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Volumn 43, Issue 1, 2019, Pages 73-81

Causal relationships between adiposity and childhood asthma: bi-directional Mendelian Randomization analysis

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ALLERGIC ASTHMA; ARTICLE; ASTHMA; BODY FAT; BODY MASS; CHILD; CHILDHOOD OBESITY; FAT FREE MASS; FEMALE; GENE FREQUENCY; GENETIC VARIABILITY; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MENDELIAN RANDOMIZATION ANALYSIS; PLEIOTROPY; PRIORITY JOURNAL; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; SKINFOLD; WAIST HIP RATIO; COMPLICATION; GENETICS; OBESITY; ODDS RATIO; TAIWAN;

EID: 85050299479     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/s41366-018-0160-8     Document Type: Article
Times cited : (29)

References (34)
  • 1
    • 84874019600 scopus 로고    scopus 로고
    • Gender difference of childhood overweight and obesity in predicting the risk of incident asthma: a systematic review and meta-analysis
    • COI: 1:STN:280:DC%2BC3s7islygsQ%3D%3D
    • Chen YC, Dong GH, Lin KC, Lee YL. Gender difference of childhood overweight and obesity in predicting the risk of incident asthma: a systematic review and meta-analysis. Obes Rev. 2013;14:222–31.
    • (2013) Obes Rev , vol.14 , pp. 222-231
    • Chen, Y.C.1    Dong, G.H.2    Lin, K.C.3    Lee, Y.L.4
  • 2
    • 33745571971 scopus 로고    scopus 로고
    • Asthma and body weight change: a 20-year prospective community study of young adults
    • COI: 1:STN:280:DC%2BD28zosFSmsA%3D%3D
    • Hasler G, Gergen PJ, Ajdacic V, Gamma A, Eich D, Rössler W, et al. Asthma and body weight change: a 20-year prospective community study of young adults. Int J Obes. 2006;30:1111–8.
    • (2006) Int J Obes , vol.30 , pp. 1111-1118
    • Hasler, G.1    Gergen, P.J.2    Ajdacic, V.3    Gamma, A.4    Eich, D.5    Rössler, W.6
  • 4
    • 79951677811 scopus 로고    scopus 로고
    • C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization
    • COI: 1:CAS:528:DC%2BC3MXhvFWltr0%3D
    • Timpson NJ, Nordestgaard BG, Harbord RM, Zacho J, Frayling TM, Tybjærg-Hansen A, et al. C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization. Int J Obes. 2011;35:300–8.
    • (2011) Int J Obes , vol.35 , pp. 300-308
    • Timpson, N.J.1    Nordestgaard, B.G.2    Harbord, R.M.3    Zacho, J.4    Frayling, T.M.5    Tybjærg-Hansen, A.6
  • 5
    • 84874505939 scopus 로고    scopus 로고
    • Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts
    • Vimaleswaran KS, Berry DJ, Lu C, Tikkanen E, Pilz S, Hiraki LT, et al. Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med. 2013;10:e1001383–e1001383.
    • (2013) PLoS Med , vol.10 , pp. e1001383
    • Vimaleswaran, K.S.1    Berry, D.J.2    Lu, C.3    Tikkanen, E.4    Pilz, S.5    Hiraki, L.T.6
  • 6
    • 84905401194 scopus 로고    scopus 로고
    • Effects of BMI, fat mass, and lean mass on asthma in childhood: a Mendelian randomization study
    • Granell R, Henderson AJ, Evans DM, Smith GD, Ness AR, Lewis S, et al. Effects of BMI, fat mass, and lean mass on asthma in childhood: a Mendelian randomization study. PLoS Med. 2014;11:e1001669.
    • (2014) PLoS Med , vol.11
    • Granell, R.1    Henderson, A.J.2    Evans, D.M.3    Smith, G.D.4    Ness, A.R.5    Lewis, S.6
  • 8
    • 84986222446 scopus 로고    scopus 로고
    • Mediating pathways from central obesity to childhood asthma: a population-based longitudinal study
    • COI: 1:CAS:528:DC%2BC2sXhvFSit73J
    • Chih AH, Chen YC, Tu YK, Huang KC, Chiu TY, Lee YL. Mediating pathways from central obesity to childhood asthma: a population-based longitudinal study. Eur Respir J. 2016;48:748–57.
