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Volumn 4, Issue 3, 2015, Pages 500-519

Specialized cilia in mammalian sensory systems

Author keywords

Connecting cilium; Inner ear; Intraflagellar transport; Kinocilium; Olfactory epithelium; Primary cilia; Retina

Indexed keywords

CENTROSOME; CILIARY DYSKINESIA; CILIATE; COCHLEA; DROSOPHILA; FLAGELLUM; HAIR CELL; KIDNEY POLYCYSTIC DISEASE; NONHUMAN; OLFACTORY EPITHELIUM; PHOTORECEPTOR; PIGMENT EPITHELIUM; POLYDACTYLY; RESPIRATORY EPITHELIUM; RETINA; RETINITIS PIGMENTOSA; REVIEW; SENSORY SYSTEM; SMELLING;

EID: 85050578150     PISSN: None     EISSN: 20734409     Source Type: Journal    
DOI: 10.3390/cells4030500     Document Type: Review
Times cited : (88)

References (109)
  • 1
  • 2
    • 0032428685 scopus 로고    scopus 로고
    • Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein
    • Nonaka, S.; Tanaka, Y.; Okada, Y.; Takeda, S.; Harada, A.; Kanai, Y.; Kido, M.; Hirokawa, N. Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein. Cell 1998, 95, 829–837
    • (1998) Cell , vol.95 , pp. 829-837
    • Nonaka, S.1    Tanaka, Y.2    Okada, Y.3    Takeda, S.4    Harada, A.5    Kanai, Y.6    Kido, M.7    Hirokawa, N.8
  • 3
  • 4
    • 33947384151 scopus 로고    scopus 로고
    • Overview of structure and function of mammalian cilia
    • Satir, P.; Christensen, S.T. Overview of structure and function of mammalian cilia. Annu Rev. Physiol. 2007, 69, 377–400
    • (2007) Annu Rev. Physiol , vol.69 , pp. 377-400
    • Satir, P.1    Christensen, S.T.2
  • 5
    • 38349000827 scopus 로고    scopus 로고
    • Intraflagellar transport motors in cilia: Moving along the cell’s antenna
    • Scholey, J.M. Intraflagellar transport motors in cilia: Moving along the cell’s antenna. J. Cell Biol. 2008, 180, 23–29
    • (2008) J. Cell Biol , vol.180 , pp. 23-29
    • Scholey, J.M.1
  • 6
    • 0037744859 scopus 로고    scopus 로고
    • The intraflagellar transport machinery of chlamydomonas reinhardtii
    • Cole, D.G. The intraflagellar transport machinery of chlamydomonas reinhardtii. Traffic 2003, 4, 435–442
    • (2003) Traffic , vol.4 , pp. 435-442
    • Cole, D.G.1
  • 8
    • 67649635952 scopus 로고    scopus 로고
    • Intraflagellar transport and the generation of dynamic, structurally and functionally diverse cilia
    • Silverman, M.A.; Leroux, M.R. Intraflagellar transport and the generation of dynamic, structurally and functionally diverse cilia. Trends Cell Biol. 2009, 19, 306–316
    • (2009) Trends Cell Biol , vol.19 , pp. 306-316
    • Silverman, M.A.1    Leroux, M.R.2
  • 9
    • 58149326846 scopus 로고    scopus 로고
    • Intraflagellar transport (IFT) role in ciliary assembly, resorption and signalling
    • Pedersen, L.B.; Rosenbaum, J.L. Intraflagellar transport (IFT) role in ciliary assembly, resorption and signalling. Curr. Top. Dev. Biol. 2008, 85, 23–61
    • (2008) Curr. Top. Dev. Biol , vol.85 , pp. 23-61
    • Pedersen, L.B.1    Rosenbaum, J.L.2
  • 10
    • 77951101203 scopus 로고    scopus 로고
    • The primary cilium: A signalling centre during vertebrate development
    • Goetz, S.C.; Anderson, K.V. The primary cilium: A signalling centre during vertebrate development. Nat. Rev. Genet. 2010, 11, 331–344
    • (2010) Nat. Rev. Genet , vol.11 , pp. 331-344
    • Goetz, S.C.1    Anderson, K.V.2
  • 11
    • 84855921143 scopus 로고    scopus 로고
    • The RABL5 homolog IFT22 regulates the cellular pool size and the amount of IFT particles partitioned to the flagellar compartment in chlamydomonas reinhardtii
    • Silva, D.A.; Huang, X.; Behal, R.H.; Cole, D.G.; Qin, H. The RABL5 homolog IFT22 regulates the cellular pool size and the amount of IFT particles partitioned to the flagellar compartment in chlamydomonas reinhardtii. Cytoskelet. (Hoboken NJ) 2012, 69, 33–48
    • (2012) Cytoskelet. (Hoboken NJ) , vol.69 , pp. 33-48
    • Silva, D.A.1    Huang, X.2    Behal, R.H.3    Cole, D.G.4    Qin, H.5
  • 12
    • 84899629599 scopus 로고    scopus 로고
    • The gtpase IFT27 is involved in both anterograde and retrograde intraflagellar transport
    • Huet, D.; Blisnick, T.; Perrot, S.; Bastin, P. The gtpase IFT27 is involved in both anterograde and retrograde intraflagellar transport. eLife 2014, 3, e02419, doi:10.7554/eLife.02419
    • (2014) Elife , vol.3
    • Huet, D.1    Blisnick, T.2    Perrot, S.3    Bastin, P.4
  • 14
    • 17244366458 scopus 로고    scopus 로고
    • Kupffer’s vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut
    • Essner, J.J.; Amack, J.D.; Nyholm, M.K.; Harris, E.B.; Yost, H.J. Kupffer’s vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut. Development 2005, 132, 1247–1260
    • (2005) Development , vol.132 , pp. 1247-1260
    • Essner, J.J.1    Amack, J.D.2    Nyholm, M.K.3    Harris, E.B.4    Yost, H.J.5
  • 15
    • 18844393668 scopus 로고    scopus 로고
    • Cilia-driven fluid flow in the zebrafish pronephros, brain and kupffer’s vesicle is required for normal organogenesis
    • Kramer-Zucker, A.G.; Olale, F.; Haycraft, C.J.; Yoder, B.K.; Schier, A.F.; Drummond, I.A. Cilia-driven fluid flow in the zebrafish pronephros, brain and kupffer’s vesicle is required for normal organogenesis. Development 2005, 132, 1907–1921
    • (2005) Development , vol.132 , pp. 1907-1921
    • Kramer-Zucker, A.G.1    Olale, F.2    Haycraft, C.J.3    Yoder, B.K.4    Schier, A.F.5    Drummond, I.A.6
  • 16
    • 84905757257 scopus 로고    scopus 로고
    • Symmetry breakage in the vertebrate embryo: When does it happen and how does it work?
