Genetic mannose binding lectin deficiency is associated with airway microbiota diversity and reduced exacerbation frequency in COPD

Thorax

Volumn 73, Issue 6, 2018, Pages 510-518

  Dicker, Alison J ^a   Crichton, Megan L ^a   Cassidy, Andrew J ^a   Brady, Gill ^b   Hapca, Adrian ^c   Tavendale, Roger ^c   Einarsson, Gisli G ^d   Furrie, Elizabeth ^e   Elborn, J Stuart ^d,f   Schembri, Stuart ^a   Marshall, Sara E ^a   Palmer, Colin N A ^c   Chalmers, James D ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b Tayside Respiratory Research Group   (United Kingdom)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

^d UKCRC Centre of Excellence for Public Health (NI)   (United Kingdom)

^e NINEWELLS HOSPITAL   (United Kingdom)

^f NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Bacterial Infection; COPD Epidemiology; COPD Exacerbations; Innate Immunity; Macrophage Biology

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; C REACTIVE PROTEIN; CD40 LIGAND; INTERLEUKIN 1BETA; INTERLEUKIN 8; MYELOPEROXIDASE; PADGEM PROTEIN; TUMOR NECROSIS FACTOR; MANNOSE BINDING LECTIN;

ADULT; AGED; ALL CAUSE MORTALITY; ARTICLE; BURKHOLDERIA CENOCEPACIA; CARDIOVASCULAR MORTALITY; CHRONIC OBSTRUCTIVE LUNG DISEASE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE SEVERITY; ESCHERICHIA COLI; FEMALE; FORCED EXPIRATORY VOLUME; GENE SEQUENCE; GENOTYPING TECHNIQUE; HAEMOPHILUS; HAEMOPHILUS INFLUENZAE; HAPLOTYPE; HUMAN; LONGITUDINAL STUDY; LUNG MICROBIOTA; MAJOR CLINICAL STUDY; MALE; MANNOSE BINDING LECTIN DEFICIENCY; MICROBIAL DIVERSITY; MICROFLORA; MORTALITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DEFECT; PSEUDOMONAS AERUGINOSA; RESPIRATORY MORTALITY; RESPIRATORY TRACT INFLAMMATION; SINGLE NUCLEOTIDE POLYMORPHISM; SPECIES DOMINANCE; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; DEFICIENCY; GENETIC ASSOCIATION STUDY; GENETICS; GENOTYPE; INBORN ERROR OF METABOLISM; LUNG FUNCTION TEST; MICROBIOLOGY; MIDDLE AGED; PATHOPHYSIOLOGY; SPUTUM;

ADULT; AGED; DISEASE PROGRESSION; FEMALE; GENETIC ASSOCIATION STUDIES; GENOTYPE; HUMANS; MALE; MANNOSE-BINDING LECTIN; METABOLISM, INBORN ERRORS; MICROBIOTA; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY FUNCTION TESTS; SPUTUM;

EID: 85049591800     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thoraxjnl-2016-209931     Document Type: Article

References (31)

