A review of ketamine’s role in ECT and non-ECT settings

Neuropsychiatric Disease and Treatment

Volumn 14, Issue , 2018, Pages 1437-1450

  Jankauskas, Vytautas ^a   Necyk, Candace ^b   Chue, James ^c   Chue, Pierre ^b  

^a GREY NUNS COMMUNITY HOSPITAL   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

^c UNIVERSITY AT BUFFALO   (United States)

Author keywords

Anesthesia; ECT; Ketamine; Major depressive disorder

Indexed keywords

CLONIDINE; DICLOFENAC; ESCITALOPRAM; FENTANYL; KETAMINE; PLACEBO; PROPOFOL; RILUZOLE;

BECK DEPRESSION INVENTORY; BRADYCARDIA; DEPRESSION; DISEASE DURATION; DRUG EFFICACY; ELECTROCONVULSIVE THERAPY; FAMILY HISTORY; FOOD AND DRUG ADMINISTRATION; HAMILTON DEPRESSION RATING SCALE; HUMAN; HYPERTENSION; HYPOTENSION; MAJOR DEPRESSION; MONTGOMERY ASBERG DEPRESSION RATING SCALE; OUTCOME ASSESSMENT; PREDICTOR VARIABLE; REVIEW; SEIZURE; TACHYCARDIA; TREATMENT RESISTANT DEPRESSION; YOUNG MANIA RATING SCALE;

EID: 85048705222     PISSN: None     EISSN: 11782021     Source Type: Journal    
DOI: 10.2147/NDT.S157233     Document Type: Review

References (39)

