Molecular analysis of a new variant of the CBF β-MYH11 gene fusion

Leukemia and Lymphoma

Volumn 43, Issue 10, 2002, Pages 2021-2026

  Stulberg, Jennifer ^a   Kamel Reid, Suzanne ^a   Chun, Kathy ^a   Tokunaga, Jason ^a   Wells, Richard A ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Acute myelogenous leukemia; Alternative; AML M4Eo; CBF MYH11; Fusion transcript

Indexed keywords

CORE BINDING FACTOR; CYTARABINE; DAUNORUBICIN; GENE PRODUCT; RNA; CBFBETA MYH11 FUSION PROTEIN; CBFBETA-MYH11 FUSION PROTEIN; ONCOPROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; AGED; ALTERNATIVE RNA SPLICING; ARTICLE; BONE MARROW BIOPSY; CASE REPORT; CHROMOSOME 16; CHROMOSOME ANALYSIS; CHROMOSOME REARRANGEMENT; FEMALE; GENE FUSION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC IDENTIFICATION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; LEUKEMIA CELL; MOLECULAR CLONING; PRIORITY JOURNAL; PROGNOSIS; CHROMOSOME BREAKAGE; CHROMOSOME INVERSION; DIAGNOSTIC PROCEDURE; GENE REARRANGEMENT; GENETICS; MYELOMONOCYTIC LEUKEMIA; NUCLEOTIDE SEQUENCE;

AGED; ALTERNATIVE SPLICING; CHROMOSOME BREAKAGE; CHROMOSOMES, HUMAN, PAIR 16; DNA MUTATIONAL ANALYSIS; FEMALE; GENE REARRANGEMENT; HUMANS; INVERSION, CHROMOSOME; LEUKEMIA, MYELOCYTIC, ACUTE; LEUKEMIA, MYELOMONOCYTIC, ACUTE; MOLECULAR DIAGNOSTIC TECHNIQUES; ONCOGENE PROTEINS, FUSION; PROGNOSIS; RNA, NEOPLASM; VARIATION (GENETICS);

EID: 85047685464     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.1080/1042819021000015989-1     Document Type: Article

References (18)

1. Look, T.A. (1997) "Oncogenic transcription factors in the human acute leukemias", Science 278, 1059-1064.
2. Le Beau, M.M., Larson, R.A., Bitter, M.A., et al. (1983) "Association of an inversion of chromosome 16 with abnormal marrow eosinophils in acute myelomonocytic leukemia", N. Engl. J. Med. 309, 630-636.
3. Arthur, D.C. and Bloomfield, C.D. (1983) "Partial deletion of the long arm of chromosome 16 and bone marrow eosinophilia in acute non-lymphocytic leukemia, a new association", Blood 61, 994-998.
4. Campbell, L., Challis, J., Fok, T., et al. (1991) "Chromosome 16 abnormalities associated with myeloid malignancies", Genes Chromosomes Cancer 3, 55-61.
5. Liu, P., Tarlé, S.A., Hajra, A., et al. (1993) "Fusion between transcription factor CBFβ/PEBP2β and a myosin heavy chain in acute myeloid leukemia", Science 261, 1041-1044.
6. Lutterbach, B. and Hiebert, S.W. (2000) "Role of transcription factor AML-1 in acute leukemia and hematopoietic differentiation", Gene 245, 223-235.
7. Speck, N.A. and Stacy, T. (1995) "A new transcription factor family associated with human leukemias", Crit. Rev. Eukaryot. Gene Expr. 5, 337-364.
8. Tahirov, T.H., Inoue-Bungo, T., Morii, H., et al. (2001) "Structural analysis of DNA recognition by the AML1/Runx-1 runt domain and its allosteric control by CBFβ", Cell 104, 755-767.
9. Adya, N., Stacy, T., Speck, N.A., et al. (1998) "The leukemic protein core binding factorβ (CBFβ)-smooth-muscle myosin heavy chain sequesters CBFα2 into cytoskeletal filaments and aggregates", Mol. Cell Biol. 18(12), 7432-7443.
10. Shurtleff, S.A., Meyers, S., Hiebert, S.W., et al. (1995) "Heterogeneity in CBFβ/MYH11 fusion messages encoded by the inv(16)(p13q22) and the t(16;16)(p13q22) in acute myelogenous leukemia", Blood 85(12), 3695-3703.
11. van der Reijden, B.A., Lombardo, M., Dauwerse, D.H., et al. (1995) "RT-PCR diagnosis of patients with acute nonlymphocytic leukemia and inv(16)(p13q22) and identification of new alternative splicing in CBFβ-MYH11 transcripts", Blood 86(1), 277-282.
12. Liu, P.P., Hajra, A., Wijmenga, C., et al. (1995) "Molecular pathogenesis of the chromosome 16 inversion in the M4Eo subtype of acute myeloid leukemia", Blood 85(9), 2289-2302.
13. van der Reijden, M., Dauwerse, H.G., Giles, R.H., et al. (1999) "Genomic acute myeloid leukemia associated inv(16)(p13q22) breakpoints are tightly clustered", Oncogene 18, 543-550.
14. Wong, S. and Witte, O.N. (2001) "Modeling Philadelphia chromosome positive leukemias", Oncogene 20(40), 5644-5659.
15. Gallagher, R.E., Willman, C.L., Slack, J.L., et al. (1997) "Association of PML-RAR alpha fusion mRNA type with pretreatment hematologic characteristics but not treatment outcome in acute promyelocytic leukemia: an intergroup molecular study", Blood 90(4), 1656-1663.
16. Poirel, H., Radford-Weiss, I., Rack, K., et al. (1995) "Detection of the chromosome 16 CBFβ-MYH11 fusion transcript in myelomonocytic leukemias", Blood 85(5), 1313-1322.
17. Lichty, B.D., Keating, A., Callum, J., et al. (1998) "Expression of p210 and p190 BCR-ABL due to alternative splicing in chronic myelogenous leukaemia", Br. J. Haematol. 103(3), 711-715.
18. Lichty, B.D. and Kamel-Reid, S. (2000) "Exon-skipping in BCR/ABL is induced by ABL exon 2", Biochem. J. 348, 63-69.