    • Blum, M.; Schweickert, A.; Vick, P.; Wright, C.V.; Danilchik, M.V. Symmetry breakage in the vertebrate embryo: When does it happen and how does it work? Dev. Biol 2014, 393, 109–123
    • (2014) Dev. Biol , vol.393 , pp. 109-123
    • Blum, M.1    Schweickert, A.2    Vick, P.3    Wright, C.V.4    Danilchik, M.V.5
  • 18
    • 84920077246 scopus 로고    scopus 로고
    • Map4-dependent regulation of microtubule formation affects centrosome, cilia, and golgi architecture as a central mechanism in growth regulation
    • Zahnleiter, D.; Hauer, N.N.; Kessler, K.; Uebe, S.; Sugano, Y.; Neuhauss, S.C.; Gießl, A.; Ekici, A.B.; Blessing, H.; Sticht, H.; et al. Map4-dependent regulation of microtubule formation affects centrosome, cilia, and golgi architecture as a central mechanism in growth regulation. Hum. Mutat. 2015, 36, 87–97
    • (2015) Hum. Mutat , vol.36 , pp. 87-97
    • Zahnleiter, D.1    Hauer, N.N.2    Kessler, K.3    Uebe, S.4    Sugano, Y.5    Neuhauss, S.C.6    Gießl, A.7    Ekici, A.B.8    Blessing, H.9    Sticht, H.10
  • 21
  • 22
    • 84938127692 scopus 로고    scopus 로고
    • A missense mutation in DCDC2 causes human recessive deafness DFNB66, likely by interfering with sensory hair cell and supporting cell cilia length regulation
    • Grati, M.; Chakchouk, I.; Ma, Q.; Bensaid, M.; Desmidt, A.; Turki, N.; Yan, D.; Baanannou, A.; Mittal, R.; Driss, N., et al. A missense mutation in DCDC2 causes human recessive deafness DFNB66, likely by interfering with sensory hair cell and supporting cell cilia length regulation. Hum. Mol. Genet. 2015, 24, 2482–2491
    • (2015) Hum. Mol. Genet , vol.24 , pp. 2482-2491
    • Grati, M.1    Chakchouk, I.2    Ma, Q.3    Bensaid, M.4    Desmidt, A.5    Turki, N.6    Yan, D.7    Baanannou, A.8    Mittal, R.9    Driss, N.10
  • 23
    • 0032509405 scopus 로고    scopus 로고
    • Characterization of the major bovine brain go alpha isoforms. Mapping the structural differences between the alpha subunit isoforms identifies a variable region of the protein involved in receptor interactions
    • McIntire, W.E.; Dingus, J.; Schey, K.L.; Hildebrandt, J.D. Characterization of the major bovine brain go alpha isoforms. Mapping the structural differences between the alpha subunit isoforms identifies a variable region of the protein involved in receptor interactions. J. Biol. Chem. 1998, 273, 33135–33141
    • (1998) J. Biol. Chem , vol.273 , pp. 33135-33141
    • McIntire, W.E.1    Dingus, J.2    Schey, K.L.3    Hildebrandt, J.D.4
  • 27
    • 77956112944 scopus 로고    scopus 로고
    • Interaction of retinitis pigmentosa gtpase regulator (Rpgr) with RAB8A gtpase: Implications for cilia dysfunction and photoreceptor degeneration
    • Murga-Zamalloa, C.A.; Atkins, S.J.; Peranen, J.; Swaroop, A.; Khanna, H. Interaction of retinitis pigmentosa gtpase regulator (rpgr) with RAB8A gtpase: Implications for cilia dysfunction and photoreceptor degeneration. Hum. Mol. Genet. 2010, 19, 3591–3598
    • (2010) Hum. Mol. Genet , vol.19 , pp. 3591-3598
    • Murga-Zamalloa, C.A.1    Atkins, S.J.2    Peranen, J.3    Swaroop, A.4    Khanna, H.5
  • 28
    • 27144460671 scopus 로고    scopus 로고
    • Fisher, S.; et al. Disruption of bardet-biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates
    • Ross, A.J.; May-Simera, H.; Eichers, E.R.; Kai, M.; Hill, J.; Jagger, D.J.; Leitch, C.C.; Chapple, J.P.; Munro, P.M.; Fisher, S.; et al. Disruption of bardet-biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates. Nat. Genet. 2005, 37, 1135–1140
    • (2005) Nat. Genet , vol.37 , pp. 1135-1140
    • Ross, A.J.1    May-Simera, H.2    Eichers, E.R.3    Kai, M.4    Hill, J.5    Jagger, D.J.6    Leitch, C.C.7    Chapple, J.P.8    Munro, P.M.9
  • 30
    • 33749019339 scopus 로고    scopus 로고
    • Usher syndrome: Molecular links of pathogenesis, proteins and pathways
    • Kremer, H.; van Wijk, E.; Marker, T.; Wolfrum, U.; Roepman, R. Usher syndrome: Molecular links of pathogenesis, proteins and pathways. Hum. Mol. Genet. 2006, 15, R262–R270
    • (2006) Hum. Mol. Genet , vol.15
    • Kremer, H.1    Van Wijk, E.2    Marker, T.3    Wolfrum, U.4    Roepman, R.5
  • 31
    • 84969312999 scopus 로고
