Quercetin-3-methyl ether suppresses human breast cancer stem cell formation by inhibiting the Notch1 and PI3K/Akt signaling pathways

International Journal of Molecular Medicine

Volumn 42, Issue 3, 2018, Pages 1625-1636

  Cao, Longbin ^a   Yang, Yunxiao ^a   Ye, Ziyu ^a   Lin, Bihua ^a   Zeng, Jincheng ^a   Li, Caihong ^a   Liang, Tong ^a   Zhou, Keyuan ^a   Li, Jixia ^a  

^a GUANGDONG MEDICAL UNIVERSITY   (China)

Author keywords

Breast cancer; Cancer stem cells; Natural compound; Quercetin 3 methyl ether

Indexed keywords

QUERCETIN 3 METHYL ETHER; SOMATOMEDIN C; EZH2 PROTEIN, HUMAN; NOTCH1 PROTEIN, HUMAN; NOTCH1 RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; QUERCETIN; QUERCETIN 3-O-METHYL ETHER; TRANSCRIPTION FACTOR EZH2;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER STEM CELL; CELL CYCLE; COLONY FORMATION; CONTROLLED STUDY; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; NOTCH1 SIGNALING; PI3K/AKT SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; BIOLOGICAL MODEL; BREAST TUMOR; CELL CYCLE CHECKPOINT; CELL CYCLE G2 PHASE; CELL MOTION; CELL PROLIFERATION; DRUG EFFECT; FEMALE; METABOLISM; MITOSIS; PATHOLOGY; TUMOR CELL LINE; TUMOR INVASION;

APOPTOSIS; BREAST NEOPLASMS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; ENHANCER OF ZESTE HOMOLOG 2 PROTEIN; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; G2 PHASE; HUMANS; MITOSIS; MODELS, BIOLOGICAL; NEOPLASM INVASIVENESS; NEOPLASTIC STEM CELLS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; QUERCETIN; RECEPTOR, NOTCH1; SIGNAL TRANSDUCTION;

EID: 85049598840     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2018.3741     Document Type: Article

References (36)