    • (2016) Eur Respir J , vol.48 , pp. 748-757
    • Chih, A.H.1    Chen, Y.C.2    Tu, Y.K.3    Huang, K.C.4    Chiu, T.Y.5    Lee, Y.L.6
  • 9
    • 85016973212 scopus 로고    scopus 로고
    • Rapid adiposity growth increases risks of new-onset asthma and airway inflammation in children
    • Chen YC, Chih AH, Chen JR, Liou TH, Pan WH, Lee YL. Rapid adiposity growth increases risks of new-onset asthma and airway inflammation in children. Int J Obes. 2017;41:1035–41.
    • (2017) Int J Obes , vol.41 , pp. 1035-1041
    • Chen, Y.C.1    Chih, A.H.2    Chen, J.R.3    Liou, T.H.4    Pan, W.H.5    Lee, Y.L.6
  • 11
    • 84901008940 scopus 로고    scopus 로고
    • Pathway from central obesity to childhood asthma. Physical fitness and sedentary time are leading factors
    • Chen YC, Tu YK, Huang KC, Chen PC, Chu DC, Lee YL. Pathway from central obesity to childhood asthma. Physical fitness and sedentary time are leading factors. Am J Respir Crit Care Med. 2014;189:1194–203.
    • (2014) Am J Respir Crit Care Med , vol.189 , pp. 1194-1203
    • Chen, Y.C.1    Tu, Y.K.2    Huang, K.C.3    Chen, P.C.4    Chu, D.C.5    Lee, Y.L.6
  • 12
    • 84903826340 scopus 로고    scopus 로고
    • Adiposity fractional exhaled nitric oxide, and asthma in U.S. children
    • Han YY, Forno E, Celedon JC. Adiposity fractional exhaled nitric oxide, and asthma in U.S. children. Am J Respir Crit Care Med. 2014;190:32–9.
    • (2014) Am J Respir Crit Care Med , vol.190 , pp. 32-39
    • Han, Y.Y.1    Forno, E.2    Celedon, J.C.3
  • 13
    • 84964314917 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index
    • COI: 1:CAS:528:DC%2BC28XhtFOnt7fF
    • Wen W, Zheng W, Okada Y, Takeuchi F, Tabara Y, Hwang JY, et al. Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. Hum Mol Genet. 2014;23:5492–504.
    • (2014) Hum Mol Genet , vol.23 , pp. 5492-5504
    • Wen, W.1    Zheng, W.2    Okada, Y.3    Takeuchi, F.4    Tabara, Y.5    Hwang, J.Y.6
  • 14
    • 84859650621 scopus 로고    scopus 로고
    • Study of eight GWAS-identified common variants for association with obesity-related indices in Chinese children at puberty
    • Wang J, Mei H, Chen W, Jiang Y, Sun W, Li F, et al. Study of eight GWAS-identified common variants for association with obesity-related indices in Chinese children at puberty. Int J Obes. 2012;36:542–7.
    • (2012) Int J Obes , vol.36 , pp. 542-547
    • Wang, J.1    Mei, H.2    Chen, W.3    Jiang, Y.4    Sun, W.5    Li, F.6
  • 15
    • 84960096843 scopus 로고    scopus 로고
    • Association of common variants identified by recent genome-wide association studies with obesity in Chinese children: a case-control study
    • Wang HJ, Hinney A, Song JY, Scherag A, Meng X-R, Grallert H, et al. Association of common variants identified by recent genome-wide association studies with obesity in Chinese children: a case-control study. BMC Med Genet. 2016;17:7.
    • (2016) BMC Med Genet , vol.17
    • Wang, H.J.1    Hinney, A.2    Song, J.Y.3    Scherag, A.4    Meng, X.R.5    Grallert, H.6
  • 16
    • 84902535992 scopus 로고    scopus 로고
    • Triglyceride-raising APOA5 genetic variants are associated with obesity and non-HDL-C in Chinese children and adolescents
    • Zhu WF, Wang CL, Liang L, Shen Z, Fu JF, Liu PN, et al. Triglyceride-raising APOA5 genetic variants are associated with obesity and non-HDL-C in Chinese children and adolescents. Lipids Health Dis. 2014;13:93.