    • Usher syndrome: Hearing loss, retinal degeneration and associated abnormalities
    • Mathur, P.; Yang, J. Usher syndrome: Hearing loss, retinal degeneration and associated abnormalities. Biochim. Biophys. Acta 2015, 1852, 406–420
    • (1852) Biochim. Biophys. Acta , vol.2015 , pp. 406-420
    • Mathur, P.1    Yang, J.2
  • 33
    • 0002861418 scopus 로고
    • The ultrastructure of the kinocilium of the sensory cells in the inner ear and lateral line organs
    • Flock, A.; Duvall, A.J., III. The ultrastructure of the kinocilium of the sensory cells in the inner ear and lateral line organs. J. Cell Biol. 1965, 25, 1–8
    • (1965) J. Cell Biol , vol.25 , pp. 1-8
    • Flock, A.1    Duvall, A.J.2
  • 34
    • 37549032486 scopus 로고    scopus 로고
    • Basal bodies, kinocilia and planar cell polarity
    • Axelrod, J.D. Basal bodies, kinocilia and planar cell polarity. Nat. Genet. 2008, 40, 10–11
    • (2008) Nat. Genet , vol.40 , pp. 10-11
    • Axelrod, J.D.1
  • 35
    • 58149349805 scopus 로고    scopus 로고
    • Primary cilia in planar cell polarity regulation of the inner ear
    • Jones, C.; Chen, P. Primary cilia in planar cell polarity regulation of the inner ear. Curr. Top. Dev. Biol. 2008, 85, 197–224
    • (2008) Curr. Top. Dev. Biol , vol.85 , pp. 197-224
    • Jones, C.1    Chen, P.2
  • 39
    • 78651094693 scopus 로고    scopus 로고
    • Alstrom syndrome protein ALMS1 localizes to basal bodies of cochlear hair cells and regulates cilium-dependent planar cell polarity
    • Jagger, D.; Collin, G.; Kelly, J.; Towers, E.; Nevill, G.; Longo-Guess, C.; Benson, J.; Halsey, K.; Dolan, D.; Marshall, J.; et al. Alstrom syndrome protein ALMS1 localizes to basal bodies of cochlear hair cells and regulates cilium-dependent planar cell polarity. Hum. Mol. Genet. 2011, 20, 466–481
    • (2011) Hum. Mol. Genet , vol.20 , pp. 466-481
    • Jagger, D.1    Collin, G.2    Kelly, J.3    Towers, E.4    Nevill, G.5    Longo-Guess, C.6    Benson, J.7    Halsey, K.8    Dolan, D.9    Marshall, J.10
  • 40
    • 39149139311 scopus 로고    scopus 로고
    • Architecture of the mouse utricle: Macular organization and hair bundle heights
    • Li, A.; Xue, J.; Peterson, E.H. Architecture of the mouse utricle: Macular organization and hair bundle heights. J. Neurophysiol. 2008, 99, 718–733
    • (2008) J. Neurophysiol , vol.99 , pp. 718-733
    • Li, A.1    Xue, J.2    Peterson, E.H.3
  • 41
    • 0027968244 scopus 로고
    • Globose basal cells are neuronal progenitors in the olfactory epithelium: A lineage analysis using a replication-incompetent retrovirus
    • Caggiano, M.; Kauer, J.S.; Hunter, D.D. Globose basal cells are neuronal progenitors in the olfactory epithelium: A lineage analysis using a replication-incompetent retrovirus. Neuron 1994, 13, 339–352
    • (1994) Neuron , vol.13 , pp. 339-352
    • Caggiano, M.1    Kauer, J.S.2    Hunter, D.D.3
  • 42
    • 84931006592 scopus 로고    scopus 로고
    • Horizontal basal cell-specific deletion of PAX6 impedes recovery of the olfactory neuroepithelium following severe injury
    • Suzuki, J.; Sakurai, K.; Yamazaki, M.; Abe, M.; Inada, H.; Sakimura, K.; Katori, Y.; Osumi, N. Horizontal basal cell-specific deletion of PAX6 impedes recovery of the olfactory neuroepithelium following severe injury. Stem Cells Dev. 2015, 24, 1923–1933
    • (2015) Stem Cells Dev , vol.24 , pp. 1923-1933
    • Suzuki, J.1    Sakurai, K.2    Yamazaki, M.3    Abe, M.4    Inada, H.5    Sakimura, K.6    Katori, Y.7    Osumi, N.8
  • 43
    • 0020361788 scopus 로고
    • Electron microscopy of human olfactory epithelium reveals a new cell type: The microvillar cell
    • Moran, D.T.; Rowley, J.C., III; Jafek, B.W. Electron microscopy of human olfactory epithelium reveals a new cell type: The microvillar cell. Brain Res. 1982, 253, 39–46
    • (1982) Brain Res , vol.253 , pp. 39-46
    • Moran, D.T.1    Rowley, J.C.2    Jafek, B.W.3
  • 44
    • 0021323556 scopus 로고
    • Ciliated and microvillous structures of rat olfactory and nasal respiratory epithelia. A study using ultra-rapid cryo-fixation followed by freeze-substitution or freeze-etching
