Expression of p53, cyclin D1 and EGFR correlates with histological grade of adult soft tissue sarcomas: A study on tissue microarrays

Neoplasma

Volumn 56, Issue 3, 2009, Pages 239-244

  Vesely, K ^a   Jurajda, M ^b   Nenutil, R ^c   Vesela, M ^a  

^a ST ANNE S UNIVERSITY HOSPITAL   (Czech Republic)

^b MASARYK UNIVERSITY   (Czech Republic)

^c MASARYK MEMORIAL CANCER INSTITUTE   (Czech Republic)

Author keywords

Cyclin D1; EGFR; Histological grade; Immunohistochemistry; Ki 67; p53; Soft tissue sarcoma; Tissue microarrays

Indexed keywords

CYCLIN D1; EPIDERMAL GROWTH FACTOR RECEPTOR; FORMALDEHYDE; KI 67 ANTIGEN; NUCLEOSIDE DIPHOSPHATE KINASE NM23; PARAFFIN; PROTEIN MDM2; PROTEIN P16; PROTEIN P53; CCND1 PROTEIN, HUMAN; NME1 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LABELING INDEX; LIMB; MAJOR CLINICAL STUDY; MALE; NECROSIS; PROTEIN EXPRESSION; SOFT TISSUE SARCOMA; TISSUE MICROARRAY; TRUNK; ADOLESCENT; CHEMISTRY; METHODOLOGY; MIDDLE AGED; PATHOLOGY; SARCOMA;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CYCLIN D1; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NM23 NUCLEOSIDE DIPHOSPHATE KINASES; RECEPTOR, EPIDERMAL GROWTH FACTOR; SARCOMA; TISSUE ARRAY ANALYSIS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 85047684468     PISSN: 00282685     EISSN: None     Source Type: Journal    
DOI: 10.4149/neo_2009_03_239     Document Type: Article

References (32)

