Interplay between oxidative stress and platelet activation in coronary thrombus of STEMI patients

Antioxidants

Volumn 7, Issue 7, 2018, Pages

  Calvieri, Camilla ^a   Tanzilli, Gaetano ^a   Bartimoccia, Simona ^a   Cangemi, Roberto ^a   Arrivi, Alessio ^b   Dominici, Marcello ^b   Cammisotto, Vittoria ^a   Viceconte, Nicola ^a   Mangieri, Enrico ^a   Frati, Giacomo ^a,c   Violi, Francesco ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b Santa Maria University Hospital   (Italy)

^c IRCCS NEUROMED   (Italy)

Author keywords

Coronary thrombus; Oxidative stress; Platelet activation; STEMI; Thrombolysis in myocardial infarction (TIMI) thrombus score

Indexed keywords

EID: 85050147623     PISSN: None     EISSN: 20763921     Source Type: Journal    
DOI: 10.3390/antiox7070083     Document Type: Article

References (24)

1. Naghavi, M.; Libby, P.; Falk, E.; Casscells, S. W.; Litovsky, S.; Rumberger, J.; Badimon, J. J.; Stefanadis, C.; Moreno, P.; Pasterkamp, G. et al. From vulnerable plaque to vulnerable patient: A call for new definitions and risk assessment strategies: Part I. Circulation 2003, 108, 1664-1672.
2. Yunoki, K.; Naruko, T.; Sugioka, K.; Inaba, M.; Itoh, A.; Haze, K.; Yoshiyama, M.; Ueda, M. Thrombus aspiration therapy and coronary thrombus components in patients with acute ST-elevation myocardial infarction. J. Atheroscler. Thromb. 2013, 20, 524-537.
3. Silvain, J.; Collet, J. P.; Nagaswami, C.; Beygui, F.; Edmondson, K. E.; Bellemain-Appaix, A.; Cayla, G.; Pena, A.; Brugier, D.; Barthelemy, O. et al. Composition of coronary thrombus in acute myocardial infarction. J. Am. Coll. Cardiol. 2011, 57, 1359-1367.
4. Ferrante, G.; Nakano, M.; Prati, F.; Niccoli, G.; Mallus, M. T.; Ramazzotti, V.; Montone, R. A.; Kolodgie, F. D.; Virmani, R.; Crea, F. High levels of systemic myeloperoxidase are associated with coronary plaque erosion in patients with acute coronary syndromes: A clinicopathological study. Circulation 2010, 122, 2505-2513.
5. Yunoki, K.; Naruko, T.; Sugioka, K.; Inaba, M.; Iwasa, Y.; Komatsu, R.; Itoh, A.; Haze, K.; Inoue, T.; Yoshiyama, M. et al. Erythrocyte-rich thrombus aspirated from patients with ST-elevation myocardial infarction: Association with oxidative stress and its impact on myocardial reperfusion. Eur. Heart J. 2012, 33, 1480-1490.
6. Carnevale, R.; Pignatelli, P.; Lenti, L.; Buchetti, B.; Sanguigni, V.; Di Santo, S.; Violi, F. LDL are oxidatively modified by platelets via GP91(phox) and accumulate in human monocytes. FASEB J. 2007, 21, 927-934.
7. Violi, F.; Pignatelli, P. Platelet oxidative stress and thrombosis. Thromb. Res. 2012, 129, 378-381.
8. Niccoli, G.; Celestini, A.; Calvieri, C.; Cosentino, N.; Falcioni, E.; Carnevale, R.; Nocella, C.; Fracassi, F.; Roberto, M.; Antonazzo, R. P. et al. Patients with microvascular obstruction after primary percutaneous coronary intervention show a gp91phox (NOX2) mediated persistent oxidative stress after reperfusion. Eur. Heart J. Acute Cardiovasc. Care 2013, 2, 379-388.
9. Kolh, P.; Windecker, S.; Alfonso, F.; Collet, J. P.; Cremer, J.; Falk, V.; Filippatos, G.; Hamm, C.; Head, S. J.; Juni, P. et al. 2014 ESC/EACTS Guidelines on myocardial revascularization: The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Developed with the special contribution of the European Association of Percutaneous Cardiovascular Interventions (EAPCI). Eur. J. Cardiothorac. Surg. 2014, 46, 517-592.
10. Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC); Steg, P. G.; James, S. K.; Atar, D.; Badano, L. P.; Blomstrom-Lundqvist, C.; Borger, M. A.; Di Mario, C.; Dickstein, K.; Ducrocq, G. et al. ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur. Heart J. 2012, 33, 2569-2619.