    • Menco, B.P. Ciliated and microvillous structures of rat olfactory and nasal respiratory epithelia. A study using ultra-rapid cryo-fixation followed by freeze-substitution or freeze-etching. Cell Tissue Res. 1984, 235, 225–241
    • (1984) Cell Tissue Res , vol.235 , pp. 225-241
    • Menco, B.P.1
  • 45
    • 84923369097 scopus 로고    scopus 로고
    • Direct evidence for bbsome-associated intraflagellar transport reveals distinct properties of native mammalian cilia
    • Williams, C.L.; McIntyre, J.C.; Norris, S.R.; Jenkins, P.M.; Zhang, L.; Pei, Q.; Verhey, K.; Martens, J.R. Direct evidence for bbsome-associated intraflagellar transport reveals distinct properties of native mammalian cilia. Nat. Commun. 2014, 5, 5813, doi:10.1038/ncomms6813
    • (2014) Nat. Commun , vol.5 , pp. 5813
    • Williams, C.L.1    McIntyre, J.C.2    Norris, S.R.3    Jenkins, P.M.4    Zhang, L.5    Pei, Q.6    Verhey, K.7    Martens, J.R.8
  • 46
    • 0035899865 scopus 로고    scopus 로고
    • Localization of intraflagellar transport protein IFT52 identifies basal body transitional fibers as the docking site for IFT particles
    • Deane, J.A.; Cole, D.G.; Seeley, E.S.; Diener, D.R.; Rosenbaum, J.L. Localization of intraflagellar transport protein IFT52 identifies basal body transitional fibers as the docking site for IFT particles. Curr. Biol. 2001, 11, 1586–1590
    • (2001) Curr. Biol , vol.11 , pp. 1586-1590
    • Deane, J.A.1    Cole, D.G.2    Seeley, E.S.3    Diener, D.R.4    Rosenbaum, J.L.5
  • 47
    • 84889593986 scopus 로고    scopus 로고
    • Transition fibre protein FBF1 is required for the ciliary entry of assembled intraflagellar transport complexes
    • Wei, Q.; Xu, Q.; Zhang, Y.; Li, Y.; Zhang, Q.; Hu, Z.; Harris, P.C.; Torres, V.E.; Ling, K.; Hu, J. Transition fibre protein FBF1 is required for the ciliary entry of assembled intraflagellar transport complexes. Nat. Commun. 2013, 4, 2750, doi:10.1038/ncomms3750
    • (2013) Nat. Commun , vol.4
    • Wei, Q.1    Xu, Q.2    Zhang, Y.3    Li, Y.4    Zhang, Q.5    Hu, Z.6    Harris, P.C.7    Torres, V.E.8    Ling, K.9    Hu, J.10
  • 48
    • 0030912534 scopus 로고    scopus 로고
    • Ultrastructural aspects of olfactory signaling
    • Menco, B.P. Ultrastructural aspects of olfactory signaling. Chem. Senses 1997, 22, 295–311
    • (1997) Chem. Senses , vol.22 , pp. 295-311
    • Menco, B.P.1
  • 49
    • 66049086534 scopus 로고    scopus 로고
    • Olfactory cilia: Linking sensory cilia function and human disease
    • Jenkins, P.M.; McEwen, D.P.; Martens, J.R. Olfactory cilia: Linking sensory cilia function and human disease. Chem. Senses 2009, 34, 451–464
    • (2009) Chem. Senses , vol.34 , pp. 451-464
    • Jenkins, P.M.1    McEwen, D.P.2    Martens, J.R.3
  • 50
    • 21544477531 scopus 로고    scopus 로고
    • Formation and maturation of olfactory cilia monitored by odorant receptor-specific antibodies
    • Schwarzenbacher, K.; Fleischer, J.; Breer, H. Formation and maturation of olfactory cilia monitored by odorant receptor-specific antibodies. Histochem. Cell Biol. 2005, 123, 419–428
    • (2005) Histochem. Cell Biol , vol.123 , pp. 419-428
    • Schwarzenbacher, K.1    Fleischer, J.2    Breer, H.3
  • 51
    • 0026655910 scopus 로고
    • Ultrastructural studies of microtubules and microtubule organizing centers of the vertebrate olfactory neuron
    • Burton, P.R. Ultrastructural studies of microtubules and microtubule organizing centers of the vertebrate olfactory neuron. Microsc. Res. Tech. 1992, 23, 142–156
    • (1992) Microsc. Res. Tech , vol.23 , pp. 142-156
    • Burton, P.R.1
  • 52
    • 0142091376 scopus 로고    scopus 로고
    • Evolution of olfactory receptor genes in the human genome
    • Niimura, Y.; Nei, M. Evolution of olfactory receptor genes in the human genome. Proc. Natl. Acad. Sci. USA 2003, 100, 12235–12240
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 12235-12240
    • Niimura, Y.1    Nei, M.2
  • 53
    • 84943583836 scopus 로고    scopus 로고
    • Mechanisms of olfactory receptor neuron specification in drosophila
    • Barish, S.; Volkan, P.C. Mechanisms of olfactory receptor neuron specification in drosophila. Wiley Interdiscip. Rev. Dev. Biol. 2015, doi:10.1002/wdev.197
    • (2015) Wiley Interdiscip. Rev. Dev. Biol
