Clinical responses to antidepressants among 1036 acutely depressed patients with bipolar or unipolar major affective disorders

Acta Psychiatrica Scandinavica

Volumn 127, Issue 5, 2013, Pages 355-364

  Tondo, L ^a,b   Baldessarini, R J ^a,c   Vazquez G ^a,d   Lepri, B ^b   Visioli, C ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Lucio Bini Mood Disorder Center   (Italy)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF PALERMO   (Argentina)

Author keywords

Antidepressant response; Bipolar disorder; Depression; Major depressive disorder; Switching

Indexed keywords

ANTIDEPRESSANT AGENT; ARIPIPRAZOLE; CARBAMAZEPINE; DULOXETINE; LAMOTRIGINE; LITHIUM CARBONATE; MAPROTILINE; MIANSERIN; MONOAMINE OXIDASE INHIBITOR; OLANZAPINE; QUETIAPINE; SEROTONIN UPTAKE INHIBITOR; TRANYLCYPROMINE; VALPROIC ACID; VENLAFAXINE;

ADULT; ARTICLE; BIPOLAR I DISORDER; BIPOLAR II DISORDER; DEPRESSION; DISEASE ASSOCIATION; DISEASE DURATION; FEMALE; HAMILTON SCALE; HUMAN; HYPOTHESIS; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MANIA; PRIORITY JOURNAL; REMISSION; SURVIVAL; TREATMENT OUTCOME; UNIPOLAR MAJOR DEPRESSION;

ADULT; ANTIDEPRESSIVE AGENTS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; BIPOLAR DISORDER; DEPRESSIVE DISORDER, MAJOR; FEMALE; HUMANS; MALE; MIDDLE AGED; MONOAMINE OXIDASE INHIBITORS; SEROTONIN UPTAKE INHIBITORS; TREATMENT OUTCOME;

EID: 84876475748     PISSN: 0001690X     EISSN: 16000447     Source Type: Journal    
DOI: 10.1111/acps.12023     Document Type: Article

References (40)