1. Vestbo J, Hurd SS, Agustí AG, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2013;187:347-65
2. E rb-Downward JR, Thompson DL, Han MK, et al. Analysis of the lung microbiome in the "healthy" smoker and in COPD. PLoS One 2011;6:e16384
3. Vestbo J, Agusti A, Wouters EF, et al. Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints Study Investigators. Should we view chronic obstructive pulmonary disease differently after ECLIPSE?. A clinical perspective from the study team. Am J Respir Crit Care Med 2014;189:1022-30
4. C asanova C, de Torres JP, Aguirre-Jaíme A, et al. The progression of chronic obstructive pulmonary disease is heterogeneous: the experience of the BODE cohort. Am J Respir Crit Care Med 2011;184:1015-21
5. Fidler KJ, Hilliard TN, Bush A, et al. Mannose-binding lectin is present in the infected airway: a possible pulmonary defence mechanism. Thorax 2009;64:150-5
6. Garred P, Honoré C, Ma YJ, et al. MBL2, FCN1, FCN2 and FCN3-The genes behind the initiation of the lectin pathway of complement. Mol Immunol 2009;46:2737-44
7. Chalmers JD, McHugh BJ, Doherty C, et al. Mannose-binding lectin deficiency and disease severity in non-cystic fibrosis bronchiectasis: a prospective study. Lancet Respir Med 2013;1:224-32
8. Garred P, Pressler T, Madsen HO, et al. Association of mannose-binding lectin gene heterogeneity with severity of lung disease and survival in cystic fibrosis. J Clin Invest 1999;104:431-7
9. Yang IA, Seeney SL, Wolter JM, et al. Mannose-binding lectin gene polymorphism predicts hospital admissions for COPD infections. Genes Immun 2003;4:269-74
10. Mandal J, Malla B, Steffensen R, et al. Mannose-binding lectin protein and its association to clinical outcomes in COPD: a longitudinal study. Respir Res 2015;16:150
11. E agan TM, Aukrust P, Bakke PS, et al. Systemic mannose-binding lectin is not associated with chronic obstructive pulmonary disease. Respir Med 2010;104:283-90
12. T ran HB, Ahern J, Hodge G, et al. Oxidative stress decreases functional airway mannose binding lectin in COPD. PLoS One 2014;9:e98571
13. Donnelly LE, Barnes PJ. Defective phagocytosis in airways disease. Chest 2012;141:1055-62
14. Seemungal TA, Donaldson GC, Paul EA, et al. Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998;157:1418-22
15. Altman DG, Bland JM. Interaction revisited: the difference between two estimates. BMJ 2003;326:219
16. Bafadhel M, McKenna S, Terry S, et al. Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers. Am J Respir Crit Care Med 2011;184:662-71
17. Berenson CS, Garlipp MA, Grove LJ, et al. Impaired phagocytosis of nontypeable Haemophilus influenzae by human alveolar macrophages in chronic obstructive pulmonary disease. J Infect Dis 2006;194:1375-84
18. Dransfield MT, Bourbeau J, Jones PW, et al. Once-daily inhaled fluticasone furoate and vilanterol versus vilanterol only for prevention of exacerbations of COPD: two replicate double-blind, parallel-group, randomised controlled trials. Lancet Respir Med 2013;1:210-23
19. Møller-Kristensen M, Ip WK, Shi L, et al. Deficiency of mannose-binding lectin greatly increases susceptibility to postburn infection with Pseudomonas aeruginosa. J Immunol 2006;176:1769-75
20. C halmers JD, Goeminne P, Aliberti S, et al. The bronchiectasis severity index. An international derivation and validation study. Am J Respir Crit Care Med 2014;189:576-85
21. R ogers GB, Zain NM, Bruce KD, et al. A novel microbiota stratification system predicts future exacerbations in bronchiectasis. Ann Am Thorac Soc 2014;11:496-503
22. E isen DP, Osthoff M. If there is an evolutionary selection pressure for the high frequency of MBL2 polymorphisms, what is it?. Clin Exp Immunol 2014;176:165-71
23. A lbert RK, Connett J, Curtis JL, et al. Mannose-binding lectin deficiency and acute exacerbations of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2012;7:767-77
24. A guirre E, Galiana A, Mira A, et al. Analysis of microbiota in stable patients with chronic obstructive pulmonary disease. APMIS 2015;123:427-32
25. G arcia-Nuñez M, Millares L, Pomares X, et al. Severity-related changes of bronchial microbiome in chronic obstructive pulmonary disease. J Clin Microbiol 2014;52:4217-23
26. Millares L, Ferrari R, Gallego M, et al. Bronchial microbiome of severe COPD patients colonised by Pseudomonas aeruginosa. Eur J Clin Microbiol Infect Dis 2014;33:1101-11
27. Morris A, Beck JM, Schloss PD, et al. Comparison of the respiratory microbiome in healthy nonsmokers and smokers. Am J Respir Crit Care Med 2013;187:1067-75
28. Boixeda R, Almagro P, Díez-Manglano J, et al. Bacterial flora in the sputum and comorbidity in patients with acute exacerbations of COPD. Int J Chron Obstruct Pulmon Dis 2015;10:2581-91
29. A ydemir Y, Aydemir O, Kalem F. Relationship between the GOLD combined COPD assessment staging system and bacterial isolation. Int J Chron Obstruct Pulmon Dis 2014;9:1045-51
30. Brusselle G, Bracke K. Targeting immune pathways for therapy in asthma and chronic obstructive pulmonary disease. Ann Am Thorac Soc 2014;11(Suppl 5):S322-S328
31. Sprong T, Jack DL, Klein NJ, et al. Mannose binding lectin enhances IL-1beta and IL-10 induction by non-lipopolysaccharide (LPS) components of Neisseria meningitidis. Cytokine 2004;28:59-66.