    • Barish, S.1    Volkan, P.C.2
  • 54
    • 9444291355 scopus 로고    scopus 로고
    • Olfactory receptors and odor coding in mammals
    • Buck, L.B. Olfactory receptors and odor coding in mammals. Nutr. Rev. 2004, 62, S184–S188
    • (2004) Nutr. Rev , vol.62
    • Buck, L.B.1
  • 55
    • 0037357440 scopus 로고    scopus 로고
    • Population differences in the human functional olfactory repertoire
    • Gilad, Y.; Lancet, D. Population differences in the human functional olfactory repertoire. Mol. Biol. Evol. 2003, 20, 307–314
    • (2003) Mol. Biol. Evol , vol.20 , pp. 307-314
    • Gilad, Y.1    Lancet, D.2
  • 56
    • 0033525727 scopus 로고    scopus 로고
    • Combinatorial receptor codes for odors
    • Malnic, B.; Hirono, J.; Sato, T.; Buck, L.B. Combinatorial receptor codes for odors. Cell 1999, 96, 713–723
    • (1999) Cell , vol.96 , pp. 713-723
    • Malnic, B.1    Hirono, J.2    Sato, T.3    Buck, L.B.4
  • 57
    • 0035855833 scopus 로고    scopus 로고
    • How the olfactory system makes sense of scents
    • Firestein, S. How the olfactory system makes sense of scents. Nature 2001, 413, 211–218
    • (2001) Nature , vol.413 , pp. 211-218
    • Firestein, S.1
  • 58
    • 29244489159 scopus 로고    scopus 로고
    • Molecular neurobiology of olfactory transducin
    • Doty, R.L., Ed.; Information Health: New York, NY, USA
    • Moon, C.; Ronnett, G.V. Molecular neurobiology of olfactory transducin. In Handbook on Olfaction and Gustation; Doty, R.L., Ed.; Information Health: New York, NY, USA, 2003; pp. 75–91
    • (2003) Handbook on Olfaction and Gustation , pp. 75-91
    • Moon, C.1    Ronnett, G.V.2
  • 60
    • 84890618777 scopus 로고    scopus 로고
    • Olfaction: Anatomy, physiology, and disease
    • Patel, R.M.; Pinto, J.M. Olfaction: Anatomy, physiology, and disease. Clin. Anat. (N. Y.) 2014, 27, 54–60
    • (2014) Clin. Anat. (N. Y.) , vol.27 , pp. 54-60
    • Patel, R.M.1    Pinto, J.M.2
  • 61
    • 58149345025 scopus 로고    scopus 로고
    • Olfactory cilia: Our direct neuronal connection to the external world
    • McEwen, D.P.; Jenkins, P.M.; Martens, J.R. Olfactory cilia: Our direct neuronal connection to the external world. Curr. Top. Dev. Biol. 2008, 85, 333–370
    • (2008) Curr. Top. Dev. Biol , vol.85 , pp. 333-370
    • McEwen, D.P.1    Jenkins, P.M.2    Martens, J.R.3
  • 62
    • 0242581681 scopus 로고    scopus 로고
    • Hedgehog signalling in the mouse requires intraflagellar transport proteins
    • Huangfu, D.; Liu, A.; Rakeman, A.S.; Murcia, N.S.; Niswander, L.; Anderson, K.V. Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature 2003, 426, 83–87
    • (2003) Nature , vol.426 , pp. 83-87
    • Huangfu, D.1    Liu, A.2    Rakeman, A.S.3    Murcia, N.S.4    Niswander, L.5    Anderson, K.V.6
  • 63
    • 84905566797 scopus 로고    scopus 로고
    • G-protein-coupled receptors, hedgehog signaling and primary cilia. Semin
    • Mukhopadhyay, S.; Rohatgi, R. G-protein-coupled receptors, hedgehog signaling and primary cilia. Semin. Cell Dev. Biol. 2014, 33, 63–72
    • (2014) Cell Dev. Biol , vol.33 , pp. 63-72
    • Mukhopadhyay, S.1    Rohatgi, R.2
  • 64
  • 66
    • 38449090748 scopus 로고    scopus 로고
    • Protein networks and complexes in photoreceptor cilia
    • Roepman, R.; Wolfrum, U. Protein networks and complexes in photoreceptor cilia. Subcell. Biochem. 2007, 43, 209–235
    • (2007) Subcell. Biochem , vol.43 , pp. 209-235
    • Roepman, R.1    Wolfrum, U.2
  • 67
    • 58149485065 scopus 로고    scopus 로고
    • Targeting proteins to the ciliary membrane
    • Pazour, G.J.; Bloodgood, R.A. Targeting proteins to the ciliary membrane. Curr. Top. Dev. Biol. 2008, 85, 115–149
    • (2008) Curr. Top. Dev. Biol , vol.85 , pp. 115-149
    • Pazour, G.J.1    Bloodgood, R.A.2
  • 68
    • 84890789300 scopus 로고    scopus 로고
    • Molecular complexes that direct rhodopsin transport to primary cilia
    • Wang, J.; Deretic, D. Molecular complexes that direct rhodopsin transport to primary cilia. Prog. Retin. Eye Res. 2014, 38, 1–19
    • (2014) Prog. Retin. Eye Res , vol.38 , pp. 1-19
    • Wang, J.1    Deretic, D.2
  • 69
    • 84871730850 scopus 로고    scopus 로고