1. Goodwin FK, Jamison KR. Manic-depressive illness, 2nd edn, 2007. New York: Oxford University Press: 754-756.
2. Baldessarini RJ, Vieta E, Calabrese JR, Tohen M, Bowden C. Bipolar depression: overview and commentary. Harv Rev Psychiatry 2010;18:143-157.
3. Amit BH, Weizman A. Antidepressant treatment for acute bipolar depression: update. Depress Res Treat 2012;684-725.
4. Gijsman HJ, Geddes JR, Rendell JM, Nolen WA, Goodwin GM. Antidepressants for bipolar depression: systematic review of randomized, controlled trials. Am J Psychiatry 2004;161:1537-1547.
5. Sachs GS, Nierenberg AA, Calabrese JR et al. Effectiveness of adjunctive antidepressant treatment for bipolar depression. N Engl J Med 2007;356:1711-1722.
6. Ghaemi SN, Wingo AP, Filkowski MA, Goodwin FK, Baldessarini RJ. Effectiveness of long-term antidepressant treatment in bipolar disorder: meta-analysis. Acta Psychiatr Scand 2008;118:347-356.
7. Sidor MM, MacQueen GM. Antidepressants for the acute treatment of bipolar depression: systematic review and meta-analysis. J Clin Psychiatry 2011;72:156-167.
8. Rybakowski JK. Bipolarity and inadequate response to antidepressant drugs: clinical and psychopharmacological perspective. J Affect Disord 2012;136:e13-e19.
9. Möller H-J, Bottlender R, Grunze H, Strauss A, Wittmann J. Are antidepressants less effective in the acute treatment of bipolar I compared to unipolar depression? J Affect Disord 2001;67:141-146.
10. Bottlender R, Rudolf D, Jäger M, Strauss A, Möller H-J. Are bipolar-I depressive patients less responsive to treatment with antidepressants than unipolar depressive patients? Results from a case-control study. Eur Psychiatry 2002;17:200-205.
11. Vázquez G, Tondo L, Baldessarini RJ. Comparison of antidepressant responses in patients with bipolar vs. unipolar depression: meta-analytic review. Pharmacopsychiatry 2011;44:21-26.
12. Baldessarini RJ, Leahy L, Arcona S, Gause D, Zhang W, Hennen J. Patterns of psychotropic drug prescription for U.S. patients with diagnoses of bipolar disorders. Psychiatr Serv 2007;58:85-91.
13. Baldessarini R, Henk H, Sklar A, Chang J, Leahy L. Psychotropic medications for patients with bipolar disorder in the United States: polytherapy and adherence. Psychiatr Serv 2008;59:1175-1183.
14. Sussman M, Friedman M, Korn JR, Hassan M, Kim J, Menzin J. Relationship between use of antidepressants and resource utilization among patients with manic or mixed bipolar disorder episodes: findings from a managed care setting. J Affect Disord 2012;138:425-432.
15. Spitzer RL, Williams JB, Gibbon M, First MB. Structured Clinical Interview for DSM-III-R (SCID). Arch Gen Psychiatry 1992;49:624-629.
16. Tondo L, Lepri B, Baldessarini RJ. Suicidal status during antidepressant treatment in 789 Sardinian patients with major affective disorder. Acta Psychiatr Scand 2008;118:106-115.
17. Baldessarini RJ, Tondo L, Ghiani C, Lepri B. Discontinuation rate vs. recurrence risk following long-term antidepressant treatment in major depressive disorder patients. Am J Psychiatry 2010;167:934-941.
18. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23:56-62.
19. Koukopoulos A, Sani G, Koukopoulos AE, Manfredi G, Pacchiarotti I, Girardi P. Melancholia agitata and mixed depression. Acta Psychiatr Scand 2007;433:50-57.
20. Tondo L, Vázquez G, Baldessarini RJ. Mania associated with antidepressant-treatment: comprehensive meta-analytic review. Acta Psychiatr Scand 2010;121:404-414.
21. Angst J, Gamma A, Bowden CL et al. Diagnostic criteria for bipolarity based on an international sample of 5, 635 patients with DSM-IV major depressive episodes. Eur Arch Psychiatry Clin Neurosci 2012;262:3-11.
22. Dierckx B, Heijnen WT, van den Broek WW, Birkenhäger TK. Efficacy of electroconvulsive therapy in bipolar versus unipolar major depression: a meta-analysis. Bipolar Disord 2012;14:146-150.
23. Bailine S, Fink M, Knapp R et al. Electroconvulsive therapy is equally effective in unipolar and bipolar depression. Acta Psychiatr Scand 2010;121:431-436.
24. Undurraga K, Baldessarini RJ, Valenti M et al. Bipolar depression: clinical correlates of receiving antidepressants. J Affect Disord 2012;139:89-93.
25. Lorenzo L, Vázquez GH, Zaratiegui RM, Tondo L, Baldessarini RJ. Characteristics of bipolar disorder patients given antidepressants. Hum Psychopharmacol 2012;27:486-491.
26. Baldessarini RJ, Salvatore P, Khalsa HM et al. Morbidity in 303 first-episode bipolar I disorder patients. Bipolar Disord 2010;12:264-270.
27. Kukopulos A, Caliari B, Tundo A et al. Rapid cyclers, temperament, and antidepressants. Compr Psychiatry 1983;24:249-258.
28. Altshuler LL, Post RM, Leverich GS, Mikalauskas K, Rosoff A, Ackerman L. Antidepressant-induced mania and cycle acceleration: a controversy revisited. Am J Psychiatry 1995;152:1130-1138.
29. Joffe RT, MacQueen GM, Marriott M, Robb J, Begin H, Young LT. Induction of mania and cycle acceleration in bipolar disorder: effect of different classes of antidepressants. Acta Psychiatr Scand 2002;105:427-430.
30. Undurraga J, Baldessarini RJ. Randomized, placebo-controlled trials of antidepressants for acute major depression: thirty-year meta-analytic review. Neuropsychopharmacology 2012;37:851-864.
31. Mendels J, Secunda SK, Dyson WL. Controlled study of the antidepressant effects of lithium carbonate. Arch Gen Psychiatry 1972;26:154-157.
32. Akiskal HS, Benazzi F, Perugi G, Rihmer ZJ. Agitated "unipolar" depression re-conceptualized as a depressive mixed state: implications for the antidepressant-suicide controversy. J Affect Disord 2005;85:245-258.
33. Koukopoulos A, Albert MJ, Sani G, Koukopoulos AE, Girardi P. Mixed depressive states: nosologic and therapeutic issues. Int Rev Psychiatry 2005;17:21-37.
34. Balazs J, Benazzi F, Rihmer Z, Rihmer A, Akiskal KK, Akiskal HS. The close link between suicide attempts and mixed (bipolar) depression: implications for suicide prevention. J Affect Disord 2006;91:133-138.
35. Maj M, Pirozzi R, Magliano L, Fiorillo A, Bartoli L. Agitated "unipolar" major depression: prevalence, phenomenology, and outcome. J Clin Psychiatry 2006;67:712-719.
36. Olgiati P, Serretti A, Colombo C. Retrospective analysis of psychomotor agitation, hypomanic symptoms, and suicidal ideation in unipolar depression. Depress Anxiety 2006;23:389-397.
37. Bauer M, Glenn T, Grof P, Schmid R, Pfennig A, Whybrow PC. Subsyndromal mood symptoms: a useful concept for maintenance studies of bipolar disorder? Psychopathology 2010;43:1-7.
38. Pacchiarotti I, Mazzarini L, Kotzalidis GD et al. Mania and depression: mixed, not stirred. J Affect Disord 2011;133:105-113.
39. Valentí M, Pacchiarotti I, Bonnín CM et al. Risk factors for antidepressant-related switch to mania. J Clin Psychiatry 2012;73:e271-e276.
40. Ghaemi SN, Rosenquist KL, Ko JY, Baldessano CF, Kontos NJ, Baldessarini RJ. Antidepressant treatment in bipolar versus unipolar depression. Am J Psychiatry 2004;161:163-165.