Secretion of interleukin-10 from murine colon carcinoma cells suppresses systemic antitumor immunity and impairs protective immunity induced against the tumors

Cancer Gene Therapy

Volumn 9, Issue 1, 2002, Pages 109-115

  Kawamura, Kiyoko ^a   Bahar, Rumana ^a   Natsume, Waka ^a,b   Sakiyama, Shigeru ^a   Tagawa, Masatoshi ^a  

^a CHIBA CANCER CENTER   (Japan)

^b TOHO UNIVERSITY   (Japan)

Author keywords

Colon carcinoma; IL 10; Immune suppression

Indexed keywords

CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CELLULAR IMMUNITY; COLON CARCINOMA; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; GENETIC TRANSFECTION; IMMUNOSUPPRESSIVE TREATMENT; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; RETROVIRUS; TH1 CELL; TH2 CELL; TUMOR IMMUNITY;

ADENOCARCINOMA; ANIMALS; ANTIGENS, NEOPLASM; CELL DIVISION; COLONIC NEOPLASMS; DNA PRIMERS; FEMALE; FLOW CYTOMETRY; IMMUNITY, ACTIVE; IMMUNOCOMPROMISED HOST; INTERLEUKIN-10; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TH1 CELLS; TUMOR CELLS, CULTURED;

ANIMALIA; MURINAE; MUS MUSCULUS; UNIDENTIFIED RETROVIRUS;

EID: 85047695828     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700418     Document Type: Article

References (26)

1. Functional diversity of helper T lymphocytes
2. Cytokine therapy for cancer
3. Gene therapy for cancer: What have we done and where are we going?
4. Gene therapy of autoimmune diseases with vectors encoding regulatory cytokines or inflammatory cytokine inhibitors
5. Interleukin-10
6. Adenoviral transfer of the viral IL-10 gene periarticularly to mouse paws suppresses development of collagen-induced arthritis in both injected and uninjected paws
7. Allograft transduction of IL-10 prolongs survival following orthotopic liver transplantation
8. IL-10 inhibits alloreactive cytotoxic T lymphocyte generation in vivo
9. Human glioma-derived interleukin-10 inhibits antitumor immune responses in vitro
10. Serum interleukin-10 in non-Hodgkin's lymphoma: A prognostic factor
11. Interleukin 10 production by human melanoma
12. Interleukin 10 (IL-10): An immunosuppressive factor and independent predictor in patients with metastatic renal cell carcinoma
13. Antimetastatic and antitumor activities of interleukin 10 in a murine model of breast cancer
14. Interleukin-10 inhibits tumor metastasis through an NK cell-dependent mechanism
15. Loss of tumorigenicity and increased immunogenicity induced by interleukin-10 gene transfer in B16 melanoma cells
16. Interleukin 10 suppresses, tumor growth and metastasis of human melanoma cells: Potential inhibition of angiogenesis
17. Interleukin-10 gene transfer activates interferon-γ and the interferon-γ-inducible genes Gbp-1/Mag-I and Mig-1 in mammary tumors
18. Murine colon carcinoma cells engineered to produce human interleukin-2 induce tumor-specific antitumor response
19. Antitumor effect induced by the expression of granulocyte macrophage-colony stimulating factor gene in murine colon carcinoma cells
20. Protective immunity is induced in murine colon carcinoma cells by the expression of interleukin-12 or interleukin-18, which activate type 1 helper T cells
21. Improved retroviral vectors for gene transfer and expression
22. Interleukin-10 gene transfer inhibits murine mammary tumors and elevates nitric oxide
23. IL-10 expression by CT26 colon carcinoma cells inhibits their malignant phenotype and induces a T cell-mediated tumor rejection in the context of a systemic Th2 response
24. Viral interleukin 10 (IL-10), the human herpes virus 4 cellular IL-10 homologue, induced local anergy to allogeneic and syngeneic tumors
25. T cell-derived IL-10 promotes lung cancer growth by suppressing both T cell and APC function
26. Antimetastatic and antitumor activities of interleukin 10 in transfected human prostate PC-3 ML clones: Orthotopic growth in severe combined immunodeficient mice