    • (2014) Lipids Health Dis , vol.13 , pp. 93
    • Zhu, W.F.1    Wang, C.L.2    Liang, L.3    Shen, Z.4    Fu, J.F.5    Liu, P.N.6
  • 17
    • 79953279646 scopus 로고    scopus 로고
    • Genome-wide association studies for discovery of genes involved in asthma
    • Akhabir L, Sandford AJ. Genome-wide association studies for discovery of genes involved in asthma. Respirology. 2011;16:396–406.
    • (2011) Respirology , vol.16 , pp. 396-406
    • Akhabir, L.1    Sandford, A.J.2
  • 18
    • 84962613140 scopus 로고    scopus 로고
    • Four-locus gene interaction between IL13, IL4, FCER1B, and ADRB2 for asthma in Chinese Han children
    • Hua L, Zuo XB, Bao YX, Liu QH, Li JY, Lv J, et al. Four-locus gene interaction between IL13, IL4, FCER1B, and ADRB2 for asthma in Chinese Han children. Pediatr Pulmonol. 2016;51:364–71.
    • (2016) Pediatr Pulmonol , vol.51 , pp. 364-371
    • Hua, L.1    Zuo, X.B.2    Bao, Y.X.3    Liu, Q.H.4    Li, J.Y.5    Lv, J.6
  • 19
    • 84873846165 scopus 로고    scopus 로고
    • Interleukin-13 genetic variants, household carpet use and childhood asthma
    • COI: 1:CAS:528:DC%2BC3sXis1aktb4%3D
    • Tsai CH, Tung KY, Su MW, Chiang BL, Chew FT, Kuo NW, et al. Interleukin-13 genetic variants, household carpet use and childhood asthma. PLoS ONE. 2013;8:e51970.
    • (2013) PLoS ONE , vol.8
    • Tsai, C.H.1    Tung, K.Y.2    Su, M.W.3    Chiang, B.L.4    Chew, F.T.5    Kuo, N.W.6
  • 20
    • 79953736597 scopus 로고    scopus 로고
    • Microsomal epoxide hydroxylase genotypes/diplotypes, traffic air pollution, and childhood asthma
    • COI: 1:CAS:528:DC%2BC3MXmtl2hsr0%3D
    • Tung KY, Tsai CH, Lee YL. Microsomal epoxide hydroxylase genotypes/diplotypes, traffic air pollution, and childhood asthma. Chest. 2011;139:839–48.
    • (2011) Chest , vol.139 , pp. 839-848
    • Tung, K.Y.1    Tsai, C.H.2    Lee, Y.L.3
  • 21
    • 84978032854 scopus 로고    scopus 로고
    • Haplotypes of the D-amino acid oxidase gene are significantly associated with schizophrenia and its neurocognitive deficits
    • Liu YL, Wang SC, Hwu HG, Fann CS, Yang UC, Yang WC, et al. Haplotypes of the D-amino acid oxidase gene are significantly associated with schizophrenia and its neurocognitive deficits. PLoS ONE. 2016;11:e0150435.
    • (2016) PLoS ONE , vol.11
    • Liu, Y.L.1    Wang, S.C.2    Hwu, H.G.3    Fann, C.S.4    Yang, U.C.5    Yang, W.C.6
  • 23
    • 79958821064 scopus 로고    scopus 로고
    • Instrumental variable estimation of causal risk ratios and causal odds ratios in Mendelian randomization analyses
    • Palmer TM, Sterne JA, Harbord RM, Lawlor DA, Sheehan NA, Meng S, et al. Instrumental variable estimation of causal risk ratios and causal odds ratios in Mendelian randomization analyses. Am J Epidemiol. 2011;173:1392–403.
    • (2011) Am J Epidemiol , vol.173 , pp. 1392-1403
    • Palmer, T.M.1    Sterne, J.A.2    Harbord, R.M.3    Lawlor, D.A.4    Sheehan, N.A.5    Meng, S.6
  • 24
    • 84991449483 scopus 로고    scopus 로고
    • Sensitivity analyses for robust causal inference from Mendelian randomization analyses with multiple genetic variants
    • Burgess S, Bowden J, Fall T, Ingelsson E, Thompson SG. Sensitivity analyses for robust causal inference from Mendelian randomization analyses with multiple genetic variants. Epidemiology. 2017;28:30–42.