    • Ciliary signaling cascades in photoreceptors
    • Yildiz, O.; Khanna, H. Ciliary signaling cascades in photoreceptors. Vis. Res. 2012, 75, 112–116
    • (2012) Vis. Res , vol.75 , pp. 112-116
    • Yildiz, O.1    Khanna, H.2
  • 70
    • 0021964082 scopus 로고
    • Membrane assembly in retinal photoreceptors. III. Distinct membrane domains of the connecting cilium of developing rods
    • Besharse, J.C.; Forestner, D.M.; Defoe, D.M. Membrane assembly in retinal photoreceptors. III. Distinct membrane domains of the connecting cilium of developing rods. J. Neurosci. 1985, 5, 1035–1048
    • (1985) J. Neurosci , vol.5 , pp. 1035-1048
    • Besharse, J.C.1    Forestner, D.M.2    Defoe, D.M.3
  • 71
    • 0036201254 scopus 로고    scopus 로고
    • Jr. G-proteins and phototransduction. Annu
    • Arshavsky, V.Y.; Lamb, T.D.; Pugh, E.N., Jr. G-proteins and phototransduction. Annu. Rev. Physiol. 2002, 64, 153–187
    • (2002) Rev. Physiol , vol.64 , pp. 153-187
    • Arshavsky, V.Y.1    Lamb, T.D.2    Pugh, E.N.3
  • 72
    • 27644548928 scopus 로고    scopus 로고
    • Beyond counting photons: Trials and trends in vertebrate visual transduction
    • Burns, M.E.; Arshavsky, V.Y. Beyond counting photons: Trials and trends in vertebrate visual transduction. Neuron 2005, 48, 387–401
    • (2005) Neuron , vol.48 , pp. 387-401
    • Burns, M.E.1    Arshavsky, V.Y.2
  • 73
    • 51349087965 scopus 로고    scopus 로고
    • Signal transducing membrane complexes of photoreceptor outer segments
    • Wensel, T.G. Signal transducing membrane complexes of photoreceptor outer segments. Vis. Res. 2008, 48, 2052–2061
    • (2008) Vis. Res , vol.48 , pp. 2052-2061
    • Wensel, T.G.1
  • 74
    • 70349792168 scopus 로고    scopus 로고
    • Phototransduction motifs and variations
    • Yau, K.W.; Hardie, R.C. Phototransduction motifs and variations. Cell 2009, 139, 246–264
    • (2009) Cell , vol.139 , pp. 246-264
    • Yau, K.W.1    Hardie, R.C.2
  • 75
    • 77949892579 scopus 로고    scopus 로고
    • Deactivation mechanisms of rod phototransduction: The cogan lecture. Investig
    • Burns, M.E. Deactivation mechanisms of rod phototransduction: The cogan lecture. Investig. Ophthalmol. Vis. Sci 2010, 51, 1282–1288
    • (2010) Ophthalmol. Vis. Sci , vol.51 , pp. 1282-1288
    • Burns, M.E.1
  • 76
    • 84855854548 scopus 로고    scopus 로고
    • Photoreceptor signaling: Supporting vision across a wide range of light intensities
    • Arshavsky, V.Y.; Burns, M.E. Photoreceptor signaling: Supporting vision across a wide range of light intensities. J. Biol. Chem. 2012, 287, 1620–1626
    • (2012) J. Biol. Chem , vol.287 , pp. 1620-1626
    • Arshavsky, V.Y.1    Burns, M.E.2
  • 77
    • 84925282813 scopus 로고    scopus 로고
    • Chemistry and biology of the initial steps in vision: The friedenwald lecture
    • Palczewski, K. Chemistry and biology of the initial steps in vision: The friedenwald lecture. Investig. Ophthalmol. Vis. Sci 2014, 55, 6651–6672
    • (2014) Investig. Ophthalmol. Vis. Sci , vol.55 , pp. 6651-6672
    • Palczewski, K.1
  • 78
    • 40949162296 scopus 로고    scopus 로고
    • The homodimeric kinesin, KIF17, is essential for vertebrate photoreceptor sensory outer segment development
    • Insinna, C.; Pathak, N.; Perkins, B.; Drummond, I.; Besharse, J.C. The homodimeric kinesin, KIF17, is essential for vertebrate photoreceptor sensory outer segment development. Dev. Biol. 2008, 316, 160–170
    • (2008) Dev. Biol , vol.316 , pp. 160-170
    • Insinna, C.1    Pathak, N.2    Perkins, B.3    Drummond, I.4    Besharse, J.C.5
  • 79
    • 81055124186 scopus 로고    scopus 로고
    • Intraflagellar transport proteins in ciliogenesis of photoreceptor cells
    • Sedmak, T.; Wolfrum, U. Intraflagellar transport proteins in ciliogenesis of photoreceptor cells. Biol. Cell 2011, 103, 449–466
    • (2011) Biol. Cell , vol.103 , pp. 449-466
    • Sedmak, T.1    Wolfrum, U.2
  • 80
    • 0030811605 scopus 로고    scopus 로고
    • Myosin viia, the product of the usher 1B syndrome gene, is concentrated in the connecting cilia of photoreceptor cells
