Adenoviral delivery of A-FOS, an AP-1 dominant negative, selectively inhibits drug resistance in two human cancer cell lines

Cancer Gene Therapy

Volumn 9, Issue 1, 2002, Pages 62-70

  Bonovich, Maria ^a   Olive, Michelle ^a   Reed, Eddie ^b   O'Connell, Brian ^c   Vinson, Charles ^a  

^a Laboratory of Cerebral Metabolism   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

A FOS; A2780 CP70; AP 1; Cisplatin; KB85; Multidrug resistance

Indexed keywords

CISPLATIN; DNA; PROTEIN FOS; TRANSCRIPTION FACTOR AP 1;

ADENOVIRUS; ARTICLE; CANCER CELL CULTURE; CANCER RESISTANCE; CARCINOMA; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; EPIDERMIS; GENE DELIVERY SYSTEM; GENE THERAPY; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; OVARY CARCINOMA; PRIORITY JOURNAL; PROTEIN DNA BINDING;

ADENOVIRIDAE; ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; CELL SURVIVAL; CISPLATIN; COLONY-FORMING UNITS ASSAY; DNA PRIMERS; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE THERAPY; GENES, DOMINANT; GENES, FOS; GENETIC VECTORS; HUMANS; IMMUNOENZYME TECHNIQUES; OVARIAN NEOPLASMS; POLYMERASE CHAIN REACTION; SKIN NEOPLASMS; TRANSCRIPTION FACTOR AP-1; TRANSFECTION; TUMOR CELLS, CULTURED;

ADA; ADENOVIRIDAE;

EID: 85047697328     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700409     Document Type: Article

References (51)

1. Primary response genes induced by growth factors and tumor promoters
2. Nuclear proto-oncogene fos and jun
3. AP-1 function and regulation
4. A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture
5. c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms
6. Induction of apoptosis by the transcription factor c-Jun
7. The role of jun and fos gene family members in 12-O-tetradecanoylphorbol-13-acetate induced hemopoietic differentiation
8. Deregulated expression of human c-jun transforms primary rat embryo cells in cooperation with an activated c-Ha-ras gene and transforms rat-la cells as a single gene
9. A dominant-negative to AP1 that abolishes DNA binding and inhibits oncogenesis
10. Cellular transformation and malignancy induced by ras require c-jun
11. Increasing complexity of the Ras signaling pathway
12. The JUN kinase/stress-activated protein kinase pathway is required for epidermal growth factor stimulation of growth of human A549 lung carcinoma cells
13. The Jun kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin
14. cJun overexpression in MCF-7 breast cancer cells produces a tumorigenic, invasive and hormone resistant phenotype
15. Chemotherapy resistance in breast cancer
16. Resistance to chemotherapy in acute leukemia
17. Multidrug resistance in cancer chemotherapy: Invest New Drugs
18. Chemotherapy drug resistance - A panel discussion
19. Biochemistry of multidrug resistance mediated by the multidrug transporter
20. Extending dimerization interfaces: The bZIP basic region can form a coiled coil
21. Tumor necrosis factor alpha inhibits type I collagen synthesis through repressive CCAAT/enhancer-binding proteins
22. Attractive interhelical electrostatic interactions in the proline- and acid region (PAR) leucine zipper subfamily preclude heterodimerizaton with other basic leucine zipper subfamilies
23. A dominant-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos
24. Characterization of a cis-diamminedichloroplatinum(II)-resistant human ovarian cancer cell line and its use in evaluation of platinum analogues
25. Acquired cisplatin resistance in human ovarian cancer cells is associated with enhanced repair of cisplatin-DNA lesions and reduced drug accumulation
26. Cisplatin
27. ERCC1 and ERCC2 expression in malignant tissues from ovarian cancer patients
28. Messenger RNA levels of XPAC and ERCC1 in ovarian cancer tissue correlate with respopnse to platinum-based chemotherapy
29. Cisplatinin induction of ERCC-1 mRNA expression in A2780/CP70 human ovarian cancer cells
30. High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis
31. Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents
32. Isolation and genetic characterization of human KB cell lines resistant to multiple drugs
33. P-glycoproteins: Mediators of multidrug resistance
34. Biochemical, cellular, and pharmacological aspects of the multidrug transporter
35. Isolation of human mdr DNA sequences amplified in multidrugresistant KB carcinoma cells
36. Multidrug resistance of DNA-mediated transformants is linked to transfer of the human mdr1 gene
37. Expression of a multidrug-resistance gene in human tumors and tissues
38. Expression of c-fos in human and murine multidrug-resistant cells
39. Three distinct nuclear protein binding sites in the promoter of the murine multidrug resistance mdr1b gene
40. Use of recombinant adenovirus for metabolic engineering of mammalian cells
41. Cell-type-dependent activity of the ubiquitous transcription factor USF in cellular prolifertion and transcriptional activation
42. Abolishing Myc/Max DNA binding and transformation: Design of a dominant negative
43. Isolation of deletion and substitution mutants of adenovirus type 5
44. Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells
45. Overlapping roles and asymmetrical cross-regulation of the USF proteins in mice
46. Modulation of activity of the promoter of the human MDR1 gene by Ras and p53
47. Inhibition of the Jun kinase pathway blocks DNA repair, enhances p53-mediated apoptosis and promotes gene amplification
48. Modulation of cytotoxicity of chemotherapeutic drugs by activated H-ras
49. Anti-Kras ribozyme induces growth inhibition and increased chemosensitivity in human colon cancer cells
50. Radiosensitization of human tumor cell lines induced by the adenovirus-mediated expression of an anti-Ras single-chain antibody fragment