    • (2017) Epidemiology , vol.28 , pp. 30-42
    • Burgess, S.1    Bowden, J.2    Fall, T.3    Ingelsson, E.4    Thompson, S.G.5
  • 25
    • 0033816446 scopus 로고    scopus 로고
    • Body weight characteristics of subjects on asthma medication
    • COI: 1:STN:280:DC%2BD3cvosFegtg%3D%3D
    • Hedberg A, Rossner S. Body weight characteristics of subjects on asthma medication. Int J Obes. 2000;24:1217–25.
    • (2000) Int J Obes , vol.24 , pp. 1217-1225
    • Hedberg, A.1    Rossner, S.2
  • 26
    • 40949106486 scopus 로고    scopus 로고
    • Asthmatic symptoms, physical activity, and overweight in young children: a cohort study
    • Eijkemans M, Mommers M, de Vries SI, van Buuren S, Stafleu A, Bakker I, et al. Asthmatic symptoms, physical activity, and overweight in young children: a cohort study. Pediatrics. 2008;121:e666–72.
    • (2008) Pediatrics , vol.121 , pp. e666-e672
    • Eijkemans, M.1    Mommers, M.2    de Vries, S.I.3    van Buuren, S.4    Stafleu, A.5    Bakker, I.6
  • 27
    • 85008402803 scopus 로고    scopus 로고
    • Childhood asthma and physical activity: a systematic review with meta-analysis and Graphic Appraisal Tool for Epidemiology assessment
    • Lochte L, Nielsen KG, Petersen PE, Platts-Mills TA. Childhood asthma and physical activity: a systematic review with meta-analysis and Graphic Appraisal Tool for Epidemiology assessment. BMC Pediatr. 2016;16:50.
    • (2016) BMC Pediatr , vol.16 , pp. 50
    • Lochte, L.1    Nielsen, K.G.2    Petersen, P.E.3    Platts-Mills, T.A.4
  • 28
    • 84881292395 scopus 로고    scopus 로고
    • Childhood body mass index and subsequent physician-diagnosed asthma: a systematic review and meta-analysis of prospective cohort studies
    • Egan KB, Ettinger AS, Bracken MB. Childhood body mass index and subsequent physician-diagnosed asthma: a systematic review and meta-analysis of prospective cohort studies. BMC Pediatr. 2013;13:121.
    • (2013) BMC Pediatr , vol.13 , pp. 121
    • Egan, K.B.1    Ettinger, A.S.2    Bracken, M.B.3
  • 29
    • 84856367529 scopus 로고    scopus 로고
    • Relationship between body composition, inflammation and lung function in overweight and obese asthma
    • Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, et al. Relationship between body composition, inflammation and lung function in overweight and obese asthma. Resp Res. 2012;13:10–10.
    • (2012) Resp Res , vol.13 , pp. 10
    • Scott, H.A.1    Gibson, P.G.2    Garg, M.L.3    Pretto, J.J.4    Morgan, P.J.5    Callister, R.6
  • 30
    • 0034985989 scopus 로고    scopus 로고
    • Increased incidence of asthmalike symptoms in girls who become overweight or obese during the school years
    • COI: 1:STN:280:DC%2BD3M3nslGmsA%3D%3D
    • Castro-Rodriguez JA, Holberg CJ, Morgan WJ, Wright AL, Martinez FD. Increased incidence of asthmalike symptoms in girls who become overweight or obese during the school years. Am J Respir Crit Care Med. 2001;163:1344–9.
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 1344-1349
    • Castro-Rodriguez, J.A.1    Holberg, C.J.2    Morgan, W.J.3    Wright, A.L.4    Martinez, F.D.5
  • 31
    • 0018909338 scopus 로고
    • Dysanapsis in normal lungs assessed by the relationship between maximal flow, static recoil, and vital capacity
    • COI: 1:STN:280:DyaL3c7ltFOhsA%3D%3D, PID: 7362140
    • Mead J. Dysanapsis in normal lungs assessed by the relationship between maximal flow, static recoil, and vital capacity. Am Rev Respir Dis. 1980;121:339–42.
    • (1980) Am Rev Respir Dis , vol.121 , pp. 339-342
    • Mead, J.1


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