Inhibition of x-irradiation-enhanced locomotor recovery after spinal cord injury by hyperbaric oxygen or the antioxidant nitroxide tempol

Journal of Neurosurgery: Spine

Volumn 6, Issue 4, 2007, Pages 337-343

  Hillard, Virany Huynh ^a,c   Peng, Hong ^a   Das, Kaushik ^a   Murali, Raj ^a   Moorthy, Chitti R ^a   Etlinger, Joseph D ^a,b   Zeman, Richard J ^a,b  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b MotoGen Inc   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Contusion; Hyperbaric oxygen; Irradiation; Locomotor function; Rat; Spinal cord injury; Tempol

Indexed keywords

ANTIOXIDANT; TEMPOL; AMINE OXIDE;

ALOPECIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CONTUSION; CONVALESCENCE; FEMALE; HYPERBARIC OXYGEN; LOCOMOTION; NEOPLASM; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; RAT; SPINAL CORD INJURY; X IRRADIATION; ANIMAL; DRUG EFFECT; MOTOR ACTIVITY; MULTIMODALITY CANCER THERAPY; PATHOLOGY; RADIATION DOSE; RADIATION EXPOSURE; RADIATION INJURY; SPIN LABELING; WISTAR RAT;

ALOPECIA; ANIMALS; ANTIOXIDANTS; COMBINED MODALITY THERAPY; CYCLIC N-OXIDES; FEMALE; HYPERBARIC OXYGENATION; MOTOR ACTIVITY; RADIATION DOSAGE; RADIATION INJURIES, EXPERIMENTAL; RATS; RATS, WISTAR; RECOVERY OF FUNCTION; SPIN LABELS; SPINAL CORD INJURIES;

EID: 85047699242     PISSN: 15475654     EISSN: None     Source Type: Journal    
DOI: 10.3171/spi.2007.6.4.9     Document Type: Article

References (40)