1. Mrazek DA, Hornberger JC, Altar CA, Degtiar I. A review of the clinical, economic, and societal burden of treatment-resistant depression: 1996–2013. Psychiatr Serv. 2014;65(8):977–987.
2. Inc SC. Product Monograph. QC, Canada: Sandoz Canada Inc.; 2015. Available from: https://www.sandoz.ca/sites/www.sandoz.ca/files/Ketamine_HCl_PMe_20150506.pdf. Accessed July 13, 2017.
3. Naughton M, Clarke G, O’Leary OF, Cryan JF, Dinan TG. A review of ketamine in affective disorders: current evidence of clinical efficacy, limitations of use and pre-clinical evidence on proposed mechanisms of action. J Affect Disord. 2014;156:24–35.
4. Newport DJ, Carpenter LL, McDonald WM, et al. Ketamine and other NMDA antagonists: early clinical trials and possible mechanisms in depression. Am J Psychiatry. 2015;172(10):950–966.
5. Sanacora G, Frye MA, McDonald W, et al. A consensus statement on the use of ketamine in the treatment of mood disorders. JAMA Psychiatry. 2017;74(4):399–405.
6. Kennedy SH, Lam RW, McIntyre RS, et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical guidelines for the management of adults with major depressive disorder: Section 3. Pharmacological treatments. Can J Psychiatry. 2016;61(9): 540–560.
7. Jarventausta K, Chrapek W, Kampman O, et al. Effects of S-ketamine as an anesthetic adjuvant to propofol on treatment response to electroconvulsive therapy in treatment-resistant depression: a randomized pilot study. J ECT. 2013;29(3):158–161.
8. Wang X, Chen Y, Zhou X, Liu F, Zhang T, Zhang C. Effects of propofol and ketamine as combined anesthesia for electroconvulsive therapy in patients with depressive disorder. J ECT. 2012;28(2):128–132.
9. Yalcin S, Aydogan H, Selek S, et al. Ketofol in electroconvulsive therapy anesthesia: two stones for one bird. J Anesth. 2012;26(4):562–567.
10. Yoosefi A, Sepehri AS, Kargar M, et al. Comparing effects of ketamine and thiopental administration during electroconvulsive therapy in patients with major depressive disorder: a randomized, double-blind study. J ECT. 2014;30(1):15–21.
11. Abdallah CG, Fasula M, Kelmendi B, Sanacora G, Ostroff R. Rapid antidepressant effect of ketamine in the electroconvulsive therapy setting. J ECT. 2012;28(3):157–161.
12. Erdil F, Ozgul U, Colak C, Cumurcu B, Durmus M. Effect of the addition of ketamine to sevoflurane anesthesia on seizure duration in electroconvulsive therapy. J ECT. 2015;31(3):182–185.
13. Salehi B, Mohammadbeigi A, Kamali AR, Taheri-Nejad MR, Moshiri I. Impact comparison of ketamine and sodium thiopental on anesthesia during electroconvulsive therapy in major depression patients with drug-resistant; a double-blind randomized clinical trial. Ann Card Anaesth. 2015;18(4):486–490.
14. Rybakowski JK, Bodnar A, Krzywotulski M, et al. Ketamine anesthesia, efficacy of electroconvulsive therapy, and cognitive functions in treatment-resistant depression. J ECT. 2016;32(3):164–168.
15. Anderson IM, Blamire A, Branton T, et al. Randomised controlled trial of ketamine augmentation of electroconvulsive therapy to improve neuropsychological and clinical outcomes in depression (Ketamine-ECT study). Efficacy Mech Eval. 2017;4(2).
16. Kuscu OO, Karacaer F, Biricik E, Gulec E, Tamam L, Gunes Y. Effect of ketamine, thiopental and ketamine-thiopental combination during electroconvulsive therapy for depression. Turk J Anaesthesiol Reanim. 2015;43(5):313–317.
17. Fernie G, Currie J, Perrin JS, et al. Ketamine as the anaesthetic for electroconvulsive therapy: the KANECT randomised controlled trial. Br J Psychiatry. 2017;210(6):422–428.
18. Zhong X, He H, Zhang C, et al. Mood and neuropsychological effects of different doses of ketamine in electroconvulsive therapy for treatment-resistant depression. J Affect Disord. 2016;201:124–130.
19. Rasmussen KG, Kung S, Lapid MI, et al. A randomized comparison of ketamine versus methohexital anesthesia in electroconvulsive therapy. Psychiatry Res. 2014;215(2):362–365.
20. Loo CK, Katalinic N, Garfield JB, Sainsbury K, Hadzi-Pavlovic D, Mac-Pherson R. Neuropsychological and mood effects of ketamine in electroconvulsive therapy: a randomised controlled trial. J Affect Disord. 2012;142(1–3):233–240.
21. Erdil F, Begec Z, Kayhan GE, Yologlu S, Ersoy MO, Durmus M. Effects of sevoflurane or ketamine on the QTc interval during electroconvulsive therapy. J Anesth. 2015;29(2):180–185.
22. Kudoh A, Takahira Y, Katagai H, Takazawa T. Small-dose ketamine improves the postoperative state of depressed patients. Anesth Analg. 2002;95(1):114–118.
23. Lenze EJ, Farber NB, Kharasch E, et al. Ninety-six hour ketamine infusion with co-administered clonidine for treatment-resistant depression: A pilot randomised controlled trial. World J Biol Psychiatry. 2016; 17(3):230–238.
24. Li CT, Chen MH, Lin WC, et al. The effects of low-dose ketamine on the prefrontal cortex and amygdala in treatment-resistant depression: a randomized controlled study. Hum Brain Mapp. 2016;37(3): 1080–1090.
25. Ibrahim L, Diazgranados N, Franco-Chaves J, et al. Course of improvement in depressive symptoms to a single intravenous infusion of ketamine vs add-on riluzole: results from a 4-week, double-blind, placebo-controlled study. Neuropsychopharmacology. 2012;37(6): 1526–1533.
26. Mathew SJ, Murrough JW, aan het Rot M, Collins KA, Reich DL, Charney DS. Riluzole for relapse prevention following intravenous ketamine in treatment-resistant depression: a pilot randomized, placebo-controlled continuation trial. Int J Neuropsychopharmacol. 2010;13(1): 71–82.
27. Hu YD, Xiang YT, Fang JX, et al. Single i.v. ketamine augmentation of newly initiated escitalopram for major depression: results from a randomized, placebo-controlled 4-week study. Psychol Med. 2016;46(3): 623–635.
28. Jafarinia M, Afarideh M, Tafakhori A, et al. Efficacy and safety of oral ketamine versus diclofenac to alleviate mild to moderate depression in chronic pain patients: a double-blind, randomized, controlled trial. J Affect Disord. 2016;204:1–8.
29. Daly EJ, Singh JB, Fedgchin M, et al. Intranasal esketamine in treatment resistant depression – a double-blind, randomized, efficacy and dose response study. Society of Biological Psychiatry’s (SOBP) 71st Annual Meeting; May 12–14, 2016; Atlanta, GA, USA.
30. Canuso C, Singh J, Fedgchin M, et al. A novel study design to evaluate the rapid reduction of the symptoms of major depressive disorder, including suicidal ideation, in subjects assessed to be at imminent risk for suicide. Neuropsychopharmacology. 2015;40(22):S480.
31. Zanos P, Gould TD. Intracellular signaling pathways involved in (S)-and (R)-ketamine antidepressant actions. Biol Psychiatry. 2018;83(1):2–4.
32. FDA Drug Safety Communication. FDA review results in new warnings about using general anesthetics and sedation drugs in young children and pregnant women issued on December 14, 2016. Safety Announcement [4-27-2017]. 2017. Available from: https://www.fda.gov/downloads/Drugs/DrugSafety/UCM554644.pdf. Accessed September 1, 2017.
33. Niciu MJ, Luckenbaugh DA, Ionescu DF, et al. Clinical predictors of ketamine response in treatment-resistant major depression. J Clin Psychiatry. 2014;75(5):e417–e423.
34. Niciu MJ, Luckenbaugh DA, Ionescu DF, et al. Ketamine’s antidepressant efficacy is extended for at least four weeks in subjects with a family history of an alcohol use disorder. Int J Neuropsychopharmacol. 2014;18(1):pii.
35. Ionescu DF, Luckenbaugh DA, Niciu MJ, et al. Effect of baseline anxious depression on initial and sustained antidepressant response to ketamine. J Clin Psychiatry. 2014;75(9):e932–e938.
36. Murrough JW, Burdick KE, Levitch CF, et al. Neurocognitive effects of ketamine and association with antidepressant response in individuals with treatment-resistant depression: a randomized controlled trial. Neuropsychopharmacology. 2015;40(5):1084–1090.
37. Sun L, Li Q, Li Q, et al. Chronic ketamine exposure induces permanent impairment of brain functions in adolescent cynomolgus monkeys. Addict Biol. 2014;19(2):185–194.
38. Sheline YI. Neuroimaging studies of mood disorder effects on the brain. Biol Psychiatry. 2003;54(3):338–352.
39. Fournier JC, DeRubeis RJ, Hollon SD, et al. Antidepressant drug effects and depression severity: a patient-level meta-analysis. JAMA. 2010; 303(1):47–53.