1. Felipe Lima J, Nofech-Mozes S, Bayani J and Bartlett JM: EMT in breast carcinoma-A review. J clin Med 5: E65, 2016.
2. Siegel RL, Miller KD and Jemal A: Cancer statistics, 2015. Ca cancer J clin 65: 5-29, 2015.
3. Wu Y, Sarkissyan M and Vadgama JV: Epithelial-mesenchymal transition and breast cancer. J clin Med 5: E13, 2016.
4. Wang Y and Zhou BP: Epithelial-mesenchymal transition in breast cancer progression and metastasis. Chin J cancer 30: 603-611, 2011.
5. Asiedu MK, Beauchamp-Perez FD, Ingle JN, Behrens MD, Radisky DC and Knutson KL: AXL induces epithelial-to-mesenchymal transition and regulates the function of breast cancer stem cells. Oncogene 33: 1316-1324, 2014.
6. Czerwinska P and Kaminska B: Regulation of breast cancer stem cell features. Contemp Oncol 19: A7-A15, 2015.
7. Zhao Z, Lu P, Zhang H, Xu H, Gao N, Li M and Liu C: Nestin positively regulates the Wnt/β-catenin pathway and the proliferation, survival and invasiveness of breast cancer stem cells. Breast cancer Res 16: 408, 2014.
8. Geng SQ, Alexandrou AT and Li JJ: Breast cancer stem cells: Multiple capacities in tumor metastasis. Cancer Lett 349: 1-7, 2014.
9. Bao B, Wang Z, Ali S, Kong D, Li Y, Ahmad A, Banerjee S, Azmi AS, Miele L and Sarkar FH: Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells. Cancer Lett 307: 26-36, 2011.
10. Clementz AG, Rogowski A, Pandya K, Miele L and Osipo C: NOTcH-1 and NOTcH-4 are novel gene targets of PEA3 in breast cancer: Novel therapeutic implications. Breast cancer Res 13: R63, 2011.
11. Zhong Y, Shen S, Zhou Y, Mao F, Lin Y, Guan J, Xu Y, Zhang S, Liu X and Sun Q: NOTcH1 is a poor prognostic factor for breast cancer and is associated with breast cancer stem cells. Onco Targets Ther 9: 6865-6871, 2016.
12. Callahan R and Raafat A: Notch signaling in mammary gland tumorigenesis. J Mammary Gland Biol Neoplasi 6: 23-36, 2001.
13. Reedijk M, Odorcic S, Chang L, Zhang H, Miller N, Mccready DR, Lockwood G and Egan SE: High-level coexpression of JAG1 and NOTcH1 is observed in human breast cancer and is associated with poor overall survival. Cancer Res 65: 8530-8537, 2005.
14. Farnie G and Clarke RB: Mammary stem cells and breast cancer-role of Notch signalling. Stem cell Rev 3: 169-175, 2007.
15. Palomero T, Dominguez M and Ferrando AA: The role of the PTEN/AKT Pathway in NOTcH1-induced leukemia. Cell cycle 7: 965-70, 2008.
16. Marty B, Maire V, Gravier E, Rigaill G, Vincent-Salomon A, Kappler M, Lebigot I, Djelti F, Tourdès A, Gestraud P, Et AL: Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells. Breast cancer Res 10: R101, 2008.
17. Baselga J: Targeting the phosphoinositide-3 (PI3) kinase pathway in breast cancer. Oncologist 16 (Suppl 1): S12-S19, 2011.
18. Singh JK, Farnie G, Bundred NJ, Simtes BM, Shergill A, Landberg G, Howell SJ and Clarke RB: Targeting cXcR1/2 significantly reduces breast cancer stem cell activity and increases the efficacy of inhibiting HER2 via HER2-dependent and - independent mechanisms. Clin cancer Res 19: 643-656, 2013.
19. Hernandez-Aya LF and Gonzalez-Angulo AM: Targeting the phosphatidylinositol 3-kinase signaling pathway in breast cancer. Oncologist 16: 404-414, 2011.
20. Kleer CG, Cao Q, Varambally S, Shen R, Ota I, Tomlins SA, Ghosh D, Sewalt RG, Otte AP, Hayes DF, Et AL: EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc Natl Acad Sci USA 100: 11606-11611, 2003.
21. Inari H, Suganuma N, Kawachi K, Yoshida T, Yamanaka T, Nakamura Y, Yoshihara M, Nakayama H, Yamanaka A, Masudo K, Et AL: Expression of enhancer of zeste homolog 2 correlates with survival outcome in patients with metastatic breast cancer: Exploratory study using primary and paired metastatic lesions. BMc cancer 17: 160, 2017.
22. Pourakbar S, Pluard TJ, Accurso AD and Farassati F: Ezh2, a novel target in detection and therapy of breast cancer. Onco Targets Ther 10: 2685-2687, 2017
23. Rubio S, Quintana J, Eiroa JL, Triana J and Estévez F: Acetyl derivative of quercetin 3-methyl ether-induced cell death in human leukemia cells is amplified by the inhibition of ERK. Carcinogenesis 28: 2105-2113, 2007
24. Lee EH, Kim HJ, Song YS, Jin C, Lee KT, Cho J and Lee YS: Constituents of the stems and fruits of Opuntia ficus-indica var saboten. Arch Pharm Res 26: 1018-1023, 2003.
25. Takeara R, Albuquerque S, Lopes NP and Lopes JL: Trypanocidal activity of Lychnophora staavioides Mart. (Vernonieae, Asteraceae). Phytomedicine 10: 490-493, 2003.
26. Wei BL, Lu CM, Tsao LT, Wang JP and Lin CN: In vitro anti-inflammatory effects of quercetin 3-O-methyl ether and other constituents from Rhamnus species. Planta Med 67 745-747, 2001.
27. 2 induced cytotoxicity in lung and liver cells. BMc complement Altern Med 16: 376, 2016.
28. Martino R, Arcos ML, Alonso R, Sülsen V, Cremaschi G and Anesini C: Polyphenol-rich fraction from Larrea divaricata and its main flavonoid quercetin-3-methyl ether induce apoptosis in lymphoma cells through nitrosative stress. Phytother Res 30: 1128-1136, 2016.
29. Li J, Mottamal M, Li H, Liu K, Zhu F, Cho YY, Sosa CP, Zhou K, Bowden GT, Bode AM, Et AL: Quercetin-3-methyl ether suppresses proliferation of mouse epidermal JB6 P+ cells by targeting ERKs. Carcinogenesis 33: 459-465, 2012.
30. 2/M arrest and apoptosis. Mol carcinog 52: 134-143, 2013.
31. Kim HY, Lee KM, Kim SH, Kwon YJ, Chun YJ and Choi HK: Comparative metabolic and lipidomic profiling of human breast cancer cells with different metastatic potentials. Oncotarget 7: 67111-67128, 2016.
32. Gonzalez ME, Moore HM, Li X, Toy KA, Huang W, Sabel MS, Kidwell KM and Kleer CG: EZH2 expands breast stem cells through activation of NOTcH1 signaling. Proc Natl Acad Sci USA 111: 3098-3103, 2014.
33. Armstrong AJ, Marengo MS, Oltean S, Kemeny G, Bitting RL, Turnbull JD, Herold CI, Marcom PK, George DJ and Garcia-Blanco MA: Circulating tumor cells from patients with advanced prostate and breast cancer display both epithelial and mesenchymal markers. Mol cancer Res 9: 997-1007, 2011.
34. Lombaerts M, Van Wezel T, Philippo K, Dierssen J W, Zimmerman RM, Oosting J, Van Eijk R, Eilers PH, Van De Water B, Cornelisse CJ, Et AL: E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines. Br J cancer 94: 661-671, 2006.
35. Zhu H, Bhaijee F, Ishaq N, Pepper DJ, Backus K, Brown AS, Zhou X and Miele L: Correlation of Notch1, pAKT and nuclear NF-κB expression in triple negative breast cancer. Am J cancer Res 3: 230-239, 2013.
36. Meurette O, Stylianou S, Rock R, Collu GM, Gilmore AP and Brennan K: Notch activation induces Akt signaling via an autocrine loop to prevent apoptosis in breast epithelial cells. Cancer Res 69: 5015-5022, 2009.