    • Liu, X.; Vansant, G.; Udovichenko, I.P.; Wolfrum, U.; Williams, D.S. Myosin viia, the product of the usher 1B syndrome gene, is concentrated in the connecting cilia of photoreceptor cells. Cell Motil. Cytoskelet. 1997, 37, 240–252
    • (1997) Cell Motil. Cytoskelet , vol.37 , pp. 240-252
    • Liu, X.1    Vansant, G.2    Udovichenko, I.P.3    Wolfrum, U.4    Williams, D.S.5
  • 82
    • 77950589400 scopus 로고    scopus 로고
    • Wolfrum, U. Intraflagellar transport molecules in ciliary and nonciliary cells of the retina
    • Sedmak, T.; Wolfrum, U. Intraflagellar transport molecules in ciliary and nonciliary cells of the retina. J. Cell Biol. 2010, 189, 171–186
    • (2010) J. Cell Biol , vol.189 , pp. 171-186
    • Sedmak, T.1
  • 83
    • 33750607737 scopus 로고    scopus 로고
    • A role for rhodopsin in a signal transduction cascade that regulates membrane trafficking and photoreceptor polarity
    • Deretic, D. A role for rhodopsin in a signal transduction cascade that regulates membrane trafficking and photoreceptor polarity. Vis. Res. 2006, 46, 4427–4433
    • (2006) Vis. Res , vol.46 , pp. 4427-4433
    • Deretic, D.1
  • 84
    • 0033603239 scopus 로고    scopus 로고
    • Rhodopsin’s carboxy-terminal cytoplasmic tail acts as a membrane receptor for cytoplasmic dynein by binding to the dynein light chain tctex-1
    • Tai, A.W.; Chuang, J.Z.; Bode, C.; Wolfrum, U.; Sung, C.H. Rhodopsin’s carboxy-terminal cytoplasmic tail acts as a membrane receptor for cytoplasmic dynein by binding to the dynein light chain tctex-1. Cell 1999, 97, 877–887
    • (1999) Cell , vol.97 , pp. 877-887
    • Tai, A.W.1    Chuang, J.Z.2    Bode, C.3    Wolfrum, U.4    Sung, C.H.5
  • 85
    • 50349096426 scopus 로고    scopus 로고
    • Light-dependent compartmentalization of transdu cin in rod photoreceptors
    • Artemyev, N.O. Light-dependent compartmentalization of transdu cin in rod photoreceptors. Mol. Neurobiol. 2008, 37, 44–51
    • (2008) Mol. Neurobiol , vol.37 , pp. 44-51
    • Artemyev, N.O.1
  • 86
    • 42949171611 scopus 로고    scopus 로고
    • Hurley, J.B. Mechanism of light-induced translocation of arrestin and transducin in photoreceptors: Interaction-restricted diffusion
    • Slepak, V.Z.; Hurley, J.B. Mechanism of light-induced translocation of arrestin and transducin in photoreceptors: Interaction-restricted diffusion. IUBMB Life 2008, 60, 2–9
    • (2008) IUBMB Life , vol.60 , pp. 2-9
    • Slepak, V.Z.1
  • 88
    • 34547480479 scopus 로고    scopus 로고
    • Deletion of prbp/delta impedes transport of GRK1 and PDE6 catalytic subunits to photoreceptor outer segments
    • Zhang, H.; Li, S.; Doan, T.; Rieke, F.; Detwiler, P.B.; Frederick, J.M.; Baehr, W. Deletion of prbp/delta impedes transport of GRK1 and PDE6 catalytic subunits to photoreceptor outer segments. Proc. Natl. Acad. Sci. USA 2007, 104, 8857–8862
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 8857-8862
    • Zhang, H.1    Li, S.2    Doan, T.3    Rieke, F.4    Detwiler, P.B.5    Frederick, J.M.6    Baehr, W.7
  • 90
    • 77956530128 scopus 로고    scopus 로고
    • Signal transduction and signal transmission: The two faces of a photoreceptor
    • Gießl, A.; Regus-Leidig, H.; Brandstätter, J.H. Signal transduction and signal transmission: The two faces of a photoreceptor. e-Neuroforum 2010, doi:10.1007/s13295-010-0007-9
    • (2010) E-Neuroforum
    • Gießl, A.1    Regus-Leidig, H.2    Brandstätter, J.H.3
  • 91
    • 84860769609 scopus 로고    scopus 로고
    • Mouse models of ciliopathies: The state of the art. Dis
    • Norris, D.P.; Grimes, D.T. Mouse models of ciliopathies: The state of the art. Dis. Models Mech. 2012, 5, 299–312
    • (2012) Models Mech , vol.5 , pp. 299-312
    • Norris, D.P.1    Grimes, D.T.2
  • 96
    • 33744757686 scopus 로고    scopus 로고
    • In-frame deletion in a novel centrosomal/ciliary protein CEP290/NPHP6 perturbs its interaction with RPGR and results in early-onset retinal degeneration in the RD16 mouse
    • Chang, B.; Khanna, H.; Hawes, N.; Jimeno, D.; He, S.; Lillo, C.; Parapuram, S.K.; Cheng, H.; Scott, A.; Hurd, R.E., et al. In-frame deletion in a novel centrosomal/ciliary protein CEP290/NPHP6 perturbs its interaction with RPGR and results in early-onset retinal degeneration in the RD16 mouse. Hum. Mol. Genet. 2006, 15, 1847–1857
