. Am J Psychiatry 2013;170:31–42
17. Tondo L, Baldessarini RJ, Vázquez G, Lepri B, Visioli C. Clinical responses to antidepressants among 1036 acutely depressed patients with bipolar or unipolar major affective disorders. Acta Psychiatr Scand 2013;127:355–364
18. Sani G, Vöhringer PA, Napoletano F et al. Koukopoulos’ diagnostic criteria for mixed depression: a validation study. J Affect Disord 2014;164:14–18
19. Vieta E, Grunze H, Azorin JM, Fagiolini A. Phenomenology of manic episodes according to the presence or absence of depressive features as defined in DSM-5: results from the IMPACT self-reported online survey. J Affect Disord 2014;156:206–213
20. Takeshima M, Oka T. DSM-5-defined ‘mixed features’ and Benazzi's mixed depression: which is practically useful to discriminate bipolar disorder from unipolar depression in patients with depression? Psychiatry Clin Neurosci 2015;69:109–116
21. Weibel S, Bertschy G. Dépression mixte et DSM-5: mise au point critique. Encephale 2016;42:90–98
22. Koukopoulos A, Reginaldi D, Tondo L, Visioli C, Baldessarini RJ. Course sequences in bipolar disorder: depressions preceding or following manias or hypomanias. J Affect Disord 2013;151:105–110
23. Tondo L, Visioli C, Preti A, Baldessarini RJ. Bipolar disorders following initial depression: modeling predictive clinical factors. J Affect Disord 2014;167:44–49
24. Rosenblat JD, McIntyre RS. Treatment recommendations for DSM-5-defined mixed features. CNS Spectr 2017;22:147–154
25. Solé E, Garriga M, Valentí M, Vieta E. Mixed features in bipolar disorder. CNS Spectr 2017;22:134–140
26. Akiskal HS, Mendlowicz MV, Jean-Louis G et al. TEMPS-A: validation of a short version of a self-rated instrument designed to measure variations in temperament. J Affect Disord 2005;85:45–52
27. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23:56–62
28. Hamilton M. Hamilton anxiety rating scale (HAM-A). J Med 1959;61:81–82
29. Montgomery SA, Åsberg M. A new depression scale designed to be sensitive to change. Br J Psychiatry 1979;134:382–389
30. Hirschfeld RM, Williams JB, Spitzer RL et al. Development and validation of a screening instrument for bipolar spectrum disorder: the mood disorder questionnaire. Am J Psychiatry 2000;157:1873–1875
31. Young RC, Biggs JT, Ziegler VE, Meyer DA. A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry 1978;133:429–435
32. Koukopoulos A, Sani G. DSM-5 criteria for depression with mixed features: a farewell to mixed depression. Acta Psychiatr Scand 2014;129:4–16
33. Vázquez GH, Lolich M, Cabrera C et al. Mixed symptoms in major depressive and bipolar disorders: systematic review. J Affect Disord 2018;225:756–760
34. Hasin DS, Sarvet AL, Meyers JL et al. Epidemiology of adult DSM-5 major depressive disorder and Its specifiers in the United States. JAMA Psychiatry 2018;75:336–346
35. Persons JE, Coryell WH, Solomon DA, Keller MB, Endicott J, Fiedorowicz JG. Mixed state and suicide: is the effect of mixed state on suicidal behavior more than the sum of its parts? Bipolar Disord 2018;20:35–41
36. Tundo A, Musetti L, Benedetti A et al. Predictors of recurrence during long-term treatment of bipolar I and II disorders. A 4 year prospective naturalistic study. J Affect Disord 2018;225:123–128
37. Stahl SM, Morrissette DA, Faedda GL et al. Guidelines for the recognition and management of mixed depression. CNS Spectr 2017;22:203–219