Detectable high-sensitivity cardiac troponin within the population reference interval conveys high 5-year cardiovascular risk: An observational study

Clinical Chemistry

Volumn 64, Issue 7, 2018, Pages 1044-1053

  Than, Martin P ^a   Aldous, Sally J ^a   Troughton, Richard W ^a,b   Pemberton, Christopher J ^b   Richards, A Mark ^b,c   Frampton, Christopher M A ^b   Florkowski, Christopher M ^a   George, Peter M ^a   Bailey, Samantha ^a   Young, Joanna M ^a   Cullen, Louise ^d,e,f   Greenslade, Jaimi H ^d,f   Parsonage, William A ^d   Everett, Brendan M ^g   Peacock, W Frank ^h   Jaffe, Allan S ⁱ   Pickering, John W ^a,b  

^a CHRISTCHURCH HOSPITAL   (New Zealand)

^b UNIVERSITY OF OTAGO   (New Zealand)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^e QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^f UNIVERSITY OF QUEENSLAND   (Australia)

^g BRIGHAM AND WOMEN S HOSPITAL   (United States)

^h BAYLOR COLLEGE OF MEDICINE   (United States)

ⁱ MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TROPONIN; TROPONIN I; TROPONIN T;

ACUTE CORONARY SYNDROME; ADULT; AGED; ALL CAUSE MORTALITY; ARTICLE; CARDIOGENIC SHOCK; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CONFIDENCE INTERVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; EMERGENCY WARD; FEMALE; FOLLOW UP; HAZARD RATIO; HEART ARREST; HEART DEATH; HEART VENTRICLE ARRHYTHMIA; HIGH RISK PATIENT; HUMAN; LIMIT OF DETECTION; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; NEW ZEALAND; NON ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; POPULATION RESEARCH; PROPORTIONAL HAZARDS MODEL; PROSPECTIVE STUDY; REFERENCE VALUE; RISK ASSESSMENT; SECOND DEGREE ATRIOVENTRICULAR BLOCK; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; STATISTICAL ANALYSIS; BLOOD; RISK FACTOR; STANDARD;

CARDIOVASCULAR DISEASES; HUMANS; LIMIT OF DETECTION; REFERENCE STANDARDS; RISK FACTORS; TROPONIN I; TROPONIN T;

EID: 85049390030     PISSN: 00099147     EISSN: 15308561     Source Type: Journal    
DOI: 10.1373/clinchem.2017.285700     Document Type: Article

References (32)

1. Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR. ESC/ACCF/AHA/WHF Expert Consensus Document: Third universal definition of myocardial infarction. Circulation 2012;126:2020 -35.
2. Rubini Gimenez M, Hoeller R, Reichlin T, Zellweger C, Twerenbold R, Reiter M, et al. Rapid rule out of acute myocardial infarction using undetectable levels of highsensitivity cardiac troponin. Int J Cardiol 2013;168: 3896 -901.
3. Amsterdam EA, Kirk JD, Bluemke DA, Diercks D, Farkouh ME, Garvey JL, et al. Testing of low-risk patients presenting to the emergency department with chest pain: A scientific statement from the American Heart Association. Circulation 2010;122:1756 -76.
4. Than MP, Aldous S, Lord SJ, Goodacre S, Frampton CMA, TroughtonR, et al. A2-hourdiagnosticprotocolforpossible cardiac chest pain in the emergency department: A randomized clinical trial. JAMA Intern Med 2014;174:51-8.
5. Aroney N, Aylward PE, Kelly A-M, Chew DPB, Clune E. Guidelines for the management of acute coronary syndromes 2006. Med J Aust 2006;184:S1-30.
6. Thelin J, Melander O, Ohlin B. Early rule-out of acute coronary syndrome using undetectable levels of high sensitivity troponin T. Eur Heart J Acute Cardiovasc Care 2015;4:403-9.
7. Roffi M, Patrono C, Collet J-P, Mueller C, Valgimigli M, Andreotti F, et al. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Euro Heart J 2016;37:267-315.
8. Body R, Mueller C, Giannitsis E, Christ M, Ordóñ ez-Llanos J, de Filippi CR, et al. The use of very low concentrations of high-sensitivity troponin T to rule out acute myocardial infarction using a single blood test. Acad Emerg Med 2016;23:1004 -13.
9. deFilippi CR, de Lemos JA, Christenson RH, Gottdiener JS, Kop WJ, Zhan M, et al. Association of serial measures of cardiac troponin T using a sensitive assay with incident heart failure and cardiovascular mortality in older adults. JAMA 2010;304:2494 -502.
10. Everett BM, Brooks MM, Vlachos HEA, Chaitman BR, Frye RL, Bhatt DL. Troponin and cardiac events in stable ischemic heart disease and diabetes. N Engl J Med 2015;373:610 -20.
11. Everett BM, Zeller T, Glynn RJ, Ridker PM, Blankenberg S. High-sensitivity cardiac troponin I and B-type natriuretic Peptide as predictors of vascular events in primary prevention: Impact of statin therapy. Circulation 2015;131:1851- 60.
12. de Lemos JA, Drazner MH, Omland T, Ayers CR, Khera A, Rohatgi A, et al. Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population. JAMA 2010;304: 2503-12.
13. Omland T, de Lemos JA, Sabatine MS, Christophi CA, Rice MM, Jablonski KA, et al. A sensitive cardiac troponin T assay in stable coronary artery disease. N Engl J Med 2009;361:2538 - 47.
14. Roos A, Bandstein N, Lundback M, Hammarsten O, Ljung R, Holzmann MJ. Stable high-sensitivity cardiac troponin T levels and outcomes in patients with chest pain. JACC 2017;70:2226 -36.
15. Zhu K, Knuiman M, Divitini M, Murray K, Lim E-M, St John A, et al. High-sensitivity cardiac troponin I and risk of cardiovascular disease in an Australian populationbased cohort. Heart 2018;104:895-903.
16. Omland T, Pfeffer MA, Solomon SD, de Lemos JA, Røsjø H, Šaltyte Benth J, et al. Prognostic value of cardiac troponin I measured with a highly sensitive assay in patients with stable coronary artery disease. JACC 2013; 61:1240 -9.
17. Eggers KM, Venge P, Lindahl B, Lind L. Cardiac troponin I levels measured with a high-sensitive assay increase over time and are strong predictors of mortality in an elderly population. JACC 2013;61:1906 -13.
18. Aldous SJ, Florkowski CM, Crozier IG, George P, Mackay R, Than MP, et al. High sensitivity troponin outperforms contemporary assays in predicting major adverse cardiac events up to two years in patients with chest pain. Ann Clin Biochem 2011;48:249 -55.
19. Than MP, Cullen LA, Aldous S, Parsonage WA, Reid CM, Greenslade JH, et al. 2-Hour accelerated diagnostic protocol to assess patients with chest pain symptoms using contemporary troponins as the only biomarker: The ADAPT trial. JACC 2012;59:2091- 8.
20. Thygesen K, Alpert JS, White HD, on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction. Universal definition of myocardial infarction. Circulation 2007;116:2634 -53.
21. Cullen LA, Than MP, Brown AFT, Richards M, Parsonage WA, Flaws D, et al. Comprehensive standardized data definitions for acute coronary syndrome research in emergency departments in Australasia. Emerg Med Australas 2010;22:35-55.
22. Pickering JW, Greenslade JH, Cullen LA, Flaws D, ParsonageWA, George, P, et al. Validationofpresentationand3h high-sensitivitytroponintorule-inandrule-outacutemyocardial infarction. Heart 2016;102:1270-78.
23. Buuren S, Groothuis-Oudshoorn K. Mice: Multivariate imputation by chained equations in R. J Statistical Software 2011;45:1- 67.
24. Grambsch PM, Therneau TM. Proportional hazards tests and diagnostics based on weighted residuals. Biometrika 1994;81:515-26.
25. Harrell FE. Regression Modeling Strategies. 2nd ed. New York (NY): Springer; 2015.
26. Haaf P, Reichlin T, Twerenbold R, Hoeller R, Rubini Gimenez M, Zellweger C, et al. Risk stratification in patients with acute chest pain using three high-sensitivity cardiac troponin assays. Euro Heart J 2014;35:365-75.
27. James S, Flodin M, Johnston N, Lindahl B, Venge P. The antibody configurations of cardiac troponin I assays may determine their clinical performance. Clin Chem 2006;52:832-7.
28. Jaffe AS, Vasile VC, Milone M, Saenger AK, Olson KN, Apple FS. Diseased skelet al muscle: A noncardiac source of increased circulating concentrations of cardiac troponin T. JACC 2011;58:1819 -24.
29. Rittoo D, Jones A, Lecky B, Neithercut D. Elevation of cardiac troponin T, but not cardiac troponin I, in patients with neuromuscular diseases: Implications for the diagnosis of myocardial infarction. JACC 2014;63:2411-20.
30. Moore BJ, Stocks C, Owens PL. STATISTICAL BRIEF #227. Healthcare Cost and Utilization Project (HCUP) [Internet]. Agency for Healtcare Research and Quality. Agency for Healthcare Research and Quality (US); 2017 Sep. Report No.: 227. https://hcup-us.ahrq.gov/ reports/statbriefs/sb227-Emergency-Department-Visit-Trends.jsp (Accessed December 4, 2017).
31. Aldous SJ, Florkowski CM, Crozier IG, Than MP. The performance of high sensitivity troponin for the diagnosis of acute myocardial infarction is underestimated. Clin Chem Lab Med 2011;50:727-9.
32. Egger M, Dieplinger B, Mueller T. One-year in vitro stability of cardiac troponins and galectic-3 in different sample types. Clin Chim Acta 2018;476:117-22.