11. Gibson, C. M.; de Lemos, J. A.; Murphy, S. A.; Marble, S. J.; McCabe, C. H.; Cannon, C. P.; Antman, E. M.; Braunwald, E.; Group, T. S. Combination therapy with abciximab reduces angiographically evident thrombus in acute myocardial infarction: A TIMI 14 substudy. Circulation 2001, 103, 2550-2554.
12. Pignatelli, P.; Carnevale, R.; Cangemi, R.; Loffredo, L.; Sanguigni, V.; Stefanutti, C.; Basili, S.; Violi, F. Atorvastatin inhibits gp91phox circulating levels in patients with hypercholesterolemia. Arterioscler. Thromb. Vasc. Biol. 2010, 30, 360-367.
13. Sadowski, M.; Zabczyk, M.; Undas, A. Coronary thrombus composition: Links with inflammation, platelet and endothelial markers. Atherosclerosis 2014, 237, 555-561.
14. Pignatelli, P.; Carnevale, R.; Di Santo, S.; Bartimoccia, S.; Sanguigni, V.; Lenti, L.; Finocchi, A.; Mendolicchio, L.; Soresina, A. R.; Plebani, A. et al. Inherited human gp91phox deficiency is associated with impaired isoprostane formation and platelet dysfunction. Arterioscler. Thromb. Vasc. Biol. 2011, 31, 423-434.
15. Delaney, M. K.; Kim, K.; Estevez, B.; Xu, Z.; Stojanovic-Terpo, A.; Shen, B.; Ushio-Fukai, M.; Cho, J.; Du, X. Differential Roles of the NADPH-Oxidase 1 and 2 in Platelet Activation and Thrombosis. Arterioscler. Thromb. Vasc. Biol. 2016, 36, 846-854.
16. Sambola, A.; Ruiz-Meana, M.; Barba, I.; Del Blanco, B. G.; Barrabes, J. A.; Lip, G. Y.; Vilardosa, U.; Sansaloni, S.; Rello, P.; Garcia-Dorado, D. Glycative and oxidative stress are associated with altered thrombus composition in diabetic patients with ST-elevation myocardial infarction. Int. J. Cardiol. 2017, 243, 9-14.
17. Krijnen, P. A.; Meischl, C.; Hack, C. E.; Meijer, C. J.; Visser, C. A.; Roos, D.; Niessen, H. W. Increased Nox2 expression in human cardiomyocytes after acute myocardial infarction. J. Clin. Pathol. 2003, 56, 194-199.
18. Carnevale, R.; Bartimoccia, S.; Nocella, C.; Di Santo, S.; Loffredo, L.; Illuminati, G.; Lombardi, E.; Boz, V.; Del Ben, M.; De Marco, L. et al. LDL oxidation by platelets propagates platelet activation via an oxidative stress-mediated mechanism. Atherosclerosis 2014, 237, 108-116.
19. Magwenzi, S.; Woodward, C.; Wraith, K. S.; Aburima, A.; Raslan, Z.; Jones, H.; McNeil, C.; Wheatcroft, S.; Yuldasheva, N.; Febbriao, M. et al. Oxidized LDL activates blood platelets through CD36/NOX2-mediated inhibition of the cGMP/protein kinase G signaling cascade. Blood 2015, 125, 2693-2703.
20. Majumder, B.; Koganti, S.; Lowdell, M. W.; Rakhit, R. D. Intracoronary platelet and monocyte activation status within platelet-monocyte complexes are determinants of inflammation in ST elevation myocardial infarction1. Clin. Hemorheol. Microcirc. 2016, 64, 35-46.
21. Gresele, P.; Falcinelli, E.; Loffredo, F.; Cimmino, G.; Corazzi, T.; Forte, L.; Guglielmini, G.; Momi, S.; Golino, P. Platelets release matrix metalloproteinase-2 in the coronary circulation of patients with acute coronary syndromes: Possible role in sustained platelet activation. Eur. Heart J. 2011, 32, 316-325.
22. Ko, Y. G.; Le, V. C.; Kim, B. H.; Shin, D. H.; Kim, J. S.; Kim, B. K.; Choi, D.; Jang, Y.; Hong, M. K. Correlations between coronary plaque tissue composition assessed by virtual histology and blood levels of biomarkers for coronary artery disease. Yonsei Med. J. 2012, 53, 508-516.
23. Loffredo, L.; Martino, F.; Carnevale, R.; Pignatelli, P.; Catasca, E.; Perri, L.; Calabrese, C. M.; Palumbo, M. M.; Baratta, F.; Del Ben, M. et al. Obesity and hypercholesterolemia are associated with NOX2 generated oxidative stress and arterial dysfunction. J. Pediatr. 2012, 161, 1004-1009.
24. Carnevale, R.; Loffredo, L.; Sanguigni, V.; Plebani, A.; Rossi, P.; Pignata, C.; Martire, B.; Finocchi, A.; Pietrogrande, M. C.; Azzari, C. et al. Different degrees of NADPH oxidase 2 regulation and in vivo platelet activation: Lesson from chronic granulomatous disease. J. Am. Heart Assoc. 2014, 3, e000920.