    • (2006) Hum. Mol. Genet , vol.15 , pp. 1847-1857
    • Chang, B.1    Khanna, H.2    Hawes, N.3    Jimeno, D.4    He, S.5    Lillo, C.6    Parapuram, S.K.7    Cheng, H.8    Scott, A.9    Hurd, R.E.10
  • 97
    • 34247558062 scopus 로고    scopus 로고
    • The graded response to sonic hedgehog depends on cilia architecture
    • Caspary, T.; Larkins, C.E.; Anderson, K.V. The graded response to sonic hedgehog depends on cilia architecture. Dev. Cell 2007, 12, 767–778
    • (2007) Dev. Cell , vol.12 , pp. 767-778
    • Caspary, T.1    Larkins, C.E.2    Anderson, K.V.3
  • 100
    • 84876338226 scopus 로고    scopus 로고
    • Combined ngs approaches identify mutations in the intraflagellar transport gene IFT140 in skeletal ciliopathies with early progressive kidney disease
    • Schmidts, M.; Frank, V.; Eisenberger, T.; Al Turki, S.; Bizet, A.A.; Antony, D.; Rix, S.; Decker, C.; Bachmann, N.; Bald, M., et al. Combined ngs approaches identify mutations in the intraflagellar transport gene IFT140 in skeletal ciliopathies with early progressive kidney disease. Hum. Mutat. 2013, 34, 714–724
    • (2013) Hum. Mutat , vol.34 , pp. 714-724
    • Schmidts, M.1    Frank, V.2    Eisenberger, T.3    Al Turki, S.4    Bizet, A.A.5    Antony, D.6    Rix, S.7    Decker, C.8    Bachmann, N.9    Bald, M.10
  • 101
    • 70349663509 scopus 로고    scopus 로고
    • Pericentrin, a centrosomal protein related to microcephalic primordial dwarfism, is required for olfactory cilia assembly in mice
    • Miyoshi, K.; Kasahara, K.; Miyazaki, I.; Shimizu, S.; Taniguchi, M.; Matsuzaki, S.; Tohyama, M.; Asanuma, M. Pericentrin, a centrosomal protein related to microcephalic primordial dwarfism, is required for olfactory cilia assembly in mice. FASEB J. 2009, 23, 3289–3297
    • (2009) FASEB J , vol.23 , pp. 3289-3297
    • Miyoshi, K.1    Kasahara, K.2    Miyazaki, I.3    Shimizu, S.4    Taniguchi, M.5    Matsuzaki, S.6    Tohyama, M.7    Asanuma, M.8
  • 104
    • 0035168151 scopus 로고    scopus 로고
    • Mutations in CDH23, encoding a new type of cadherin, cause stereocilia disorganization in waltzer, the mouse model for usher syndrome type 1D
    • Di Palma, F.; Holme, R.H.; Bryda, E.C.; Belyantseva, I.A.; Pellegrino, R.; Kachar, B.; Steel, K.P.; Noben-Trauth, K. Mutations in CDH23, encoding a new type of cadherin, cause stereocilia disorganization in waltzer, the mouse model for usher syndrome type 1D. Nat. Genet. 2001, 27, 103–107
    • (2001) Nat. Genet , vol.27 , pp. 103-107
    • Di Palma, F.1    Holme, R.H.2    Bryda, E.C.3    Belyantseva, I.A.4    Pellegrino, R.5    Kachar, B.6    Steel, K.P.7    Noben-Trauth, K.8
  • 105
    • 0345530996 scopus 로고    scopus 로고
    • Mouse models of USH1C and DFNB18: Phenotypic and molecular analyses of two new spontaneous mutations of the USH1C gene
    • Johnson, K.R.; Gagnon, L.H.; Webb, L.S.; Peters, L.L.; Hawes, N.L.; Chang, B.; Zheng, Q.Y. Mouse models of USH1C and DFNB18: Phenotypic and molecular analyses of two new spontaneous mutations of the USH1C gene. Hum. Mol. Genet. 2003, 12, 3075–3086
    • (2003) Hum. Mol. Genet , vol.12 , pp. 3075-3086
    • Johnson, K.R.1    Gagnon, L.H.2    Webb, L.S.3    Peters, L.L.4    Hawes, N.L.5    Chang, B.6    Zheng, Q.Y.7
  • 106
    • 79251538069 scopus 로고    scopus 로고
    • Analysis of subcellular localization of MYO7A, PCDH15 and sans in USH1C knockout mice
    • Yan, D.; Kamiya, K.; Ouyang, X.M.; Liu, X.Z. Analysis of subcellular localization of MYO7A, PCDH15 and sans in USH1C knockout mice. Int. J. Exp. Pathol. 2011, 92, 66–71
    • (2011) Int. J. Exp. Pathol , vol.92 , pp. 66-71
    • Yan, D.1    Kamiya, K.2    Ouyang, X.M.3    Liu, X.Z.4
  • 107
    • 80054837002 scopus 로고    scopus 로고
    • The centrosomal protein pericentrin identified at the basal body complex of the connecting cilium in mouse photoreceptors
    • Mühlhans, J.; Brandstätter, J.H.; Gießl, A. The centrosomal protein pericentrin identified at the basal body complex of the connecting cilium in mouse photoreceptors. PLoS ONE 2011, 6, e26496
    • (2011) Plos ONE , vol.6
    • Mühlhans, J.1    Brandstätter, J.H.2    Gießl, A.3


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