1. Bartholdi D, Rubin BP, Schwab ME: VEGF mRNA induction correlates with changes in the vascular architecture upon spinal cord damage in the rat. Eur J Neurosci 9:2549-2560, 1997
2. Basso DM, Beattie MS, Bresnahan JC: A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 12:1-21, 1995
3. Basso DM, Beattie MS, Bresnahan JC: Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp Neurol 139:244-256, 1996
4. Brizel DM, Hage WD, Dodge RK, Munley MT, Piantadosi CA, Dewhirst MW: Hyperbaric oxygen improves tumor radiation response significantly more than carbogen/nicotinamide. Radiat Res 147:715-720, 1997
5. Chikawa T, Ikata T, Katoh S, Hamada Y, Kogure K, Fukuzawa K: Preventive effects of lecithinized superoxide dismutase and methylprednisolone on spinal cord injury in rats: transcriptional regulation of inflammatory and neurotrophic genes. J Neurotrauma 18:93-103, 2001
6. Cuscela D, Coffin D, Lupton GP, Cook JA, Krishna MC, Bonner RF, et al: Protection from radiation-induced alopecia with topical application of nitroxides: fractionated studies. Cancer J Sci Am 2:273-278, 1996
7. Garcia-Barros M, Paris F, Cordon-Cardo C, Lyden D, Rafii S, Haimovitz-Friedman A, et al: Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science 300:1155-1159, 2003
8. Gilmore SA, Phillips N, Liu KM, Houle JD: Radiation-induced modulation of the microglial population in the normal and injured mature spinal cord. Exp Neurol 182:169-179, 2003
9. Goffman T, Cuscela D, Glass J, Hahn S, Krishna CM, Lupton G, et al: Topical application of nitroxide protects radiation-induced alopecia in guinea pigs. Int J Radiat Oncol Biol Phys 22:803-806, 1992
10. Gruner JA: A monitored contusion model of spinal cord injury in the rat. J Neurotrauma 9:123-128, 1992
11. Hahn SM, Sullivan FJ, DeLuca AM, Krishna CM, Wersto N, Venzon D, et al: Evaluation of tempol radioprotection in a murine tumor model. Free Radic Biol Med 22:1211-1216, 1997
12. Hahn SM, Tochner Z, Krishna CM, Glass J, Wilson L, Samuni A, et al: Tempol, a stable free radical, is a novel murine radiation protector. Cancer Res 52:1750-1753, 1992
13. Harrison LB, Chadha M, Hill RJ, Hu K, Shasha D: Impact of tumor hypoxia and anemia on radiation therapy outcomes. Oncologist 7:492-508, 2002
14. Higgins AC, Pearlstein RD, Mullen JB, Nashold BS Jr: Effects of hyperbaric oxygen therapy on long-tract neuronal conduction in the acute phase of spinal cord injury. J Neurosurg 55:501-510, 1981
15. Hillard VH, Peng H, Zhang Y, Das K, Murali R, Etlinger JD, et al: Tempol, a nitroxide antioxidant, improves locomotor and histological outcomes after spinal cord contusion in rats. J Neurotrauma 21:1405-1414, 2004
16. Huang L, Mehta MP, Nanda A, Zhang JH: The role of multiple hyperbaric oxygenation in expanding therapeutic windows after acute spinal cord injury in rats. J Neurosurg 99 (2 Suppl):198-205, 2003
17. Kalderon N: Cell elimination as a strategy for repair in acute spinal cord injury. Curr Pharm Des 11:1237-1245, 2005
18. Kalderon N, Fuks Z: Severed corticospinal axons recover electrophysiologic control of muscle activity after x-ray therapy in lesioned adult spinal cord. Proc Natl Acad Sci U S A 93:11185-11190, 1996
19. Kalderon N, Fuks Z: Structural recovery in lesioned adult mammalian spinal cord by x-irradiation of the lesion site. Proc Natl Acad Sci U S A 93:11179-11184, 1996
20. Kalderon N, Xu S, Koutcher JA, Fuks Z: Fractionated radiation facilitates repair and functional motor recovery after spinal cord transection in rat. Brain Res 904:199-207, 2001
21. Kelly DL Jr, Lassiter KR, Vongsvivut A, Smith JM: Effects of hyperbaric oxygenation and tissue oxygen studies in experimental paraplegia. J Neurosurg 36:425-429, 1972
22. Kunugita N, Kohshi K, Kinoshita Y, Katoh T, Abe H, Tosaki T, et al: Radiotherapy after hyperbaric oxygenation improves radio-response in experimental tumor models. Cancer Lett 164:149-154, 2001
23. Mink RB, Dutka AJ: Hyperbaric oxygen after global cerebral ischemia in rabbits does not promote brain lipid peroxidation. Crit Care Med 23:1398-1404, 1995
24. Mitchell JB, DeGraff W, Kaufman D, Krishna MC, Samuni A, Finkelstein E, et al: Inhibition of oxygen-dependent radiation-induced damage by the nitroxide superoxide dismutase mimic, tempol. Arch Biochem Biophys 289:62-70, 1991
25. Mitchell JB, Samuni A, Krishna MC, DeGraff WG, Ahn MS, Samuni U, et al: Biologically active metal-independent superoxide dismutase mimics. Biochemistry 29:2802-2807, 1990
26. Nawashiro H, Tasaki K, Ruetzler CA, Hallenbeck JM: TNF-α pretreatment induces protective effects against focal cerebral ischemia in mice. J Cereb Blood Flow Metab 17:483-490, 1997
27. Noble LJ, Wrathall JR: Spinal cord contusion in the rat: morphometric analyses of alterations in the spinal cord. Exp Neurol 88:135-149, 1985
28. Ridet JL, Pencalet P, Belcram M, Giraudeau B, Chastang C, Philippon J, et al: Effects of spinal cord x-irradiation on the recovery of paraplegic rats. Exp Neurol 161:1-14, 2000
29. Sherman ML, Datta R, Hallahan DE, Weichselbaum RR, Kufe DW: Ionizing radiation regulates expression of the c-jun proto-oncogene. Proc Natl Acad Sci U S A 87:5663-5666, 1990
30. Takenaga M, Ohta Y, Tokura Y, Hamaguchi A, Nakamura M, Okano H, et al: Lecithinized superoxide dismutase (PC-SOD) improved spinal cord injury-induced motor dysfunction through suppression of oxidative stress and enhancement of neurotrophic factor production. J Control Release 110:283-289, 2006
31. Thews O, Koenig R, Kelleher DK, Kutzner J, Vaupel P: Enhanced radiosensitivity in experimental tumours following erythropoietin treatment of chemotherapy-induced anaemia. Br J Cancer 78:752-756, 1998
32. Toyoda T, Kassell NF, Lee KS: Induction of ischemic tolerance and antioxidant activity by brief focal ischemia. Neuroreport 8:847-851, 1997
33. Vitolo JM, Cotrim AP, Sowers AL, Russo A, Wellner RB, Pillemer SR, et al: The stable nitroxide tempol facilitates salivary gland protection during head and neck irradiation in a mouse model. Clin Cancer Res 10:1807-1812, 2004
34. Wada K, Ito M, Miyazawa T, Katoh H, Nawashiro H, Shima K, et al: Repeated hyperbaric oxygen induces ischemic tolerance in gerbil hippocampus. Brain Res 740:15-20, 1996
35. Wamil AW, Wamil BD, Hellerqvist CG: CM101-mediated recovery of walking ability in adult mice paralyzed by spinal cord injury. Proc Natl Acad Sci U S A 95:13188-13193, 1998
36. Widenfalk J, Lipson A, Jubran M, Hofstetter C, Ebendal T, Cao Y, et al: Vascular endothelial growth factor improves functional outcome and decreases secondary degeneration in experimental spinal cord contusion injury. Neuroscience 120:951-960, 2003
37. 2-adrenoceptor agonist, improves locomotor and histological outcomes after spinal cord contusion in rats. Exp Neurol 159:267-273, 1999
38. Zeman RJ, Feng Y, Peng H, Visintainer PF, Moorthy CR, Couldwell WT, et al: X-irradiation of the contusion site improves locomotor and histological outcomes in spinal cord-injured rats. Exp Neurol 172:228-234, 2001
39. 2-adrenoceptor agonist-enhanced recovery of locomotor function after spinal cord injury is glutathione dependent. J Neurotrauma 23:170-180, 2006
40. Zhang SX, Geddes JW, Owens JL, Holmberg EG: X-irradiation reduces lesion scarring at the contusion site of adult rat spinal cord. Histol Histopathol 20:519-530, 2005