1. Fletcher CDM, Unni KK, Mertens F, eds. Pathology and Genetics of Tumours of Soft Tissue and Bone. World Health Organization Classification of Tumours; vol 5. Lyon, France: iaRc press; 2002.
2. Clark MA, Fisher C, Judson I et al. Soft-tissue sarcomas in adults. N Engl J Med. 2005; 353: 701-711 doi:10.1056/NEJMra041866
3. Kotilingam D, Lev DC, Lazar AJ et al. Staging soft tissue sarcoma: evolution and change. Ca Cancer J Clin. 2006; 56: 282-291 doi:10.3322/canjclin. 56.5.282 (Pubitemid 44527490)
4. Cormier JN, Pollock RE. Soft tissue sarcomas. Ca Cancer J clin. 2004; 54: 94-109. doi:10.3322/canjclin.54.2.94
5. Borden EC, Baker LH, Bell RS et al. Soft tissue sarcomas of adults: state of the translational science. Clin Cancer Res. 2003; 9: 1941-1956
6. Coindre JM, Terrier P, Guillou L et al. Predictive value of grade for metastasis development in the main histologic types of adult soft tissue sarcomas: a study of 1240 patients from the French Federation of Cancer Centers Sarcoma Group. Cancer. 2001; 91: 1914-1926. doi:10.1002/1097-0142(20010515)91:- 10〈1914::aiD-cncR1214〉3.0.co;2-3 (Pubitemid 32424119)
7. Brown FM, Fletcher CD. Problems in grading soft tissue sarcomas. Am J Clin Pathol. 2000; 114 suppl: s82-9.
8. Trojani M, Contesso G, Coindre JM et al. Soft tissue sarcomas of adults: study of pathological prognostic variables and definition of histopathological grading system. Int J Cancer. 1984; 33: 37-42. doi:10.1002/ijc.2910330108 (Pubitemid 14223231)
9. Costa J, Wesley RA, Glatstein E et al. The grading of soft tissue sarcomas. Results of a clinicohistopathologic correlation in a series of 163 cases. Cancer. 1984; 53: 530-541 doi:10.1002/1097-0142(19840201)53:3〈530:: AID-CNC- R2820530327〉3.0.CO;2-D
10. Coindre JM. Grading of soft tissue sarcomas: review and update. Arch Pathol Lab Med. 2006; 130: 1448-1453 (Pubitemid 44520711)
11. Guillou L, Coindre JM, Bonichon F et al. Comparative study of the National Cancer Institute and French Federation of Cancer Centers Sarcoma Group Grading Systems in a Population of 410 adult patients with soft tissue sarcoma. J Clin Oncol. 1997; 15: 350-362 (Pubitemid 27020593)
12. Yoo J, Park SY, Kang SJ et al. Altered expression of G1 regulatory proteins in human soft tissue sarcomas. Arch Pathol lab Med 2002; 126: 567-573 (Pubitemid 34477952)
13. Kim SH, Lewis JJ, Brennan MF et al. Overexpression of cyclin D1 is associated with poor prognosis in extremity soft-tissue sarcomas. Clin Cancer Res 1998; 4: 2377-2382
14. Kersting C, Packeisen J, Leidinger B et al. Pitfalls in immunohistochemical assessment of EGFR expression in soft tissue sarcomas. J Clin Pathol 2006; 59: 585-590 doi:10.1136/ jcp.2005.028373 (Pubitemid 43886041)
15. Hoos A, Stojadinovic A, Mastorides S et al. High Ki-67 proliferative index predicts disease specific survival in patiens with high-risk soft tissue sarcomas. Cancer 2001; 92:8 69-74. (Pubitemid 32783075)
16. Jensen V, Sřrensen FB, Bentzen SM et al. Proliferative activity (MIB-1 index) is an independent prognostic parameter in patients with high-grade soft tissue sarcomas of subtypes other than malignant fibrous histiocytomas: a retrospective immunohistological study including 216 soft tissue sarcomas. Histopathology 1998; 32: 536-546 (Pubitemid 28277554)
17. Ueda T, Aozasa K, Tsujimoto M et al. Prognostic significance of Ki-67 reactivity in soft tissue sarcomas. Cancer 1989; 63: 1607-1611 doi:10.1002/1097-0142(19890415)63:8〈1607::AIDCNCR2820630827〉 3.0.co;2-1 (Pubitemid 19093290)
18. Gerdes J, Lemke H, Baisch H et al. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 1984; 133: 1710-1715 (Pubitemid 14035254)
19. Wurl P, Meye A, Lautenschlager C et al. Clinical relevance of pRb and p53 co-overexpression in soft tissue sarcomas. Cancer Lett 1999; 139: 159-65. doi:10.1016/ S0304-3835(99)00034-38 (Pubitemid 29225115)
20. Nakanishi H, Ohsawa M, Naka N et al. Immunohistochemical detection of bcl-2 and p53 proteins and apoptosis in soft tissue sarcoma: their correlations with prognosis. Oncology. 1997; 54: 238-244 (Pubitemid 27160592)
21. Cordon-Cardo C, Latres E, Drobnjak M et al. Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas. Cancer Res 1994; 54: 794-799 (Pubitemid 24068339)
22. Zhang Y, Xiong Y, Yarbrough WG. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 1998; 92: 725-734 doi:10.1016/s0092-8674(00)81401-4 (Pubitemid 28155312)
23. Chin L, Pomerantz J, Depinho Ra. The INK4a/ARF tumor suppressor: one gene - two products - two pathways. Trends Biochem Sci 1998; 23:291-6. doi:10.1016/ S0968-0004(98)01236-1245 (Pubitemid 28461894)
24. Kratzke RA, Greatens TM, Rubins JB et al. Rb and p16INK4a expression in resected non-small cell lung tumors. Cancer Res 1996; 56: 3415-3420 (Pubitemid 26251629)
25. Orlow I, Drobnjak M, Zhang ZF et al. Alterations of INK4a and INK4B genes in adult soft tissue sarcomas: effect on survival. J Natl Cancer Inst 1999; 91: 73-79 doi:10.1093/ jnci/91.1.73 (Pubitemid 29042446)
26. Cordon-Cardo C. Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia. Am J pathol. 1995; 147: 545-560
27. Kim SH, Lewis JJ, Brennan MF et al. Overexpression of cyclin D1 is associated with poor prognosis in extremity soft-tissue sarcomas. Clin Cancer Res 1998; 4: 2377-2382
28. Royds JA, Robinson MH, Stephenson TJ et al. The association between nm23 gene expression and survival in patients with sarcomas. Br J Cancer 1997; 75: 1195-1200
29. D'Souza RJ, Sheikh ZA, Busund Lt et al. Expression of nm23 protein in adult soft tissue sarcoma is correlated with histological grade. Anticancer Res 2003; 23: 3289-3294 (Pubitemid 36975425)
30. Ranson M. Epidermal growth factor receptor tyrosine kinase inhibitors. Br J Cancer. 2004; 90: 2250-2255 (Pubitemid 38961885)
31. Beech D, Pollock RE, Tsan R et al. Epidermal growth factor receptor and insulin-like growth factor-I receptor expression and function in human soft-tissue sarcoma cells. Int J Oncol. 1998; 12: 329-336 (Pubitemid 28064857)
32. Sato O, Wada T, Kawai A et al. Expression of epidermal growth factor receptor, HER2/neu, and CD117/c-kit in adult soft tissue sarcomas: a clinicopathological study of 281 cases. Cancer 2005; 103: 1881-1890 doi:10.1002/cncr.20986 (Pubitemid 40563261)